Abstract: The present application relates to methods for maintaining core body temperature in a subject. Heat is applied to peripheral thermoregulatory control tissue of the subject to increase or maintain perfusion of blood in glabrous tissue of the subject, and a warming stimulus is applied to the glabrous tissue. The application of heat to the peripheral thermoregulatory control tissue occurs discretely and simultaneously with application of the warming stimulus to the glabrous tissue, without application of a heating device or a warming device to tissue other than the tissue subjected to the applied heat or to the applied warming stimulus, thereby maintaining the core body temperature of the subject.

Abstract: The present invention relates to a method of preparing an aqueous dispersion of polymer encapsulated particulate material, the method comprising: providing a dispersion of the particulate material in a continuous aqueous phase, the dispersion comprising ethylenically unsaturated monomer and a stabilizer for the particulate material; and polymerizing the ethylenically unsaturated monomer by non-living free radical polymerization to form polymer that encapsulates the particulate material, thereby providing the aqueous dispersion of polymer encapsulated particulate material; wherein polymerization of the ethylenically unsaturated monomer comprises: (a) polymerizing a monomer composition that includes ionizable ethylenically unsaturated monomer so as to form a base responsive water swellable non-living polymer layer that encapsulates the particulate material; and (b) polymerizing a monomer composition that includes non-ionizable ethylenically unsaturated monomer so as to form an extensible, water and base permeab

Abstract: This invention is directed to a modular staged simulator and a process of simulating medical trauma and maladies for the purpose of training or certifying individuals including medical professionals. More specifically, this disclosure relates to ex vivo training exercises as opposed to traditional forms of training using intact cadavers, in vivo surgery on animal subjects; and supervised apprenticeship performing surgery on human subjects with trauma or maladies under the watch of a skilled medical practitioner.

Abstract: The present invention relates generally to an oral device, or mouthpiece, for delivering a fluid to the mouth or oropharynx of a user. In one embodiment, the oral device includes an intraoral portion, an extraoral portion, and an auxiliary support device that serves to stabilize the oral device. In various embodiments, the auxiliary support device may be configured with ear loops, a support band, a support frame and/or a support member. The intraoral portion generally includes at least one outlet port through which the fluid is delivered to the oral cavity or oropharynx. A method of dispensing a fluid using the oral device is also provided.

Abstract: A depletion-mode phototransitor is disclosed. The phototransistor having a substrate, a gate, a source, a drain and a channel. The source, drain and channel are doped to be the same type of semiconductor. The substrate can be made of silicon and/or germanium. The gate can be made of either aluminum or polysilicon.

Abstract: The present invention provides methods of treating diseases and disorders associated with aberrant erythropoiesis. Specifically, the present invention provides a method for treating polycythemia in a subject by administering an inhibitor of miR-451. Methods of increasing red blood cell count and treating anemia in a subject by administering miR-451 mimetics are also disclosed.

Abstract: The present invention provides a self assembly molecule having an affinity for one or more target molecules, for use in formation of a heptameric complex, comprising: a) a monomer comprising a multimerization domain of Archaeal Sm1 (AF-Sm1) protein or SM-like ribonucleoprotein from other organisms, able to interact with other molecules of the same monomer comprising a multimerization domain of AF-Sm1 protein or SM-like ribonucleoprotein to self-assemble into a heptamer; and b) a target binding domain or peptide attached directly or via a linker to the monomer of (a). Also provided are heptamers comprising these self assembly molecules and methods for their use in therapy, imaging and diagnostics.

Abstract: Certain embodiments are directed to a sensitive isothermal amplification test based on the recombinase polymerase amplification (RPA) method that is capable of detecting <2 parasites in a biological sample.

Abstract: A combination child carrier and stroller including a stroller (12; 200) having a frame to which is secured wheels; and a child carrier (14; 216) having a saddle-like seating arrangement in which a child is to be seated vertically is provided. The child carrier is configured to be releasably secured to the stroller. Additionally, the child carrier 5 includes a child harness assembly (44; 216) and a carrier harness assembly (50; 226), the child harness assembly including a back support and a child safety harness (64), while the carrier harness assembly includes a carrier frame structure (42) and shoulder straps (46) secured to the frame structure, in order to carry the child carrier on the back of a caregiver. The child harness assembly and the carrier harness assembly are 10 configured to be releasably secured to each other to form a backpack child carrier (14).

