Abstract: The present invention is directed to methods for identifying the presence of one or more target nucleotide sequences in a sample that involve a nuclease-ligation reaction. In some embodiments, the ligation products formed in the nuclease-ligation process of the present invention are subsequently amplified using a polymerase chain reaction. The ligated product sequences or extension products thereof are detected, and the presence of one or more target nucleotide sequences in the sample is identified based on the detection.

Abstract: The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2?, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.

Abstract: The present invention provides an ?-1,3 fucosyltransferase mutant having an increased expression level of soluble protein and increased activity, a DNA encoding the ?-1,3 fucosyltransferase mutant, a recombinant vector comprising the DNA encoding the ?-1,3 fucosyltransferase mutant, a host cell transformed with the recombinant DNA vector, an extract of the host cell, a method for producing 3-fucosyloligosaccharide, a method for preparing an ?-1,3 fucosyltransferase mutant, and a method for screening an ?-1,3 fucosyltransferase mutant. The ?-1,3 fucosyltransferase mutant of the present invention has a significantly increased soluble protein expression level and activity.

Abstract: A device includes a control unit that includes an oscillator circuit. The control unit is configured to generate, based on the oscillator circuit, at least one switching signal. The device also includes a direct current (DC)-to-DC conversion circuit comprising at least one electronic switch that is operatively coupled to the control unit. The DC-to-DC conversion circuit is configured to convert, based on the at least one switching signal, a DC input voltage to a DC output voltage, and the control unit is further configured to input, to the oscillator circuit, a current signal that is generated based on a measured output current of the DC-to-DC conversion circuit.

Abstract: An ultrafast electromechanical switch having a drive mechanism comprising three non-movable contacts, an actuator and two movable contacts. The switch further including a switching chamber to provide a self-contained environment that may consist of a high-pressure gas or a vacuum and one or more precision adjustment screws coupled to the non-movable contacts for adjusting the contact pressure. The provided ultrafast electrical (e.g., transfer, disconnect, etc.) switch is simple, compact, clean, exhibits ultralow loss, does not require high energy to operate and is capable of being automatically reset.

Abstract: A composite magnetic matrix comprising a porous metal-organic framework (MOF) and a plurality of molecular magnets, where a plurality of pores of the MOF each comprise one of the plurality of molecular magnets, and where the each of the plurality of molecular magnets retains its magnetic properties in the matrix. The molecular magnet may be, for example, a single-molecule magnet or a single-chain magnet. For example, the composite magnetic matrix Mn12Ac@MOF comprises Mn12O12(O2CCH3)16(OH2)4 (Mn12Ac) as the single-molecule magnet and [Al(OH)(SDC)]n (H2SDC=4,4?-stilbenedicarboxylic acid) (CYCU-3) as the porous metal-organic framework.

Abstract: Provided herein is a pharmaceutical composition for treating, preventing or ameliorating a bone or cartilage condition and methods of making and using the same.

Abstract: The ear-mounted dental mirror support includes two arms, each having a hooked end configured to wrap around the back of an ear. The arms are connected to a cross-member at the end opposite the hook. A multi-rod adjustment member is pivotally attached to the cross-member. A mirror is pivotally attached to the free end of the adjustment member. The device is designed to be secured to a patient's ears by the arms with the cross-member resting on the patient's chin. The mirror can be adjusted to reflect different portions of the patient's mouth to help a person applying treatment visualize the treatment zone. The arms and cross-member may include projections to assist in securing a dental dam in place around the patient's mouth.

Abstract: A multiplex hand-held diagnostic biosensor, using two inflammatory salivary biomarkers, Human Neutrophil Elastase (HNE) and Cathepsin-G, was constructed made to potentially detect Periodontitis at an early stage is described. The use of magnetic nanoparticle biosensor method used as a device was based on the measurement of proteolytic activity using specific proteases probes. The magnetic nanoparticle biosensor device is capable of specific and quantitative detection of HNE and Cathepsin-G in solution and in spiked saliva samples with a lower detection limit of 1 pg/mL and 100 fg/mL for HNE and Cathepsin-G, respectively.

