Abstract: The disclosure relates to a nozzle device for emitting at least one emission medium onto a component, preferably onto a fold, an edge or a transition joint of the component. The nozzle device comprises at least two nozzle plates arranged adjoining one another, wherein a first nozzle plate comprises at least one opening for emitting at least one emission jet and a second nozzle plate comprises at least two openings for emitting at least two emission jets.

Abstract: The invention relates to a medical product for a fastening duration of at least 7 days having good skin compatibility. The medical product includes a central adhesive compartment (3) and an over-patch. The over-patch is free of active ingredients and is formed from a water-vapor-permeable back layer (1) and an adhesive polymer layer (2) that is free of active ingredients. The invention further relates to a method for the production of the foregoing medical product, and to kits of parts containing laminates of layers 1 and 2.

Abstract: The invention relates to an emergency stop switch, having: a switch mechanism with a manually operable switch and with a first contact element which is operatively connected to the switch, wherein the switch is configured to bring the first contact element into contact with a second contact element to trigger an emergency stop function. A cable pull mechanism with a switch tongue guided in a switch tongue guide is connected to a first end of a cable, wherein a switch tongue spring preloads the switch tongue during operation in a direction away from the cable. The cable is connected on its second end with preload to an equalizing spring during operation, wherein the first contact element is operatively connected to the switch tongue.

Abstract: The present invention relates to a transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising: A) a backing layer; and B) a guanfacine-containing layer; wherein the transdermal therapeutic system comprises at least one silicone polymer.

Abstract: The disclosure concerns a coating device and a corresponding coating process for coating components, in particular motor vehicle body components, with a coating agent (e.g. paint), with a coating robot with a first printhead which is mounted on the coating robot. The disclosure provides that the first printhead is exchangeably mounted on the coating robot and can be exchanged for a second printhead during a color change. Another variant of the disclosure, on the other hand, provides for a second printhead to be mounted on the coating robot in addition to the first printhead, the two printheads each applying a specific coating agent in order to enable a color change without changing the printhead.

Abstract: For the purposes of working on eye tissue, an ophthalmological apparatus comprises a laser source that is configured to produce a pulsed laser beam, a focusing optical unit that is configured to focus the pulsed laser beam into the eye tissue, a scanner system for deflecting the pulsed laser beam onto work target points in the eye tissue, and a measurement system for optically capturing structures in the eye tissue. A circuit controls the measurement system in such a way that the latter captures a cut first outer face of a lenticule to be cut. The circuit controls the scanner system in such a way that the latter guides the pulsed laser beam onto work target points on a second outer face, positioned in relation to the captured first outer face, of the lenticule to be cut, in order to cut the second outer face of the lenticule.

Abstract: A medical drug devices for transdermal drug delivery systems (TDDS) comprising a novel iontophoretic polymeric microneedle device and its use in administration of drugs.

Abstract: The invention relates to developing a novel water and capsule formulation using fenofibrate which is difficult to dissolve and control its release rate in vitro. For example, the invention relates to the creation of capsules and wafers comprising: fenofibrate, a surfactant, a carrier wax, a film former, a plasticizer, and optionally a super disintegrant or other ingredients. The invention further relates to the process of forming such capsules and wafers.

Abstract: In order to provide a separating device for separating two spatial regions, which has a simple structure and provides for efficient fluid separation, it is proposed that the separating device comprises a supply device for supplying a separating fluid to be introduced between the two spatial regions, the supply device preferably comprising at least two guide elements for guiding the separating fluid, which guide elements are designed in particular as guide plates

Abstract: The present invention is directed to transdermal therapeutic systems that are free of fibrous constituents, as well methods for producing such transdermal therapeutic systems. A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system. Exemplary printing methods include application methods based upon a distributor plate of an application device.

Abstract: The invention relates to an apparatus comprising a separating tool and comprising a counterpressure plate for producing contour geometries in adhesive-containing composite materials, wherein the separating tool can be moved in translational tool stroke directions between an inoperative position and a parting position normal to the counterpressure plate, and also to a method for producing contour geometries in adhesive-containing composite materials by means of an apparatus of this kind. The separating tool and the counterpressure plate can be actuated relative to one another by means of at least one actuator in at least one excitation direction with a ramp function and/or with a jump function. Each of these excitation directions lies in a parallel plane to a cutting edge plane of the separating tool. The present invention permits reliable separation of a stamped grid from laminate sections which remain on a carrier film.

Abstract: The present invention relates to frigostable compositions suitable for iontophoretic transdermal delivery of a triptan compound that includes: a salt of a triptan compound, preferably sumatriptan succinate, a polyamine, one or more dicarboxylic acids, 0.5 to 10.0 wt.-% (based on the total weight of the composition) of one or more monocarboxylic acids, and water or an aqueous solvent mixture. The invention further relates to the use of the composition as an integral component of an iontophoretic patch, preferably as an anodic reservoir of the patch.

