Abstract: The invention discloses a synchronous self-locking pneumatic adaptive fixture used for the machining of annular thin-walled parts, belonging to the technical field of mechanical machining. The synchronous self-locking pneumatic adaptive fixture includes a zero point positioning system, a base body, a plurality of pressure plate mechanism assemblies, a plurality of columns, a plurality of support mechanism assemblies and a plurality of adaptive support body assemblies. Among them, the pressure plate mechanism assemblies complete the axial compression of the workpiece through the lever force increasing mechanisms and the orthogonal self-locking mechanisms. And the support mechanism assemblies complete the radial support of the workpiece through the rod slider mechanisms and the orthogonal self-locking mechanisms. The invention not only has high clamping efficiency and good stability, but also can ensure the reliable clamping and safe machining of the workpiece when the air source is disconnected.

Abstract: Provided herein are methods for treating melanoma in a subject.

Abstract: Example embodiments associated with characterizing a sample using NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals and a characterization logic that characterizes a tissue in the object as a result of comparing acquired signals to reference signals. Example embodiments facilitate distinguishing diseased tissue from healthy tissue based on tissue component fractions identified using the NMR fingerprinting.

Abstract: Eye-tracked head-mounted displays are provide which, in one aspect, may utilize the same optics for eyetracking and image viewing, with a selected portion of the optics used for an eyetracking optical path and a selected portion of the display optics used for an image viewing optical path.

Abstract: Provided are compositions and methods that include one or more of: (1) a “CasZ” protein (also referred to as a CasZ polypeptide), a nucleic acid encoding the CasZ protein, and/or a modified host cell comprising the CasZ protein (and/or a nucleic acid encoding the same); (2) a CasZ guide RNA that binds to and provides sequence specificity to the CasZ protein, a nucleic acid encoding the CasZ guide RNA, and/or a modified host cell comprising the CasZ guide RNA (and/or a nucleic acid encoding the same); and (3) a CasZ transactivating noncoding RNA (trancRNA) (referred to herein as a “CasZ trancRNA”), a nucleic acid encoding the CasZ trancRNA, and/or a modified host cell comprising the CasZ trancRNA (and/or a nucleic acid encoding the same).

Abstract: A high-frequency resonant power conversion system for transferring power from an oscillator to a load or vice-versa, the system including components with at least one fluctuating parameter and is configured to control the value of a defined variable selected from: a certain current, a certain voltage, a phase difference between a certain voltage and a certain current, and a certain power; the system further including a virtual impedance creation loop which is configured to create a virtual component, the virtual component forming a basis for changing amplitude and a phase of the oscillator, thereby to compensate for a deviation from the controlled variable due to the fluctuations.

Abstract: The present invention provides a method for preparing ferrovanadium alloys based on aluminothermic self-propagating gradient reduction and slag washing refining. The method includes the steps of (1) performing aluminothermic self-propagating gradient reduction; (2) performing heat preserving and smelting to obtain an upper layer alumina-based slag and a lower layer alloy melt; (3) jetting refining slags into the lower layer alloy melt, and performing stirring and slag washing refining; and (4) cooling the refined high-temperature melt to room temperature, and removing an upper layer smelting slag to obtain the ferrovanadium alloys.

Abstract: The present invention relates to oligooxopiperazines for modulating the p53-Mdm2 interaction. Exemplary oligooxopiperazines include those of Formula IA, Formula IB, and Formula IC below (wherein the various substituents are as defined herein). Methods of using the oligooxopiperazines are also disclosed.

Abstract: The present disclosure provides compounds of Formula (I?), Formula (II), and Formula (III). The compounds described herein may useful in treating and/or preventing protozoan infections in a subject in need thereof, treating and/or preventing trypanosomal infections (e.g., Trypanosoma cruzi (T. cruzi) or Trypanosoma brucei infections) and/or plasmodial infections in a subject in need thereof, treating and/or preventing diseases in a subject in need thereof (e.g., Chagas disease, malaria, and/or sleeping sickness), and may be useful in treating and/or preventing infectious diseases in a subject in need thereof. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.

Abstract: Driver fingerprinting using sensor data was known to be feasible only with access to in-car data. This disclosure presents a novel technique for identifying a vehicle driver from only one vehicle turn and using zero-permission sensors residing in the mobile device. Through extensive evaluations, extracted features are shown to reflect only the drivers unique turning style and thus functions as the core of driver fingerprinting.

