Abstract: A tetravalent platinum compound-bicyclic double-bond-containing amphiphilic polymer prodrug, which has the structure as shown in formula (I): when m=1, represents when m=0, represents R represents —CH3 or —CH2CH3; L1 and L2 independently represent Cl, N3, NO3, and n is from 10 to 80. A preparation method of the prodrug is also disclosed. The method includes a step of reacting an axially dihydroxy-coordinated tetravalent platinum compound with a bicyclic double-bond-containing orthoester precursor. In addition, a nano-micelle formed by the prodrug and an application thereof are further disclosed. The amphiphilic polymer prodrug and the micelle formed therefrom have pH hypersensitivity and reduction dual responsiveness.

Abstract: A regenerated block concrete prefabricated laminated slab includes a new concrete, waste concrete blocks, and a steel bar mesh on a bottom of the slab. The waste concrete blocks can protrude out from a surface part of the new concrete, but a protruding height is no more than 25 mm, and the protruding height is limited by an assembling die. The assembling die comprises a casting die and a height-limiting cover plate, a side die of the casting die is reserved with a steel bar positioning hole, and a vertical position of the height-limiting cover plate is positioned at four corners of the casting die through screws, limiting nuts and gaskets of different thicknesses. A manufacturing process of the regenerated block concrete prefabricated laminated slab is also provided.

Abstract: Disclosed are a device for preparing stem cell spheroids, a method for preparing stem cell spheroids and a method for preserving stem cells which relate to the technical field of preservation and transportation of stem cells. The device for preparing stem cell spheroids disclosed herein includes a substrate. The substrate is provided thereon with culture chambers, each of which has side walls and a bottom wall made of a material incompatible with stem cells. By culturing stem cells with this device, the stem cells may be made into spheroids and thus form stem cell spheroids. The device may be used as a means of preserving or transporting stem cells which makes it possible for stem cells to still have a higher viability and pluripotency even after a long time of preservation, storage and transportation under ambient temperature condition in the form of spheroids.

Abstract: The disclosure relates to a method for forming aryl carbon-nitrogen bonds and to photoreactors useful in these and other light-driven reactions. The method comprises contacting an aryl halide with an amine in the presence of a Ni salt catalyst solution and an optional base, thereby forming a reaction mixture; exposing the reaction mixture to light under reaction condition sufficient to produce the aryl carbon-nitrogen bonds. In certain embodiments, the amine may be present in a molar excess to the aryl halide. In certain embodiments, the Ni salt catalyst solution includes a Ni(II) salt and a polar solvent, wherein the Ni(II) salt is dissolved in the polar solvent. In certain embodiments, the reactions conditions include holding the reaction mixture at between about room temperature and about 80° C. for between about 1 hour and about 20 hours such that at least about 50% yield is obtained.

Abstract: A complex has a structure of formula (1A): SnXn·(m)L, wherein X is at least one type of halogen atoms, L is a polar solvent molecule, n is a value from 1.5 to 2.5, and m is a value from 0.3 to 1.9. A perovskite compound has a structure of formula (2A): RSnXj, wherein Sn has an oxidation number from 1.5 to 2.5, R is at least one type of a monovalent cation, X is at least one type of halogen atoms, and j is a value from 2.5 to 3.5, and the perovskite compound is free of tin oxide; or a perovskite compound has a structure of formula (2B): R2M2BiX1, wherein R is at least one type of a monovalent cation, X is at least one type of halogen atoms; M2 is a monovalent metal, and i is a value from 5.0 to 7.0.

Abstract: A method of using protein kinase A (PKA) activator and inhibitor in preparations of drugs for treating diseases associated with changes in platelet counts. Protein kinase A regulates platelet apoptosis by means of regulating the phosphorylation of serine at BAD position 155; the activation of protein kinase A activity may inhibit the occurrence of endogenous platelet apoptosis, and may also increase circulating platelet counts in experimental animals; in addition, inhibiting PKA activity may induce platelet apoptosis in vitro, while also reducing circulating platelet counts in the body, indicating that PKA inhibitors may participate in the treatment of thrombocytosis, and reduce platelet counts in peripheral circulating blood.

Abstract: A method for detecting clogging of a subsurface flow constructed wetland, including the steps of firstly emptying water in the subsurface flow constructed wetland, and then measuring the apparent resistivity of the subsurface flow constructed wetland bed after the water is emptied, wherein the water holding capacity of clogging sediments in the clogged region after emptying is strong, the apparent resistivity of this region is further measured to be lower than an unclogged region and the clogged region can thus be positioned and analyzed, the apparent resistivity of the region clogged more seriously is lower and the degree of clogging can thus be quantitatively analyzed.

Abstract: Methods measuring properdin function and uses thereof are described.

