Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.

Abstract: Disclosed is an underwater robot for a mine flooding rescue, including a starting unit configured to control the implementation of a whole rescue action; a drive unit connected with the starting unit and configured to provide a robot with power to move; and an execution unit connected with the drive unit and configured to salvage underwater life sources.

Abstract: A hydrogen generation and carbon dioxide storage system for producing an alkali bicarbonate is provided. The system may include: a metal-carbon dioxide battery comprising an anode, a cathode, and a separator interposed between the anode and the cathode; a first supplier configured to provide a first electrolyte to the anode; a second supplier configured to provide a second electrolyte to the cathode; a reaction unit configured to manufacture a precursor material by reacting starting materials comprising aqueous alkali carbonate solution and carbon dioxide; a third supplier configured to provide the aqueous alkali carbonate solution to the reaction unit; a fourth supplier configured to provide the carbon dioxide to the reaction unit; and a hydrogen gas separator configured to separate hydrogen gas from a product discharged from the cathode and to provide a remainder of the product to the reaction unit.

Abstract: Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.

Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

Abstract: The present disclosure provides the ABI1-based seven-gene prognostic signature that predicts survival of metastatic breast cancer patients. The present disclosure reveals that ABI1 is a prognostic metastatic biomarker in breast cancer. The present disclosure further provides that lung metastasis is associated with an ABI1 gene dose and specific gene expression aberration in primary breast cancer tumors and indicates that targeting ABI1 may provide a therapeutic advantage in breast cancer patients.

Abstract: The present disclosure provides an ionic gel film preparation method, a chemical sensor and preparation method thereof, relating to the field of sensor technology. The preparation method of ionic gel film includes: blending a vinyl-free ionic liquid with a vinyl-containing ionic liquid and a specified additive to obtain a homogenous solution, taking a predetermined amount of the homogenous solution and dropping it onto a first substrate equipped with interdigital electrodes, flattening the homogenous solution on the first substrate using a second substrate, curing the flattened homogenous solution on the first substrate using ultraviolet light of a preset wavelength, and curing until the vinyl-containing ionic liquid polymerizes in situ to form an ionic gel film. The preparation method of ionic gel film, chemical sensor, and preparation method thereof of the present disclosure have the advantages of good device consistency, high conductivity, and good sensing performance when using the ionic gel film.

Abstract: Methods, assays, and compositions for identifying molecular subtypes of metastatic cancer are disclosed. Methods include determining expression levels of genes and/or miRNAs in a sample of metastatic tissue and identifying the molecular subtype of the metastasis based on the determined expression levels using a neural network-based classifier. Methods may further include providing a prognosis and making treatment decision based on the molecular subtype of the metastasis.

Abstract: Disclosed herein are an infectious clone capable of inoculating Nanovirus DNA-C, DNA-M, DNA-N, and DNA-U1, and uses thereof. A recombinant vector comprising the nucleotide sequences of Nanovirus DNA-C, DNA-M, DNA-N, and DNA-U1 represented by SEQ ID NOS: 1 to 8, and E. coli and Agrobacterium tumefaciens, each transformed therewith, can effectively induce the infection of Nanovirus into crops even without any insect vectors. Therefore, the disclosure can be applied to various studies, such as investigating the host range and the correlation with hosts of Nanovirus DNA-C, DNA-M, DNA-N, and DNA-U1. This can help in preemptively preventing economic losses due to virus infections, making it beneficially applicable in the related fields.

Abstract: The present invention provides a method for amplifying, in a reaction solution, at least one target gene having a GC content of at least 60%, wherein the method contains a step of amplifying a specific base sequence in a target gene by using a primer set consisting of a first primer and a second primer for target gene amplification, and wherein one primer in the primer set is added to the reaction solution at a molar ratio higher than the other primer and neither primer is a hot start primer that contains an inactivating chemical modification that is restored by an action of an activating enzyme.

Abstract: Disclosed is a eutectic mixture containing a first component and a second component as main components. The first component is a quaternary ammonium salt, and the second component is an aminocarboxylic acid and/or a derivative thereof, the aminocarboxylic acid having a —COOH group and an —NH— group in the same molecule. The eutectic mixture has a melting point, Tm, which is lower than the melting point of the first component, T1, and which is lower than the melting point of the second component, T2. The eutectic mixture is in a homogeneous liquid state at a temperature higher than the melting point, Tm. Disclosed is a liquid composition containing a third component dissolving in the eutectic mixture. The third component contains one or two or more selected from cellulose, hemicellulose, and lignin.

Abstract: Molecular markers linked to main QTL for regulating resistance of rice to whitebacked planthopper are provided. The QTL is located on rice chromosome 1, with a genetic distance of 30.88-34.32 cM and a physical distance of 7203302-8007653 bp. Then the molecular markers are set on both sides of the QTL, and the molecular markers are used to screen rice varieties resistant to whitebacked planthopper, which improves the selection efficiency of ideal plant types of rice.

