Abstract: An articulating chair and a method of using same, include at least one actuator, a programmable controller, and movable upper back, lower back and seat bottom sections. In another aspect, an articulating wheelchair and a method of using same, include a seat bottom section, a lower frame to which the seat bottom section is coupled, floor-contacting wheels rotatably coupled to the lower frame, an upper back section, a lower back section, a back frame to which the upper back section and the lower back section are movably coupled, electromagnetic actuators coupled to the back sections, a battery mounted to at least one of the frames, and a programmable controller connected to the actuators and the battery.

Abstract: A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures.

Abstract: Provided herein are methods of removing carbon dioxide from an aqueous stream or gaseous stream by: contacting the gaseous stream comprising carbon dioxide, when present, with an aqueous solution comprising ions capable of forming an insoluble carbonate salt; contacting the aqueous solution comprising carbon dioxide with an electroactive mesh that induces its alkalinization thereby forcing the precipitation of a carbonate solid from the solution and thereby the removal of dissolved inorganic carbon by electrolysis; and removing the precipitated carbonate solids from the solution, or the surface of the mesh where they may deposit. Also provided herein are flow-through electrolytic reactors comprising an intake device in fluid connection with a rotating cylinder comprising an electroactive mesh, and a scraping device and/or liquid-spray based device for separating a solid from the mesh surface.

Abstract: The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by administration of a therapeutically effective amount of ifetroban, or a pharmaceutically acceptable salt thereof.

Abstract: The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of symptoms of a disease selected from the group consisting of: Ebola virus infection, HIV infection, ataxia, environmental enteropathy, cancer, hangover, inflammatory disease, and porcine epidemic diarrhea. In preferred embodiments, the composition includes a combination of one or more amino acids selected from the group comprising lysine, aspartic acid, glycine, isoleucine, threonine, tyrosine, valine, tryptophan, asparagine and/or serine.

Abstract: Methods are provided for treatment of PACS1 syndrome and PACS2 syndrome.

Abstract: The present invention relates in part to a filter comprising a tubular housing having a proximal end, a distal end and a housing lumen therethrough; a tubular membrane having a proximal end, a distal end and a membrane lumen therethrough, wherein the tubular membrane is positioned within the housing lumen; a contaminated fluid sample inlet fluidly connected to the proximal end of the membrane, and a contaminated fluid sample outlet fluidly connected to the distal end of the membrane, thereby creating a sample flow-path from the sample inlet through the membrane lumen to the sample outlet; and a purification material inlet fluidly connected to a distal region of the housing lumen, and a purification material outlet fluidly connected to a proximal region of the housing lumen, thereby creating a purification material flow-path from the purification material inlet through the housing lumen to the purification material outlet; wherein the direction of the sample flow-path is in the opposite direction of the purifi

Abstract: An exemplary random number generation system leverages the r includes at least one solar power panel of a solar power system, at least one sensor and a random number generator. The sensor senses one or more output parameters (e.g., voltage or current) from the solar power system and provides the sensed parameter to the random number generator, which uses the sensed parameter to generate a number that is truly random (i.e., is not deterministic). As an example, the random number generator may receive multiple samples of the measured parameter and generate a random number based on a difference of the multiple samples. If desired, the random number generator may include an algorithm to remove biasing in the random number.

Abstract: This disclosure relates to the genetic modification of DNMT3A gene in immune cells. In certain embodiments, the modified immune cells may be used in adoptive T cells therapies to enhance immune responses against cancer or chronic infections. In certain embodiments, the disclosure relates to deleting, changing, or inserting nucleotides within the DNMT3A gene in immune cells, e.g., human CD8 T cells, such that the DNMT3A gene product does not function for methylation. In certain embodiments, modification of the DNMT3A gene provides an improvement in antigen-specific T cells functions and/or an enhancement of the longevity of the cells.

Abstract: The invention is directed generally to oligonucleotide compositions for the treatment of DNA repeat expansion diseases. The invention also relates to oligonucleotides directed to subunits of the DNA mismatch repair system.

