Patents Assigned to University
  • Therapeutic compounds
    Patent number: 10464941
    Abstract: and salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: November 5, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Philip S. Portoghese, Eyup Akgun
  • Methods for treating cardiovascular dysfunction and improving fluid homeostasis with Elabela peptide hormone
    Patent number: 10463716
    Abstract: The present invention generally to methods of treating subjects suffering from a cardiac condition or having a risk factor for developing a cardiac condition by administering an ELA peptide or fusion protein to a subject in need. The invention relates to fusion proteins of Fc-ELA-32 and Fc-ELA-21 that exhibit improved properties for use as therapeutic agents, e.g. in the treatment of cardiac conditions. In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: November 5, 2019
    Assignee: University of Maryland, Baltimore
    Inventors: Da-Wei Gong, Daozhan Yu, Rongze Yang, Alan Shuldiner, Ling Chen
  • Grain refinement in iron-based materials
    Patent number: 10465258
    Abstract: A process for manufacturing an iron-based alloy comprising forming targeted fine oxide and/or carbide dispersoids in a melt, and sequentially precipitating transition-metal nitrides on the dispersoids for heterogeneous nucleation of equiaxed grains. An iron-based cast alloy having a highly equiaxed fine grain structure.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: November 5, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Simon Lekakh, Von Richards, Ronald O'Malley, Jun Ge
  • Apparatus and methods for depth-of-interaction positron tomography detector using dichotomous sensing
    Patent number: 10466371
    Abstract: Apparatus and methods for depth-of-interaction (DOI) positron tomography detection are disclosed herein. Certain embodiments utilize dichotomous sensing to obtain DOI information.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: November 5, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Yuxuan Zhang, Wai-hoi Wong
  • Visual storytelling authentication
    Patent number: 10467400
    Abstract: Method, system and media for authenticating a subject as a user. Embodiments generate visual stories specific to the user and for which the subject must select the corresponding images from among a plurality of decoy images. Gaze tracking can be used to determine which images the user has selected without allowing an observer to learn which images have been selected. Images for the visual story can be retrieved from the user's social networking profile, and corresponding text storied generated to indicate which images should be selected. Multiple security levels are possible by varying the number of story images and decoy images.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: November 5, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Chi-Ren Shyu, Hongfei Cao, Matthew Klaric, Jeffrey Uhlmann
  • Method for treating a neurovascular complication of diabetes mellitus
    Patent number: 10463632
    Abstract: A method of preventing and/or treating a disease caused by diabetes complications includes administering to a patient in need thereof, an effective amount of thymoquinone or a pharmaceutically acceptable salt thereof, either singly or in combination with a pharmaceutically acceptable carrier, diluent or excipient. The disease can be at least one of retinopathy, nephropathy, neuropathy, and neurological disorder.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: November 5, 2019
    Assignee: King Saud University
    Inventors: Khalid Mohammed Alkharfy, Ghulam Mohammad, Ajaz Ahmad, Mohammad Mairaj Siddiquei, Ahmed Abu El-Asrar
  • Apparatus and method for controlling narrow road driving of vehicle
    Patent number: 10466715
    Abstract: An apparatus for controlling narrow road driving of a vehicle includes: an image transform unit generating a depth map using depth information of an object in a front image of a road on which the vehicle travels and generating a height map of the front image by transforming the generated depth map; a map analysis unit recognizing the object and calculating a driving allowable area of the road based on the generated height map; a determination unit determining whether the road is a narrow road based on the calculated driving allowable area and, when the road is determined to be the narrow road, determining whether the vehicle is able to pass through the narrow road; and a signal processing unit controlling driving of the vehicle on the narrow road based on the determination of whether the vehicle is able to pass through the narrow road.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: November 5, 2019
    Assignees: Hyundai Motor Company, Kia Motors Corporation, Industry-University Cooperation Foundation Hanyang University
    Inventors: Byung Yong You, Jong Woo Lim, Keon Chang Lee
  • Printed wireless inductive-capacitive (LC) sensor for heavy metal detection
    Patent number: 10466287
