Patents Assigned to University
  • METHOD FOR SELECTING AN IMPROVED GENETICALLY MODIFIED PLANT
    Publication number: 20250129380
    Abstract: The present invention, is directed to a method for selecting an improved genetically modified Solanum plant, the method including: determining the presence of at least one inactive allele of auxin responsive factor (ARF) 8 gene in the genome of the genetically modified Solanum plant or a part derived therefrom; and (b) selecting a genetically modified Solanum plant determined as having a genome including the at least one inactive allele of ARF8 gene, wherein the improvement is at least any one of: (i) increased yield; (ii) increased resistance to a pathogen; (iii) earlier fruit setting; and (iv) any combination of (i) to (iii), compared to a wild-type variant of said Solanum plant, thereby, selecting an improved genetically modified Solanum plant.
    Type: Application
    Filed: February 1, 2023
    Publication date: April 24, 2025
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization
    Inventors: Naomi ORI, Alon ISRAELI, Maya BAR
  • PHOTOREACTIVE ANTIBODY BINDING DOMAINS WITH EPITOPE TAGS FOR MULTIPLEXED ANTIBODY LABELING, DETECTION, AND PURIFICATION
    Publication number: 20250130224
    Abstract: Provided are systems and methods for tagging biomolecules of interest, methods of generating tagged biomolecules, and methods of use thereof. An adapter system comprises one or more epitope tags operably linked to an antibody binding domain (AbBD), which may be a photoreactive antibody binding domain (pAbBD). A pAbBD may be used to covalently photocrosslink epitope tags to immunoglobulins or immunoglobulin fragments, which may in turn be used to label biomolecules of interest. Such epitope-tagged immunoglobulins may be used in various biological research applications, including multiplexed staining assays and tandem affinity pulldown assays.
    Type: Application
    Filed: August 3, 2022
    Publication date: April 24, 2025
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, ALPHATHERA LLC
    Inventors: Andrew TSOURKAS, Yi Shu
  • Engineered Probiotics for Colorectal Cancer Screening, Prevention, and Treatment
    Publication number: 20250127826
    Abstract: Orally-deliverable programmable bacteria cells that colonize colorectal tumors and produce diagnostic and therapeutic molecules, as well as related compositions and methods.
    Type: Application
    Filed: November 4, 2024
    Publication date: April 24, 2025
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Tal DANINO, Candice GURBATRI
  • BACILLUS VELEZENSIS STRAINS AND COMPOSITION FOR PREVENTING, TREATING, OR IMPROVING TUBERCULOSIS COMPRISING THE SAME
    Publication number: 20250127828
    Abstract: The present disclosure relates to a novel Bacillus velezensis strain and a method for preventing, treating, or improving tuberculosis comprising the same. More specifically, the present disclosure relates to a Bacillus velezensis PMC 206 strain extracted from vinegar and a use thereof, for example, an antibacterial composition having antibacterial activity against bacteria belonging to the genus Mycobacterium, a pharmaceutical composition or food composition for improving, treating, or preventing tuberculosis having antibacterial activity against bacteria belonging to the genus Mycobacterium.
    Type: Application
    Filed: August 20, 2024
    Publication date: April 24, 2025
    Applicant: SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
    Inventors: Ho Yeon SONG, Hoon Hee SEO, Su Kyung KIM
  • HYBRID SPATIAL LIGHT MODULATOR
    Publication number: 20250130444
    Abstract: Spatial light modulators and associated methods are described. In one embodiment, a spatial light modulator includes a photonic integrated circuit configured for emitting a plurality of light beams as a first waveform by a plurality of pixels. The light beams are individually controllable. The spatial light modulator also includes a meta-optic having a plurality of nanostructures configured for receiving the first waveform and aggregating the plurality of light beams as a second waveform at a surface of the meta-optic. The spatial light modulator also includes an aperture array configured for converting the second waveform into a third waveform, where the third waveform is smaller than the second waveform.
    Type: Application
    Filed: July 30, 2024
    Publication date: April 24, 2025
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Virat Tara, Anna-Wirth Singh, Abhi Saxena, Johannes Emanuel Fröch, Matthew S. Reynolds, Rui Chen, Arka Majumdar
  • HIGH THERMAL CONDUCTIVITY COMPOSITE MATERIAL STITCHED WITH PITCH-BASED CARBON FIBER, AND METHOD FOR MANUFACTURING THE SAME
    Publication number: 20250128482
    Abstract: The present disclosure relates to a highly thermally conductive composite material in which PITCH-based carbon fiber is stitched into a prepreg laminate in which a prepreg including carbon fiber and a thermosetting resin is laminated, and a method for manufacturing the same, and the highly thermally conductive composite material may have excellent through-thickness thermal conductivity, in-plane thermal conductivity and strength.
