Abstract: The invention provides a strategy for site specific covalent modification of antibodies using a specialized targeting covalent heterobivalent ligand (cHBL), and corresponding design for a covalent heterobivalent inhibitor (cHBI) that can be used to prevent Immunoglobulin E (IgE) mediated allergic reactions triggered by drug molecules, according to one embodiment. These molecules contain four important components: (1) an IgE antigen binding site (ABS) ligand that can be a mimotope for the allergen protein, a small molecule, or a peptidomimetic, (2) an appropriate linker, which can be any flexible or rigid chemical linker, providing spacing between the ABS binder and the other moieties, (3) a nucleotide binding site (NBS) ligand, and (4) a reactive moiety to form a covalent link with an amino acid side chain of target IgE antibodies.

Abstract: A high-purity calcium carbonate sintered body containing less impurities and available for biological and like applications, a production method, a high-purity calcium carbonate porous sintered body containing less impurities and available for biological and like applications, and a production method. A method for producing a high-purity calcium carbonate sintered body includes the steps of: compaction molding calcium carbonate with a purity of 99.7% by mass or more to make a green body; and sintering the green body to produce a calcium carbonate sintered body. A method for producing a high-purity calcium carbonate porous sintered body according to the present invention includes the steps of: preparing a dispersion liquid containing calcium carbonate with a purity of 99.7% by mass or more; adding a foaming agent to the dispersion liquid, followed by stirring until foamy to make a foam; and sintering the foam to produce a calcium carbonate porous sintered body.

Abstract: The present disclosure provides a low-cost beam scanning antenna and method of beam scanning in which two phase shifts are performed in an array of antenna elements. One of the phase shifts is performed in discrete stepwise increments in a feedline of the antenna element and another phase shift is performed by radiating a signal through variable phase shifters. The amount of phase shift provided by the variable phase shifters is varied by changing a rotation angle of the variable phase shifters.

Abstract: A porous microsphere and a method for preparing the same includes the following steps. A copolymer having a vinylbenzyl chloride unit and a vinylbenzyl alcohol unit is dissolved in an organic solvent, and inorganic particles are dispersed in the organic solvent to form a mixed suspension. An aqueous solution containing a surfactant is provided. The mixed suspension is emulsified in the aqueous solution to form an emulsion. The emulsion is heated to evaporate the organic solvent to obtain inorganic-composite porous microspheres suspended in water. The copolymer in the formed porous microspheres can be further carbonized or removed to produce inorganic-based porous microspheres containing carbon or not containing carbon.

Abstract: An eye treatment apparatus is described. The apparatus includes an annular body that has a hollow optical zone in its center. An inner perimeter of the annular body surrounds the optical zone. The inner perimeter has a diameter that corresponds to a diameter of the eye's cornea. An outer perimeter of the annular body has a diameter such that the annular body can extend to underneath the eye lid in an open eye position when the eye treatment apparatus is in operation. In this way, the apparatus can be worn on the eye, where the hollow optical zone substantially corresponds to the cornea and does not interfere with the field of vision. The annular body also includes a storage chamber that stores therapeutic liquid for an eye. An outlet is coupled with the storage chamber such that, in operation, the therapeutic liquid can be dispensed to the eye.

Abstract: The present disclosure concerns embodiments of an implantable perfusion device that can be implanted in an injured blood vessel to control bleeding without occluding the vessel. In one specific implementation, the perfusion device can be implanted percutaneously into a patient's descending aorta to control bleeding at the site of a ruptured portion of the aorta (known as torso hemorrhage) while still allowing for the antegrade flow of blood from a location upstream of the ruptured portion of the aorta to a location downstream of the ruptured portion of the aorta. The perfusion device can be left inside the patient as the patient is transported to a medical facility where the injury can be repaired. Following repair of the vessel, the perfusion device can be withdrawn from the patient.

Abstract: Aspects of the disclosure provide an antenna system. The antenna system can include a dielectric substrate that has a top surface and a bottom surface covered by a ground plane, and four identical antenna elements symmetrically distributed on each corner of the bottom surface. Each antenna element can have a concentric-pentagonal-slot-based structure that is etched out of the ground plane, and includes an outer pentagonal slot and an inner pentagonal slot. Each side of the outer pentagonal slot can be parallel with a corresponding side of the inner pentagonal slot.

Abstract: Provided are a method of generating a respiratory status classifier and a method of determining respiratory status. The method of generating a respiratory status classifier includes segmenting collected respiratory signals according to respiratory cycles, acquiring data pairs of a calculated power spectrum of frequency components and a designated respiratory status indication value for a plurality of cycle-specific respiratory signals selected from among the segmented cycle-specific respiratory signals, selecting specific frequency components from among the frequency components, inputting data pairs of a power spectrum and a designated respiratory status indication value corresponding to the specific frequency components to a respiratory status classifier, and training the respiratory status classifier according to output values from the classifier.

Abstract: The invention provides a photonic package system comprising at least two optical alignment pins integrated on a package substrate. A key feature of this invention is the addition of alignment structures within the package. When combined with the use of micro optics it enables a ‘fiber-less’ photonic package system that requires no physical connection between and optical fiber and the photonic package system.

