Abstract: Composite materials with adjustable spectral properties comprised of IR-reflecting micro-domains overlaying an IR-transparent elastomeric matrix, and capable of dynamically controlling IR radiation transmission are described, as well as methods of fabrication thereof. Systems with capabilities to regulate IR radiation (including heat) transmission based thereon, and methods of regulating IR radiation transmission (including thermal regulation) using the same are also provided.

Abstract: Synergistic drug combinations with the small molecule PAC-1 against uveal or cutaneous melanoma. There are no current targeted drug treatments for the mutations associated with uveal melanoma. Despite primary radiation or surgical therapy, up to 50% of patients eventually develop metastatic disease, for which there is no standard therapy nor treatment shown to improve overall survival. Drug combinations with PAC-1 allow the use of lower dosages of this compound that result in cancer cell death in uveal melanoma. Drug combinations of PAC-1 with the kinase inhibitor entrectinib have shown a synergistic effect against uveal melanoma cell lines. Specifically, PAC-1 and entrectinib are synergistic against wild-type and mutant uveal melanoma cell lines (e.g., GNAQ and GNA11).

Abstract: The present invention relates to a repurposed antibiotic compound for the treatment of cancer with minimal nuclear gene damage and an anticancer pharmaceutical composition comprising same. Since the repurposed antibiotic compound has a therapeutic effect in a manner that targets only the mitochondria of cancer cells, the modified antibiotic compound does not cause gene degeneration unlike conventional chemotherapy which damages nuclear DNAs to kill cancer cells, thereby preventing the recurrence of cancer. In addition, a mitochondria targeted therapy using the compound according to the present invention can effectively treat malignant tumors that are difficult to treat due to acquiring drug resistance by general anticancer treatment.

Abstract: A surgical protective equipment includes: a first boundary surface having a horseshoe shape in a plan view; a second boundary surface disposed face-to-face with the first boundary surface and having a horseshoe shape in a plan view; an inner surface disposed between the first boundary surface and the second boundary surface, and forming a groove by connecting an inner end of the first boundary surface and an inner end of the second boundary surface to each other; and an outer surface connecting an outer end of the first boundary surface and an outer end of the second boundary surface, wherein a surgical incision area is inserted in the groove.

Abstract: Self-sterilizing filtration materials are disclosed that include at least one polydopamine-functionalized layer. The at least one polydopamine-functionalized layer is configured to heat to a sterilization temperature when illuminated by light with a light intensity. The self-sterilizing filtration materials may be included in a filtering respirator mask. Methods of sterilizing filtration materials and filtering respirator masks containing at least one polydopamine-functionalized layer by exposing to sunlight are also disclosed. In addition, methods of producing a self-sterilizing filtering respirator mask by polydopamine-functionalizing at least one layer of the filtration material in an existing filtering respirator mask.

Abstract: The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.

Abstract: A pharmaceutical composition or a health functional food composition for preventing or treating Behcet's disease have Tetragenococcus halophilus, a culture thereof or a lysate thereof. In addition, a pharmaceutical composition or a health functional food composition for preventing or treating a herpes simplex virus infection have Tetragenococcus halophilus, a culture thereof or a lysate thereof. The composition may further include a prebiotic compound. The Tetragenococcus halophilus produces lactate, and the lactate can be converted into short-chain fatty acids such as butyrate in the body, can control the expression of activating molecules of dendritic cells, and can effectively prevent or treat Behcet's disease or herpes simplex virus infection.

Abstract: The present invention relates to modifications of berberine bridge enzyme-like nucleic acids and their use in modulation of nicotine biosynthesis in plants.

Abstract: The disclosure herein discloses L. plantarum CCFM1019, fermented foods thereof, and application thereof in preparation of a medicine for promoting excretion of plasticizers and metabolites thereof from the body. The L. plantarum CCFM1019 not only is significantly better than the intestinal resident bacteria E. coli and E. faecalis in terms of the effect of promoting the excretion of DEHP and MEHP, but also is better than the commercial strain L. rhamnosus LGG. Therefore, the L. plantarum CCFM1019 of the disclosure can be used as an effective means to prevent and alleviate body damage caused by DEHP and MEHP, and has no toxic side effects of drugs. L. plantarum CCFM1019 can be used to prepare pharmaceutical compositions and fermented foods for alleviating and preventing the toxicity of DEHP and metabolites thereof, and has a very broad application prospect.

Abstract: Through the use of a rhodamine appended chelate, a versatile strategy has been demonstrated to generate mitochondria-targeting photosensitizers via the incorporation of variety of luminescent transition metal systems. The generation of triplet excited state of rhodamine moiety endows the complexes with mitochondria-targeting photosensitizing ability to form singlet oxygen (1O2) for use as photodynamic therapy (PDT) agent. The combination of rhodamine organic dye and luminescent transition metal centers in such hybrid systems exhibits the synergistic merits, including low dark cytotoxicity, selective tumor cell uptake, high molar absorptivity for low-energy excitation in the visible region, and high photostability.