Abstract: Disclosed are methods for minimizing x-ray scattering artifacts, the method comprising: contacting an object with an x-ray scattering mitigation material. The contacting can comprise coating the x-ray scattering material on the object, including spraying a solution of suspension of an x-ray scattering mitigation material onto the object or dry powder coating the object with a x-ray scattering mitigation material. Alternatively, the contacting can comprise immersing the object in a fluid comprising the x-ray scattering material. The fluid can be a gas, a liquid, or a gel. The disclosed x-ray scattering mitigation material can be optimized for mitigating Compton radiation scattering or for mitigating Rayleigh radiation scattering. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: According to a machining principle of the CNC gear hobbing machine, a functional relation between a geometric error of a gear and a tracking error of each motion axis of the machine tool is constructed; a machining error mathematical model of tooth profile deviation, tooth pitch deviation and tooth direction deviation at each position control time point is established by tracking errors of each motion axis; a compensation quantity required for a workpiece rotation axis at the next position control time point is calculated by establishing a decoupling compensation model; average absolute values of machining errors and a total compensation quantity of the machining errors under the conditions of not adopting the synchronous control method and adopting the synchronous control method in the total position control time are obtained by calculating machining error values of each position controls time point, and the synchronized multi-axis motion control is completed.

Abstract: The present invention relates to organoids derived from a single cell, such as a prostate cancer cell, and methods and compositions relating to the production and use thereof, including cell culture medium for producing organoids and methods of personalized treatment for prostate cancer. The invention further provides a humanized mouse comprising a prostate organoid derived from a patient's prostate cell.

Abstract: A method and apparatus for electro-hydrodynamic destruction of an aerosol. The method includes receiving air having large aerosols, greater than about 1 micron, and small aerosols, smaller than about 1 micron, and entraining the large aerosols and small aerosols within an airflow. The airflow is directed to an electric field, which causes the large aerosols to react with the electric field to accumulate an electric charge resulting in extraction of the large aerosols from the airflow. The airflow is also directed to a non-thermal plasma such that the small aerosols remain entrained in the airflow and are subject to electro-hydrodynamic (EHD) phenomena. The non-thermal plasma outputs at least one of radicals, excited species, and ionized atoms and molecules capable of reacting with the small aerosols to result in physical and/or chemical destruction of the small aerosols.

Abstract: A method for the preparation of a dense HfC(Si)—HfB2 composite ceramic. hafnium oxide powders, nano-sized carbon black and silicon hexaboride powders are mixed in a molar ratio of (1-10):(1-20):(1-5) to obtain a powder mixture. The powder mixture is subjected to ball milling, dried and transferred to a graphite mold for spark plasma sintering. In this way, an in-situ carbon-boron reduction reaction and the sintering densification are completed in one step, and the obtained HfC(Si)—HfB2 composite ceramic has a density of 94.0%-100% and uniformly dispersed grains.

Abstract: Described herein are compositions and methods relating to light converting luminescent Zero-D perovskite composite materials.

Abstract: A device and a method for preparing pure titanium by electrolysis-chlorination-electrolysis, wherein the device includes a first electrolytic cell, a second electrolytic cell, a chlorination reactor and guide tubes. The Cl2 generated at the anode of the first electrolytic cell is introduced into a chlorination reactor containing the TiCxOy or TiCxOyNz raw materials via a guide tube, and a chlorination is carried out to generate TiCl4 gas at a temperature of 200° C.-600° C. The TiCl4 gas passes through a guide tube into a cathode of the second electrolytic cell, and then an electrolysis is performed to obtain the high-purity titanium in the second electrolytic cell. At the same time, the Cl2 generated at the anode of the second electrolytic cell is recycled into the chlorination reactor in the first electrolytic cell to continue to participate in the chlorination of TiCxOy or TiCxOyNz.

Abstract: This document provides methods and materials related to genetic variations of neurological disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Parkinson's disease.

Abstract: The present application discloses a method and a system for person re-identification, the method including: inputting a training set to a model-to-be-trained, and determining a single-class label and memory features of each image data in the training set; determining multi-class labels through positive label prediction according to the single-class labels and a memory feature set; determining classification scores according to image features of each image data in the training set and the memory feature set; determining a multi-label classification loss according to the multi-class labels and the classification scores; and updating and training the model-to-be-trained to obtain a re-identification model according to the multi-label classification loss.

Abstract: A method of wet spinning poly (3,4-ethylenedioxythiopene):poly (styrenesulfonate) or PEDOT:PSS fibers produces PEDOT:PSS fibers having a unique combination of electrical conductivity, thermal conductivity and Young's modulus properties.