Abstract: It has been revealed that, from a pre-onset stage of Alzheimer's disease, enhancement of phosphorylations of MARCKS and the like causes abnormal spine formation or the like, consequently developing the disease. It also has been revealed that the phosphorylations of MARCKS and the like are caused by PKC and the like, and further that b-raf is involved in phosphorylation of tau protein important for the progression of Alzheimer's disease. Thus, these proteins have been found to be target molecules useful in the diagnosis and treatment of Alzheimer's disease. In addition, it has also been revealed that, in a pre-onset stage of frontotemporal lobar degeneration, b-RAF phosphorylation enhancement causes a decrease in the number of spines and the like, consequently developing the disease. Thus, b-RAF has been found to be a target molecule useful in the diagnosis and treatment of frontotemporal lobar degeneration.

Abstract: The present disclosure relates to a full-color light-emitting diode (LED) display, and more particularly, to a full-color LED display that may be driven by direct current (DC) and a method of manufacturing the same.

Abstract: The present invention relates to a ?LED light emitting device without electrical contact based on a wavelength down-conversion. The ?LED light emitting device without electrical contact comprises ?LED crystal grains, wavelength down-conversion light emitting lavers, ate upper driving electrode and a lower driving electrode, insulators, an optical micro-structure and a control module. The upper driving electrode and the lower driving electrode are free from direct electrical contact with each of the ?LED crystal grains, the control module is electrically connected with the upper driving electrode and the lower driving electrode respectively to provide alternating driving signals to the upper driving electrode and the lower driving electrode so as to form a driving electric field, and the driving electric field controls an electron-hole recombination of the ?LED crystal grain and emits a first light source which is converted into a second light source via the wavelength down-conversion light emitting layer.

Abstract: A method for achieving voltage-controlled gate-modulated light emission using monolithic integration of fin- and nanowire-n-i-n vertical FETs with bottom-tunnel junction planar InGaN LEDs is described. This method takes advantage of the improved performance of bottom-tunnel junction LEDs over their top-tunnel junction counterparts, while allowing for strong gate control on a low-cross-sectional area fin or wire without sacrificing LED active area as in lateral integration designs. Electrical modulation of 5 orders, and an order of magnitude of optical modulation are achieved in the device.

Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Abstract: There is provided herein, the use of mammalian derived HLA class I molecule for in vitro peptide exchange. For example, there is provided a method of producing an HLA class I molecule complexed to a pre-selected peptide comprising: (a) providing a mammalian derived HLA class I molecule complexed to an existing peptide; (b) incubating, in vitro, the HLA class I molecule complexed to the existing peptide with the pre-selected peptide, wherein the pre-selected peptide is at a concentration sufficient to replace the existing peptide to produce the HLA class I molecule complexed to the pre-selected peptide; and the HLA class I molecule comprises ?1, ?2, ?3 and ?2m domains.

Abstract: The present invention relates to an animal model for oxidative stress research and use thereof, and more specifically, the present invention can utilize a mutant of RCAT having a regulatory function for an antioxidant stress regulator in Caenorhabditis elegans and a human cell line expressing RCAT as animal and human cell line models for oxidative stress research, using the mutant and the human cell line.

Abstract: The disclosure provides compositions, kits, and methods for detecting/identifying amino acids and sequencing polypeptide molecules.

Abstract: The present application provides a composite solid state electrolyte slurry, a film, a preparation method, and an all solid state battery. The method includes: adding a polymer into a non-polar solvent and mixing the polymer and the non-polar solvent to obtain a sol; adding a solid state electrolyte powder and a lithium salt solution into the sol and mixing the solid state electrolyte powder, the lithium salt solution and the sol to obtain a composite solid state electrolyte slurry; the non-polar solvent is an organic solvent that does not react with the solid state electrolyte powder; the high shear force of the sol is used to disperse the solid state electrolyte powder and lithium salt solution, thereby the solid state electrolyte powder and the lithium salt solution are uniformly dispersed in the sol.

Abstract: Described herein is a method to create dendritic biocompatible polymers from pairs of complementary dendritic nucleic acid monomers in a controlled manner, using polymerization triggers. The dendritic monomers are constituted of nucleic acids and an organic polymer capable of self-assembly. Each polymer contains approximately 200 dendrites that can be used to attach labels and constitute a biologically compatible signal amplification technology. Depending on the context this technology could be used to reveal the presence of a large variety of analytes such as specific nucleic acid molecules, small molecules, proteins, and peptides.

Abstract: This invention relates to predicting a subjects responsiveness to biologic therapy of rheumatoid arthritis. The invention provides a method for predicting responsiveness to anti-tumour necrosis factor therapy of rheumatoid arthritis in a subject, the method comprising the steps of: (a) Providing a biological sample; (b) detecting the presence, absence, or quantitative level of a first marker or an expression product thereof, wherein the first marker is at the HLA DRB1 gene; (c) detecting the presence, absence, or quantitative level of a second marker, or an expression product thereof, wherein the second marker is at the CD226 gene; (d) correlating the presence, absence, or quantitative level of the first marker and the presence, absence, or quantitative level of the second marker; to the predicted responsiveness to anti-tumour necrosis factor therapy of rheumatoid arthritis in the subject.

