Patents Assigned to SANDOZ
  • Patent number: 3991066
    Abstract: The invention concerns novel indenopyridine derivatives of the formula: ##SPC1##Wherein m is 1, 2, 3 or 4, andR.sub.3 is an --O--R.sub.4 group,Wherein R.sub.4 is alkyl of 1 to 5 carbon atoms, phenyl or phenylalkyl, wherein the alkyl radical is of 1 to 4 carbon atoms, or an ##EQU1## group, WHEREIN EACH OFR.sub.5 and R.sub.6 is, independently, hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or phenyl-alkyl, wherein the alkyl radical is of 1 to 4 carbon atoms, orR.sub.5 and R.sub.6 together with the nitrogen atom form a saturated 5- or 6-membered heterocyclic ring, the heterocycle being selected from heterocycles containing 1 nitrogen atom, 1 nitrogen atom and 1 oxygen atom, and 1 nitrogen atom and a further nitrogen atom substituted by an alkyl radical of 1 to 4 carbon atoms,Useful as anti-aggressives and in the treatment of excitation conditions.
    Type: Grant
    Filed: May 16, 1975
    Date of Patent: November 9, 1976
    Assignee: Sandoz Ltd.
    Inventors: Jean-Michel Bastian, Anton Ebnother, Erwin Rissi
  • Patent number: 3991102
    Abstract: 10-(2-substituted-aminoethyl)-10,11-dihydro-5-methyl-2 or 3, 7 or 8-substituted or unsubstituted-5H-dibenzo[a,d]cycloheptenes, e.g., 10-(2-dimethylaminoethyl)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepte ne, are prepared by hydrogenating a corresponding 10-(2-dimethyl-aminoethyl)-10,11-dihydro-5-methylene-2 or 3, 7 or 8-substituted or unsubstituted-5H-dibenzo[a,d]cycloheptenes and are useful as anti-depressants.
    Type: Grant
    Filed: April 22, 1974
    Date of Patent: November 9, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Patent number: 3989704
    Abstract: 3-Substituted-4-aryl isoquinolines, e.g. 3-tertiary butyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, prepared from corresponding isoquinoline intermediates, are useful as anti-diabetic agents.
    Type: Grant
    Filed: January 21, 1975
    Date of Patent: November 2, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Patent number: 3988346
    Abstract: Disclosed are optical brightening agents of formula I, ##SPC1##whereinR.sub.1 is hydrogen or chlorine,R.sub. 2 is hydrogen or methyl,R.sub.3 is hydrogen or C.sub.1.sub.-6 alkyl, andM is hydrogen or a non-chromophoric cation.
    Type: Grant
    Filed: June 12, 1975
    Date of Patent: October 26, 1976
    Assignee: Sandoz Ltd.
    Inventor: Horst Schmid
  • Patent number: 3987808
    Abstract: The invention concerns a novel automatic metering system for producing a liquor containing a predetermined concentration of at least one component thereof, which comprises a mixing tank in which the liquor components are mixed, a metering device adapted to meter out at least one of the components into the mixing tank, an analyzer adapted to measure the concentration of the component(s) required at a predetermined concentration and a data processing unit, with an input from the analyzer and an output to the metering device, being programmed to effect an operational cycle which comprises computing the deviation of the measured concentration from the predetermined concentration of the component(s), correlating the deviation with the amount of at least one of the components necessary to be metered out, substantially to reduce said deviation by a reduction factor of less than 100 percent, and automatically operating the metering device to meter out the correlated amount, and to repeat said operational cycle until
    Type: Grant
    Filed: January 7, 1975
    Date of Patent: October 26, 1976
    Assignee: Sandoz Ltd.
    Inventors: Jose Carbonell, Rolf Hasler, Roland Walliser
  • Patent number: 3988328
    Abstract: The present invention concerns novel 2-dialkylamino propane derivatives of the formula: ##EQU1## wherein either, R.sub.1 and R.sub.2 are each alkyl; R.sub.3 is hydrogen or alkyl; Q is --OM, wherein M is hydrogen or a cation, --OR.sub.4, wherein R.sub.4 is alkyl or unsubstituted or substituted phenyl or --NR.sub.5 R.sub.6, wherein R.sub.5 is hydrogen, alkyl or unsubstituted or substituted phenyl and R.sub.6, independently has one of the significances of R.sub.5 or is --NHR.sub.7, wherein R.sub.7 is hydrogen and n is an integer 1, 2 or 3, in free base or acid addition salt form.The compounds possess plant growth regulating and herbicidal properties and are accordingly useful in agriculture.
