Abstract: Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia.

Abstract: A gate-last ferroelectric field effect transistor includes a substrate, isolation regions, a gate structure, a side wall spacer, source and drain regions, a first metal silicide layer and an interlayer dielectric layer which are sequentially arranged from bottom to top; the present disclosure further provides a manufacturing method of a gate-last ferroelectric field effect transistor; according to structural characteristics of the gate-last ferroelectric field effect transistor and crystalline characteristics of a hafnium oxide-based ferroelectric film, a dummy gate is first introduced in a manufacturing process of the gate-last ferroelectric field effect transistor; afterwards, high-temperature annealing is performed to make sure that an unannealed hafnium oxide-based film is crystallized to form a ferroelectric phase; finally the dummy gate is removed and a gate electrode layer is deposited to meet performance requirements of the gate-last ferroelectric field effect transistor; and the gate-last ferroelectr

Abstract: Provided herein are methods of using BMP7 levels as a marker for the selection of patients, such as non-small cell lung cancer patients, who will clinically respond to combination therapy comprising a BMP7 inhibitor and an immune checkpoint therapy, such as an anti-PD1 therapy and/or an anti-CTLA-4 therapy. Also provided are methods of treating the selected patients with a combination of a BMP7 inhibitor and an immune checkpoint therapy.

Abstract: The invention provides a series wound DC motor driving device and electrical equipment. The series wound DC motor driving device provided by the invention comprises a series wound DC motor, a DC power supply and a chopper, wherein the chopper comprises m chopping units; control signals comprise m unit control signals formed according to preset phase stagger rules and corresponding to the m chopping units separately, and each unit control signal comprises w switch control signals corresponding to w switch control ends in the corresponding chopping units; m pairs of power output terminals are formed at m first power output ends and m second power output ends of the chopping units correspondingly, and m pairs of external terminals of the series wound DC motor are connected with m pairs of power output terminals correspondingly one by one; m is a positive integer not smaller than 2, and w is 1, 2 or 4.

Abstract: Volumetric Electromagnetic Phase Shift Spectroscopy (VEPS)-based methods of analyzing a tissue are provided. Aspects of the methods comprise obtaining a VEPS-based tissue classifier, or “signature” for a tissue at a single point in time. These methods find particular use in non-invasively determining the condition of a tissue, e.g. brain tissue, lung tissue, heart tissue, muscle tissue, skin tissue, kidney tissue, cornea tissue, liver tissue, abdomen tissue, head tissue, leg tissue, arm tissue, pelvis tissue, chest tissue, trunk tissue, prostate tissue, breast tissue, esophagus tissue, GI tract tissue, etc., in an individual. Devices and systems thereof that find use in practicing the subject methods are also provided.

Abstract: A system for synthesizing a real-time image by using optical surface motion signals includes: an acquisition unit configured to acquire an image of a patient before treatment and real-time optical surface data of the patient during treatment; and a synthesis unit configured to synthesize the acquired image of the patient before treatment and the real-time optical surface data of the patient during treatment into a real-time image that is synchronized with a change of the optical surface motion signals according to a certain mapping relationship. The synthesized real-time image achieves precise, real-time, non-invasive, visual dynamic tracking of the moving target volumes without concomitant dose during radiotherapy on the existing traditional accelerator platform.

Abstract: The disclosure relates to a method and system for evaluating the stability of HVDC receiving end system and storage medium, which relates to the technical field of high voltage direct current transmission. The method includes: collecting voltage at a generator port, current at the generator port and rotational speed of the generator after eliminating fault; determining a corresponding relationship between the generator dynamic energy and the time according to the voltage at the generator port, the current at the generator port and the rotational speed of the generator; determining the attenuation intensity of the generator dynamic energy according to the corresponding relationship between the generator dynamic energy and the time; determining stability of the HVDC receiving end system according to the attenuation intensity of the generator dynamic energy.

Abstract: A functional structure which can prevent metal fine particles from aggregating, can suppress bonding of an active metal species and a support, and can easily undergo catalyst activation before being used for reactions. The functional structure includes supports each having a porous structure and including a zeolite-type compound, and at least one functional material precursor present in the supports and including a metal element (M), in which each of the supports has channels communicating with one another, the functional material precursor is present at least in the channel of each of the supports, and the metal element (M) having constituted the functional material precursor is partially substituted with an element having constituted the supports.