Abstract: A graphene and in-situ nano-ZrB2 particle-co-reinforced aluminum matrix composite (AMC) and a preparation method thereof are provided. The preparation method includes: heating an aluminum alloy for melting, adding potassium fluoroborate and potassium fluorozirconate to produce ZrB2 particles in-situ, additionally adding a mixture of pre-prepared copper-coated graphene and an aluminum powder, and stirring with an electromagnetic field for uniform dispersion; and ultrasonically treating the resulting melt to improve the dispersion of the in-situ nano-ZrB2 particles and the graphene, casting for molding to obtain a casting, and subjecting the casting to homogenization and rolling for deformation to obtain the graphene and in-situ nano-ZrB2 particle-co-reinforced AMC. The in-situ generation of the reinforcement nano-ZrB2 particles in an aluminum alloy melt increases the number of interfaces in the composite and also increases the dislocation density.

Abstract: The system includes a track lining apparatus and two tamping apparatuses arranged in parallel, wherein the track lining apparatus includes two track lining hydro-cylinders, and the track lining hydro-cylinder communicates with a hydraulic control system through an oil inlet pipeline and an oil return pipeline; pressure sensors configured to detect pressures of the pipelines are provided on the oil inlet pipeline and the oil return pipeline; the tamping apparatus includes two pairs of tamping components arranged on both sides, where the tamping component includes a pair of packer arms and two pairs of packers; a dynamic force sensor is provided at a joint between the packer arm and the packer, and the dynamic force sensor can detect a transient dynamic downward insertion force generated when the packer is inserted into the ballast bed.

Abstract: An X-ray-based test device for a plugging removal effect of a sulfur dissolvent on a sulfur deposition rock sample includes a constant speed and pressure pump, a first intermediate container, a second intermediate container, a first pressure transmitter, a core holder, a second pressure transmitter, a first electric pump, a third intermediate container, a back-pressure valve, a gas flow meter, an H2S neutralization tank, a second electric pump, a back-pressure transmitter, a confining pressure transmitter, an X-ray generator, an X-ray detector and a thermotank. A sour gas sample is placed in the first intermediate container, and nitrogen is filled in the second intermediate container. The sulfur dissolvent is placed into the third intermediate container. A confining pressure inlet is formed in the core holder. The test device may be used for evaluating the plugging removal effect of the sulfur dissolvent injected into the sulfur deposition rock sample.

Abstract: A device for measuring the complex dielectric permittivity of a material under test (MUT) includes an electromagnetic wave generating/receiving unit, a transmission line, a self-referencing waveguide section and a sensing waveguide section. The electromagnetic wave generating/receiving unit is configured to generate an electromagnetic wave signal. The transmission line has a first characteristic impedance and transmits the electromagnetic wave signal. The self-referencing waveguide section has a second characteristic impedance, and includes a front end and a back end, wherein a first reflection signal is sent from the front end. The sensing waveguide section is connected to the back end, and configured to cooperate with the back end to send out remaining subsequent reflection signals, wherein the electromagnetic wave generating/receiving unit receives the first reflection signal and the remaining subsequent reflection signals to measure the complex dielectric permittivity of the MUT.

Abstract: Disclosed are cathodes comprising a conductive support substrate having an electrocatalyst coating containing nickel hosphide nanoparticles and a co-catalyst. The conductive support substrate is capable of incorporating a material to be reduced, such as CO2 or CO. A cocatalyst, either incorporated into the electrolyte solution, or into the conductive support, or adsorbed to, deposited on, or incorporated into the bulk cathode material, alters the electrocatalyst properties by increasing the carbon product selectivity through interactions with the reaction intermediates.

Abstract: Among the various aspects of the present disclosure is the provision of engineered cells, animal models, and uses thereof for modeling low grade glioma (LGG). An aspect of the present disclosure provides for a population of cells engineered to silence, downregulate, knock out, or reduce or knock down Cxcl10 expression. Another aspect of the present disclosure provides for an animal engineered to be deficient in Cxcl10, downregulate or reduce expression of Cxcl10, knock out Cxcl10, or knock down Cxcl10 (e.g., Cxcl10?/? mice). Yet another aspect of the present disclosure provides for a method of growing tumor cell lines or patient-derived xenografts for LGG tumors in an animal (e.g., mouse, rat) including providing a mouse or rat harboring somatic homozygous deletion in the Rag1 or Cxcl10 gene, and implanting an amount of the cells in mice sufficient to grow a tumor.

Abstract: The present invention relates to composite materials based on a graphene-like substrate, decorated with nanoparticles of at least two different metals. The composite materials show superior antibacterial activity in a variety of contexts, notably in phytosanitary applications.

Abstract: Provided is a method for producing serum that exhibits improved cell proliferation activity. A method for producing serum for culturing mammalian cells, comprising: maintaining blood collected from a first mammal at a temperature between 15° C. and 25° C. for up to 48 hours and preparing serum from the blood.

Abstract: Relay-aided intelligent reconfigurable surfaces (IRSs) are provided. A novel relay-aided intelligent surface architecture is described herein that has the potential of achieving the promising gains of IRSs with a much smaller number of elements, opening the door for realizing these surfaces in practice. A half-duplex or full-duplex relay is connected to one or more IRSs. This merges the gains of relays and reconfigurable surfaces and splits the required signal-to-noise ratio (SNR) gain between them. This architecture can hen significantly reduce the required number of reconfigurable elements in the IRS(s) while achieving the same spectral efficiencies. Consequently, the proposed relay-aided intelligent surface architecture needs far less channel estimation/beam training overhead and provides enhanced robustness compared to traditional IRS solutions.