Abstract: The present invention relates to frigostable compositions suitable for iontophoretic transdermal delivery of a triptan compound. The inventive compositions include a salt of a triptan compound, preferably sumatriptan succinate, a polyamine, a dicarboxylic acid, and water or an aqueous solvent mixture, with the composition being free of monocarboxylic acids. The invention further relates to the use of the composition as an integral component of an iontophoretic patch, preferably as an anodic reservoir of the patch.

Abstract: Disclosed is a patient interface for affixment on onto a patient eye, said patient interface including a negative pressure cavity with a top wall and a circumferential outer wall, an optical passage, wherein the top wall circumferentially surrounds the optical passage and wherein the circumferential outer wall projects from the top wall and circumferentially surrounds the optical passage; a number of rib members, the rib members projecting separately from each other from the top wall into the negative pressure cavity between the circumferential outer wall and the optical passage.

Abstract: The invention relates to transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing self-adhesive layer structure comprising A) a buprenorphine-impermeable backing layer, and B) e a buprenorphine-containing pressure-sensitive adhesive layer on said buprenorphine-impermeable backing layer, the adhesive layer comprising a) at least one polymer-based pressure-sensitive adhesive, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof and c) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid and linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein to form a mixture, and the carboxylic acid buprenorphine mixture forms dispersed deposits in the said pressure-sensitive adhesive, wherein said buprenorphine-containing pressure-sensitive adhesive layer is the skin contact

Abstract: An ophthalmological device for treating eye tissue with laser pulses comprises a projection optical unit for focused projection of the laser pulses, a scanner system for dynamically deflecting the laser pulses and a zoom system, which is arranged between the projection optical unit and the scanner system and which is configured to adjust the focused projection of the laser pulses in the projection direction in different zoom settings. The ophthalmological device moreover comprises a displacement device, which is configured to displace the scanner system depending on the zoom setting of the zoom system. What the displacement of the scanner system coupled to the zoom setting of the zoom system renders possible is the adaptation of the position of the scanner system in a dynamic and synchronized fashion to the setting of the zoom system and hence to the current position of the virtual entry pupil of the zoom system.

Abstract: The present disclosure provides a coating plant components and an assembly of such components for a rotary atomizer. The components may be a bell cup and/or an atomizer ring. The component includes a metal main part and a non-metal material at least partially covering or coating the main part. The coating or insert of non-metal material is positioned to provide a barrier to inhibit metal-on-metal contact between, e.g., a bell cup and an atomizer ring. The present disclosure further provides a method for applying non-metal material to a coating plant component.

Abstract: The invention relates to a transdermal therapeutic system (TTS) which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system incorporates a back layer and an active substance-containing layer that includes at least one peptide and a carrier substance.

Abstract: The invention relates to a method for producing aerogels, in particular silica aerogels, by way of a sol-gel process.

Abstract: An edible orally disintegrating tablet dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible orally disintegrating tablet dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.

Abstract: In an ultrasound cutting device comprising an ultrasound transducer connected to a generator and provided with a sound conductor which is connected to a cutting blade and extends along a line which deviates from a straight line, the generator includes means for running the ultrasound waves in a controlled manner through a predetermined frequency range.

Abstract: The present invention relates to a transmucosal administration system to administer quinones, benzoquinones, and especially 1,4-benzoquinones, via the oromucosal route.

Abstract: A burner head for a burner defines a burner longitudinal axis along which the burner extends. The burner head includes a base body and at least one oxidant duct defining a duct longitudinal axis. The oxidant duct is arranged in the base body at a radial spacing to the burner longitudinal axis. A fuel duct body is inserted into the oxidant duct and at least one fuel nozzle is configured on the fuel duct body so as to open into the oxidant duct.

Abstract: The invention relates to a transdermal therapeutic system on the basis of polysiloxane which contains microreservoirs filled with an active substance and one ambiphilic solvent.

Abstract: An ophthalmological laser treatment system comprising a laser source (2) for producing laser radiation, a light projector (3) for focusing the laser radiation onto a focus (F) and a scanner system (5) for moving the focus (F) along a work line (p) comprises a monitoring system (6), which comprises a light detector (60) and is configured to monitor, by way of a light path (r), a monitored region (m) moving together with the focus (F). The monitoring system (6) is configured to monitor a monitored region (m), which moves together with the focus (F) with a fixed geometric assignment to the focus (F) and is for example disposed upstream of the focus (F) in the work direction and not yet worked on by laser radiation.

Abstract: A coating apparatus for coating a component with a coating agent includes an applicator for delivering at least one coating agent jet of the coating agent to the component. The coating apparatus includes an intercepting device which in an active position intercepts the at least one coating agent jet between the applicator and the component so that the at least one coating agent jet does not strike the component.

Abstract: The disclosure relates to an overpressure encapsulation system for explosion protection, comprising the following: a device (1), in particular a painting robot (1), an overpressure-encapsulated device housing (2) comprising a housing outlet (6) for discharging gas out of the device housing (2), a compressed air system (3, 4) for operating the device (1), said compressed air system (3, 4) being arranged within the device housing (2), a sensor assembly (7, 8, 9) for measuring at least one fluid variable (Q, PI, PA), and an analysis unit (11) which analyzes the fluid variable (Q, PI, PA) measured by the sensor assembly (7, 8, 9), in particular in order to detect a leakage of the device housing (2).

Abstract: An exhaust air conduit for a pneumatically powered pump, in particular, from a coating agent pump in a painting plant, is provided. The conduit includes an inlet for receiving the exhaust air from the pump, an outlet for discharging the exhaust air, and an exhaust air channel in which the exhaust air flows from the inlet to the outlet of the exhaust air conduit, and a housing member in which the exhaust air channel extends. A first thermal insulation element is provided in the region of a direction change of the exhaust air channel, in order to prevent an accumulation of the exhaust air directly at the inner wall of the exhaust air channel and thereby to lessen the cooling of the housing member.

Abstract: In order to provide a treatment installation for treating workpieces that is of simple construction and enables optimised workpiece treatment, it is proposed that the treatment installation should include a treatment chamber and a conveying device, by means of which the workpieces are suppliable to the treatment chamber, are removable from the treatment chamber, and/or are conveyable through the treatment chamber in a conveying direction.

Abstract: According to an aspect of the invention, a computerised system, in particular control system is provided, which is configured, from an input vector (In) which represents a discrete number of input variables and from a state vector (Zn) which represents a discrete number of state variables, to determine a new state vector (Zn+1) whose state variables are updated, as well as an output vector (On) which represents a discrete number of output variables, wherein the output variables are provided for controlling at least one appliance and/or for outputting information. The system comprises a plurality of computation units which in parallel determine the new state vector and the output vector from the input vector and the state vector. According to the invention, the system is configured such that at least all news state vectors are exchanged between the computation units after each cycle.