Abstract: Solid phase extraction (SPE) sorbents and liquid chromatography (LC) stationary phases are provided, as well as methods of fabricating the same. The SPE sorbents and LC stationary phases can use microcrystalline cellulose particles as the substrate and sol-gel sorbent coating technology as the polymer/sorbent immobilization technology. The SPE sorbents and LC stationary phases are stable in a pH range of 1-13 and at a temperature of up to 350 ° C.

Abstract: Among the various aspects of the present disclosure is the provision of a methods for increasing chemotherapy sensitivity or decreasing chemotherapy resistance using BET inhibitors.

Abstract: The present invention provides pyrazole derivatives, e.g., a compound of Formula (I), and their uses in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.

Abstract: The disclosure relates to an active damping control method and system for sub-synchronous oscillation of DFIG, and storage medium. The method comprises the following steps: collecting oscillation components of stator current and/or stator voltage; determining each energy branch in DFIG converter according to the flow path of the oscillation component(s) of the stator current and/or the stator voltage in DFIG converter; determining the corresponding function of each energy branch according to oscillation component(s) the stator current and/or the stator voltage; determining the energy compensation branch and its corresponding energy compensation function in DFIG converter according to the corresponding function of each energy branch and converter parameters; controlling the sub-synchronous oscillation of DFIG by controlling the energy compensation branch according to the energy compensation function.

Abstract: A copper-based nanocomposite includes a matrix including copper, and nanostructures dispersed in the matrix, wherein the nanocomposite has a yield strength of about 300 MPa or greater, and a ductility of about 5% or greater. Manufacturing methods of a copper-based nanocomposite are also provided.

Abstract: In the field of medical technologies, there is a triglyceride prodrug based on lymphatic-mediated transport, particularly a triglyceride prodrug with different linking chains for lymphatic-mediated transport, and a method for preparing the same and use thereof in drug delivery. The prodrugs are linked by different linking bonds and methods for synthesizing the same. The structures of the prodrugs are as follows: wherein X, R1, R2, n, m are as described in the claims and specification. A mechanism of digestion and absorption of glycerol in the gastrointestinal tract is simulated by using a triglyceride-like structure, so as to promote the lymphatic transport of the drugs and avoid a first-pass effect. The prodrugs have targeting properties and can significantly increase or improve oral bioavailability.

Abstract: This application is drawn to a method of using an isoform NELL-1 peptide, and compositions thereof for bone formation or for treating, preventing, or ameliorating osteoporosis.

Abstract: A semiconductor nanoparticle includes a core and a shell covering a surface of the core. The shell has a larger bandgap energy than the core and is in heterojunction with the core. The semiconductor nanoparticle emits light when irradiated with light. The core is made of a semiconductor that contains M1, M2, and Z. M1 is at least one element selected from the group consisting of Ag, Cu, and Au. M2 is at least one element selected from the group consisting of Al, Ga, In and Tl. Z is at least one element selected from the group consisting of S, Se, and Te. The shell is made of a semiconductor that consists essentially of a Group 13 element and a Group 16 element.

Abstract: In various embodiments a capture surface for capturing high velocity and hypervelocity dust and ice particles is provided. In certain embodiments the capture surface is comprised of a soft metal that is chosen to optimize particle capture efficiency, to minimize thermal degradation of chemicals and biochemical in the particles, and to present the captured particles to an analyzer for chemical and biochemical analysis of the particles and their contents. In various embodiments capture chambers comprising one or more such capture surfaces are provided as well as methods of use thereof.

Abstract: Provided herein is a method for treating a cancer in a subject by quantitating the concentration of a soluble form of Semaphorin 4D (sSema4D) in a blood sample obtained from the subject and administering an immunotherapy when the blood concentration of sSema4D is below a threshold value of 155 ng/ml. Also provided is a method for determining the continued susceptibility of a tumor tissue to immunotherapy in a subject by identifying the inflammatory subtype of the tumor tissue from a blood sample from the subject and administering immunotherapy over at least one interval as long as the tumor tissue exhibits an inflamed subtype.

