Abstract: The present invention relates to a medium composition for culture of extraembryonic endoderm stem cells, and more specifically, to a medium composition for in vitro culture of extraembryonic endoderm stem cells.

Abstract: Embodiments of the present disclosure provide a multi-mode 3D print head and a collaborative printing method applying the same. The print head body is provided with an extrusion hole, a feeding mechanism is provided above the extrusion hole, and a heating mechanism is provided below the extrusion hole. The print head body is further provided with a plurality of droplet addition holes and auxiliary side holes connected to the plurality of droplet ejection holes. The auxiliary side holes are provided perpendicular to the droplet addition holes and are detachably connected with an injection auxiliary component. The injection auxiliary component includes a sleeve secured to the auxiliary side hole, the sleeve is provided with a moving block. The sleeve is connected to an air pipe at an end away from the auxiliary side hole and is provided with an induction coil.

Abstract: An intraocular lens (IOL) has a small, central lens suspended within a pliable housing and, when the housing is filled with liquid, is coaxially aligned with a second small lens embedded in the wall of the housing. The suspension is on a dome- or other-shaped webbing attached to an inner circumference of the wall. When filled with liquid, forces squeezing or pulling the equator of the housing, as with ciliary muscles in the eye, adjust a distance between the lenses in order to adjust focus. Optional haptics may project from points on or above and below the equator. A recess in the posterior hemisphere of the housing can keep cell growth away from an optical axis of the lens system. A third small lens can be embedded in an opposite wall of the housing and coaxially aligned with the other lenses to form a three-lens, ultra-zoom system.

Abstract: A gripper mechanism is provided, which relates to the technical field of grippers. The gripper mechanism includes a motor, a cylinder barrel, a piston and a guide assembly. The piston reciprocates in the cylinder barrel under the action of the motor and the guide assembly. The piston includes a piston body and a piston rod located in the piston body. Both ends of the cylinder barrel are respectively provided with cylinder heads for limiting the maximum distance and the minimum distance between the piston body and a part to be gripped. The piston rod includes a driving shaft, a cross slider coupling and a gripping head which are connected in turn. The power output by the motor is transmitted to the gripping head through the driving shaft and the cross slider coupling in turn.

Abstract: The present invention relates to an all-solid-state ion-selective electrode having an insertion material, and a method of manufacturing such an all-solid-state ion-selective electrode. The all-solid-state potassium ion-selective electrode (1) includes: a conductor (2); an insertion material (10) formed on a surface of the conductor (2); and a potassium ion-sensitive membrane (20) covering the insertion material (10). The insertion material (10) includes at least a Prussian blue analog represented by a structural formula KxFe[Fe(CN)6]y·nH2O, where x is a numerical number larger than 0 and less than or equal to 2, y is a numerical number larger than 0 and less than or equal to 1, and n is a numerical number larger than or equal to 0.

Abstract: This application provides an event data processing method, including: obtaining event data shot by an event camera, where the event data includes a timestamp of occurrence of an event, pixel coordinates, and a brightness change status; and generating an event frame matrix based on a plurality of pieces of event data within a preset time period, where a location of a matrix element in the event frame matrix corresponds to pixel coordinates, a value of the matrix element indicates whether there is an event at a corresponding pixel and an event polarity of a pixel with an event, if there is an event at the pixel, it indicates that brightness of the pixel is changed within the preset time period, or if there is no event at the pixel, it indicates that brightness of the pixel is not changed, and the event polarity includes increased brightness and decreased brightness.

Abstract: A metal porous body includes a framework having a three-dimensional mesh structure, wherein the framework includes a plurality of columnar supporting portions and a node portion that connects the plurality of columnar supporting portions, the framework is provided with a plurality of opening holes opened in a surface of the framework, and the framework contains at least one selected from a group consisting of nickel, cobalt, iron, tin, copper, and chromium.

Abstract: Recombinant antibodies are provided that comprise engineered human IgG1 Fc domains that have reduced affinity for viral Fc?Rs, such as HCMV gp34 and gp68, as compared to a wild-type human IgG1 Fc domain. The engineered human IgG1 Fc domains have equivalent affinity for CD16A and FcRn as compared to a wild-type human IgG1 Fc domain. Also provided are engineered forms of HCMV gp34 and their use in a vaccine.

Abstract: Disclosed herein are methods to make hydrogen titanium oxide (HxTiyOz) compositions. The nano-HxTiyOz can be used to remove pollutants and recover valuable materials. For example, the nano-HxTiyOz can be used to isolate lithium from various aqueous mixtures, such as brines, seawater, oil gas-produced water, and lithium battery waste solutions.

Abstract: Disclosed herein are compounds of Structural Formula I. Compounds of Structural Formula I inhibit aldehyde dehydrogenase isoform 1a3 (ALDH1a3) and are useful for treating cancer, for example, metastatic or chemoresistant cancer, such as metastatic cancer resistant to chemotherapy. Also disclosed herein are compositions comprising compounds of Structural Formula I and uses of compounds of Structural Formula I for treating cancer, for example, metastatic or chemoresistant cancer.