    Type: Application
    Filed: June 18, 2024
    Publication date: April 24, 2025
    Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY
    Inventors: Byeong Su Kwak, Hun Cheol Choi, Gyu Beom Park, Yeong Deok Noh, Jin Hwe Kweon, Young Woo Nam
  • METHODS OF ADJUSTING CARBON AND SILICA CONTENT IN RICE HULL ASH (RHA) BYPRODUCTS TO CONTROL CARBOTHERMAL REDUCTION FORMING NANOSTRUCTURED SILICON CARBIDE, SILICON NITRIDE, SILICON OXYNITRIDE NANOCOMPOSITES
    Publication number: 20250132323
    Abstract: In various aspects, methods of making a silicon carbide or silicon nitride from rice hull ash (RHA) byproduct are provided. A treated silica depleted rice hull ash product (SDRHA) comprising silicon oxide at ?about 65% by weight and carbon ?about 35% by weight may be heated in an environment free of any additional carbon sources, but in an inert atmosphere, having a temperature of ?about 1,200° C. to ?about 1,700° C. for a carbothermal reaction that forms a product (e.g., nanocomposite product) comprising at least one of silicon carbide (SiC), silicon nitride (Si3N4), and silicon oxynitride (Si2N2O or non-stoichiometric SiNxO4-x, where x ranges from greater than 0 to less than 4). A negative electroactive material is also provided that includes silicon oxynitride (Si2N2O), which may be used in a lithium ion battery.
    Type: Application
    Filed: September 8, 2022
    Publication date: April 24, 2025
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Mengjie YU, Richard LAINE, Eleni TEMECHE
  • COMPOSITIONS AND METHODS FOR TREATING CORONAVIRUS INFECTIOUS DISEASE-19 (COVID-19)
    Publication number: 20250127890
    Abstract: Compositions and methods for treating and/or diagnosing a subject having COVID-19. The treatment composition includes an inhibitor of at least one of doublecortin-like kinase 1 (DCLK1, including DCLK1 isoforms 1-4), and doublecortin-like kinase 2 (DCLK2, including DCLK2 isoforms 1-3). The treatment composition may optionally include an inhibitor of SI 00 calcium binding protein A9 (S100A9), calprotectin (S100A8/S100A9 complex), S100A4, Granulocyte-macrophage colony-stimulating factor (GM-CSF), Vascular endothelial growth factor (VEGF), Interleukin-6 (IL-6), or combinations thereof. The subject may also have a chronic liver disease, disorder, or condition. A method of determining if a patient having COVID-19 should be administered a treatment protocol for severe or critical COVID-19.
    Type: Application
    Filed: October 11, 2022
    Publication date: April 24, 2025
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventors: Naushad ALI, Mark M. HUYCKE
  • ECHO PLANAR IMAGING METHOD CAPABLE OF REDUCING IMAGE DISTORTION
    Publication number: 20250130300
    Abstract: An echo planar imaging method capable of reducing image distortion is provided. Two radio frequency (RF) pulses ? and ? are used to respectively flip over a longitudinal magnetization into a transverse plane at different moments, so as to obtain observable transverse magnetization; the transverse magnetization obtained by flipping over the longitudinal magnetization by means of ? and ? are respectively rephased in two different echo trains by means of gradient pulses. Navigator echo signals are respectively collected before the two gradient echo trains, and the amplitude difference between two gradient echo train signals is corrected on the basis of the amplitude difference between the two navigator echo signals. Correcting the signals collected by the two gradient echo trains, so as to obtain two pieces of image data, and the two pieces of image data are averaged to obtain a final image.
    Type: Application
    Filed: August 23, 2023
    Publication date: April 24, 2025
    Applicant: Shanghai Jiao Tong University
    Inventors: Zhiyong ZHANG, Hao CHEN
  • MICRONEEDLE STRUCTURE WITH HIGH SEPARATION YIELD, DEVICE CONTAINING THE SAME, AND METHOD FOR MANUFACTURING THE SAME
    Publication number: 20250128038
    Abstract: A highly-removable microneedle structure, a microneedle device including the same, and a method for manufacturing the structure are disclosed. The highly-removable microneedle structure includes: a tip tapered downwardly; a base extending upwardly from an upper surface of the tip and having an area size in a plan view thereof smaller than an area size in a plan view of an upper surface of the tip; and a tube surrounding the base and extending upwardly from the upper surface of the tip and beyond an upper surface of the base.
