Abstract: Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials, dental bonding agents or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capability. Such dental restorative materials may help reduce the level of dental caries in patients, particularly the level of caries occurring on the margins of the restorative materials.
Type:
Grant
Filed:
May 30, 2012
Date of Patent:
December 3, 2013
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: The present invention provides devices for generating scalable patterned features on a substrate. In some embodiments, the device includes a means for forming and ejecting a succession of droplets, a charge tunnel, a quadrupole mechanism, a means for reducing the size of one or more of the droplets and one or more stream deflectors.
Type:
Application
Filed:
August 6, 2013
Publication date:
November 28, 2013
Applicant:
North Carolina Agricultural and Technical State University
Abstract: Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an active compound as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an active compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or plant defense activator.
Type:
Application
Filed:
July 19, 2013
Publication date:
November 28, 2013
Applicant:
North Carolina State University
Inventors:
Christian Melander, John Cavanagh, David F. Ritchie, Steven A. Rogers, Robert W. Huigens, III, Catherine S. Reed
Abstract: Provided are methods for decreasing carbon flow into lignin in plants, comprising reducing or eliminating, using mutagenesis and/or recombinant means, expression and/or activity of at least one chloroplast-localized arogenate dehydratase (ADT) sufficient to reduce phenylalanine (Phe) availability for metabolism into Phe-derived phenylpropanoids, wherein the amount, level or distribution of lignin is reduced relative to control plants. In particular aspects, the plant has a plurality of chloroplast-localized ADTs, and reducing or eliminating comprises reducing or eliminating expression and/or activity of at least two of the plurality of ADTs. Also provided are recombinant plants or parts or cells thereof, comprising at least one mutation, genetic alteration or transgene that reduces or eliminates the expression and/or activity of at least one chloroplast-localized ADT, wherein the amount, level or distribution of lignin is reduced relative to normal. Further provided are reduced lignin plant products.
Type:
Application
Filed:
November 9, 2011
Publication date:
November 28, 2013
Applicant:
Washington State University
Inventors:
Norman G. Lewis, Laurence B. Davin, Oliver R.A. Corea, Sung-Jin Kim
Abstract: Systems and methods for screening whether a candidate compound inhibits delta-6 desaturase activity are disclosed. Also disclosed is a transgenic mammal which overexpresses a gene encoding delta-6 desaturase and an animal model of a cardiometabolic disorder or disease that includes the transgenic mammal. A method of treating a cardiometabolic disorder or disease is also disclosed.
Type:
Application
Filed:
May 24, 2013
Publication date:
November 28, 2013
Applicant:
Colorado State University Research Foundation
Abstract: Malignant tumors that are intrinsically resistant to conventional therapies are significant therapeutic challenges. An embodiment of the present invention provides an oncolytic virus capable of killing target cells, such as a tumor cells. In various embodiments presented herein, the oncolytic virus is armed or encodes a therapeutic polypeptide. In at least one embodiment, a recombinant oncolytic virus has been generated that can specifically replicate in cancer cells leading to their destruction and at the same time secrete robust amounts of a therapeutic polypeptide. Compositions and methods disclosed herein have broad therapeutic applicability.
Type:
Application
Filed:
May 28, 2013
Publication date:
November 28, 2013
Applicant:
The Ohio State University Research Foundation
Inventor:
The Ohio State University Research Foundation
Abstract: Described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a targeting agent. The composition can include a therapeutic agent. The therapeutic agent can be an antisense oligonucleotide (ASO). Exemplary ASOs are targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1; or targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Also described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a therapeutic agent that is an ASO such as an ASO targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1 or an ASO targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Pharmaceutical formulations, methods of making the lipid nanoparticles, and methods of using the lipid nanoparticles, for example for treating cancers, are also disclosed.
Type:
Application
Filed:
May 23, 2013
Publication date:
November 28, 2013
Applicant:
The Ohio State University
Inventors:
Robert J. Lee, Young Bok Lee, Deog Joong Kim, Chang Ho Ahn
Abstract: High-quality bimetallic PtxCu100-x (x=54-80 at. %) nanocubes can be prepared from a hot organic solution. Synthetic conditions, such as the ratio of oleylamine/tetraoctylammonium bromide as well as the doses of 1-dodecanethiol and 1,2-tetradecanediol have been optimized to ensure a formation of Pt—Cu nanocubes. Electrochemical evaluation shows that the catalytic activity of Pt60Cu40 nanocubes for methanol oxidation is superior, in comparison with those of spherical Pt60Cu40 nanocubes and Pt nanocubes with similar sizes, implying that the {100}-terminated Pt60Cu40 nanocubes offer a higher activity for methanol oxidation reaction than those with mixed crystallographic facets do.
Type:
Grant
Filed:
November 23, 2010
Date of Patent:
November 26, 2013
Assignee:
The Research Foundation for the State University of New York
Abstract: A method and apparatus for producing an arbitrary broadband waveform includes generating a first narrowband waveform and generating a frequency-shifted replica by frequency shifting the first narrowband waveform by a frequency shift. A second narrowband waveform is also generated. A broadband waveform is generated by combining the frequency-shifted replica and the second narrowband waveform.