    Type: Grant
    Filed: August 20, 1974
    Date of Patent: October 26, 1976
    Assignee: Sandoz Ltd.
    Inventor: Rupert Schneider
  • Patent number: 3987097
    Abstract: The invention provides a process for increasing the affinity for anionic dyes of undyed water-insoluble high molecular weight organic compounds containing groups which can be alkylated, which process comprises reacting the high molecular weight compound with an ammonium salt of the formula: ##EQU1## in which X signifies chlorine or bromine.Y signifies a radical of formula --CH=CH-- or a phenylene radical which is unsubstituted or substituted by up to a total of 2 alkyl groups which may be methyl or ethyl,R.sub.1, r.sub.2 and R.sub.3, independently signify hydrocarbon radicals consisting of aromatic and/or saturated aliphatic units, orTwo of R.sub.1, R.sub.2 and R.sub.3 jointly with the N atom form a heterocyclic ring, which is selected from heterocyclic rings containing one nitrogen atom, two nitrogen atoms and one nitrogen atom and one oxygen atom, and the other signifies a hydrocarbon radical as defined above or a further bond when the ring is unsaturated,The total number of carbon atoms in R.sub.1, R.sub.
    Type: Grant
    Filed: April 26, 1974
    Date of Patent: October 19, 1976
    Assignee: Sandoz Ltd.
    Inventors: Max Matter, Giuseppe Raspanti, Hermann Ulshoefer
  • Patent number: 3987179
    Abstract: Substituted or unsubstituted isoxazolyl benzamides, e.g., o-(3-phenylisoxazol-5-yl)-N-methylbenzamide, are prepared by cyclizing a corresponding 1-hydroxy-1-[substituted or unsubstituted-.beta.-(hydroxyimino)phenethyl]-2-alkyl phthalimidine with a strong acid and are useful as minor tranquilizers, muscle relaxants, and sleep inducers.
    Type: Grant
    Filed: February 14, 1975
    Date of Patent: October 19, 1976
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 3987059
    Abstract: Highly branched .alpha.-substituted indoles, e.g., 2-(1-methylcyclohexyl)-indole, are prepared by treating N-(.alpha.-branched carbonyl) toluidines with alkyl lithium.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: October 19, 1976
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 3987231
    Abstract: The present invention concerns a novel method of antistatically treating synthetic, semi-synthetic or natural porous material, particularly fibrous material, which comprises applying thereto a polychlorohydrin ether of tris-(hydroxymethyl)-aminomethane and a polyglycol bis-epichlorohydrin in admixture and/or in partially condensed form, and curing the compound(s) on the material. The treatment is particularly resistant to washing.
    Type: Grant
    Filed: September 6, 1974
    Date of Patent: October 19, 1976
    Assignee: Sandoz Ltd.
    Inventor: Richard Hochreuter
  • Patent number: 3985883
    Abstract: The compounds are cyclic acetals of 4'-(.alpha.-hydroxy-.alpha.-pyridyl-p-tolyloxy)pivalophenones, and are useful as anti-obesity agents.
    Type: Grant
    Filed: March 28, 1975
    Date of Patent: October 12, 1976
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 3985799
    Abstract: 2,6-halo and trifluoromethyl-substituted-benzoic acids, e.g., 2,3,4,6-tetrafluorobenzoic acid or 2-chloro-6-trifluoromethylbenzoic acid, are prepared from substituted 2,4-halo and trifluoromethyl-substituted benzene compounds and are useful as plant growth regulators.
    Type: Grant
    Filed: August 20, 1973
    Date of Patent: October 12, 1976
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 3985729
    Abstract: Substituted 7,12-methano-dibenzazocines, e.g., 7,13-dihydro-6,12-dimethyl-7,12-methano-6H-dibenz[c,f]azocine, are prepared by cyclizing 3-benzylamino-alkyl-indan-1-ols and are useful as anti-inflammatory agents.
    Type: Grant
    Filed: December 23, 1974
    Date of Patent: October 12, 1976
    Assignee: Sandoz, Inc.