Abstract: The present disclosure discusses methods for producing stereoisomerically enriched carbohydrate-based surfactants. In particular, methods of the invention include producing stereoisomerically enriched hydrophobic portion of the carbohydrate-based surfactants.

Abstract: An autonomous landing system for vertical landing aircraft includes a vertical landing aircraft including a powertrain and an onboard camera, a motion-stabilized visual cue including a visual indicator, wherein the visual cue is configured to maintain a fixed orientation of the visual indicator with respect to a horizon, and an autonomous control system configured to control a position of the aircraft with respect to the visual indicator of the visual cue based on image data captured by the onboard camera.

Abstract: Embodiments of the present disclosure belongs to the technical field of animal feed and provides a method for rapidly evaluating metabolizable energy of goose diet by using a technique of simulative digestion gross energy. By using the technical means combining the biological method and the simulative digestion gross energy technique, metabolizable energy of goose feed can be evaluated quickly. Based on the “stomach-small intestine” two-step enzymatic methods, it is the first time to establish a regression equation between the metabolizable energy change and fiber level in the cecum to rectify the value of simulative digestion gross energy in the cecal microbial digestion phase, making the simulative digestion gross energy technique more reasonable in the assessment of metabolizable energy in geese. Results show that the use of simulative digestion gross energy technique to assess the metabolizable energy of goose feed value is highly feasible.

Abstract: The present invention relates to a composition for preventing or treating Parkinson's disease comprising AEG-1 (S298D) as an active ingredient, and in the present invention, a point mutation was introduced into AEG-1 to induce a constitutively active form of AEG-1 (S298D), to construct AAV-AEG-1 (S298D), and to apply an animal model for Parkinson's disease, and accordingly, it was confirmed that it exhibits a protective effect on brain tissue by preserving dopaminergic neurons and dopamine nerve fibers and thus AEG-1 is useful as a composition for preventing or treating Parkinson's disease, a health food composition for preventing or improving Parkinson's disease, etc.

Abstract: A light emitting device includes a metal reflective layer including a phase modulation surface on which oblong phase modulation elements are formed; a first electrode provided on the metal reflective layer; an organic emission layer that is provided on the first electrode and that emits light; and a second electrode provided on the organic emission layer, wherein the oblong phase modulation elements are arranged to form a geometric phase lens.

Abstract: The present invention relates to methods of preparing peptide-based prodrugs having enhanced oral bioavailability and intestinal penetration. Said prodrugs are characterized in improved lipophilicity, reduced electric charge and tendency to undergo biotransformation through enzymatic reaction (e.g. in the blood stream) to form biologically active peptides.

Abstract: The present invention relates to microRNA biomarkers for the diagnosis, monitoring and therapy of neurodegenerative disorders including Parkinson's Disease, Alzheimer's Disease and prion diseases.

Abstract: The present invention provides for a device and method for the rapid detection (within seconds) of viruses and virions (proteins and nucleic acids) found in novel coronavirus (SARS-CoV-2) and other viruses through testing of an air sample. The device can be used at front line, hospitals, clinical laboratories, airports, groceries, homes, and the like. The device can be used as a single probe for single use or home use for fast detection of multiple samples simultaneously. The present invention would facilitate multiple testing at times of pandemics caused by airborne viruses when a large number of samples have to be tested in short periods of time.

Abstract: A ground surface estimation method include: performing first estimation in which the continuous region having a largest number of the grids among the continuous regions is estimated as a ground surface; and performing second estimation including: calculating an average altitude value of the representative point of the grids in the non-adjacent continuous region for each of the non-adjacent continuous regions; calculating an average altitude value of the representative point of the grids in the predetermined range of the continuous region estimated as the ground surface; and estimating that a non-adjacent continuous region as the ground surface when a difference between the average altitude value of the representative point of the grids in the non-adjacent continuous region and the average altitude value of the representative point of the grids in a predetermined range of the continuous region estimated as the ground surface is equal to or less than a threshold.

Abstract: A method for applying a regional block of the articular sensory branch of femoral (FN), obturator (ON) and accessory obturator nerves (AON) comprising injection of an anesthetic at a single needle entry point into a these nerves anatomical sites. Another aspect of this technology is a kit for performing this method.