Abstract: A graphene and in-situ nano-ZrB2 particle-co-reinforced aluminum matrix composite (AMC) and a preparation method thereof are provided. The preparation method includes: heating an aluminum alloy for melting, adding potassium fluoroborate and potassium fluorozirconate to produce ZrB2 particles in-situ, additionally adding a mixture of pre-prepared copper-coated graphene and an aluminum powder, and stirring with an electromagnetic field for uniform dispersion; and ultrasonically treating the resulting melt to improve the dispersion of the in-situ nano-ZrB2 particles and the graphene, casting for molding to obtain a casting, and subjecting the casting to homogenization and rolling for deformation to obtain the graphene and in-situ nano-ZrB2 particle-co-reinforced AMC. The in-situ generation of the reinforcement nano-ZrB2 particles in an aluminum alloy melt increases the number of interfaces in the composite and also increases the dislocation density.

Abstract: The system includes a track lining apparatus and two tamping apparatuses arranged in parallel, wherein the track lining apparatus includes two track lining hydro-cylinders, and the track lining hydro-cylinder communicates with a hydraulic control system through an oil inlet pipeline and an oil return pipeline; pressure sensors configured to detect pressures of the pipelines are provided on the oil inlet pipeline and the oil return pipeline; the tamping apparatus includes two pairs of tamping components arranged on both sides, where the tamping component includes a pair of packer arms and two pairs of packers; a dynamic force sensor is provided at a joint between the packer arm and the packer, and the dynamic force sensor can detect a transient dynamic downward insertion force generated when the packer is inserted into the ballast bed.

Abstract: Transducer systems disclosed herein include self-sensing capabilities. In particular, electrostatic transducers include a low voltage electrode and a high voltage electrode. A low voltage sensing unit is coupled with the low voltage electrode of the electrostatic transducer. The low voltage sensing unit is configured to measure a capacitance of the electrostatic transducer, from which displacement of the electrostatic transducer may be calculated. High voltage drive signals received by the high voltage electrode during actuation may be isolated from the low voltage sensing unit. The isolation may be provided by dielectric material of the electrostatic transducer, a voltage suppression component, and/or a voltage suppression module comprising a low impedance ground path. In the event of an electrical failure of the transducer, the low voltage sensing unit may be isolated from high voltages.

Abstract: In an aspect, an artificial selenomelanin material comprises: one or more selenomelanin polymers; wherein the one or more selenomelanin polymers comprise a plurality of covalently bonded selenomelanin base units; and wherein a chemical formula of each of the one or more selenomelanin base units comprises at least one selenium atom. Optionally, each selenomelanin polymer is a pheomelanin. Preferably, the chemical formula of each of the one or more selenomelanin base units comprises at least one covalent bond with each of the at least one selenium atom.

Abstract: The present invention provides compositions and methods for the treatment of diseases and disorders. In some embodiments the compositions and methods involve administration of a microparticle, or composition thereof that includes an antifibrotic.

Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease encompassing chronic bronchitis, emphysema and remodeling of small airways that can be treated by the caveolin-1 peptide CSP7 (SEQ ID NO:1). Chronic tobacco smoke exposure (TSE)-induced lung injury includes increased alveolar and airway inflammation, type II alveolar epithelial cells (A2Cs) senescence and apoptosis, and mucus hypersecretion by AECs. Interleukin 17A-mediated induction of plasminogen activator inhibitor-1 (PAI-1) expression through caveolin-1 led to TSE-induced lung injury, which was abrogated by CSP7 treatment which abolished A2Cs senescence and apoptosis, and AECs mucus hypersecretion in TSE wild type (WT) mice. Ex vivo CSP7 treatment of lung tissue of COPD patients decreased A2C apoptosis and AEC mucus hypersecretion. Lung injury induced by PAI-1 expression in COPD lung tissue and WT mice (20 weeks TSE), with A2Cs senescence and apoptosis, and AEC mucus hypersecretion was abolished by CSP7.

Abstract: A method of manufacturing inorganic binder by reduction furnace slag includes a raw material preparation step, a stirring step, a maintaining step and a drying step. The raw material preparation step is to provide a powder mixture containing 30 wt % to 55 wt % of reduction furnace slag, and 45 wt % to 70 wt % of glass powder. The stirring step is to place the powder mixture in a mixing tank, and add an alkali activator to the mixing tank to stir and react to form mixed slurry. The alkali equivalent (AE) of the mixed slurry is 2% to 7%, and the water-binder ratio is 0.25 to 0.4. The maintaining step is to place the mixed slurry in a high-temperature and high pressure maintaining environment for a maintaining time to get a binder. The drying step is to dry the binder.

Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Abstract: The disclosure provides compositions, kits, and methods for detecting/identifying amino acids and sequencing polypeptide molecules.

Abstract: A composition of drug targets and the use the method of using thereof. The composition comprises a vector and a drug using FKBP10 and PCOLCE genes and/or the encoded proteins thereof as drug targets.

Abstract: A method for computation with recurrent neural networks includes receiving an input drive and a recurrent drive, producing at least one modulatory response; computing at least one output response, each output response including a sum of: (1) the input drive multiplied by a function of at least one of the at least one modulatory response, each input drive including a function of at least one input, and (2) the recurrent drive multiplied by a function of at least one of the at least one modulatory response, each recurrent drive including a function of the at least one output response, each modulatory response including a function of at least one of (i) the at least one input, (ii) the at least one output response, or (iii) at least one first offset, and computing a readout of the at least one output response.