Abstract: [Problem] An electrostatic capacitive pressure sensor capable of detecting a pressure of a fluid with high accuracy, capable of miniaturization, and having a wider pressure detection range, and a pressure detection method using the same. [Solution] The electrostatic capacitive pressure sensor comprises: a reference chamber provided between a fixed electrode and a movable electrode that deflects in accordance with fluid pressure; a measurement chamber filled with a fluid for causing deflection of the movable electrode; a means for sequentially applying a first potential and a second potential to the fixed electrode and generating a first output signal corresponding to the first potential and a second output signal corresponding to the second potential; and a means for generating a difference signal between the first output signal and the second output signal.

Abstract: Synthetic cassiterite used as a standard substance for in-situ tin isotope testing, a preparation thereof, and a method for in-situ tin isotope analysis using the synthetic cassiterite are provided. The preparing method includes: grinding a natural cassiterite into ultrafine powder; and obtaining a synthetic cassiterite that can be used as a standard substance.

Abstract: An electrically tunable liquid crystal lens includes a carrier substrate, a common electrode layer disposed on the carrier substrate, a liquid crystal unit, a patterned electrode layer, a terminal electrode layer, a dielectric insulating layer, and a cover. The liquid crystal unit is disposed on the common electrode layer opposite to the carrier substrate, and includes a plurality of liquid crystal molecules. The patterned electrode layer is disposed on the liquid crystal unit opposite to the common electrode layer, and has a plurality of aperture patterns located within a projection of the liquid crystal unit on the patterned electrode layer. The terminal electrode layer is disposed on the patterned electrode layer opposite to the liquid crystal unit. The dielectric insulating layer is disposed between the patterned electrode layer and the terminal electrode layer. The cover is disposed on the terminal electrode layer opposite to the dielectric insulating layer.

Abstract: The compound of the present invention includes a structure having: a chelating part capable of coordinating with a radioactive metal ion; a first atomic group containing an albumin-binding part; and a second atomic group containing a PSMA molecule-binding part, wherein the first atomic group and the second atomic group are bonded with each other through the chelating part, or the chelating part is bonded from between the first atomic group and the second atomic group so that it makes a branch. The present invention also provides: a radiolabeled compound in which the compound is coordinated with a radioactive metal ion; and a method for manufacturing a radiolabeled compound.

Abstract: For constructing an asymmetric RF pulse for an MRI system, a first RF amplitude for a first part of a time interval is determined and an RF amplitude curve, which depends on at least one RF curve parameter is received. A combined RF amplitude curve for the time interval is determined by combining the first RF amplitude for the first part of the time interval and the RF amplitude curve for a second part of the time interval, which succeeds the first part of the time interval. The combined RF amplitude curve is optimized using a loss function, which comprises an energy loss term, which depends on a pulse energy of the combined RF amplitude curve, and using the at least one RF curve parameter as at least one optimization variable. A combined amplitude of the asymmetric RF pulse is given by the optimized combined RF amplitude curve.

Abstract: Disclosed is a method of manufacturing a transparent stretchable structure according to various embodiments of the present invention for achieving the above-described objects. The method includes providing a stretchable film and performing a rolling process on the stretchable film to form a transparent stretchable structure, wherein the stretchable film is provided through a thermoplastic elastomer based on physical crosslinking, and nanostructures in the transparent stretchable structure are oriented in one direction through the rolling process.

Abstract: A composite is provided which comprises planar molybdenum oxide microstructures and cobalt oxyhydroxide microstructures disposed on the planar molybdenum oxide microstructures. A method of forming the composite is also provided. The composite is used in the fabrication of an electrochemical sensor, which comprises the composite, an electrode, and a polymeric coating. The electrochemical sensor is used in a method of detecting the presence of glucose in an analyte. The method involves applying a voltage to the electrochemical sensor relative to a counter electrode and measuring a current response. The method in insensitive to common oxidative interfering analytes such as urea, lactate, and NaCl.

Abstract: A coupling process for producing biodiesel from a waste FOG including: among others, 1) removing solid impurities from a waste FOG, then mixing with an alcohol and liquid acid catalyst to generate a pre-esterified mixture; 2) mixing the mixture with water, and charging the mixture to separate an aqueous phase to remove metal ions to obtain an esterification product II; 3) mixing the product II with a vulcanizator and H2 to generate a product I; 4) and separating the product I to obtain an oil phase, mixing the oil phase with H2 and passing the mixture into a fixed-bed reactor, and using a gas-liquid separator for separation to obtain an oil phase product II.