Abstract: A fitting device for delivering mixed water, comprising a first inflow line for feeding hot water and a second inflow line for cold water, wherein the first and second inflow lines lead into a mixing chamber for mixing cold and hot water, wherein provision is made of a first shut-off device for controlling and/or for shutting off the flow from the first inflow line into the mixing chamber, wherein the first shut-off device has a temperature-sensitive element to control the flow from the first inflow line in a manner dependent on the temperature, wherein the second inflow line has an inflow to the mixing chamber that is formed independently of the first shut-off device, wherein the mixing chamber has an outlet line for the outflow of the mixed water, wherein provision is made of a temperature-setting device for setting the temperature of the mixed water.

Abstract: Use of an additive in a transdermal therapeutic system with an active agent-containing layer in the form of a biphasic layer having a hydrophilic inner phase and a hydrophobic outer phase, in which the inner phase comprises the additive and an active agent dissolved therein, the additive has a higher affinity to water than to the active agent, for the control of the permeation rate of the active agent in a manner which is independent from its concentration in the biphasic layer, with the maintenance of the permeation rate proportional to the amount of active agent in the biphasic layer.

Abstract: An ophthalmic device for treating an eye includes a laser source, a scanner system and an application head with a focusing optic and a patient interface for docking the application head onto the eye. Moreover, the ophthalmic device includes a measurement system for optically capturing eye structures when the application head is docked to the eye and a circuit which is configured to determine reference structures of the eye, which are arranged in ring-shaped fashion about the center axis of the anterior chamber of the eye, from the captured eye structures and to arrange a defined three-dimensional treatment model with respect to these reference structures in order to process a three-dimensional treatment pattern in accordance with the arranged three-dimensional treatment model in the eye.

Abstract: An application device for the application in series of a paint or other coating compositions to motor vehicle bodies or add-on parts thereof has a nozzle print head which contains a plurality of nozzles arranged, for example, in one or more rows, which apply the coating composition to the surface to be coated as continuous jets or individual drops. The nozzle print head is arranged on a multi-axis coating robot. In contrast to application devices of this type known hitherto, the coating composition consists of at least two components which are to be mixed together, such as, for example, 2K paint, which are fed to the nozzle print head via separate supply lines for jointly supplying the nozzles.

Abstract: The invention relates to a transdermal therapeutic system (TTS) for delivering pharmaceutical active ingredients. The TTS includes a cover layer and at least one active-ingredient-containing carrier material. At least one retaining element is located between the active-ingredient-containing carrier material and the cover layer, with the retaining element fixing the active-ingredient-containing carrier material onto the cover layer. The invention further relates to a method for fastening an active-ingredient-containing carrier material to a cover layer of a TTS in the presence of hook-and-loop strip segments and the use of a hook-and-loop strip in transdermal or iontophoretic administration of pharmaceutical or therapeutic active ingredients to patients.

Abstract: The present invention relates to the use of an additive in a transdermal therapeutic system with an active agent-containing layer in the form of a biphasic layer having a hydrophilic inner phase and a hydrophobic outer phase, in which the inner phase includes the additive and an active agent dissolved therein. The additive has a higher affinity to water than to the active agent and controls the permeation rate of the active agent in a manner which is independent from its concentration in the biphasic layer, with the maintenance of the permeation rate being proportional to the amount of active agent in the biphasic layer.

Abstract: A transparent or translucent medical active substance patch is provided that includes a matrix of monolayer or multilayer configuration with at least one active substance-containing layer contained therein and a backing layer connected with the matrix. The patch, having been applied to the skin of a first person, has a lightness color value L1 at a place of the skin covered by the patch which is not less than 50% and not more than 200% of a lightness color value L2, with L2 being the lightness value of the region of skin of the same person which surrounds the applied patch, with the same being true of the skin of a second or any other person, provided that for all the persons mentioned, the L2 of their respective skin is in the range from 5° to 100°, especially in the range from 20° to 90°.

Abstract: Disclosed is an ophthalmological treatment apparatus for modifying a shape of a corneal surface of a human eye. The apparatus includes a surgical laser device for implementing tissue cuts. The apparatus further includes a computerized control device in operative coupling with the surgical laser device, the control device being designed to control the laser device to implement tissue cuts according to a cut geometry with a primary tissue cut and a secondary tissue cut, wherein the primary tissue cut is a relief cut and extends into the depth of the corneal eye tissue, and wherein the secondary tissue cut lies within the corneal eye tissue, such that the secondary tissue cut adds to the relieving effect of the primary tissue cut.