Abstract: Disclosed are anionic optical brightening agents, such agents being 1,3-diphenyl pyrazolines characterized by having, in the 4- or 5-position of the pyrazoline ring, a sulphoalkyl substituent, their production and use.

Abstract: The compounds are 13-(lower)alkyl-9.alpha.-methyl-17.alpha.-propadienylgona-4-en-17.beta.-ol -3-ones and derivatives thereof, e.g. 9.alpha.-methyl-17.alpha.-propadienylestra-17.beta.-ol-3-one, and are useful as progestational agents.

Abstract: 1-dioxolanylpropyl-3-indoleacrylic acid esters, e.g., 1-[3-(2-methyl-2-dioxolanyl)propyl]-3-indoleacrylic acid ethyl ester, are prepared by reacting a corresponding 1-dioxolanylpropyl-3-indolecarboxaldehyde with carbalkoxymethylene triphenylphosphorane and are useful as hypolipidemic agents.

Abstract: Disclosed are compounds of the class of 1-alkyl-4-phenyl and 4-(2-thienyl)-6,7-methylenedioxy-2(1H)-quinazolinones and quinazolinthiones, including the 3,4-dihydro derivatives thereof, useful as pharmaceutical agents, e.g. as anti-inflammatory agents. Such compounds, e.g. 1-isopropyl-4-phenyl-6,7-methylenedioxy-2(1H)-quinazolinones and 1-isopropyl-4-phenyl-6,7-methylenedioxy-2(1H)-quinazolinthiones, may be prepared by reacting the corresponding N-alkyl-N-(3,4-methylenedioxyphenyl)urea or thiourea with an aromatic aldehyde, e.g. benzaldehyde, in the presence of an acid at elevated temperatures to obtain the 3,4-dihydro-2(1H)-quinazolinones or 3,4-dihydro-2(1H)-quinazolinthiones which may then be oxidized to the corresponding 3,4-unsaturated compounds.

Abstract: Compounds of the formula ##STR1## wherein each R.sub.1 is alkyl of 1 to 3 carbon atoms, andA is phenylene, substituted phenylene, diphenylene, substituted diphenylene or naphthylene, wherein each substituent of substituted phenylene is independently fluoro, chloro, bromo, methyl, methoxy, ethoxy, trifluoromethyl or cyano and each substituent of substituted diphenylene is independently chloro, bromo, methyl or methoxy,With the proviso the two CO--O--R.sub.1 groups on each ring are meta or para to each other. These compounds are eminently suitable as pigments for the mass pigmentation of synthetic polymers and resins such as polyethylene, polystyrene, polyvinyl chloride, poromerics and rubber latices.

Abstract: Hypolipidemic agents of the formula: ##SPC1##WhereinR is hydrogen, alkyl or halo,R' and R" are hydrogen, halo, alkyl or alkoxy, andn is 1 or 2.

Abstract: Compounds of the formula I: ##SPC1##whereinR.degree. is lower alkyl,n is 0, 1 or 2,R is lower alkyl,R' is a radical of the formula ##SPC2##In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula ##SPC3##In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms,Are prepared by cyclizing a compound of formula II ##SPC4##in which R, R', R.degree. and n are as defined above, with phosgene, or,Where R is not a tertiary alkyl group in which the tertiary carbon atom is directly attached to the ring nitrogen atom, with a C.sub.1 -C.sub.2 alkyl chlorocarbonate or 1,1'carbonyldiimidazole. The compounds of formula I possess pharmaceutical activity in animals.

Abstract: Monobenzoxazolylstilbenes of formula ##STR1## wherein R--O is lower alkoxy and stands in one of the positions 5 or 6,R.sub.1 is hydrogen or lower alkyl andR.sub.2 is hydrogen, chlorine or lower alkyl.

Abstract: The invention discloses optionally substituted 3-methylsulfinyl indazoles having pharmacological activity in animals and useful as sleep-inducing agents. The compounds may be prepared by diazotization of an optionally substituted .alpha.-methylsulfinyl-o-toluidine.

Abstract: Acyl substituted phenyl alkanoic acids, e.g. p-pivaloyl phenyl acetic acid, are prepared by hydrolyzing p-pivaloyl phenyl acetonitriles and are useful as hypolipidemic agents.

Abstract: N-(3-chloro-4-methoxyphenyl)-N',N'-dimethylurea of the formula: ##SPC1##Is disclosed as possessing a surprising selective herbicidal activity. A method is disclosed for selectively combating weeds in a cereal locus and in particular a barley locus, which comprises applying to the locus to be protected from weeds, a dosage of from 2 to 10 kilograms per hectare of the above compound.