Type:
Grant
Filed:
June 6, 2011
Date of Patent:
November 26, 2013
Assignee:
Montana State University
Inventors:
Charles W. Thiel, Peter B. Sellin, Kristian D. Merkel
Abstract: Disclosed herein are methods and compositions comprising fingolimod and anti-CD74 antibodies or fragments thereof. In preferred embodiments, the fingolimod increases the expression of CD74 in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 antibodies. The compositions and methods are of use to treat diseases involving CD74+ cells, such as cancer cells, autoimmune disease cells or immune dysfunction disease cells.
Type:
Grant
Filed:
July 18, 2012
Date of Patent:
November 26, 2013
Assignees:
The Ohio State University, Immunomedics, Inc.
Inventors:
Lapo Alinari, Robert A. Baiocchi, Natarajan Muthusamy, Hans J. Hansen, David M. Goldenberg
Abstract: A method of recovering two data columns in a row diagonal parity redundant array comprising at least four data columns and two parity columns, comprising: (1) calculating as an accelerator row, a missing chain parity based on available data columns and the two parity columns; (2) defining a recoverable data cell in each of the two columns to be recovered; and (3) iteratively calculating a value for each recoverable data cell based on the available columns, parity information, previously recovered data cells, and the accelerator row and storing the calculated value in the data matrix.
Type:
Grant
Filed:
July 14, 2011
Date of Patent:
November 26, 2013
Assignee:
The Research Foundation of State University of New York
Abstract: Methods of applying dicyclopropene compounds and compositions thereof to block ethylene receptors in plants are disclosed. Methods include applying to the plant an effective ethylene response-inhibiting amount of a dicyclopropene compound or composition thereof. Dicyclopropene compounds, enantiomers, stereoisomers or salts thereof are also provided.
Abstract: Compounds according to formula (I) are disclosed where Q is S, N, or O; X is optional, and can be O?, S?, ?N—NH2, ?N—OH, or —OH; Y is optional and can be —N(H)—, O, or C1 to C20 hydrocarbon; and R1 and R2 are each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
Type:
Grant
Filed:
June 16, 2009
Date of Patent:
November 26, 2013
Assignees:
University of Tennessee Research Foundation, The Ohio State University Research Foundation
Inventors:
Duane D. Miller, Wei Li, Zhao Wang, Yan Lu, Jianjun Chen, James T. Dalton, Chien-Ming Li
Abstract: A high sensitivity desorption electrospray ionization mass spectrometry system that employs a heated platform, along with means for directing a liquid stream containing an analyte of interest onto a target location on the heated platform to heat the stream, an electrospray emitter for generating an electrospray and directing the electrospray at the target location on the heated platform to produce an ionized, desorbed analyte, and a mass spectrometer for receiving and detecting the ionized, desorbed analyte.
Abstract: Embodiments of embedded MEMS sensors and related methods are described herein. Other embodiments and related methods are also disclosed herein.
Type:
Grant
Filed:
June 14, 2012
Date of Patent:
November 26, 2013
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on behalf of Arizona State University
Inventors:
Narendra V. Lakamraju, Sameer M. Venugopal
Abstract: An apparatus and method for non-surgically creating a restriction in a tissue is provided where a binding mechanism (36) is inserted into the issue. This invention also relates to an apparatus for creating a stoma of variable and reproducible size in a hollow organ.
Type:
Grant
Filed:
February 6, 2008
Date of Patent:
November 26, 2013
Assignee:
The Ohio State University Research Foundation
Inventors:
Bradley J. Needleman, Jeffrey W. Hazey, Richard Peters
Abstract: The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating ultrasound waves, such as ultrasonic emitters, transducers or piezoelectric transducers, composite transducers, CMUTs, and which may be provided as single or multiple transducers or in an array configurations. The ultrasound waves may be of any shape, and may be focused or unfocused.
Type:
Grant
Filed:
July 14, 2009
Date of Patent:
November 26, 2013
Assignee:
Arizona Board of Regents for and on Behalf of Arizona State University
Abstract: A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named ‘Seleno-Orange’ is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the ‘Seleno-Orange’ cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The ‘Seleno-Orange’ cultivar has yellow flowers, mature green cladodes without glochids, and orange fruit.
Type:
Grant
Filed:
March 21, 2012
Date of Patent:
November 26, 2013
Assignees:
California State University, Fresno, Red Rock Ranch, LLC, USDA
Inventors:
Gary Banuelos, John Leonard Freeman, John Diener
Abstract: A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named ‘Seleno-Green,’ is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the ‘Seleno-Green’ cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The ‘Seleno-Green’ cultivar has yellow-orange flowers, mature green cladodes without glochids, and yellow-green fruit.
Type:
Grant
Filed:
March 21, 2012
Date of Patent:
December 3, 2013
Assignees:
California State University, Fresno, Red Roche Ranch, LLC, USDA
Inventors:
Gary Banuelos, John Diener, John Leonard Freeman