Abstract: A QCL (10) includes a first electrode (15), a first contact layer (11) that is in contact with the first electrode (15) and is made of a first compound semiconductor, a second electrode (14) having a polarity opposite to that of the first electrode (15), a second contact layer (13) that is in contact with the second electrode (14) and is made of a second compound semiconductor, and an active layer (12) disposed between the first contact layer (11) and the second contact layer (13) and including two or more active layer units. Each of the active layer units includes one or more quantum well layers made of a third compound semiconductor and one or more barrier layers made of a fourth compound semiconductor, and each of the quantum well layers and each of the barrier layers are alternately stacked.

Abstract: Methods of detecting a sulfur-containing compound in a sample are described, for example using NMR-SABRE hyperpolarization of the sulfur-containing compounds in the sample. The methods can comprise, for example, contacting a sample comprising a sulfur-containing compound with parahydrogen and a catalyst to form a mixture. A spin order can be transferred from the parahydrogen to the sulfur-containing compound thereby hyperpolarizing the sulfur-containing compound during a temporary association of the parahydrogen, the sulfur-containing compound, and the catalyst. The methods can further comprise, for example, performing an NMR measurement on the mixture comprising the hyperpolarized sulfur-containing compound to detect the hyperpolarized sulfur-containing compound (e.g., from the hyperpolarized NMR signals. In some examples, the methods described herein can be used for detecting a sulfur-containing contaminant in a fuel.

Abstract: Disclosed herein are embodiments of a composition for use in forming films or coatings that prevent damage in foodstuffs, including plants, fruits, and vegetables. The disclosed compositions comprise a cellulose nanomaterial and can further comprise a nanoscale mineral compound and one or more additional components. Also disclosed are films or coatings made using the disclosed compositions, as well as methods for making the disclosed compositions and methods for using the disclosed compositions.

Abstract: An example method for analyzing quantitative information obtained from radiological images includes identifying a ROI or a VOI in a radiological image, segmenting the ROI or the VOI from the radiological image and extracting quantitative features that describe the ROI or the VOI. The method also includes creating a radiological image record including the quantitative features, imaging parameters of the radiological image and clinical parameters and storing the radiological image record in a data structure containing a plurality of radiological image records. In addition, the method includes receiving a request with the patient's radiological image or information related thereto, analyzing the data structure to determine a statistical relationship between the request and the radiological image records and generating a patient report with a diagnosis, a prognosis or a recommended treatment regimen for the patient's disease based on a result of analyzing the data structure.

Abstract: Among other aspects, various embodiments include encoding wavelength-based characteristics, in addition to three-dimensional positions, of a plurality of objects of a plurality of different wavelengths directly in an image of the objects.

Abstract: Treatment of neurodegenerative diseases is achieved using small molecule purine scaffold compounds that inhibit Hsp90 and that possess the ability to cross the blood-brain barrier or are other wise delivered to the brain.

Abstract: A polymeric article includes an electrorheological (ER) fluid in a polymer medium. In some applications, the polymer medium forms a body ply of a tire. The ER fluid can be incorporated into the polymeric article in a number of particular ways. The ER fluid may simply fill a pocket in the polymeric article or may be part of an electrorheological composite or electrorheological microsphere. The ER fluid is responsive to the application of an electric field to change the apparent viscosity or elastic modulus of the polymeric article.

Abstract: An FPGA-based square-wave generator and a square-wave generation method.

Abstract: A system and method for adaptively utilizing transmitter windowing, receiver windowing and alignment signals for minimizing interference and maximizing capacity and energy efficiency based upon the received power ratios of links in adjacent bands of a cellular communication network.

Abstract: The present invention provides for a composition comprising: (a) a first host cell capable of producing L-DOPA; and (b) a modified host cell is capable of converting L-DOPA into hydroxytyrosol (HTy); wherein any one or both of the first host cell and second host cell is a genetically modified host cell.

Abstract: Isolated peptides are disclosed. The peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-5 and 11-15, with the proviso that the amino acid sequence does not consist of SEQ ID NO: 11, SEQ ID NO: 15 or SEQ ID NO: 1, wherein the peptide is no longer than 50 amino acids. Pharmaceutical compositions comprising same and uses thereof for treatment of diseases associated with serotonin transport and/or ?V?3 activity are also disclosed.