Abstract: A method and related microfluidic chip and kit for high throughput detection of proteins of interest contained in a sample is disclosed. The method comprises of specifically labeling fusion proteins in a complex sample with fusion tag specific fluorophores that specifically bind the fusion tags coupled to the proteins of interest, and subjecting the sample to automated capillary electrophoresis, wherein the presence of the proteins of interest in the sample is detected by fluorescence signals associated with the fusion tag specific fluorophores.
Type:
Grant
Filed:
November 6, 2013
Date of Patent:
January 3, 2017
Assignee:
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
Inventors:
Justin Saul, Ji Qiu, Joshua LaBaer, Mitch Magee, John Chaput, Sujay Sau
Abstract: Reconfigurable power systems and converters and operating methods therefor are disclosed. Reconfigurable power systems may include a DC power source, an electrical energy storage device, an AC power grid connection, and a power converter configured to selectively couple two or more of the DC power source, the electrical energy storage device, and the AC power grid connection.
Type:
Grant
Filed:
March 29, 2012
Date of Patent:
January 3, 2017
Assignees:
North Carolina State University, ABB Research Ltd.
Abstract: This application discloses a new family of inorganic-organic hybrid semiconductor bulk materials built on periodic nanostructured 2D layers of ZnS that emit bright white light with high quantum efficiency. These ZnS-based crystalline inorganic-organic hybrid semiconductors have well defined and precisely controllable crystal structure and composition. Their optical emission properties, including intensity, quantum yield, and color quality, can be systematically tuned by varying the composition of both inorganic and organic components. Methods for preparing these materials, use of these materials as a new type of single-phased white light emitting phosphors, and their applications in making WLED devices are also disclosed.
Type:
Grant
Filed:
August 19, 2012
Date of Patent:
January 3, 2017
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Abstract: Functionalized titanium nanotubes can be utilized to detect compounds of interest, for example peroxide-based explosives. The nanotubes may desirably be coated, for example with a silicon oxynitride coating, in order to improve detection performance and/or functionality in the presence of moisture, saline, or other conditions typically unfavorable to titanium nanotube detection devices and methods. Inexpensive, compact, reusable, and responsive sensors may be fabricated from the coated nanotubes.
Type:
Grant
Filed:
November 26, 2013
Date of Patent:
January 3, 2017
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: Benzofuran compound, composition thereof, kit thereof, and/or method thereof. A benzofuran-2-carboxamide moiety may be N-arylated and/or N-alkylated, and the resulting benzofuran compound may be a sigma receptor ligand that binds to, e.g., a ?1 receptor and/or a ?2 receptor with relatively high affinity and/or selectivity. For example, the benzofuran compound may be 5,6-dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide, 3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide, or 6-methoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide. The composition may include the benzofuran compound and a pharmaceutically acceptable carrier.
Abstract: A plastication unit for an injection molding machine, combining a heated plastication barrel with an entrance port and an exit port on opposing ends of the barrel; a hopper positioned to deliver ingredients to be compounded for injection molding to the entrance port of the barrel; and a helical plastication screw rotatably carried within the barrel and running the length of the barrel between the entrance and exit ports, which is operable to rotate and transmit the ingredients along the length of the barrel; wherein the plastication screw has at least one axial fluted extensional mixing element segment and the ingredients include at least one polymer for injection molding. Methods for injection molding with the plastication unit of the present invention and articles formed by the inventive methods are also disclosed.
Type:
Grant
Filed:
April 23, 2012
Date of Patent:
January 3, 2017
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Inventors:
Thomas Nosker, Jennifer Lynch, Keith Luker
Abstract: A cranial cap dressing for dressing a craniotomy wound comprising a breathable elastic outer layer sized to fit snuggly on a human head of a patient and an absorbent inner layer attached to the breathable elastic outer layer.
Type:
Application
Filed:
June 24, 2016
Publication date:
December 29, 2016
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: Unique methods and systems are introduced herein for the determination of unique spatial light modulator based optical signatures of intrinsic and extrinsic scattering surface markers. These techniques can be used to authenticate semiconductor components and systems at various stages during the manufacturing process by measuring and cross correlating the surface marker's unique optical signature. In addition, these techniques can be used with extrinsic surface markers which are added to existing hardware (e.g. containers, locks, doors, etc.). These markers can then be measured for their unique optical signatures, which can be stored and used at a later time for cross-correlation to authenticate the surface marker and verify the hardware's provenance.
Type:
Application
Filed:
June 24, 2016
Publication date:
December 29, 2016
Applicant:
Washington State University
Inventors:
Hergen Eilers, Benjamin Richard Anderson, Ray Gunawidjaja, Patrick David Price
Abstract: A hybrid fastener is provided in combination with a structural insert. The insert is disposed about a shank of the fastener at an unthreaded section. In another aspect, a sleeve surrounds the shank of the fastener and has apertures for receiving the insert therethrough. Methods of using the above-described hybrid fastener for securing workpieces are also disclosed.
Type:
Application
Filed:
September 7, 2016
Publication date:
December 29, 2016
Applicant:
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
Abstract: Disclosed herein are formulations for the local delivery of therapeutically effective doses of curcumin that provide sufficient serum levels of curcumin to treat diseases such as head and neck disorders and upper aerodigestive disorders.