Abstract: The present disclosure describes a unique plasticized pyrotechnic material which can be easily portioned and formed or molded into a desired shape and which burns at a high temperature (>2000° C.) but does not detonate. The plasticized pyrotechnic material may preferably include a combination of about 70-99% by weight of a pyrotechnic composition and about 1-30% by weight of a plasticizer composition comprising various low to mid molecular weight polyisobutylenes. The pyrotechnic material comprises inorganic oxidizers (e.g. metal oxides, oxohalide salts, nitrates, nitrites, chlorates/perchlorates) and metal or metal oxides powders mixed intimately. The plasticizer may include a small amount of a fluoropolymer, such as polytetrafluoroethylene (PTFE) and may also include up to 1-2% by weight of a processed oil, such as a mineral oil or motor oil. Some embodiments may also include a biocide precursor molecule.

Abstract: A sub-sampling phase-locked loop includes a first phase output unit sub-sampling an output clock of a digitally-controlled oscillator and outputting a sign bit corresponding to a voltage-domain phase and a second phase output unit outputting a gain bit corresponding to a time-domain phase based on a pulse width set according to the output clock and a threshold time set according to the reference clock.

Abstract: The present technology relates to methods for predicting the risk of acute myeloid leukemia (AML) in a subject prior to the onset of AML symptoms, and whether such a subject will benefit from treatment with an AML therapy. The methods disclosed herein are based on detecting the presence of mutations in the nucleic acid sequences of IDH1/2, TP53, DNMT3A, TET2, and spliceosome genes. Kits for use in practicing the methods are also provided.

Abstract: Provided herein are reagents and methods for targeting the ELANE gene for inhibition. Further provided herein is a method for producing a progenitor cell or a population of progenitor cells having decreased ELANE mRNA or protein expression.

Abstract: Provided is a light beam emission device and a light beam projection device, that are downsizable, have a simple configuration, and simplify complicated processing of video signals, such as the timing adjustment of video output signals, without generating color irregularity. The devices include: a plurality of light sources; and a condensing member. A range in the light source array direction, in which emission spots of the light beams emitted from the plurality of light sources respectively exist, is within a size in the array direction of a light beam, immediately after the light beam emitted from an emission spot located most closely to the center of the plurality of light sources, with respect to the condensing member, passed through the condensing member.

Abstract: A method for preparing biochar and hydrogen by utilizing anaerobic fermentation byproducts, the method including: (1) mixing a first straw, seeding sludge and distilled water, and then carrying out anaerobic fermentation to obtain a mixed product after fermentation; (2) performing separation on the mixed product to obtain a second straw and biogas slurry; and (3) carbonizing the second straw to obtain biochar, and collecting gas after a pressurized catalytic reaction on the biogas slurry to obtain hydrogen.

Abstract: An objective of the present invention is to provide a novel biomarker for predicting the prognosis of an endometrial cancer patient. A biomarker that comprises a claudin 6 protein or a peptide fragment thereof, or a transcription product of a claudin 6 gene or a nucleic acid fragment thereof is provided so as to predict the prognosis of an endometrial cancer patient.

Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.

Abstract: A removable dual gold marker implantation device with minor damage comprises a gold marker and a puncture needle, the gold marker is arranged in the needle barrel of the puncture needle when in use; the gold marker comprises a gold marker head and a connecting wire connected with the gold marker head; the gold marker head comprises a first gold marker, a connecting part and a second gold marker connected in sequence. The disclosure reduces the damage to the body when removing the gold marker, and the dual gold marker structure makes the implantation of multiple gold markers at the same time possible and reduces the number of times of implantation and improves the efficiency.

Abstract: A compound, or a pharmaceutically acceptable salt or isomer thereof, of Formula I: wherein R is hydrogen, alkyl, substituted alkyl, alkenyl, or substituted alkenyl; R1 is hydrogen, alkoxy, or substituted alkoxy; R2 is hydrogen, alkyl, or substituted alkyl; and R3 is hydrogen, alkyl, or substituted alkyl.

Abstract: The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to MAVS compositions and their use in cancer therapeutics that may be used to treat various cancers alone or in combination with other anti-cancer therapeutic agents.

Abstract: An apparatus including direct-current (DC)-alternating-current (AC) inverter circuitry, first and second circuits, and output circuitry. The DC-AC inverter circuitry inverts a DC input signal corresponding to an input voltage to an AC signal. The first circuit and second circuits respectively include inductive isolation circuits driven in response to power from the at least one AC signal, and rectifier circuits that responds to the inductive isolation circuits by outputting first and second rectified signals, where at least one of the first and second rectifier circuits characterized as being limited by a voltage breakdown rating. The output circuitry provides a DC output voltage signal and to cascade a plurality of signals, including the first and second rectified signals, to provide a voltage source that is dependent on the first and second rectified signals and greater than voltage breakdown rating.