Abstract: A method for designing a channel estimation and data detection networks is provided herein. The problem of channel estimation for linear systems has effectively been solved—not the case for non-linear systems. A deep learning framework for channel estimation, data detection, and pilot signal design is described to address the nonlinearity in such systems.

Abstract: A detection device includes a frame body and a main pipe positioning assembly, a branch pipe positioning assembly, and a first driving assembly disposed on the frame body. One side of the frame body is provided with an opening. The branch pipe positioning assembly is disposed inside the opening. The first driving assembly adjusts the branch pipe positioning assembly, so that the branch pipe positioning assembly is adapted to positions of the two branch pipes. During detection, the branch pipes are located in the opening, the main pipe positioning assembly connects two ends of the main pipe, and the branch pipe positioning assembly connects the two branch pipes. Two limiting members are slidably disposed on the frame body to open and close the opening, and the limiting members abut against an outer wall of the main pipe, such that the main pipe is located inside or outside the opening.

Abstract: A nanofluid manufactured by nuclear irradiating a mixture that comprises a precursor and a base fluid, a method of manufacturing the nanofluid, and a system for use in manufacturing the nanofluid. The combination of the uniform irradiation dosage results in substantially no sedimentation of the suspended nanoparticles. The formed nanofluid has been observed to have better properties compared to those known in the art.

Abstract: The present invention relates to novel synthetic odorant receptors capable of cell surface localization upon cellular expression. Specifically, the present invention provides synthetic odorant receptors having a consensus amino acid sequence deduced from a plurality of odorant receptors within an odorant receptor family, wherein the consensus amino acid sequence represents the mostly frequently present amino acid residues for each amino acid position deduced from a plurality of odorant receptors within an odorant receptor family. Additionally, the present invention provides methods of use, methods of synthesis, and cell lines expressing one or more of such novel synthetic odorant receptors.

Abstract: An insole for offloading injuries on an area of a plantar surface of a patient's foot includes a body having a shape corresponding to the plantar surface of the patient's foot including a top surface and a bottom surface; and at least one supportive, deformable, deflatable bubble chamber. The at least one bubble chamber extends from the top surface of the body. The at least one bubble chamber is configured to be deflated to relieve pressure on the plantar surface of the patient's foot. A kit including the insole and an article of footwear including a sole, an upper connected about a periphery of the sole defining an interior of the article of footwear, and the insole positioned in the interior of the article, are also provided.

Abstract: The present invention provides a composite membrane suitable for liquid-liquid filtration/reverse osmosis. The invention also provides a copolymer useful in the composite membrane, the copolymer comprising an anchoring repeating unit and a foulant-repelling repeating unit, as well as methods for preparing the composite membrane and copolymers. In a preferred embodiment, a copolymer (P [SBMA-co-HEMA]) is synthesized via the free radical copolymerization of a zwitterionic monomer of sulfobetaine methacrylate (SBMA) and an anchoring monomer of hydroxyl ethyl methacrylate (HEMA).

Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo.

Abstract: According to an exemplary embodiment of the present disclosure, a static random access memory apparatus which stably maintains the writing performance in a low-power environment is applied to determine whether a writing performance of the SRAM is degraded based on a voltage difference of a first bit line and a second bit line connected to a memory cell and triggers an operation of the writing performance assist circuit of the SRAM.

Abstract: Provided is a method, and pharmaceutical composition, to treat or prevent cyanide poisoning and/or methylmercaptan poisoning comprising administering to a subject in need an effective amount of tetrathionate by intramuscular injection or by intranasal administration. Also provided is a method for detecting the presence of tetrathionate in a sample by reacting it with cyanide and measuring the resulting thiocyanate with ferric nitrate.

Abstract: A system and method implementing an acoustic mapping suite that equips intelligent vehicles with the ability to identify and respond to primary sounds of interest in their environment. The invention performs sound separation, localization and classification techniques, while also generating a sound-based map of the vicinity as well as making inferences and qualitative assessments about sound sources with information over time.