Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.

Abstract: The present invention discloses a 3D weaving and printing integrated structure construction equipment including: a printing matrix material preparation device, processing the printing matrix raw materials and then delivering them to a printing matrix extrusion device; a printing matrix extrusion device, having the functions of promoting extrusion and lamination molding, and printing a matrix; a wire pushing and spatial anchoring device, using a nail-shooting to position and tow a rope/wire/cable for continuously weaving layer by layer stacking along the vertical direction; an electromagnetic guided shuttle dropping device, weaving the rope wire/cable material along the longitude and latitude directions; a locking device, positioning and fixing the rope/wire/cable woven along the longitude and latitude directions; a tensioning traction device, performing spatial multi-directional prestress tensioning on the rope/wire/cable woven along the longitude and latitude directions.

Abstract: Disclosed herein is an improved few-shot detector which utilizes a dynamic semantic network which takes as input a language feature and generates trainable parameters for a visual network. The visual network takes a visual feature as input and generates a classification and localization of an object.

Abstract: Using deep learning, imaging harmonization among images produced with differing PET tracers is achieved. A method may include providing an original PET image of the brain using an original PET tracer, providing a target PET tracer, and converting, using a deep learning neural network, the original PET image into a target PET image simulating the image that would be obtained had the target PET tracer been used.

Abstract: A method, apparatus, system, and computer program products for managing a set of outliers in test data. A computer system analyzes a set of features derived from the test data using different outlier detection methods to generate a result of the set of outliers identified by the different outlier detection methods. The test data is obtained from testing a physical structure. The computer system determines a causality for the set of outliers in the result. The physical structure is retested with a set of changes determined using the causality identified for the set of outliers. The retesting generates new test data for the physical structure.

Abstract: An acrylate-based single-chain nanoparticle is disclosed, which includes 10-20 parts of methacrylic acid, 1-2 parts of tetramethylguanidine and 1-2 parts of halohydrocarbon. The scheme provided by the disclosure establishes a “meta template” for synthesizing various single-chain nanoparticles, unifies the preparation method of the polyacrylate, simultaneously carries out high-concentration preparation in an aqueous phase only through ultraviolet irradiation, which reduces the production cost, reduces the carbon emission in production, and provides possibility for the industrialized production of the polyacrylate-based single-chain nanoparticle.

Abstract: An eye-gaze tracking apparatus and a method of eye-gaze tracking. The eye-gaze tracking apparatus comprises: a plurality of foreground cameras each arranged to capture at least a portion of a target view area of a user; and an eye-gaze estimation module having at least one eye-gaze camera each arranged to capture an image an eye of the user, so as to estimate a position of a pupil of the eye based on the image of the eye; wherein each of the plurality of foreground cameras includes a field-of-view (FOV) being different from each other.

Abstract: An amplifying device includes a main amplifier; a first feedback circuit coupled between an input terminal of the main amplifier and an output terminal of the main amplifier; an input coupling circuit coupled between the input terminal of the main amplifier and a first node; and an amplifying feedback circuit coupled between the output terminal of the main amplifier and the first node, wherein the first feedback circuit and the amplifying feedback circuit are negative feedback circuits.

Abstract: Provided herein are devices for monitoring nucleic acid amplification, nucleic acid amplification monitors, methods of quantifying nucleic acid amplification, methods of identifying an unknown nucleic acid molecule, and systems for monitoring nucleic acid amplification. The disclosed devices, methods, and systems comprise at least one nuclemeter, comprising at least one sample chamber and at least one reaction-diffusion conduit in fluid communication with the chamber.

Abstract: A state monitoring method for vibration drilling of a stack structure material is provided. A load power and a torque value of a drilling spindle is monitored during machining. Drilling state are divided according to a machining material of a drill. According to a data of a test library, reference thresholds of two monitoring objects for judging the change of the drilling state are set to achieve the state monitoring for the drilling process. The method monitors the machining process through the monitoring module in the machining system.

Abstract: A stable emulsifiable concentrate (EC) formulation includes a solvent mixture including dimethylformamide (DMF), methanol, and xylene. The EC formulation includes one or more anionic surfactants, one or more non-ionic surfactants, and a neonicotinoid pesticide. The neonicotinoid pesticide is present in an amount of 15 to 40% weight over volume (w/v) of the solvent mixture. The EC formulation has a room temperature shelf life of at least 2 years under CIPAC guidelines.

Abstract: The present disclosure provides variant major histocompatibility complex class II (MHCII) beta chains, as well as heterodimers and multimers including MHCII alpha chains and the variant MHCII beta chains. Also provided by the present disclosure are nucleic acids, expression cassettes, and expression vectors encoding the MHCII beta chains. The heterodimers and multimers of the present disclosure have a higher affinity for CD4 co-receptors than comparable reagents including wild type MHCII beta chains, and therefore are advantageous for use in methods of phenotyping or activating CD4+ T cells.

