Abstract: Disclosed is a solvent dispensing system that includes a plurality of air-operated double diaphragm pumps, which are adapted to couple to a plurality of solvent supply containers, and coupled to a plurality of dispensing nozzles, wherein each air-operated double diaphragm pump is powered by a separate air supply line carrying pressurized air, and is controlled by a separate air directional control valve. The solvent dispensing system further includes a sealing cap device for coupling a solvent container to a solvent supply line. The sealing cap device is adapted to form a seal around a solvent discharge opening in a solvent container. The sealing cap device has a check valve and breather combination and a fitting for coupling the solvent container to a solvent supply line. Also disclosed is a clamping system for pressing the sealing cap device around the solvent discharge opening in the solvent container.

Abstract: Processes of forming Csp2—Csp3 bonds at the allylic carbon of a cyclic allylic compound starting material are disclosed, in which a racemic mixture of a cyclic allylic compound having a leaving group attached to the allylic carbon is reacted with a compound having a nucleophilic carbon atom in the presence of a Rh(I), Pd(II) or Cu(I) pre-catalyst and a chiral ligand. The reaction products containing the newly-formed Csp2—Csp3 bond are generated in high stereoisomeric excess, and may therefore serve as important organic building blocks in the preparation of new agrochemicals and pharmaceuticals.

Abstract: The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

Abstract: The present invention provides compositions and methods for printing a predetermined pattern on silk fibroin materials using water based “inks.” Such technique may be useful for micro- and nano-engineering applications.

Abstract: Described is a method of stabilizing blood vessel wall abnormality. The method includes ultrasonically heating at least a portion of the blood vessel wall having the abnormality; monitoring a parameter related to a property of at least a portion of the heated portion of the blood vessel wall; and stopping the heating when the monitored parameter changes by a predetermined factor or after the monitored parameter changes in a slow enough rate. The slow enough rate may be, for instance, a predetermined fraction of a maximal rate change observed during heating.

Abstract: Provided is a method for catalytically reducing selenium. Hydrogen peroxide is used as a catalyst, and a reducer is added to a hexavalent-selenium-containing solution for reaction so as to reduce the selenium to elemental selenium, wherein the standard oxidation-reduction potential of the reducer is lower than the standard oxidation-reduction potential of the conversion of the hexavalent selenium to elemental selenium. The present method can further reduce a hexavalent-selenium element-containing selenic acid or selenate solution to an elemental selenium product in one step.

Abstract: A mobile device, an authentication device and authentication methods thereof are provided. The mobile device displays a QR code on its display panel, and continuously transmits a wireless signal carrying a hardware serial number of the mobile device. The QR code stores service data including an identification code assigned to the mobile device and the hardware serial number of the mobile device. The authentication device captures the QR code from the mobile device and determines whether there is a received wireless signal carrying the hardware serial number of the mobile device. If there is a received wireless signal carrying the hardware serial number of the mobile device, the authentication device determines that the QR code passes authentication.

Abstract: The present system and method allow for preemptive, self-healing computer security. The system includes a user device processor and a PSS server processor. The two processors perform an initial Data Structure & Key Mutation (DSKM) method and an interval DSKM method at a given interval to protect secret information and prevent its exposure by attackers. When a user requests a site or service that is an attractive target for attackers, such as a bank site or monetary transfer service, the processors perform a Man in the Browser attack prevention method. When a packet is received or generated, the processors perform a Deep Protocol and Stateful Inspection and Prevention method to prevent receipt of malicious packets or the loss of sensitive information. Various forensics modules allow accurate forensic examination of the type, scope, and method of attack, as well as real-time protection of cloud-based services.