Abstract: A method for producing an MTW-type zeolite, comprising (1) mixing an alumina source, an alkali source, a lithium source, and water so as to obtain a reaction mixture (2) Adding a seed crystal of an MTW-type zeolite before or while a silica source is added to the reaction mixture in a proportion of 0.1 to 20% by weight relative to the silica component in the reaction mixture. Mixing and stirring the reaction mixture. Wherein the MTW-type zeolite of the seed crystal has a SiO2/Al2O3 ratio of 10 to 500 and does not contain an organic compound. The reaction mixture has a composition represented by the following molar ratios: SiO2/Al2O3=12 to 200, Na2O/SiO2=0.1 to 0.3, Li2O/(Na2O+Li2O)=0.05 to 0.5 and H2O/SiO2=10 to 50. (3) Air tightly heating the reaction mixture, to which the seed crystal of the MTW type zeolite has been added, at 100 to 200° C.

Abstract: Substantial reduction of the radiation dose in computed tomography (CT) imaging is shown using a machine-learning dose-reduction technique. Techniques are provided that (1) enhance low-radiation dosage images, beyond just reducing noise, and (2) may be combined with other approaches, such as adaptive exposure techniques and iterative reconstruction, for radiation dose reduction.

Abstract: Certain embodiments of the invention are directed to methods for inducing an immunologic response to a tumor in a patient using mature dendritic cells transfected with a nucleic acid composition encoding one or more tumor antigens and loaded with a corresponding tumor antigen composition.

Abstract: Compounds, compositions and methods are provided that comprise selective ?-glucuronidase inhibitors for both aerobic and anaerobic bacteria, especially enteric bacteria normally associated with the gastrointestinal tract. The compounds, compositions and methods can be for inhibiting bacterial ?-glucuronidase and for improving efficacy of camptothecin-derived antineoplastic agents or glucuronidase-substrate agents or compounds by attenuating the side effects caused by reactivation by bacterial ?-glucuronidases of glucuronidated metabolites of camptothecin-derived antineoplasatic agents or glucuronidase-substrate agents or compounds.

Abstract: A new apparatus and method of delivering light to the hack aperture of a High Numerical Aperture (NA) Microscopy Objective lens for Total Internal Reflectance Microscopy (TIRFM) is provided. The apparatus and method include pumping light generated by a laser through an optical fiber which is optically coupled to the objective lens by a collimating optical element, such as, for example a lens or prism. The apparatus and method also include providing a fiber axial translator which is mechanically adjustable for focusing the laser light optically coupled to the objective lens. The apparatus also includes a mechanical coupler for mechanically coupling the apparatus to the object lens such that the laser light optically coupled to the objective lens can be adjusted to exceed, or not exceed, a critical angle associated with TIRFM illumination.

Abstract: An unknown surface shape of a physical object can be extracted with good precision. Image data of a projective image that has been acquired by radiation projection to an object is acquired. Next, a predetermined mesh structure is used to acquire cross-sectional images of the subject from image data of the projective images by reconstruction using tomography. Lattice points constituting the mesh structure are then moved in conformity with the surface shape of the object, based on the cross-sectional image that has been acquired by reconstruction. Reconstruction is carried out again using the mesh whose lattice point positions have been corrected. Movement on the reconstruction of the lattice points is then repeated as many times as required.

Abstract: Provided are methods and compositions for treating a wound in a subject. The methods include applying a pharmaceutical composition that includes a first precursor material agent including fibrinogen, a second precursor material agent including thrombin, and silver particles to an abdominal incision site in an amount effective to treat the abdominal incision site. Also provided are pharmaceutical compositions and devices for use in the subject methods.

Abstract: Bi-functional cobalt-containing catalysts useful for making stereo specific compounds and compositions, along with methods of making, and uses thereof in the syntheses of optically pure ?-lactones from aldehydes and ketene are described. Precursors, intermediates, compositions, and particular features of the use if the compositions, such as high enantiomeric selectivity, high yield and low mole percent of catalyst useful are provided.

Abstract: Provided herein are devices, systems and methods for treating a vocal fold pathology by forming a substantially planar void below the epithelium of the vocal fold using optical energy. Also provided are devices, systems, and methods for combined imaging and treating of a vocal fold pathology.

Abstract: A compound can destabilize a binding interaction between an epidermal growth factor receptor (EGFR) and a sodium/glucose co-transporter 1 (SGLT 1). In one embodiment, the compound is a peptide derived from the interacting domain of EGFR. In another embodiment, the peptide is administered to a patient to treat cancer.

Abstract: A protein-immobilizing solid phase is a protein-immobilizing solid phase comprising an mRNA-nucleic acid linker-protein complex, obtained by linking the mRNA and the protein encoded by that mRNA through the nucleic acid linker, immobilized on the solid phase, wherein the nucleic acid linker has a photocleavage site and a solid phase binding site.