Abstract: A pure integer quantization method for a lightweight neural network (LNN) is provided. The method includes the following steps: acquiring a maximum value of each pixel in each of the channels of the feature map of a current layer; dividing a value of each pixel in each of the channels of the feature map by a t-th power of the maximum value, t?[0,1]; multiplying a weight in each of the channels by the maximum value of each pixel in each of the channels of the corresponding feature map; and convolving the processed feature map with the processed weight to acquire the feature map of a next layer. The algorithm is verified on SkyNet and MobileNet respectively, and lossless INT8 quantization on SkyNet and maximum quantization accuracy so far on MobileNetv2 are achieved.

Abstract: A cooling apparatus for a power module including a plurality of cooling modules provided to be in contact with each of both surfaces of the power module, in which the cooling module includes a manifold cover provided with a plurality of guide walls extending in a first direction in a state of being spaced apart from each other and a pin plate having one surface being in contact with the power module and having a plurality of pins extending in a second direction crossing the first direction formed on the other surface thereof.

Abstract: An amphibious robot is provided. An aspect of the robot includes an elongated flexible body, actuators in the flexible body and spaced apart along a length of the flexible body. The actuators are configured to move the flexible body in a serpentine or concertina motion on land and in water. An additional aspect includes a camera coupled adjacent to an end of the flexible body, at least one sensor coupled to the flexible body, and a buoyancy controller located in the flexible body. Another aspect includes a power source coupled to the flexible body and configured to power the actuators, the camera, the sensors, and the buoyancy controller. Yet another aspect employs an electric controller to control the actuators and receive data from the sensors.

Abstract: Described herein are methods and systems for the preparation of a brain targeted cerium oxide nanop article (CeNP) and its application in treating central neuronal system diseases. The brain targeted CeNP (T-CeNP) can effectively pass the blood brain barrier and specifically target brain tissue and exhibit anti-inflammatory and anti-oxidant effects.

Abstract: A method for breeding a new germplasm of clubroot-resistant orange-heading Chinese cabbage includes: (1) obtaining F1 by hybridizing orange-heading Chinese cabbage as a female parent and clubroot-resistant Chinese cabbage as a male parent, obtaining F2 by selfing F1 individual plants, planting F2 populations, and extracting DNA from the individual plants of F2; (2) observing horticultural traits of F2, and performing observation and statistics of head color phenotypic traits through cutting head; (3) performing PCR amplification with DNA of F2 using a dominant orange gene marker Br530 and a clubroot-resistant marker SC2930-T/SC2930Q, and identifying a genotype of the individual plants; (4) performing a comprehensive evaluation according to the results of marker detection and the observation of horticultural traits, selecting double-site homozygous clubroot-resistant orange-heading Chinese cabbage plants, and selfing the individual plants for 2 consecutive generations; and (5) obtaining a new germplasm of club

Abstract: The present invention provides a high-strength and high-plasticity titanium matrix composite and a preparation method thereof. The preparation method includes: preparing high-oxygen hydride-dehydride titanium powder using a high-temperature rotary ball grinding treatment process, in which the prepared hydride-dehydride titanium powder has a particle size of 10-40 ?m, and has an oxygen content of 0.8-1.5 wt. %; preparing high-purity ultra-fine oxygen adsorbent powder using a wet grinding method of high-energy vibration ball grinding treatment process; in which a purity of the oxygen adsorbent powder is ?99.9%, and a particle size of the oxygen adsorbent powder is ?8 ?m; mixing the high-oxygen hydride-dehydride titanium powder with the oxygen adsorbent powder in a protective atmosphere, and then press-forming the powder obtained after mixing to obtain a raw material blank; and performing atmosphere protective sintering treatment on the raw material blank to obtain a titanium matrix composite.

Abstract: The present disclosure provides a method for preparing a self-floating transparent nano ultrathin film. According to the present disclosure, the MXene film layer and the nano ultrathin film layer are sequentially subjected to suction filtration on the substrate material by utilizing a vacuum suction filtration technology, and thus a double-film structure is loaded on the substrate material; then an oxidant is subjected to oxidizing and bubbling on the MXene film layer in a permeation way, and thus the substrate material and the nano ultrathin film layer can be separated in a physical isolating manner. Finally, the nano ultrathin film is completely separated in a liquid phase floating separation manner. The nano ultrathin film prepared by the method provided by the present disclosure has a specific thickness and light transmittance through different loading capacities, and the substrate material can be repeatedly utilized.

Abstract: Testing peptides in in vitro models of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Frontotemporal dementia, Amyotrophic lateral sclerosis, to evaluate systems and methods of treatment therefore.

Abstract: CS-doped SrO nanocomposite were successfully synthesized through co-precipitation route for bactericidal activities. Effect of CS doping on morphological features, optical properties, elemental composition and phase constitution on CS-doped SrO nanocomposite was analyzed. XRD analysis confirmed tetragonal and cubic structures of SrO nanoparticles and CS-doped SrO nanocomposite. UV-vis spectroscopy was used to obtain 4.19 eV of SrO nanoparticles while emission spectra of doped SrO showed blueshift upon CS doping with multi-concentration. Interlayer d-spacing attained from HRTEM micrographs well matched with XRD d-spacing. Purity content of prepared nanostructures was measured with EDS analysis. Overall, 0.06:1 showed significant antibacterial activity against both Gram +ve and -ve bacterial isolates. Thus, CS-doped SrO nanocomposite can be used in modem medicine as an alternative antibacterial to overcome the development of resistance to antibiotics.