Abstract: Disclosed are methods, systems, components, and compositions related to genomically recoded and engineered organisms. The disclosed genomically recoded and engineered organisms may be used to prepare extracts for use in platforms and methods for preparing sequence defined biopolymers in vitro. In particular, the methods, systems, components, and compositions relate to genomically recoded and engineered organisms comprising a strain deficient in release factor 1 (RF-1) or a genetic homolog thereof, wherein the genomically recoded organisms have been engineered to express a heterologous RNA polymerase that may be utilized to express a target protein from a transcription template comprising a promoter for the heterologous RNA polymerase, such as bacteriophage T7 RNA polymerase.

Abstract: Random number generator systems and method for tuning a randomness characteristic of the system are described. The random number generator system includes at least one programmable metallization cell (PMC) device and is configured to provide a random output word based on random telegraph noise caused by the at least one PMC device.

Abstract: Provided is a preparation method of copper nanostructures, characterized in that a copper precursor including halide is reacted with polyethyleneimine (PEI) and a reducing agent in an aqueous solution. According to this method, the copper nanostructures may be easily prepared in a sphere, wire, or plate form, and high-quality copper nanostructures may be produced with a high production yield of 90% or more. This method is also appropriate for large-scale production.

Abstract: Single-step synthesis processes for production of ultrahigh molecular weight block copolymers are described. The ultrahigh molecular weight copolymers can have a molecular weight of about 106 or greater and can be formed within a few hours in a surfactant-free environment. The formation process is controlled by initiator-starvation conditions in a sequential polymerization of monomers exhibiting different solubility in the solvent.

Abstract: This study describes about a new electrochemical biosensor using DNA-redox electrostatic interaction and their subsequent non-specific adsorption on graphene screen-printed electrode or biochip. The ruthenium hexamine molecule [Ru(NH3)6]3+, or RuHex, was observed to form complexes with free DNA in solution that adsorbed onto graphene surfaces, enabling the development of a rapid, high-sensitivity DNA biosensor. Reproducible cathodic current signals were generated from these low-cost graphene biochips, both in the presence and absence of dsDNA and loop-mediated isothermal amplification (LAMP) amplicons. The combination of the DNA-redox molecule complexes and the graphene surface therefore provided a novel detection strategy. This new biosensor was able to identify different meat species based on the isothermal amplification of target genes followed by electrochemical detection with square wave voltammetry.

Abstract: The present invention relates generally to the field of cataract surgery and more particularly to methods and apparatus for performing a capsulorhexis. This invention is in the field of medical devices. The present invention relates to a device constructed from metals, polymers or other materials that are amenable to precise surface modifications and methods for its use, wherein (1) the device assists in capsulorhexis and (2) a patterned surface having milli-, micron-, and/or nano-sized micropatterning characteristics that imparts surface stabilizing and self-adhesive properties.

Abstract: An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.

Abstract: A computer-implemented method includes selecting, by a virtual problem-based learning (PBL) system, information indicative of a medical profile of a patient; accessing, by the virtual PBL system, information indicative of a team of students using the virtual PBL system; generating, by the virtual PBL system and based on the medical profile, an medical PBL schema comprising a medical problem to be solved by the team of students; generating a plurality of sections in the medical PBL schema, with each section promoting solving of the medical problem, and with each section associated with (i) a private work environment for a student to privately analyze the medical problem, and (ii) a shared, anonymous work environment for the students to view analysis performed by other students in solving the medical problem; and transmitting, to one or more client systems used by the students participating in the virtual problem-based learning system, the medical PBL schema.

Abstract: In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1 inhibitor, for example, an anthracene-9,10-dione derivative to a subject in need thereof. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, head and neck cancer, and leukemia, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant.

Abstract: A method for optimizing a CT simulation protocol for different size patients for contouring and segmentation of organs and tumors. The method scanning different size phantoms, cadavers, or patients with a CT scanning x-ray tube to create a set of images and to create data sets for each different size phantoms, cadavers, or patients and then calculating an image quality index (IQI) as a benchmark for contouring accuracy. Finding an optimal IQI that characterizes patients of different sizes and using the optimal IQI to determine the accuracy of the contouring and segmentation of A CT simulation protocol for a patient.

Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.