Abstract: 10-(2-substituted-aminoethyl)-10,11-dihydro-5-methylene-2 or 3 7 or 8-substituted or unsubstituted-5H-dibenzo[a,d]cycloheptenes e.g., 10-(2-dimethylaminoethyl)-10,11-dihydro-5-methylene-5H-dibenzo[a,d]cyclohe ptane, prepared by various methods including acid dehydration of the corresponding dibenzo[a,d]cycloheptene-5-ols. The compounds are useful as anti-depressants.

Abstract: Substituted isoxazolyl benzamides, e.g., o-(3-trifluoromethyl-5-isoxazolyl)-N-methylbenzamide, are prepared by cyclizing a corresponding 1-hydroxy-1-[(2-hydroxyimino)-3-trifluoropropyl]-2-alkyl phthalimidine with a strong acid and are useful as minor tranquilizers and sleep inducers.

Abstract: Disclosed are the compounds of the following formula I, their production and use as pigments, particularly their use in pigmenting paper, plastics and as pigments in surface coating media, ##SPC1##In which eitherR.sub.1 and R.sub.1 ', independently, signify a hydrogen or halogen atom or a nitro, cyano, methyl, alkoxy, aminocarbonyl, alkylcarbonylamino, benzoylamino, phenylamino-carbonyl, alkylamino or phenylamino radical,Or R.sub.1 and R.sub.1 ', together, signify a radical of formula a, ##SPC2##In which R.sub.5 signifies a hydrogen atom or a nitro group,R.sub.6 signifies a hydrogen or halogen atom, andR.sub.7 signifies an unsubstituted amino radical or an amino radical substituted by alkyl, phenyl, benzoyl or anthraquinonyl,Or R.sub.1 and R.sub.1 ', together, signify a radical of formula b, ##SPC3##R.sub.2, r.sub.2 ' and R.sub.3, independently, signify a hydrogen or halogen atom,n signifies 1 or 2,R.sub.

Abstract: Anti-inflammatory and analgesic agents of the formula I: ##SPC1##whereinR.degree. is lower alkyl,N IS 0, 1 OR 2,R is lower alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or phenyl,R' is a radical of the formula ##SPC2##In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula ##SPC3##In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms,Are prepared by cyclizing a compound of formula II: ##SPC4##in which R, R', R" and n are as defined above, with, for example, phosgene.

Abstract: Benzocycloheptaoxazolones are prepared by a multi-step process starting with a lower alkyl ester of a 3-oxo-5-phenylvaleric acid. The compounds are useful as anti-inflammatories and as intermediates in the preparation of pharmaceutically useful compounds.

Abstract: The invention discloses compounds of the class of 5-substituted-5H-dibenzo[a,d]cycloheptenes which are 5-hydrazinoalkyl- or 5-aminoalkyl-5H-dibenzo[a,d]cyclohepten-5-ols, or their 10,11-dihydro derivatives. The compounds are pharmaceutically active and useful, for example, as anti-convulsants and tranquilizers. A key intermediate are compounds which are a spiro[5H-dibenzo[a,d]cyclohepten-5-oxazolin-2-one] which are subjected to alkaline hydrolysis to obtain the compounds of the invention.

Abstract: 2-amino-5-(substituted or unsubstituted phenylalkyl)-thiadiazoles, e.g., 2-amino-5-(4-[phenylbutyl])-thiadiazole, prepared, e.g., by ring closure, of corresponding 1-(substituted or unsubstituted phenylalkanoyl)-thiosemicarbazide in a strong acid medium. The compounds are useful as minor tranquilizers and sedative hypnotics.

Abstract: Substituted 1,2-dihydrobenz[f]isoquinolines, e.g., 4-(p-chlorophenyl)-1,2-dihydrobenz[f]isoquinoline, are prepared by cyclizing N-substituted-.alpha.-naphthylethylamines and are useful as non-estrogenic antifertility agents.

Abstract: Disclosed herein is a patient ventilator apparatus having a pneumatic control system operable in three different modes wherein the apparatus assists the breathing of the patient, controls the patient's breathing in a timed manner, or operates in a combination assist/control mode according to certain predetermined conditions. Fluidic circuitry controls a valved bellows apparatus, which in turn supplies air to a patient subject to limitations of time, volume, and pressure, wherein the gas supplied to the bellows comprises an adjustable oxygen/air mixture. Fluidic timers are provided for use in the control mode of the circuitry, and identical fluidic circuitry combinations are provided for use in the assist mode to automatically trigger the ventilator apparatus into an inspiratory state according to the patient's breathing requirements and to trigger such apparatus into an exhalation state when a predetermined inspiratory pressure is attained.