    Abstract: An inductive-capacitive (LC) wireless sensor for the detection of toxic heavy metal ions includes inductors and interdigitated electrodes (IDE) in planar form. The sensor is fabricated by screen printing silver (Ag) ink onto a flexible polyethylene-terephthalate (PET) substrate to form a metallization layer. Palladium nanoparticles (Pd NP) is drop casted onto the IDEs to form a sensing layer. The resonant frequency of the LC sensor is remotely monitored by measuring the reflection coefficient (S11) of a detection coil (planar inductor). The resonant frequency of the LC sensor changes with varying concentrations of heavy metals such as mercury (Hg2+) and lead (Pb2+) ions. Changes in the resonant frequency are used to detect the presence and/or concentration of heavy metal ions.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: November 5, 2019
    Assignee: The Board of Trustees of Western Michigan University
    Inventors: Massood Zandi Atashbar, Sai Guruva Reddy Avuthu, Binu Baby Narakathu
  • Direct dyeing color fused deposition modeling three-dimensional printing apparatus and direct dyeing color fused deposition modeling three-dimensional printing method
    Patent number: 10464302
    Abstract: A direct dyeing type color fused deposition modeling three-dimensional printing apparatus includes a forming stage, a forming unit, and a color-inkjet unit. The forming unit is located above the forming stage for providing forming-material layers on the forming stage in sequence. The color-inkjet unit is located above the forming stage for providing color-ink layers on the forming-material layers in sequence, wherein the forming-material layers and the color-ink layers are stacked alternately in sequence to form a colored three-dimensional object. A direct dyeing type color fused deposition modeling three-dimensional printing method is also provided.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: November 5, 2019
    Assignee: National Taiwan University of Science and Technology
    Inventors: Yih-Lin Cheng, Freeman Chen, Jun-Hao Chen
  • Energy harvesting for leadless pacemakers
    Patent number: 10463864
    Abstract: An energy harvester having a plurality of bimorph beams and a plurality of piezoelectric devices, wherein at least two of the piezoelectric devices are mounted to each of the plurality of bimorph beams. A plurality of rigid beams interconnect adjacent ends of the bimorph beams to define a stacked, fan-folded shape having a first end of one of the bimorph beams mounted to a structure. A tip mass is disposed on a free end of another of the plurality of bimorph beams. Upon movement of the energy harvester, the plurality of bimorph beams is caused to deflect and thereby output electrical power from the plurality of piezoelectric devices.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: November 5, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, The Research Foundation for the State University of New York
    Inventors: Mohammad Amin Karami, David J. Bradley, Daniel J. Inman, Mohammad Hossein Ansari
  • Organic electroluminescent materials and devices
    Patent number: 10468609
    Abstract: New organic materials having polyaromatic structure containing boron and high triplet energy are disclosed. The high triplet energy materials are useful as host materials in PHOLEDs and improve device quantum efficiency and stability.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: November 5, 2019
    Assignee: Universal Display Corporation
    Inventors: Chi Hang Lee, Siu Tung Lam, Raymond Kwong
  • System and method for tracking vehicles in parking structures and intersections
    Patent number: 10467481
    Abstract: A dynamic signal to noise ratio tracking system enables detection of vehicles within the field of view of the tracking system. The tracking system may include an emitter configured to emit electromagnetic radiation within an area, a detector configured to detect electromagnetic radiation reflected back from vehicles within the area, and a control unit configured to evaluate signals from the detector and control various automated devices as a result of this evaluation.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: November 5, 2019
    Assignee: Universal City Studios LLC
    Inventors: Robert J. Cortelyou, Christopher Oliver
  • Alphabetical metamaterial gate/sensor device and its use to measure mercury
    Patent number: 10466180
    Abstract: The present invention relates to a logic gate, comprising a metamaterial surface enhanced Raman scattering (MetaSERS) sensor, comprising (a) alphabetical metamaterials in the form of split ring resonators operating in the wavelength range of from 560 to 2200 nm; and (b) a guanine (G) and thymine (T)-rich oligonucleotide that can, upon presence of potassium cations (K+), fold into a G-quadruplex structure, and in presence of Hg2+, form a T-Hg2+-T hairpin complex that inhibits or disrupts the G-quadruplex structure formed in presence of K+, as well as methods of operating and using such a logic gate.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: November 5, 2019
    Assignee: Nanyang Technological University
    Inventors: Qihua Xiong, Cuong Cao, Jun Zhang