Abstract: A method includes forming a semiconductive channel layer on a substrate. A dummy gate is formed on the semiconductive channel layer. Gate spacers are formed on opposite sides of the dummy gate. The dummy gate is removed to form a gate trench between the gate spacers, resulting in the semiconductive channel layer exposed in the gate trench. A semiconductive protection layer is deposited in the gate trench and on the exposed semiconductive channel layer. A top portion of the semiconductive protection layer is oxidized to form an oxidation layer over a remaining portion of the semiconductive protection layer. The oxidation layer is annealed after the top portion of the semiconductive protection layer is oxidized. A gate structure is formed over the semiconductive protection layer and in the gate trench after the oxidation layer is annealed.

Abstract: A polymer/activated carbon composite made up of a branched polyethylenimine and magnetic cores involving Fe3O4 disposed activated carbon. The magnetic cores have activated carbonyl groups on the surface. A process for removing organic dyes, such as methyl red, as well as heavy metal ions from a polluted aqueous solution or an industrial wastewater utilizing the composite is introduced. A method of synthesizing the polymer/activated carbon composites is also specified.

Abstract: The present invention relates to an electrical nerve stimulator configured to deliver an electrical signal to a user to entrain Mu-band neural oscillations and/or Beta-band neural oscillations. The electrical nerve stimulator may be used in the treatment of neurological conditions associated with desynchronization of neural oscillations, such as Tourette's syndrome. The electrical nerve stimulator may be wearable on a wrist of a user, and may be configured to deliver rhythmic stimulation at a frequency falling within the same frequency range of Mu-band or Beta-band neural oscillations. The invention provides a convenient means of treating conditions such as Tourette's syndrome without the need for specialist medical equipment or facilities. Also disclosed is a method of delivering an electrical signal to a user to entrain Mu-band neural oscillations and/or Beta-band neural oscillations.

Abstract: A stapled antimicrobial peptide having the amino acid sequence FFRKSKEK-S5-GKE-S5-KRIV (SEQ ID NO: 1) and its use as an antimicrobial and anticancer agent are provided.

Abstract: According to the present invention, blood pressure surges are detected from time-series data on blood pressure of a subject that varies with pulsation based on predetermined determination criteria. For each blood pressure surge thus detected, an envelope connecting a plurality of pulse-corresponding peaks forming the blood pressure surge is acquired as an individual waveform. Statistical processing is performed on a plurality of individual waveforms to obtain a representative waveform and waveform variation among the blood pressure surges in the time-series data. On a display screen, a curve indicating the representative waveform is displayed with the curve superimposed on a region indicating the waveform variation among the blood pressure surges.

Abstract: A non-uniform beam spatial modulation method and system applicable to multi-antenna communication and sensing integration; the method includes: finding an ISAC beam that satisfies both sensing performance and communication performance, including: constructing a communication transmitting signal; constructing a communication receiving signal; constructing an upper bound of the integrated communication and sensing spectral efficiency of the non-uniform beam spatial modulation; constructing an objective function of the sensing performance; and finding a candidate beam matrix and a beam activation probability distribution where the spectrum frequency is maximum and the sensing performance is best; and finding a spectral efficiency of non-uniform beam spatial modulation by means of the ISAC beam. Under the condition of meeting the same sensing performance requirement, the spectral efficiency of the present invention is higher.

Abstract: A guide-type anti-climbing energy-absorbing device based on hydraulic shearing includes an energy-absorbing tube, an anti-climbing portion, a first connecting portion, a plurality of partition plates, and two guide plates. The anti-climbing portion and the first connecting portion are respectively provided at two ends of the energy-absorbing tube. The partition plates are sequentially arranged inside the energy-absorbing tube along an axial direction to divide the interior of the energy-absorbing tube into a plurality of first energy-absorbing cavities, each filled with a first honeycomb body. The two guide plates are symmetrically arranged in the energy-absorbing tube along a vertical direction of the energy-absorbing tube. Each guide plate is arranged obliquely and includes a connecting end connected to the anti-climbing portion and a free end passing through the partition plates in sequence to extend outside the first connecting portion.

Abstract: In one embodiment, a method for recovery of an oil from a porous medium comprises contacting the porous medium with an aqueous nanofluid, solubilizing oil from the porous medium via the nanoparticles to form a dispersion comprising the oil and the aqueous nanofluid, and collecting at least some of the dispersion. The aqueous nanofluid may contain a combination of amphiphilic quantum dots and hydrophilic quantum dots, in a continuous phase. At least 90% of the quantum dot nanoparticles may have an aspect ratio of from 1:1 to 1:6. In another embodiment, a method for recovery of an oil from a porous medium includes adding quantum dots to foaming surfactants to enhance foam lamella stability under reservoir conditions and provide conformance and mobility control in porous media and hydraulic fractures.