Type:
Application
Filed:
September 8, 2016
Publication date:
December 29, 2016
Applicant:
THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY & AGRICULTURAL & MECHANICAL COLLEGE
Abstract: This invention relates to a novel turbine design that increases turbine efficiency whereby turbine blades experience cyclic pitch variations while rotating about the blade axis which is accomplished by means of a concentric end cam double follower mechanism. This mechanism rotates the blades by 90 degrees about a horizontal axis which allows the blades rotating upstream and downstream to be oriented horizontally and vertically so minimum drag and maximum drag are obtained respectively. Since the aiding downstream drag is at a maximum, and the adverse upstream drag is at a minimum, this configuration allows for higher power output compared to conventional vertical axis wind turbines.
Type:
Application
Filed:
June 20, 2016
Publication date:
December 29, 2016
Applicant:
Rutgers, The State University of New Jersey
Inventors:
Jubilee Prasad Rao, Francisco Javier Diez-Garias
Abstract: Provided herein are methods and compositions for the diagnosis, prognosis and treatment of a cancer associated disorders using the Fhit gene.
Abstract: A region of the TRPV1 protein that functions as a temperature switch (FIG. 1) has been identified, and can be expressed, purified and applied in combination with other proteins. The function of the switch is maintained even when the region or domain is isolated from the entire protein. As the protein domain is a temperature switch, it can be used to control other proteins and signaling pathways in vitro and in vivo; and TRPV1 is a therapeutic target that is being pursued primarily for intervention in pain (neuropathic and inflammatory) and cancer.
Type:
Application
Filed:
June 24, 2016
Publication date:
December 29, 2016
Applicant:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Abstract: This application concerns systems and methods for compressing natural gas with an internal combustion engine. In a representative embodiment, a method is featured which includes placing a first cylinder of an internal combustion engine in a compressor mode, and compressing a gas within the first cylinder, using the cylinder as a reciprocating compressor. In some embodiments a compression check valve system is used to regulate pressure and flow within cylinders of the engine during a compression process.
Abstract: In exemplary embodiments, the invention provides Pseudomonas fluorescens 2-79 strains having pyrrolnitrin biosynthetic genes for biocontrol of soilborne diseases.
Type:
Grant
Filed:
March 13, 2014
Date of Patent:
December 27, 2016
Assignees:
The United States of America, as represented by The Secretary of Agriculture, Washington State University
Inventors:
David M Weller, Linda S Thomashow, Dmitri V Mavrodi, Mingming Yang, Jibin Zhang
Abstract: A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
Type:
Grant
Filed:
May 2, 2013
Date of Patent:
December 27, 2016
Assignees:
The Board of Regents of the University of Texas System, The Ohio State University Research Foundation
Inventors:
Mauro Ferrari, Xuewu Liu, Alessandro Grattoni, Daniel Fine, Randy Goodall, Sharath Hosali, Ryan Medema, Lee Hudson
Abstract: A system and method for designing a helmet to reduce mild traumatic brain injury sustained by a user during primary or secondary head impact include modeling a helmeted head including a head, brain, and helmet using a finite element computer model, the finite element computer model including material properties for the head, brain structures, and helmet and estimating at least intracranial pressure, brain strain and strain rate in response to an impact; and selecting at least one of a helmet cushion material and helmet shell material to limit at least one of intracranial pressure, brain strain and strain rate to a corresponding threshold for an associated impact.
Type:
Grant
Filed:
December 7, 2011
Date of Patent:
December 27, 2016
Assignee:
Wayne State University
Inventors:
Liying Zhang, King Hay Yang, Albert I King
Abstract: The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 ?m, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents and their methods of preparation. The said gel is formed by reaction of the PAMAM dendrimer with asymmetrical end groups with other polymer wherein the other polymer is selected from the group of linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms.
Type:
Grant
Filed:
March 31, 2011
Date of Patent:
December 27, 2016
Assignees:
Wayne State University, National Institutes of Health
Abstract: Provided are compositions and methods for potentiating the effect of antibiotics. The compositions comprise a non-covalent complex of alpha-lactalbumin and fatty acid. The fatty acids are cis, unsaturated, C14 to C20 fatty acids. The complex and antibiotic can be administered to an individual together or separately. The antibiotic may be one to which resistance has developed.
Type:
Grant
Filed:
July 5, 2013
Date of Patent:
December 27, 2016
Assignee:
The Research Foundation for The State University of New York
Inventors:
Anders P. Hakansson, Laura R. Marks, Hazeline Hakansson
Abstract: An automatic facial action coding system and method can include processing an image to identify a face in the image, to detect and align one or more facial features shown in the image, and to define one or more windows on the image. One or more distributions of pixels and color intensities can be quantified in each of the one or more windows to derive one or more two-dimensional intensity distributions of one or more colors within the window. The one or more two-dimensional intensity distributions can be processed to select image features appearing in the one or more windows and to classify one or more predefined facial actions on the face in the image. A facial action code score that includes a value indicating a relative amount of the predefined facial action occurring in the face in the image can be determined for the face in the image for each of the one or more predefined facial actions.
Type:
Grant
Filed:
June 23, 2014
Date of Patent:
December 27, 2016
Assignees:
The Regents Of The University Of California, The Research Foundation of State University of New York
Inventors:
Marian Stewart Bartlett, Gwen Littlewort-Ford, Javier Movellan, Ian Fasel, Mark Frank