Abstract: The present disclosure provides methods and compositions for modifying the genomes of bacteriophages, in particular by integrating a coding sequence for an anti-CRISPR protein into the bacteriophage genome together with a desired modification such as a deletion, insertion, or nucleotide substitution, and selecting for bacteriophages with the integrated anti-CRISPR coding sequence by introducing the phage into a counter selection strain comprising an RNA-targeting CRISPR-Cas system.

Abstract: The present disclosure provides an operation method of a prediction system of significant congenital heart disease in infants in infants, which includes steps as follows. The continuous wavelet transformation is performed on the electrocardiogram to obtain the processed electrocardiogram; the processed electrocardiogram is oversampled to obtain multiple electrocardiogram segments; the transfer learning through multiple pre-trained models based on the multiple electrocardiogram segments is used to establish a significant congenital heart disease model.

Abstract: An internal circulation type clathrate hydrate-based cold storage system and method are provided in the field of industrial refrigeration. The internal circulation type clathrate hydrate-based cold storage system includes a water chilling unit, a hydrate-based cold storage tank, a gas disturbance device, a concentration measurement system, a heat exchange system, a direct-current power supply and circuit control system, and a system monitoring device. The water chilling unit provides a secondary refrigerant at a low temperature. The secondary refrigerant flows through an evaporator coil in the hydrate-based cold storage tank for a heat exchange. The gas disturbance device induces hydrate nucleation. The concentration measurement system monitors a concentration of a hydrate solution in real time. The heat exchange system is equipped with a finned tube heat exchanger with a fan.

Abstract: The present disclosure describes an autonomous warehouse package delivery system. The system includes a warehouse, a plurality of unmanned ground vehicles (UGV), a plurality of UAVs, and a plurality of servers. The warehouse includes a U-shaped conveyor belt, a plurality of shelving units, a plurality of package stacks, a first plurality of robots, and a second plurality of robots. Each UGV autonomously pick-ups a package from a shelf, navigates to the UAV landing pads, and places the package on the UAV landing pad. The plurality of UAVs travel to the UAV landing pad and pick up a package, autonomously fly to a package delivery address and release the package at the package delivery address. A real-time data distribution middleware network is connected to the U-shaped conveyor belt, the first plurality of robots, the second plurality of robots, the plurality of UGVs, the plurality of UAVs and a plurality of servers.

Abstract: Methods of forming spinel ferrite nanoparticles containing a chromium-substituted copper ferrite as well as properties (e.g. particle size, crystallite size, pore size, surface area) of these spinel ferrite nanoparticles are described. Methods of preventing or reducing microbe growth on a surface by applying these spinel ferrite nanoparticles onto the surface in the form of a suspension or an antimicrobial product are also described.

Abstract: Fluidic systems, devices and methods are provided for separating and sequestering particles from a fluid flow within traps in a fluidic chip is provided. The fluidic platform is particularly suited for parallel live zebrafish embryo studies providing automated zebrafish embryo trapping and flow through culture as well as whole mount zebrafish antibody staining functions. The zebrafish on a chip testing platform uses a chaotic hydrodynamic trapping process to trap and retain zebrafish embryos in a consistent body orientation (i.e., head pointed inward) without any external adjustments. The system and apparatus can also be adapted to be a multifunctional concentration gradient generator (CGG) that can be used to automatically immobilize dechorionated zebrafish embryos and generate chemical gradients for acute fish embryo toxicity (FET) tests.

Abstract: A highly sensitive technology enabling selective recognition of aflatoxins such as in contaminated cereal samples. Methods for the synthesis of AgNP-containing MIP membranes from the monomer mixtures containing both methacrylate monomers and oligomers as well as AgNOs solution in dimethylformamide enable the detection system. The AgNP were formed in the structure of the polymeric membranes during the pre-heating step followed by the UV-initiated polymerization. The highly selective sensor elements where MIP membranes are combined with the Ag nanostructures as signal amplifiers (LSPR-MIP nanochips) can be stored separately and used with a simple optical recognition system as selective elements of point-of-care sensor devices, even in in-field conditions. Composite plasmonic membranes provide both highly selective recognition of the target toxin and the generation of an enhanced optical signal, allowing aflatoxin B1 detection at ultralow concentrations.

Abstract: Disclosed in the present invention is a synthesis method for high-purity cholesterol. The cholesterol is synthesized by using plant-derived 21-hydroxy-20-methylpregn-4-en-3-one, which is also referred to as bisnoralcohol or BA, as a raw material, and by means of steps of oxidation, Wittig reaction, acetylation, reduction, hydroxyl protection, selective hydrogenation reduction, and deprotection or hydrolysis reaction, and the purity can reach 99% or above. Aiming at defects of conventional animal-derived cholesterol, in the present invention, the cholesterol is synthesized from plant-derived raw material BA; thus, high safety is achieved, the risk of pathogenic bacteria and virus infection is avoided, high synthesis yield, high product purity, and environmental friendliness are achieved, and industrial production is facilitated.

Abstract: Actuation devices and methods for using same are disclosed. The actuation device includes a first actuation layer including a plurality of first actuators operable within a first frequency range, and a second actuation layer provided on the first actuation layer, the second actuation layer including a plurality of second actuators operable within a second frequency range different from the first frequency range.

