Patents Assigned to State University
  • PHOTOUNCAGING-ASSISTED EVALUATION OF LARGE-SCALE SYNAPTIC REORGANIZATION OF BRAIN CIRCUITS
    Publication number: 20130309709
    Abstract: Photouncaging-assisted evaluation of large-scale synaptic reorganization of brain circuits and methods in use thereof. The current invention utilizes laser-scanning photostimulation in large-scale and with higher accuracy to detect synaptic reorganization in neurological disorders, such as Alzheimer's disease, Parkinson's disease and epilepsy. Using the invention's methodology, disease and non-disease conditions can be determined, and treatments can be personalized and administered more efficiently.
    Type: Application
    Filed: May 2, 2013
    Publication date: November 21, 2013
    Applicant: The Florida State University Research Foundation, Inc.
    Inventor: The Florida State University Research Foundation, Inc.
  • QUINOLINE DERIVATIVES AND USES THEREOF
    Publication number: 20130310348
    Abstract: This disclosure provides a new class of compounds referred to as “reversed chloroquines” (RCQs), which are highly effective against CQR and CQS malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQR reversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQR or CQS Plasmodium sp. (such as P. falciparum).
    Type: Application
    Filed: July 25, 2013
    Publication date: November 21, 2013
    Applicants: State University
    Inventors: David H. Peyton, Steven Burgess
  • Methods for Improving Liver Function
    Publication number: 20130309202
    Abstract: The present invention provides methods to improve liver function utilizing tocotrienols. In particular, various liver pathologies may be treated using the present methods, including cirrhosis, hepatitis, and sclerosing cholangtitis. The present invention also provides methods to increase tissue concentrations of tocotrienols.
    Type: Application
    Filed: May 20, 2013
    Publication date: November 21, 2013
    Applicant: The Ohio State University
    Inventors: Chandan K. Sen, Cameron L. Rink, Sashwati Roy, Savita Khanna
  • MORPHINE AND MORPHINE PRECURSORS
    Publication number: 20130309326
    Abstract: Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided.
    Type: Application
    Filed: June 21, 2013
    Publication date: November 21, 2013
    Applicant: The Research Foundation of State University of New York
    Inventors: George B. Stefano, Patrick Cadet, Kirk J. Mantione, Wei Zhu
  • SYSTEM AND METHOD FOR HIGH-SPEED ATOMIC FORCE MICROSCOPY
    Publication number: 20130312142
    Abstract: A high-speed atomic force microscope (HSAFM) is disclosed herein. The HSAFM includes a cantilever, a piezotube, an optical detector, a circuit element, and a feedback controller. The cantilever has a probe, and the piezotube is arranged in proximity to the probe. The optical detector is configured to detect deflection of the cantilever, and the circuit element is abutting a first end of the cantilever and is configured to exert a force on the cantilever to resist deflection of the cantilever. The circuit element is communicably connected to the optical detector by a first feedback loop. The feedback controller is communicably connected to the piezotube and configured to modulate the piezotube along the Z-axis towards and away from the probe. And the feedback controller is communicably connected to the optical detector through a second feedback loop.