Abstract: A method and apparatus for determining a presence of a microorganism in a sample is provided. The method includes storing electrophysiological and/or impedance signatures of a plurality of microorganisms in a memory of a processor. The method also includes obtaining a sample and generating an electrophysiological and/or impedance signature of the sample. The electrophysiological and/or impedance signature of the sample is compared with the electrophysiological and/or impedance signatures in the memory. A presence of one of the plurality of microorganisms in the sample is then identified based on a correlation between the electrophysiological and/or impedance signature of the sample and the electrophysiological and/or impedance signature of the one of the plurality of microorganisms. A method is also provided for determining a growth stage of a microorganism in a sample.

Abstract: A method and a system for detecting and analyzing a mucosa of a digestive tract are provided. The method includes detecting reply signals from the mucosa of the digestive tract within a depth range, acquiring 2D vascular images by performing a vascular enhancement on the reply signals, constructing a 3D vascular contrasting image of at least part of the mucosa of the digestive tract within the depth range by recombining at least part of the 2D vascular images, and reconstructing a 3D vascular contrasting projection image by performing a projection process to the 3D vascular contrasting image, and defining a stage of the mucosa of the digestive tract within the depth range according to the 3D vascular contrasting projection image, the 3D vascular contrasting image, the 2D vascular images, and vessel morphologies shown therein.

Abstract: A display panel includes sub-pixels each including a light-emitting element and a pixel circuit including a first transistor and a second transistor; a timing control unit to generate bias data based on first characteristic information of the first transistor, and generate correction data based on second characteristic information of the second transistor; and a data sensing driving unit configured to receive the bias data and the correction data, and output a bias voltage and a grayscale voltage to the pixel circuit. The pixel circuit includes the first transistor to output a driving current to the light-emitting element; a first driving circuit to control a magnitude of the driving current based on the bias voltage; and a second driving circuit including the second transistor and configured to control a pulse width of the driving current based on the grayscale voltage.

Abstract: The present invention discloses a distributed high-frequency AC electrical system for the electric vehicle. The system divides all loads of the electric vehicle into four load areas according to their spatial positions. Four high-frequency inverters and four DC input interfaces are contained in the system, with each of the four load areas being configured with one of the four high-frequency inverters, and each of the four high-frequency inverters being configured with one of the four DC input interfaces. One end of each DC input interface is connected to the DC side of the corresponding high-frequency inverter, and the other end is connected to the storage battery of the electric vehicle. Each high-frequency inverter outputs a high-frequency AC bus to supply power for the loads in the corresponding load area, and the four high-frequency inverters are in a parallel operation state through a high-frequency connection point that connects the four high-frequency AC buses.

Abstract: A preform (10) for an antiresonant hollow core optical fibre comprises an outer jacket tube (12) having an inner surface and a central longitudinal axis (24); a plurality of antiresonant cladding tubes (14) spaced apart at predefined peripheral locations around the inner surface of the outer jacket tube (12), each antiresonant cladding tube (14) in contact with the inner surface such that a central longitudinal axis (26) of each antiresonant cladding tube (14) is at a first radial distance from the central longitudinal axis (24) of the outer jacket tube (12); and a plurality of spacing elements (22) disposed alternately with the antiresonant cladding tubes (14) and each in contact with an outer surface of each of two adjacent antiresonant cladding tubes (14) at one or more contact points (28), the contact points (28) at a second radial distance from the central longitudinal axis (24) of the outer jacket tube (12), the second radial distance being greater than the first radial distance.

Abstract: The present technology is directed to methods of inhibiting or modulating p97 and compounds and compositions useful in such methods Diseases and conditions that can be treated with the compounds and compositions of the present technology include, but are not limited to, antibacterial infection, antiviral infection, cancer and neurodegenerative disorders susceptible to treatment by inhibition or modulation of p97.

Abstract: Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.

Abstract: A recombinant coronavirus vaccine is provided. Methods of making and delivering the coronavirus vaccine also are provided. A microneedle array is provided, along with methods of making and using the microneedle array.

Abstract: The present invention provides an augmented reality service providing device, including: a sensing unit to photograph an object and to measure a current position of a mobile terminal; a communication unit to measure a communication distance between the mobile terminal and the object; a control unit to control to repeat a plurality of times the measurement of the current position and the communication distance while the mobile terminal is moving; a calculation unit to calculate an estimated position of the object based on the current position and the communication distance measured repeatedly a plurality of times; and a display unit to display virtual information on the object on the estimated position of the object.

Abstract: Methods, systems, and devices including a light guide tool for multi-axis additive manufacturing. The light guide tool includes a tubular light guide. The tubular light guide may be made from an optically transmissive material enclosed by one or more reflective side walls that are interposed between opposing optically transmissive ends. The light guide tool includes an optical coupling fixed to a first end of the optically transmissive ends of the tubular light guide. The optical coupling is configured to couple to a lens. The light guide tool includes a transparent non-stick coating. The transparent non-stick coating is adhered over a second end of the optically transmissive ends of the tubular light guide. The light guide tool includes a lens. The lens is coupled to the optical coupling and configured to emit a two-dimensional light pattern.