  • Inhibitors of Mc1-1 as drugs to overcome resistance to BRAF inhibitors and MEK inhibitors
    Patent number: 10463649
    Abstract: The present invention includes compositions and methods for inhibiting MCL-1, including novel inhibitors of MCL-1, and compositions and methods for treating a subject with cancer that is refractory to one or more MAPK pathway protein inhibitors.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: November 5, 2019
    Assignee: Texas Tech University System
    Inventors: Sanjay K. Srivastava, Neel M. Fofaria
  • Pharmaceutical formulations of nitrite and uses thereof
    Patent number: 10463689
    Abstract: The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: November 5, 2019
    Assignee: Board of Supervisors of Louisiana State University
    Inventors: Christopher Kevil, Anthony Giordano, Douglas R. Flanagan, Panayiotis P. Constantinides
  • Self-locking optoelectronic tweezer and its fabrication
    Patent number: 10465154
    Abstract: A novel Self-Locking Optoelectronic Tweezers (SLOT) for single microparticle manipulation across a large area is provided. DEP forces generated from ring-shape lateral phototransistors are utilized for locking single microparticles or cells in the dark state. The locked microparticles or cells can be selectively released by optically deactivating these locking sites.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: November 5, 2019
    Assignee: The Regents of the University of California
    Inventors: Yajia Yang, Yufei Mao, Pei-Yu E. Chiou, Chi On Chui
  • Parametrically adjustable airway training mannequin with instrumented parameter assessment
    Patent number: 10467927
    Abstract: The adjustable airway mannequin with visual feedback models the human skull, maxilla, upper teeth, lower teeth, jaw, spine and airway mounted on a backboard. Adjustments can be made to the height of the maxilla, the height of the upper teeth, the tension and distance of the jaw movement representing mouth opening, the anterior-posterior displacement of the jaw relative to the maxilla and skull, the presence or absence of the upper teeth and lower teeth, the range of motion of the spine, and tension on the airway to mimic a variety of anatomies. The mannequin may include one or more electronic proximity and position sensors that operate through magnetic field sensing, accelerometry, and optical sensing to monitor one or more of face length, jaw length, mouth opening, jaw tension, larynx position, head height off the table, and spine mobility.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: November 5, 2019
    Assignee: The Regents of the University of California
    Inventors: Randolph Hastings, Nathan Delson
  • Circuit structure and driving method thereof, chip and authentication method thereof, and electronic device
    Patent number: 10468099
    Abstract: A circuit structure for implementing a physical unclonable function and a driving method thereof, an integrated circuit chip and an authentication method thereof, an electronic device are disclosed. The circuit structure includes: a multilayer circuit, a first address circuit and an output circuit, the multilayer circuit includes a first RRAM device array which is addressable and a second RRAM device array which is addressable; the first address circuit is configured to map a resistance value of a second RRAM device in the second RRAM device array to a first address; the first address is used for positioning a selected first RRAM device; and the output circuit is configured to acquire and process a resistance value of the selected first RRAM device and output a processing result.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: November 5, 2019
    Assignee: Tsinghua University
    Inventors: Huaqiang Wu, Yachuan Pang, Bin Gao, He Qian
  • Plasmonic stimulation of electrically excitable biological cells
    Patent number: 10463878
    Abstract: A novel method to stimulate electrically active biological cells using visible wavelength light and metallic nanoparticles possessing plasmonic properties is presented herein. Using this technology, prosthetic devices such as cochlear and retinal implants and cardiac pacemakers can be developed to have superior properties as compared to the currently utilized electrical stimulation designs. These properties include improved spatial resolution; less or non-invasive devices; and higher fidelity of transduction. An additional advantage of using visible light wavelengths is the avoidance of unwanted heating of surrounding tissue that occurs with infrared stimulation.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: November 5, 2019
    Assignee: University of South Florida
    Inventors: Parveen Bazard, Robert Dana Frisina, Joseph Paul Walton, Venkat Rama Bhethanabotla
  • Grass named ‘Tift PA5’
    Patent number: PP31027
    Abstract: A new variety of Pennisetum alopecuroides plant named ‘Tift PA5’ produces a reduced number of seeds, making it less invasive.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: November 5, 2019
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Wayne W. Hanna, Brian M. Schwartz