Abstract: Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.

Abstract: The present disclosure relates to a photosensitive optoelectronic device comprising two electrodes, an inorganic subcell positioned between the two electrodes, wherein the inorganic subcell comprises at least one inorganic semiconductor material having a band gap energy (EG), and an organic sensitizing window layer disposed on the inorganic subcell. In one aspect, the organic sensitizing window layer comprises a singlet fission material. In another aspect, the organic sensitizing window layer comprises a singlet fission host and a phosphorescent emitter dopant, where the singlet fission host exhibits an excitation triplet energy (ET-SF) greater than or equal to an excitation triplet energy (ET-PE) exhibited by the phosphorescent emitter dopant.

Abstract: The present disclosure provides a multi-path combined high-low voltage plasma rock-breaking drill bit, drill bit apparatus and drilling method. The multi-path combined high-low voltage plasma rock-breaking drill bit comprises: a drill bit body, insulators, plasma generators, drilling fluid outlets, plasma integrated pipelines, a drilling fluid pipe; wherein a plurality of plasma generators are distributed on the same drill bit body; the axis of the plasma generator and the axis of the drill bit body form a certain included angle; each of the plasma generators is independently connected to the ground through its respective plasma integrated pipeline and operates independently; and drilling fluid flows out of the drilling fluid outlets, takes away the heat generated by the operation of the plasma generators, thereby cooling the plasma generators.

Abstract: Methods and apparatus for a three-stage ventricular cardioversion and defibrillation therapy that treats ventricular tachycardia and fibrillation at low energy levels. An implantable therapy generator adapted to generate and selectively deliver a three-stage ventricular therapy and at least two leads operably each having at least one electrode adapted to be positioned proximate the ventricle of the patient. The device is programmed to deliver a three-stage therapy via both a far-field configuration and a near-field configuration of the electrodes upon detection of a ventricular arrhythmia. The three-stage therapy includes a first stage for unpinning of one or more singularities associated with the ventricular arrhythmia, a second stage for anti-repinning of the one or more singularities, both of which are delivered via the far-field configuration of the electrodes, and a third stage for extinguishing of the one or more singularities associated delivered via the near-field configuration of the electrodes.

Abstract: Systems and method for active control of stationary vortices for aerodynamic structures are disclosed herein. In one embodiment, a method for active control of vortices over a solid surface includes: generating vortices proximate to the solid surface; sensing locations of vortices by printed skin sensors; and maintaining the vortices in their fixed spanwise positions with respect to the solid surface by actuation of printed skin actuators.

Abstract: Traversing, by an autonomous vehicle, a vehicle transportation network, may include operating a scenario-specific operational control evaluation module instance, wherein the scenario-specific operational control evaluation module instance includes an instance of a scenario-specific operational control evaluation model of a vehicle operational scenario wherein the vehicle operational scenario is a merge vehicle operational scenario or a pass-obstruction vehicle operational scenario, receiving a candidate vehicle control action from the scenario-specific operational control evaluation module instance, and traversing a portion of the vehicle transportation network in accordance with the candidate vehicle control action.

Abstract: Methods of treating propionic acidemia (PA), methylmalonic acidemia (MMA) and fatty acid oxidation disorders are described. The methods include administering an anaplerotic agent that can directly enter the tricarboxylic acid cycle, such as a succinate derivative or pro-drug, for example trisuccinylglycerol (TSG). Methods of restoring tricarboxylic acid (TCA) cycle function in a cell deficient for propionyl-CoA carboxylase (PCC) or methylmalonyl-CoA mutase (MUT) by contacting the cell with a succinate derivative or pro-drug, such as TSG, are also described.

Abstract: Disclosed is a subpixel circuit 310 comprising: a first switching device 311 responsive to a digital periodic signal VP to provide a digital control signal VC relating to a digital data signal VD, the digital periodic signal VP defining 2N+1 time slots within each frame cycle, where N is a predetermined integer. The digital data signal VD has a predetermined value at a predetermined one of the 2N+1 time slots; and the subpixel circuit 310 further comprises a second switching device 312 responsive to the control signal Vc to drive an associated light emitting element 320.

Abstract: A method of forming metallic particles, comprising: providing precursor particles comprising a transition metal alloy; supplying carbon monoxide (CO) under reaction conditions which differentially remove a first alloy metal from the precursor particles at a faster rate than a second alloy metal; and, maintaining the reaction conditions until the precursor particles are converted to the particles. The precursor particles may comprise PtNi4, and the particles may be Pt3Ni, formed as hollow nanoframes on a carbon support.