    Type: Application
    Filed: May 1, 2013
    Publication date: November 21, 2013
    Applicant: Boise State University
    Inventor: Boise State University
  • Reversibly deformable and mechanically tunable fluidic antennas
    Patent number: 8587493
    Abstract: A method of manufacturing a fluidic structure is disclosed. A cavity that defines a shape of an element of the fluidic structure within a material is formed. The cavity is filled with liquid metal. The cavity is sealed. The fluidic structure behaves as an antenna. A fluidic antenna includes a material that defines a shape of the fluidic antenna by a cavity filled with liquid metal formed within the material, where the material further defines at least one mechanical property of the fluidic antenna.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: November 19, 2013
    Assignee: North Carolina State University
    Inventors: Michael David Dickey, Gianluca Lazzi, Ju-Hee So, Jacob Thelen, Amit Qusba, Gerard James Hayes
  • Co-polymer stabilizers for hydrofluoroalkane dispersions
    Patent number: 8586007
    Abstract: The use of biodegradable and biocompatible lactide-based nonionic amphiphiles to stabilize a model drug (salbutamol base) dispersion in hydrofluoroalkane (HFA) propellant is disclosed. The results have industrial applicability to the development of HFA-based dispersion pressurized metered-dose inhaler formulations.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: November 19, 2013
    Assignee: Wayne State University
    Inventors: Sandro R. P. Da Rocha, Libo Wu
  • PWM control of dual active bridge converters
    Patent number: 8587975
    Abstract: A Dual Active Bridge (DAB) converter and a Pulse Width Modulation (PWM) scheme for controlling the DAB converter are disclosed. In general, the DAB converter includes a transformer, a first H-bridge that is connected to a primary winding of the transformer and controlled via first control signals, and a second H-bridge that is connected to a secondary winding of the transformer and controlled via second control signals. A controller provides the first and second control signals based on an input-to-output voltage ratio and load of the DAB converter such that, in addition to phase shift control, PWM control is simultaneously applied to both the first H-bridge and the second H-bridge when the DAB converter operates at low power and PWM control is applied to only one of the first H-bridge and the second H-bridge when the DAB converter operates above low power.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: November 19, 2013
    Assignee: Arizona Board of Regents for and on behalf of Arizona State University
    Inventors: Amit Kumar Jain, Rajapandian Ayyanar
  • TAL effector-mediated DNA modification
    Patent number: 8586363
    Abstract: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: November 19, 2013
    Assignees: Regents of the University of Minnesota, Iowa State University Research Foundation, Inc.
    Inventors: Daniel F. Voytas, Adam Bogdanove, Feng Zhang, Michelle Christian, Tomas Cermak, Clarice Lauer Schmidt, Erin Doyle, Li Wang
  • Ligand concentrating, liquid crystal biosensor system
    Patent number: 8586389
    Abstract: A method for detecting a ligand is provided. Antibodies to a predetermined ligand are attached to substrates. The substrates are superparamagnetic, dyed beads. The beads are exposed to an electromagnetic field to immobilize the beads. The beads are contacted with a sample and the antibodies are allowed to recognize and capture the ligand in the sample. The electromagnetic field is optionally removed. The beads are contacted with a liquid crystalline material and the light transmission properties of the liquid crystalline material are examined for alteration caused by the presence of aggregates of the beads and the ligand.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: November 19, 2013
    Assignee: Kent State University
    Inventor: Christopher J. Woolverton
  • Electric joint design to be used in electromagnetic coils made with high-temperature superconducting tape, aspected wire, or cable
    Patent number: 8588876
    Abstract: An electric joint design to be used in electromagnetic coils made with high-temperature superconducting tape, aspected wire, or cable. A terminal member contains an engraved twist-bend contour, which receives the coil and changes the direction of the coil by about 90 degrees without any hard-bends. A current lead is aligned with terminal section of the coil establishing an electric joint whose length is not limited by the coil geometry. Resistance is distributed along the length of the electric joint to reduce heat generation. The electric joint is placed away from the area where the magnetic forces are high to eliminate the problem of helium gas becoming trapped.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: November 19, 2013
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Ulf Peter Trociewitz, David K. Hilton, Youri Viouchkov, Matthieu Dalban-Canassy
  • Optimal excitation force design indentation-based rapid broadband nanomechanical spectroscopy
    Patent number: 8590061
    Abstract: An optimal input design method and apparatus to achieve rapid broadband nanomechanical measurements of soft materials using the indentation-based method for the investigation of fast evolving phenomenon, such as the crystallization process of polymers, the nanomechanical measurement of live cell during cell movement, and force volume mapping of nonhomogeneous materials, are presented. The indentation-based nanomechanical measurement provides unique quantification of material properties at specified locations. Particularly, an input force profile with discrete spectrum is optimized to maximize the Fisher information matrix of the linear compliance model of the soft material.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: November 19, 2013
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Qingze Zou, Zhonghua Xu
  • Electrochemical system and method thereof
    Patent number: 8585879
