Abstract: A laser device 1 demultiplexes seed light L0 into a plurality of beams of laser light L1 and then continuously optically amplifies the plurality of beams of the laser light L1 with an amplifier 14. Therefore, its amplification factor can be set higher than that in the case of amplifying pulsed laser light. When producing multiplexed light L3 by multiplexing the beams of the amplified laser light L1 with a diffraction grating 16, respective phases of the beams of the laser light L1 are controlled such that an output peak of the multiplexed light L3 repeatedly appears at a converging position P1 at a predetermined time interval. This produces pulsed laser light at the converging position P1 from a plurality of beams of laser light L2 amplified at a high amplification factor. Hence, this laser device 1 can produce pulsed laser light with a high output.

Abstract: One aspect of the present invention relates to novel compounds that can be used to prepare radiolabeled compounds in an effective manner. A second aspect of the present invention relates to a method of synthesizing radiolabeled compounds.

Abstract: The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic stabilizing agent non-covalently associated with a spacer compound that includes at least one electrophile that selectively reacts with any nucleophilic on a targeting agent and places the targeting agent on the exterior surface of a biodegradable nanoshell, wherein an active agent is loaded with the nanoshell.

Abstract: Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins, confound and degrade output from all fluorescent tags. An “optical window,” farther red than most autofluorescence sources and in a region of low hemoglobin and water absorbance, lies between 650 and 900 nm. This valley of relative optical clarity is an attractive target for fluorescence-based studies within tissues, intact organs, and living organisms. Novel fluorescent tags were developed herein, based upon a genetically targeted fluorogen activating protein and cognate fluorogenic dye that yields emission with a peak at 733 nm exclusively when complexed as a “fluoromodule”. This tool improves substantially over previously described far-red/NIR fluorescent proteins in terms of brightness, wavelength, and flexibility by leveraging the flexibility of synthetic chemistry to produce novel chromophores.

Abstract: Embodiments include an alkane oxidation catalyst having a support modified with a carboxylate group. The carboxylate group is functionalized with a manganese complex selected from the group consisting of [(C6H12N3R3)Mn(OCH3)3]Z, [(C6H12N3R3)Mn2O3]Z2, [(C6H15N3)Mn4O6]Z4. Each R is independently an alkyl group having 1 to 3 carbons, and each Z is independently PF6?, ClO4?, or Br?.

Abstract: The present invention relates to detectors for detecting fluorine-containing compounds and/or cyanide containing compounds, including hydrogen fluoride (HF) or HCN gas, hydrofluoric acid in solution, selected chemical warfare agents, selected industrial chemicals which may be hydrolyzed to release HF or HCN gas, compounds containing a cyanide group, and compounds that can release HF or HCN. The detectors comprise i) an organometallic component containing at least one bis-substituted boryl group of the formula —B(RB)(RB?) wherein each RB and each RB? is independently selected from H, halogen, C1-6 alkyl, OR6, N(R6)(R7), SR6, C3-20 aryl or heteroaryl, and C3-20 cycloalkyl or heterocycloalkyl groups, each of which may be optionally substituted, ii) a Lewis base component, and iii) a solid matrix component.

Abstract: A nanofiber-reinforced composition suited to applying to a wound site in a human body includes a carrier liquid and nanofibers dispersed therein in the carrier liquid. The viscosity of the composition is such that it is able to be applied through a tube yet adhere proximate the wound site to provide a barrier layer which assists in healing of the wound by spacing it from neighboring organs.

Abstract: Methods for enhancing or stimulating hematopoiesis including the step of administering Interleukin-12 (IL-12) to yield hematopoietic recovery in a mammal in need. Preferred methods include the step of administering IL-12 as an adjuvant therapy to alleviate the hematopoietic toxicities associated with one or more treatment regimens used to combat a disease state. Other methods include administering IL-12 to ameliorate various hematopoietic deficiencies. Still other methods are directed to uses of IL-12 for in-vivo proliferation of hematopoietic repopulating cells, hematopoietic progenitor cells and hematopoietic stem cells. Other disclosed methods are directed to uses of IL-12 for bone marrow preservation or recovery.

Abstract: The present invention relates facile method to synthesize magnetic PNCs with highly dispersed and narrow size distributed NPs. The PNCs have highly thermal stability and unique electrical and dielectric properties.

Abstract: Generally, the subject matter disclosed herein relates to the fabrication of an RRAM cell using CMOS compatible processes. A resistance random access memory device is disclosed which includes a semiconducting substrate, a top electrode, at least one metal silicide bottom electrode formed at least partially in the substrate, wherein at least a portion of the at least one bottom electrode is positioned below the top electrode, and at least one insulating layer positioned between the top electrode and at least a portion of the at least one bottom electrode.