Abstract: Methods and apparatus for reducing Miller effect in SiC MOSFETs are provided. An example apparatus includes a plurality of SiC MOSFETs and a Miller current cancellation circuit configured to mitigate Miller current induced by switching transients associated with the plurality of SiC MOSFETS. The Miller current cancellation circuit includes a two-stage voltage sampling circuit configured to sample a drain to source voltage of a SiC MOSFET of the plurality of SiC MOSFETs, a voltage inverting circuit configured to invert the sampled drain to source voltage, and an injection capacitor configured to generate, by way of receiving the inverted sampled drain to source voltage as input, inverse Miller current to mitigate the Miller current within the plurality of SiC MOSFETS.

Abstract: Compositions and methods for inducing immune tolerance to proteins and subsequence administration of the proteins are disclosed. Compositions comprise proteins complexed with liposomes comprising PS and PC, wherein at least part of the PS is present as lyso-PS.

Abstract: An ultra dense and ultra low power microhotplates using silica aerogel and method of making the same, comprising creating a sol-gel by impregnation of ethanol with functional colloidal alcogel particles is described. The technique further comprises forming tiny aerogel particles on the wafer and networking the particles together just by exposure to air during spin coating. The novelty of this technique is not limited to the processing of thin film and thick film silica aerogel.

Abstract: Methods and systems for reducing the concentration of selenium species in water, particularly water containing recalcitrant selenium species. In the methods and systems, water containing one or more selenium species is treated with permanganate to provide permanganate-treated water, which is then contacted with a zero-valent iron treatment system comprising (a) a reactive solid comprising zero-valent iron and one or more iron oxide minerals in contact therewith and (b) ferrous iron.

Abstract: A surface-enhanced Raman scattering substrate includes a floating-type first metal nanoparticle; a support body for supporting the first metal nanoparticle; and a second metal film which forms a nano gap with the first metal nanoparticle and is surrounding the circumference of the first metal nanoparticle, wherein a first metal of the first metal nanoparticle and a second metal of the second metal film, respectively, can be a metal generating surface plasmons thereon.

Abstract: The disclosure discloses a lookup table-based circuit aging detection sensor, including a control circuit, two voltage controlled oscillators (VCOs), two shaping circuits, a phase comparator, a 3-digit voter, a beat-frequency oscillator, an 8-digit counter, a latch, a lookup table array and a digital-analogue converter. The control circuit respectively connects with the phase comparator, the 3-digit voter, the 8-digit counter, the first and the second VCOs. The first and second VCOs connect with the first and second shaping circuits respectively. The first and second shaping circuits connect with the phase comparator. The phase comparator connects with the 3-digit voter. The 3-digit voter connects with the beat-frequency oscillator. The beat-frequency oscillator respectively connects with the 8-digit counter and the latch. The 8-digit counter connects with the latch. The latch connects with the lookup table array. The lookup table array connects with the digital-analogue converter.

Abstract: Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.

Abstract: Systems and methods for visually displaying instances of increased susceptibility for commission of medical errors are provided. Execution of programming instructions on a computer-readable medium causes a processor to retrieve historical workload data corresponding to environmental conditions experienced by and near misses associated with an individual or team of individuals during a first period of time from one or more data repositories. Retrieved workload data is processed to establish threshold limits for distinct working conditions represented within the workload data for the individual or team of individuals. Workload data corresponding to a second period of time is retrieved for the individual or team of individuals and compared to established threshold limits by the processor. Based on the comparison, the processor generates one or more displayable indicia indicative of the individual's or team of individuals' risk of committing a medical error due to an experienced workload.

Abstract: Disclosed are fouling resistant filtration membranes comprising a polymeric thin-film membrane comprising a surface. Also disclosed are methods of modifying thin-film filtration membranes, thereby improving, for example, the anti-fouling properties of the membranes. Also disclosed are methods of purifying water using the disclosed membranes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.

Abstract: Variant IL-13 polypeptides are provided, which are engineered to have one or more of the following properties: (a) altered affinity for IL-13R?2, relative to the native human IL-13 protein; (b) altered affinity for IL-13R?1 relative to the native human IL-13 protein; (c) a disruption in the binding site for IL-4R? relative to the native human IL-13 protein.