Abstract: The present invention provides a preparation method for a nitrogen-doped carbon-loaded metal monatomic catalyst, including: mixing a soluble metallic salt, a hydroxylamine hydrochloride, a soluble carbon source, water, and ethanol, to obtain a mixed solution, then performing drying and precipitation, to obtain a catalyst precursor, and finally performing calcination, to obtain a nitrogen-doped carbon-loaded metal monatomic catalyst. In the present invention, the metallic salt, the hydroxylamine hydrochloride, and the carbon source are fully mixed in the solution, and after being dried, are calcined, to carbonize the carbon source, so that ammonium ions are decomposed into nitrogen-doped carbon, and meanwhile, metal atoms are loaded onto the nitrogen-doped carbon. The method is simple, and costs are low.

Abstract: Systems and methods comprising an augmented reality display device to display a virtual anatomic display registered with a physical anatomic model. In certain embodiments, the virtual anatomic display can be registered with the physical anatomic model by user-selected registration points on the physical model.

Abstract: This disclosure relates to variant AAVrh.10 particles engineered to escape host neutralizing antibodies but retain or improve transduction efficiency, and their use as gene delivery vehicles.

Abstract: A three-dimensional finger vein recognition method and system, comprising the following steps: three cameras taking finger vein images from three angles to obtain three images; constructing a three-dimensional finger model according to finger contour lines; mapping two-dimensional image textures photographed by the three cameras into the three-dimensional finger model, respectively performing different processes on an overlapping region and a non-overlapping region; obtaining a three-dimensional finger vein image; and finally, performing feature extraction and matching on the three-dimensional finger vein image, to complete recognition. The method can acquire a better finger vein recognition effect, and has a higher robustness for a plurality of postures, such as finger rotation and inclination.

Abstract: An automatic straightening device includes a fully-mechanized coal mining working face, which includes a plurality of middle troughs, and each middle trough is connected to a push-pull rod of one hydraulic support. The fully-mechanized coal mining working face is provided with the automatic straightening device. The automatic straightening device includes a flexible element rope, the tensile and compressive force sensors, and a signal processing device. Each middle trough is provided with two tensile and compressive force sensors; one end of the flexible element rope is connected to a rope extend-retract control device, and the other end of the flexible element rope sequentially passes through lifting rings to be connected to the tensile and compressive force sensors and is fixed to a positioning force bearing bolt on the outermost side.

Abstract: The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.

Abstract: A compound, or a protonate or salt thereof, of formula I: wherein Y is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; n is 1 or 2; each R10 is independently alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, aryl, substituted aryl, cyano, hydroxyl, carbonylamino, aminocarbonyl, acyl, sulfonyl, or substituted sulfonyl; a is 0 to 4; is an aryl or heteroaryl ring; and each R is independently halogen, carbonylamino, sulfonamide, carboxylic acid or hydrogen, provided at least one R is a halogen; and provided that if Y is are not respectively.

Abstract: Disclosed herein are cyclodextrin molecules covalently modified to store and release nitric oxide, as well as methods of making and uses thereof. The covalently modified cyclodextrin molecules may be tailored, in several embodiments, to release nitric oxide in a controlled manner and are useful for reduction and/or eradication of bacteria and for the treatment of disease.

Abstract: An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived MSCs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysin and/or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis.

Abstract: The present invention discloses a method for rendezvous of unlicensed users having multiple transceivers in cognitive radio networks, including four stages: an initial stage: setting an initial communication environment; a stage of selecting a rendezvous method: selecting a method for generating a channel hopping sequence according to the quantity of transceivers; a stage of generating a channel hopping sequence: using a single-transceiver rendezvous method or a multiple-transceiver rendezvous method to generate a channel hopping sequence; and a rendezvous stage: running, by an unlicensed user, on a corresponding channel and attempting to rendezvous with a destination node of the unlicensed user, where if rendezvous is achieved, the rendezvous process ends; and if rendezvous is not achieved, the rendezvous process continues until rendezvous is achieved.

Abstract: A character string classification method, a character string classification system, a character string classification device, and a computer readable storage medium are provided. The method includes: acquiring a to-be-classified character string, inputting the to-be-classified character string to a feature extractor to obtain a feature vector of the to-be-classified character string, and inputting the feature vector to a classifier to obtain a classification result of the to-be-classified character string. With the character string classification method, only the features of the character string itself are used in the character string classification process. That is, the to-be-classified character string is directly inputted to the feature extractor to obtain the feature vector, and the classifier classifies the to-be-classified character string based on the feature vector, thereby eliminating requirement for other information associated with the character string.

Abstract: The present disclosure relates to a method, system and computer device for converting neural network information. The method comprises receiving neuron input information input by a preceding neuron, comprising receiving artificial neuron input information input by a preceding artificial neuron or receiving spiking neuron input information input by a preceding spiking neuron; converting the artificial neuron input information into spiking neuron conversion information through a preset artificial information conversion algorithm according to the artificial neuron input information input by the preceding artificial neuron; or converting the spiking neuron input information into artificial neuron conversion information through a preset spiking information conversion algorithm according to the spiking neuron input information input by the preceding spiking neuron; and outputting the spiking neuron conversion information or the artificial neuron conversion information.