Abstract: It has been found that by generating multiple nicks in the DNA region proximal to a specific site of homologous chromosomes, DNA exceeding 100 bp can be deleted in one of the homologous chromosomes.

Abstract: Embodiments described herein provide for a healthcare ecosystem of computing devices participating as nodes of a distributed ledger (e.g., blockchain). The distributed ledger includes NFTs representing corresponding patients, where the initial NET behaves logically as a token scaffold that represents a “digital twin” of the particular patient. The initial patient token represents personal profile data of patient personal data for the patient. The nodes may generate new data and/or new sub-tokens (or other blockchain entry type) representing new data, which the nodes associate with the token scaffold. The sub-tokens contain data for representing physical or digital specimens, health data, and data derived from the health data (e.g., cell lines, organoids, other model systems).

Abstract: A method for forming a memory device is provided. The method includes forming first and second metal-insulator-semiconductor (MIS) structures, wherein each of the first and second MIS structures comprises a semiconductor layer, an insulating layer over the semiconductor layer, and a metal electrode layer over the insulating layer; performing a first breakdown process to the first MIS structure; performing a second breakdown process to the second MIS structure; performing a first read operation by supplying a reading voltage pulse to the metal electrode layer of the first MIS structure and detecting a first read current flowing through the first MIS structure; and performing a second read operation by supplying the reading voltage pulse to the metal electrode layer of the second MIS structure and detecting a second read current flowing through the second MIS structure, wherein the second read current is greater than the first read current.

Abstract: Disclosed is an eyelid speculum including a frame, a first rotary arm coupled to one side of the frame to be rotatable, a second rotary arm coupled to an opposite side of the frame to be rotatable, a movement part configured to move the first rotary arm and the second rotary arm such that the first rotary arm and the second rotary arm are moved in a direction, in which they become closer to or more distant from each other, a first support arm coupled to the first rotary arm to be rotatable, and configured to support an upper eyelid, and a second support arm coupled to the second rotary arm, and configured to support a lower eyelid.

Abstract: Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.

Abstract: A gait management apparatus applies stimulation to a user suffering from a neurological disease (such as Parkinson's Disease) gait dysfunction. Motion sensors are arranged to be worn by a patient, and electrical stimulation electrodes are on the legs for stimulation. A controller receives motion sensing signals, and processes these signals to generate stimulation signals for operation of the electrodes to stimulate limb movement upon detection of a gait abnormality. There may be a user actuator for user actuation of electrical stimulation, and the inputs may be a series of taps. The controller may provide signals to prevent occurrence of freezing of gait when it senses that a patient is walking or has an intention to walk. Also, it may apply stimulation at an intensity level which is insufficient for functional muscle stimulation but sufficiently high to trigger activation of efferent nerves.

Abstract: Described herein is a generalizable strategy to rapidly and irreversibly activate protein function with full spatiotemporal control. Through development of an exogenously triggerable self-assembling protein construct, bioactive proteins can be stably reassembled from non-functional split fragment pairs following exposure to a stimulus (e.g., light).

Abstract: Provided are a catalyst, which enables the production of a high molecular weight olefin polymer having a polar group and being usable for various applications at a high catalytic activity, and a method for producing such an olefin polymer. Use is made of, as a polymerization catalyst for an olefin having a polar group, a metal complex represented by general formula (C1) [wherein: M represents an element in group 10 of the periodic table; X represents a phosphorus atom (P) or arsenic atom (As); R5 to R11 are as described in claims; at least one of R6 and R7 is an aralkyl group represented by general formula (2) (wherein R12 to R21 are as described in claims); L represents an electron-donating ligand; and q is 0, ½, 1 or 2].

Abstract: A method includes modeling a reservoir using a lab scale set of models and a field scale set of models. The reservoir is modeled using the lab scale set of models by scanning a sample of the reservoir into the lab scale set of models to create modeled fractures, estimating hydraulic properties of the modeled fractures, estimating multi-phase dynamic properties of the modeled fractures, and determining characteristics of a flow regime of a fluid flowing through the modeled fractures. The reservoir is modeled using the field scale set of models by modeling a discrete fracture network of the reservoir, upscaling the discrete fracture network, and calibrating the discrete fracture network. An enhanced oil recovery operation is designed and performed on the reservoir using the calibrated discrete fracture network.

Abstract: The application relates to fluorescence-quenched substrates of Formula (I) for an acid ?-glucosidase (GCase) and their use in a method for determining GCase activity in a cell or tissue, a method for localizing GCase activity within a cell, a method for determining the effect of a GCase modulator in a cell, a method for determining the efficacy if a GCase-directed therapy, and a method of screening for a GCase activity enhancer.