Abstract: Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant heteromultimeric neutralizing binding protein including two or multiple binding regions, such that the binding regions are not identical, and each binding region specifically binds a non-overlapping portion of the disease agent, thereby treating the subject for exposure to the disease agent. In a related embodiment, the heteromultimeric neutralizing binding protein includes two or multiple binding regions that neutralize a plurality of disease agents. In certain embodiments, the disease agent includes a bacterium, a bacterial protein, a virus, a viral protein, a cancer cell, and a protein or molecule produced therefrom. In certain embodiments, the disease agent is a plurality of different disease agents.

Abstract: This invention is directed to a stirring apparatus comprising: a plurality of blades having between a 5° to 180° twist along the length of their axis attached perpendicularly to a shaft so that a downward fluid flow is created when the shaft is rotated by a rotary drive; and, a plurality of standards attached to the plurality of blades separating the plurality of blades and arranged parallel to the shaft and rotated between 0° and 25° relative to a plane defined by the blades and the standards so that an inward fluid flow is created when the shaft is rotated and a bottom blade connected to the standards.

Abstract: A surgical system for small-pit closure in hollow organs is provided. The surgical system is provided with a surgical device for small-pit closure in hollow organs, with the surgical device including the following components: a suture-member cartridge in which a pair of parallel tubular members that accommodate respective suture members are feedably connected to the rear ends of a pair of arrow-shaped members that latch into tissue in a hollow organ; an auxiliary shooting unit having plungers respectively provided in a pair of cylinders open at both ends; a hollow-organ-insertable unit configured of a pair of flexible air tubes; and a gas shooter that sequentially discharges compressed air or high-pressure gas into the open-ended cylinders in response to operations of a trigger, for sequentially ejecting the arrow-shaped members and driving the same into tissue in the hollow organ on both sides of a small pit site.

Abstract: The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and disorders mediated by GPCRs and/or RSKs.

Abstract: A power plant includes a boiler, a stream turbine generator, a post combustion processing system, a feed water regeneration processing system and a heat exchanger. Heat from the heat exchanger is used to regenerate (a) a reagent that absorbs carbon dioxide from flue gas and (b) a water-lean desiccant used to increase plant operating efficiency.

Abstract: Provided are methods and devices for measuring real-time pressures on the perineum of a user positioned on a surface. In an embodiment the surface is a bicycle seat and the real-time measurement is a pressure map of the pressure distribution during a bicycle ride. The methods relate to connecting a pressure sensor to the perineum region of the user, positioning the user on the surface, wherein the pressure sensor is positioned between the perineum and the surface, and obtaining output from the pressure sensor while the user is positioned on the surface, such as during a bicycle ride. The devices relate to a plurality of pressure sensors capable of being connected to the perineum region and a microcontroller containing a drive circuit and chip for analog-to-digital conversion and storage. One use of the methods and devices are to assess risk of erectile dysfunction for bicycle riders.

Abstract: The present invention relates to the treatment of EGFR-mediated disease, particularly cancer by inhibiting or blocking EGFR and src in combination or simultaneously. The invention relates to treatment, prevention, or modulation of cancer, particularly EGFR-mediated disease, with one or more EGFR modulator and src inhibitor in combination. The invention further relates to the treatment of cancer with anti-EGFR antibodies and src inhibitors. Methods and compositions for treatment of cancer with the antibody anti-EGFR mAb806 in combination or series with a src inhibitor or src inhibitors are described.

Abstract: An intensity image is collected at each of a plurality of locations spaced apart in a propagation direction of a light beam. Information from the intensity images is combined using a Kalman filter which assumes that at least one co-variance matrix has a diagonal form. This leads to considerable reduction in computational complexity. An augmented Kalman filter model (augmented space state model) is used in place of the standard Kalman filter model. The augmented Kalman filter improves the robustness to noise.

Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.

Abstract: Of two pairs of biaxial goniometers and a uniaxial straight-ahead stage, one pair of biaxial goniometers and the uniaxial straight-ahead stage are subjected to fully-closed feedback control (follow-up control) under which output from a QPD is directly input into an axis drive motor, and the remaining pair of biaxial goniometers are subjected to semi-closed feedback control (constant-value control), encoder outputs on all the axes and QPD output are acquired simultaneously, measurement point coordinates and normal vectors derived from the encoder outputs are corrected with the QPD output, thereby eliminating influence of steady-state deviation in a goniometer control system.