    Inventors: William H. Houlihan, Jeffrey Nadelson
  • Patent number: 3984556
    Abstract: The compounds are alkyl-substituted-tricyclic quinazolinones of the class of imidazo[2,1-b]quinazolin-5-ones and pyrimido[2,1-b]quinazolin-6-one, e.g., 2-methyl-2,3-dihydro-10-(4'-fluorobenzyl)-imidazo[2,1-b]quinazolin-5(10H)- one, useful, for example, as bronchodilator agents. Processes for preparation of said compounds include the reaction of a N-carboxy anthranilic anhydride (an isatoic anhydride) with an alkyl substituted cyclic pseudothiourea such as a 2-organomercapto-4,5-dihydroimidazole or a 2-organomercapto-3,4,5,6-tetrahydropyrimidine and the cyclization of a 2-(.omega.-hydroxy(branched)alkylamino)-4-quinazolone.
    Type: Grant
    Filed: May 19, 1975
    Date of Patent: October 5, 1976
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 3983234
    Abstract: Clozapine is useful in the treatment of dyskinesias.
    Type: Grant
    Filed: June 25, 1975
    Date of Patent: September 28, 1976
    Assignee: Sandoz Ltd.
    Inventor: Anthony Campbell Sayers
  • Patent number: 3983242
    Abstract: 3-Alkylsulfinyl-2-indolinones, of the formula ##SPC1##E.g., 3-methylsulfinyl-5-trifluoromethyl-2-indolinone, are useful as minor tranquillizers, muscle relaxants and sedative-hypnotics and are obtainable by oxidizing corresponding 3-alkylthio-2-indolinones.
    Type: Grant
    Filed: September 8, 1975
    Date of Patent: September 28, 1976
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Thomas E. Jackson
  • Patent number: 3982007
    Abstract: The invention provides synergistic compositions comprising a benzisothiazolinone derivative and a 2-nitrofuryl or 2-nitrothienyl derivative. The compositions are useful as antimicrobial agents.
    Type: Grant
    Filed: February 6, 1975
    Date of Patent: September 21, 1976
    Assignee: Sandoz Ltd.
    Inventors: Georg Laber, Eberhard Schutze
  • Patent number: 3981858
    Abstract: Azo dyes bearing at least one sulphonic acid group and of formula I, ##SPC1##in whichR signifies an alkyl radical of 6 to 18 carbon atoms or a cyclohexyl radical,R.sub.1 signifies hydrogen, halogen, alkyl, or --SO.sub.3 H,R.sub.2 signifies hydrogen, halogen or alkyl, andn signifies 0, 1 or 2,Which compounds, in free acid or salt form, dye textiles, paper and leather. The dyeings have good light fastness, especially on polyamides and basic dyeable polypropylene, and good fastness to wet treatments, rubbing, gas fumes and dry cleaning. The dyes have good build-up power, are well-soluble in hot and cold water and reserve polyesters and polyacrylonitrile.
    Type: Grant
    Filed: January 15, 1973
    Date of Patent: September 21, 1976
    Assignee: Sandoz Ltd.
    Inventors: Roland Mislin, Hanspeter Uehlinger
  • Patent number: 3982020
    Abstract: Substituted benzylidene hydrazines e.g. N-(4-phenylbenzylidene)-N'-amidino hydrazine and their use as hypoglycemic-antihyperglycemic agents, anti-obesity agents and anti-inflammatory agents.
    Type: Grant
    Filed: September 5, 1972
    Date of Patent: September 21, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Robert E. Manning
  • Patent number: 3982001
    Abstract: This invention provides new compounds of formula I, ##SPC1##wherein R.sub.1 and R.sub.2 are the same or different and are in each case hydrogen, halogen, lower alkyl, hydroxy or lower alkoxy R.sub.3 is hydrogen or lower acyl and A stands for groups of formula ##EQU1## wherein R.sub.5 and R.sub.6 are independently, hydrogen or methyl and n is 0, 1 or 2, useful as analgesic agents.
    Type: Grant
    Filed: September 19, 1974
    Date of Patent: September 21, 1976
    Assignee: Sandoz, Inc.
    Inventors: Wilhelm Heffe, Fritz Hunziker, Klaus Thoma