    Abstract: An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10?21 M). In embodiments, the invention provides a cyclic voltammetry system comprising a working electrode, an oxidoreductase, and an electric field generator, wherein the oxidoreductase is immobilized on the working electrode; and the electric field generator generates an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by that the electrical field enhances quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: November 19, 2013
    Assignee: Cleveland State University
    Inventor: Siu-Tung Yau
  • Cattle vaccines
    Patent number: 8586059
    Abstract: This document provides live non-pathogenic M. bovis bacteria and compositions containing live non-pathogenic M. bovis bacteria. This document also provides methods of using live non-pathogenic M. bovis bacteria to immunize cattle against infectious diseases (e.g., diseases caused by M. bovis bacteria). In addition, methods and materials that can be used to generate live non-pathogenic M. bovis bacteria are provided.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: November 19, 2013
    Assignees: Iowa State University Research Foundation, Inc., Biotechnology Research and Development Corporation
    Inventors: Ricardo Rosenbusch, Nakhyung Lee
  • Fire and smoke retardant composite materials
    Patent number: 8585864
    Abstract: Flame retardant composite materials are provided which include at least one first paper which comprises carbon nanofibers and graphite oxide particles. The composite materials may further include at least one second paper which comprises carbon nanofibers. The composites may further include one or more structural material layers sandwiched between the first and second papers. Occupant structures are also provided with fire and smoke retardant surfaces composed of carbon nanofibers/graphite oxide particles papers at least partially surrounding occupants of the occupant structures.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: November 19, 2013
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Chuck Zhang, Zhiyong Liang, Ben Wang, Qiang Wu
  • Polycrystalline foams exhibiting giant magnetic-field-induced deformation and methods of making and using same
    Patent number: 8586194
    Abstract: Magnetic materials and methods exhibit large magnetic-field-induced deformation/strain (MFIS) through the magnetic-field-induced motion of crystallographic interfaces. The preferred materials are porous, polycrystalline composite structures of nodes connected by struts wherein the struts may be monocrystalline or polycrystalline. The materials are preferably made from magnetic shape memory alloy, including polycrystalline Ni—Mn—Ga, formed into an open-pore foam, for example, by space-holder technique. Removal of constraints that interfere with MFIS has been accomplished by introducing pores with sizes similar to grains, resulting in MFIS values of 0.12% in polycrystalline Ni—Mn—Ga foams, close to the best commercial magnetostrictive materials. Further removal of constraints has been accomplished by introducing pores smaller than the grain size, dramatically increasing MFIS to 2.0-8.7%.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: November 19, 2013
    Assignees: Boise State University, Northwestern University
    Inventors: Peter Mullner, Markus Chmielus, Cassie Witherspoon, David C. Dunand, Xuexi Zhang, Yuttanant Boonyongmaneerat
  • Stapled peptides and method of synthesis
    Patent number: 8586707
    Abstract: A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: November 19, 2013
    Assignee: The Research Foundation of State University of New York
    Inventors: Qing Lin, Mike Madden
  • Electrical resonance detection of particles and analytes in microfluidic channels
    Patent number: 8587330
    Abstract: A conductivity counter and method of determining conductivity of a fluid sample are disclosed. The counter is suitable for high-speed, accurate counting of discrete events or items, such as cancer cells, passing through a fluid sample cell. A variable frequency current source is used to supply an excitation current to a sample cell connected in parallel with an inductance or the electrical equivalence of an inductance. This configuration can be accurately modeled as a parallel RLC circuit when the system is operated at a stable frequency. The current source frequency is tuned to the resonance frequency of the equivalent RLC circuit, which effectively eliminates the capacitive and inductive components of the impedance, leaving only purely resistive components. The output signal is due to perturbations in the fluid sample, such as passing cancer cells.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: November 19, 2013
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventor: Donald A. Patterson
  • System and method having optimal, systematic q-ary codes for correcting all asymmetric and symmetric errors of limited magnitude
    Patent number: 8589364
    Abstract: A computer-implemented method and computer program product comprising optimal, systematic q-ary codes for correcting all asymmetric and symmetric errors of limited magnitude are provided.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: November 19, 2013
    Assignee: State of Oregon Acting by and through the State Board of Higher Education on behalf of Oregon State University
    Inventors: Bella Bose, Noha Elarief
  • Design, synthesis and functional characterization of rottlerin analogs
    Patent number: 8586768
    Abstract: A method of synthesizing rottlerin analogs is described. The synthesis methods described are the first known method of synthesizing rottlerin analogs from commercially-available materials to produce cost effective analogs. Rottlerin analog structures made by the synthesis methods and methods of use for treating a neurological or inflammatory response mediated by protein kinase C (PKC) are further described.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: November 19, 2013
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Anumantha G. Kanthasamy, George A. Kraus, Vellareddy Anantharam