Abstract: A memory device according to various example embodiments includes a memory cell array having a plurality of memory cells connected to word lines and bit lines; and an error correction circuit configured to perform error correction on data read from the memory cell array, wherein the error correction circuit is configured to perform at least one of a 1-bit error correction operation, a 2-bit error detection operation, or a 3-bit error detection operation using a parity check matrix, and the parity check matrix is configured so that columns are arranged in an order of odd-odd-even degree, and leading one (LO) of each row is arranged in a stepped structure.

Abstract: An information processing method, an information processing system, and a recording medium are provided.

Abstract: The present application provides an immunosuppressive agent containing a substance that is selected from anti-CD80 antibodies and anti-PD-L1 antibodies and that promotes binding between PD-L1 and PD-1.

Abstract: A High Voltage Complementary Metal-Oxide-Semiconductor, HV-CMOS, sensor comprising a p-substrate having a topside and a backside; wherein the topside comprises: an array of mutually spaced apart pixel structures, including a first pixel structure, therein and/or thereon, wherein the first pixel structure comprises: a set of PMOS and NMOS transistors, including a first PMOS transistor having an n-well, SN, layer, and a first NMOS transistor having a p-well, SP, layer; a deep n-well, DN, structure having a DN layer; a p-type buried, BP, layer disposed to mutually isolate the SN layer and the DN layer; an n-type buried, BN, layer providing a SN/BN/DN stack; and a set of contacts, including a first contact, electrically coupled to the DN layer via the SN/BN/DN stack; wherein the backside comprises: a doped p+ layer therein and/or thereon; and wherein the sensor comprises an HV bias contact electrically coupled only to the p+ layer, for backside biasing thereof.

Abstract: Disclosed is a method for quantitative detection of a small, aberrant viral nucleic acid. The method includes combining a detection mixture with a sample, and allowing a reaction with the test mixture to begin. The sample includes an RNA sample. The detection mixture includes a Cas13 enzyme, a reporter, a sequence-specific CRISPR RNA (crRNA), and a buffer. The method includes determining a quantitative value representative of the reporter in the test mixture, where the quantitative value is a measure of an amount of target RNA present in the RNA sample.

Abstract: Disclosed in the present application is a method for fitting spontaneous emission noise of a lidar system or an optical fiber sensing system. The method includes: providing a trigger collection signal by a signal source; triggering, based on the trigger collection signal, a co-located transceiver module and a distributed transceiver module to perform synchronous detection on a detection target; receiving co-located data and distributed data returned by the detection target; subtracting local noise from the co-located data and the distributed data, respectively; selecting a linear interval to normalize the co-located data; performing subtraction operation on the normalized co-located data and the distributed data to obtain spontaneous emission noise; and fitting the spontaneous emission noise by a function.

Abstract: The present disclosure relates to a technology for achieving carbon neutrality in ESG-based industrial sites. An apparatus for achieving carbon neutrality analyzes energy performance of factories, industrial facilities, and plants, derives energy saving factors and renewable energy production factors, verifies performance of facility materials and facility construction methods to comply with GRI standards, for example, optimizes internal air in accordance with the GRI standards, and quantitatively measures and evaluates environmental, social, and governance (ESG) achievement rates of factories, the industrial facilities, and the plants.

Abstract: A multi-lead electrocardiogram (ECG) signal classification method based on self-supervised learning relates to the technical field of ECG signal classification. The method includes: processing an original signal through different data augmentation methods, designing an appropriate encoder module, extracting a feature of an ECG signal through a large amount of easily available unlabeled data such that an encoder learns more class information of the ECG signal, fine-tuning the model encoder with a small amount of labeled data for feature optimization, and continuously optimizing a parameter of a feature extractor by training a model such that a generated feature well reflects a structure and information of input data. Through self-supervised learning, the method reduces obstacles caused by performing ECG signal classification through a large amount of expensive manually labeled data, improving the generalization ability of the model.

Abstract: Disclosed is a display panel. The display panel includes a substrate, first interlayer disposed on the substrate, and a light-emitting element layer disposed on one side of the first interlayer away from the substrate. A plurality of first convex portions are disposed on one side of the first interlayer away from the substrate. The light-emitting element layer includes a plurality of light-emitting elements disposed on the plurality of first convex portions. At least some of the plurality of light-emitting elements are disposed on side walls of the plurality of first convex portions. A light-emitting surface of each of the plurality of light-emitting elements extends in a first direction, an included angle formed between the first direction and a second direction is an acute angle, and the second direction is a direction in which the substrate points towards the first interlayer.

Abstract: A high performance laminated aluminum alloy manufacturing method includes: combining and fixing a front plate, a middle plate, and a rear plate, performing hot roll-bonding to obtain a laminated aluminum alloy; conducting solid solution and quenching treatment on the laminated aluminum alloy; carrying out underwater stirring friction treatment on the quenched laminated aluminum alloy; after aging heat treatment, the laminated aluminum alloy with high ballistic resistance and high interfacial bonding strength is obtained. The method uses underwater stirring friction treatment on quenched laminated aluminum alloy to break the original interlayer structure, forming a three-dimensional spatial structure composed of a stirring zone and a structural interlocked zone, and the interlayer bonding strength of the laminated aluminum alloy is greatly improved.

Abstract: Provided herein are compositions and methods directed toward the discovery of improved methods for generating deoxyATP (dATP) in cells that can be delivered to a graft site in the heart to enhance cardiac function.