    Type: Application
    Filed: October 11, 2024
    Publication date: April 24, 2025
    Applicant: UIF (University Industry Foundation), Yonsei University
    Inventors: Won Hyoung RYU, Ji Yeon YI
  • STABLE NANOEMULSIONS OF TERPENE BY-PRODUCTS FROM CANNANBIDIOL PRODUCTION AND PRODUCTS THEREOF
    Publication number: 20250127160
    Abstract: Stable nanoemulsions of a terpene-rich cannabidiol by-product (TP) and/or its distillate (DTP) can be used to effectively make pesticides, herbicides, and other bioactive products. A terpene-rich by-product (TP) can be provided, suitably by isolation from a commercial cannabidiol production process. The enriched terpene distillate (DTP) can be obtained from steam distillation of some or all of the TP. The TP and/or DTP can be combined with a surfactant to form an emulsion, which can then be sonicated to form the stable nanoemulsion. It has been discovered that the formulation of stable nanoemulsions using the terpene by-products as the lipophilic phase can effectively deliver desired levels of bioactivity while overcoming or mitigating the known drawbacks of high lipophilicity, high volatility, and propensity to thermal and oxidative degradation, all of which can lead to reduced efficacy.
    Type: Application
    Filed: October 15, 2024
    Publication date: April 24, 2025
    Applicant: University of Tennessee Research Foundation
    Inventors: Tong Wang, Kimberly D. Gwinn, Tao Fei, Zachariah R. Hansen, Duy Trinh
  • ANTIMICROBIAL PEPTIDES
    Publication number: 20250127167
    Abstract: The invention generally discloses short and ultrashort peptides with improved antimicrobial properties.
    Type: Application
    Filed: September 14, 2022
    Publication date: April 24, 2025
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventor: Meital RECHES
  • APPARATUS AND METHOD FOR PROVIDING VIRTUAL REALITY-BASED EYE MOVEMENT EXERCISE AND VISUAL PERCEPTION TRAINING
    Publication number: 20250127678
    Abstract: The present invention relates to an apparatus and method for providing virtual reality-based eye movement exercise and visual perception training, wherein a dichoptic presentation is provided in consideration of the deviation of a user's eyeball so as to prevent additional damage to stereoscopic vision due to suppression, and is provided by adjusting the degree of difficulty by changing the locations of visual stimuli on the basis of the level of deviation and training capability of the user, thus making it possible for the user to not only receive training suitable for the user's condition, but also simultaneously undergo visual perception training including eye exercise (movement) training and stereoscopic perception recognition.
    Type: Application
    Filed: December 24, 2024
    Publication date: April 24, 2025
    Applicants: THE ASAN FOUNDATION, NUNAPS INC., UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Dong Wha KANG, Hyun Taek LIM, Byung Joo LEE, Rak Kyeun HONG, Yong Hwan KIM
  • PATCH FOR TARGETED DELIVERY OF AN ONCOGENIC CARGO TO A TISSUE
    Publication number: 20250127729
    Abstract: Patches configured to hold an oncogenic cargo and deliver the cargo in a controlled manner to a predetermined location of a specified tissue are disclosed. As one example, a patch can comprise a base layer configured to adhere to a predetermined location of a tissue and a hydrogel layer. The hydrogel layer can comprise a plurality of microchannels that are configured to store and release a gene-modifying vector over a time period and in a quantity sufficient to produce a somatic cell tumor through manipulation of the genome of somatic cells at the predetermined location.
    Type: Application
    Filed: February 1, 2023
    Publication date: April 24, 2025
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Hyunjoon Kong, Byoungsoo Kim, Lawrence B. Schook, Kyle Schachtschneider, Lobna Elkhadragy, Maximillian Carlino
  • PHARMACEUTICAL COMPOSITION CONTAINING TRIAZINE DERIVATIVE
    Publication number: 20250127788
    Abstract: The present invention provides a pharmaceutical composition comprising a compound exhibiting coronavirus proliferation inhibitory activity. A pharmaceutical composition comprising a compound represented by the formula: wherein Y is N; R1 is substituted or unsubstituted aromatic heterocyclyl; R2 is substituted or unsubstituted 6-membered aromatic carbocyclyl; R3 is substituted or unsubstituted aromatic heterocyclyl; —X— is —NH—; m is 0 or 1; R5a is a hydrogen atom; R5b is a hydrogen atom; n is 1; R4a is a hydrogen atom; and R4b is a hydrogen atom, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 27, 2022
    Publication date: April 24, 2025
    Applicants: Shionogi & Co., Ltd., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yuki TACHIBANA, Shota UEHARA, Yuto UNOH, Kenji NAKAHARA, Yoshiyuki TAODA, Koji KASAMATSU, Yukiko YAMATSU, Shigeru ANDO, Keita FUKAO, Haruaki NOBORI, Takayuki KURODA, Shinsuke TOBA, Kentaro UEMURA, Yuki MARUYAMA, Michihito SASAKI, Hirofumi SAWA
  • BOREALIN TARGETING POLYPEPTIDES FOR DETECTION AND TREATMENT OF CANCER
    Publication number: 20250127814
    Abstract: Aspects of the present disclosure are directed to borealin-targeting polypeptides, including antibodies, antibody-drug conjugates, antibody fragments, antibody-like molecules, and chimeric receptors. Also disclosed herein are nucleic acids encoding for such borealin-targeting polypeptides and cells comprising such nucleic acids. Described are methods for detection, diagnosis, and treatment of cancer using borealin-targeting polypeptides.