Abstract: Provided are a CIS system and a method of processing the same using a low power multi-mode data path. In order to drive a circuit with low-power, the CMOS Image Sensor (CIS) system rearranges and transmits data in consideration of a color of pixel data and a most significant bit (MSB) and a least significant bit (LSB) of the pixel data using a low-power multi-mode data path. The CIS system can implement multi-modes including a low power mode and a high speed mode, reduce the number of data transitions by merging data of the same color in a always-on low-power mode and a photo-shooting low-power (PS-LP) mode to reduce power consumption and process data in a high speed using a pipeline in a photo-shooting high-speed (PS-HS) mode.

Abstract: Diagnostic assays and methods employ a dual-enzyme cascade system comprised of two enzymatic amplifiers and two molecular probes, by (a) incubating a target enzyme with a target enzyme substrate to liberate a thiol; (b) incubating the thiol with a disulfide inactivated amplification enzyme to activate the amplification enzyme in an interchange reaction of the thiol and the disulfide; and (c) incubating the activated amplification enzyme with an amplification enzyme substrate to generate an amplified signal.

Abstract: The method for detoxifying asbestos disclosed here includes: preparing an asbestos-containing substance that contains at least one type of asbestos; preparing an asbestos treatment agent that contains a mineral acid and N-methyl-2-pyrrolidone; and bringing the asbestos-containing substance into contact with the asbestos treatment agent so as to detoxify asbestos in the asbestos-containing substance. Due to this configuration, asbestos in the asbestos-containing substance can be favorably detoxified.

Abstract: The invention generally relates to collagen-binding agent compositions and methods of using the same. More specifically, the invention relates in part to new collagen-binding agent compositions and methods that may be used to treat damaged collagen within tissues or used to specifically target therapeutics to tissues containing undamaged or damaged collagen.

Abstract: According to various embodiments, a hierarchical health decision support system (HDSS) configured to receive data from one or more wearable medical sensors (WMSs) is disclosed. The system includes a clinical decision support system, which includes a diagnosis engine configured to generate diagnostic suggestions based on the data received from the WMSs. The HDSS is configured with a plurality of tiers to sequentially model general healthcare from daily health monitoring, initial clinical checkup, detailed clinical examination, and postdiagnostic treatment.

Abstract: [Problem] To enable three-dimensional measurement with good precision. [Solution] When three-dimensional measurement is to be performed with good precision using SLAM or the like, images of marks M1, M2, M3, M4 must be captured from various directions by a single-lens camera. In the present invention, directions of imaging by a camera are displayed as sectors C1, C2, C3, C4. For example, it is understood that whereas sectors C1 and C4 have a large central angle and imaging therein is performed from a wide range of directions, sectors C2 and C3 have a small central angle and imaging therein is performed from a narrow range of directions. A photographer seeing such a display can perform additional imaging, and images can therefore be obtained from a wide range of directions, and three-dimensional measurement can be performed with good precision.

Abstract: The present invention aims to provide a method for producing a trans-polyisoprenoid which can increase trans rubber production. The present invention is directed to a method for producing a trans-polyisoprenoid in vitro, which involves the use of a gene coding for a trans-prenyltransferase (tPT) family protein and further involves the use of rubber particles bound to a protein encoded by the gene, or a method for producing a trans-polyisoprenoid, which includes introducing into a plant a vector including a promoter having a promoter activity that drives laticifer-specific gene expression and a gene coding for a tPT family protein linked to the promoter to express a protein encoded by the gene specifically in laticifers.

Abstract: A system comprising a respirator, a biochip, and an atomizer for studying respiratory pathogens. The respirator of the system is configured to create breathe-mimicking air movement, the biochip comprises an airway lumen in fluid communication with the respirator, and the atomizer is in fluid communication with the airway lumen of the biochip, according to various embodiments. The atomizer may be configured to generate droplets of a respiratory pathogen (e.g., from liquid inoculum). In various embodiments, the breath-mimicking air movement comprises air volume as a function of time, wherein the respirator is configured to generate breathing cycles.

Abstract: The present invention encompasses methods of treating pancreatic cancer using therapeutically effective amounts of compounds represented by the structure of formula I.

Abstract: A method for manufacturing digital paper, includes: (a) forming, on a paper or plastic substrate, a thin film transistor (TFT) backplane with a size of 100 to 10,000 pixels; and (b) laminating the TFT backplane to electrophoretic ink (E-ink), an electrochromic display, or an organic light-emitting diode (OLED) through an roll-to-roll continuous process, wherein, in the step (a), the TFT backplane is formed using a printing process, wherein the printing process uses R2R gravure printing technique, wherein, in the step (a), a contact electrode for exchanging data with the outside is formed at the TFT backplane, wherein a lower layer of the contact electrode is formed by etching a silver, copper or aluminum thin film and an upper layer of the contact electrode is treated with graphite, wherein, in the step (b), an adhesive material used for the laminating is thermosetting or UV-curable epoxy resin or cyanate-based resin.

Abstract: The subject invention provides methods, assays, and products for detecting small-molecule targets in a complex sample in both clinical and field settings. The subject invention provides aptamer-based sensors and methods of use thereof. The subject invention provides exonuclease-based methods for generating structure-switching aptamers from fully folded or pre-folded aptamers and developing aptamer-based sensors for small-molecule detection. The method for detecting one or more small-molecule targets in a sample comprises contacting the sample with one or more aptamer-based sensor selective for each of the small-molecule targets, and detecting the small-molecule target in the sample.