    Type: Application
    Filed: October 6, 2022
    Publication date: April 24, 2025
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Anthony KOSSIAKOFF, Annika SÄÄF, Marcin URA, Somnath MUKHERJEE
  • A-TYPE TITANIUM ALLOY AND ITS PREPARATION METHOD
    Publication number: 20250129453
    Abstract: The present invention provides an ?-type titanium alloy, the fracture toughness and thermal creep resistance of the prepared ?-type titanium alloy are improved by controlling the content of Al, Zr, and Sn. The room temperature strength is improved by adding a certain amount of Si, and the thermal creep resistance is further improved. The addition of a certain amount of C and Cr improves the high-temperature tensile properties of the prepared ?-type titanium alloy. The method provided by the invention has a simple process and low cost and can achieve good matching of low cost, high performance, and less processing capacity. The prepared ?-type titanium alloy in example 1˜4 of the invention has an elastic modulus of 124˜132 GPa, a tensile strength of 867˜881 MPa, a yield strength of 743˜762 MPa, an elongation of 22%˜24.0%, and a section shrinkage of 47%˜51% at 600° C.
    Type: Application
    Filed: March 27, 2024
    Publication date: April 24, 2025
    Applicant: Nanjing Tech University
    Inventors: Hao WU, Xuewen LI, Guohua FAN
  • MIXED-ANION SOLID ELECTROLYTE AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20250132381
    Abstract: The invention relates to a mixed-anion solid electrolyte, having the following chemical formula: LidAl1?cYcCl3?aXb, wherein Y is selected from at least one of Si4+, Ge4+, Sn4+, Sb5+, Nb5+, Ta5+, Mo6+, and W6+, and X is selected from at least one of O2?, S2?, F?, Br?, I?, and BH4?; and wherein 0<d?2, 0<b?2, 0<a?2, 0<c<0.75 and charge balance is reached.
    Type: Application
    Filed: July 10, 2024
    Publication date: April 24, 2025
    Applicant: HEFEI UNIVERSITY OF TECHNOLOGY
    Inventors: Xuyong Feng, Liming Zhang, Hongfa Xiang
  • INTRA PREDICTION MODE, AND ENTROPY ENCODING/DECODING METHOD AND DEVICE
    Publication number: 20250133204
    Abstract: Disclosed herein are image encoding/decoding method and apparatus. The image decoding method according to the present invention includes: obtaining prediction mode information of a neighboring block for a current block from a bitstream; by using the obtained information, deriving a prediction mode of the neighboring block; and, based on the prediction mode of the neighboring block, reconstructing the current block.
    Type: Application
    Filed: December 30, 2024
    Publication date: April 24, 2025
    Applicants: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, INDUSTRY-UNIVERSITY COOPERATION FOUNDATION KOREA AEROSPACE UNIVERSITY
    Inventors: Jin Ho LEE, Jung Won KANG, Ha Hyun LEE, Sung Chang LIM, Hui Yong KIM, Jae Gon KIM, Yong Uk YOON, Do Hyeon PARK
  • STATICALLY STABLE HEXAPEDAL WALKING ROBOT PLATFORM
    Publication number: 20250128775
    Abstract: A walking rover system with a rover, a base station, and a tether extending between the rover and the base station. The rover has a rover body, a plurality of mobilizing legs, and a plurality of stabilizing legs. The stabilizing legs have one degree of freedom and the mobilizing legs have three degrees of freedom. The mobilizing legs and the stabilizing legs may alternate around the rover body such that each of the mobilizing legs is separated from adjacent mobilizing legs by a stabilizing leg and each of the stabilizing legs is separated from adjacent stabilizing legs by a mobilizing leg. The tether is configured to transmit electricity from the base station to the rover, transmit data gathered by the rover back to the base station, and support a weight of the rover and act as a mechanical rappel line between the base station and the rover.
    Type: Application
    Filed: October 24, 2024
    Publication date: April 24, 2025
    Applicant: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Gowan ROWLAND, Andrew DEROS, Connor NAIL, Tyler SMITH