Patents Examined by M. C.
  • Patent number: 4454292
    Abstract: Disclosed herein are 2,3-dihydro-1H-indole-2-carboxylic acids substitued on the nitrogen with 3-mercapto-2-alkyl-1-oxoalkyl, 3-phosphoryl-2-alkyl-1-oxopropyl, or 2-amino-2-alkyl-1-oxoalkyl derivatives which act as inhibitors of angiotensin converting enzyme and as antihypertensive agents. The compounds of the invention (excluding disclosed intermediates) have the general formula: ##STR1## wherein: n is 1 or 0;R.sub.1 is hydrogen, lower alkyl, aryl or aralkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is hydrogen, lower alkyl or aroyl;R.sub.5 is hydroxy, amino, or lower alkoxy;X is hydrogen, hydroxy, lower alkyl, lower alkoxy, or halogen; Y is hydrogen, lower alkyl, or aryl;Y is hydrogen, lower alkyl, or aryl;R.sub.4 is ##STR2## wherein: L is O, NR.sub.7 or S (where R.sub.7 is hydrogen or lower alkyl);M is R.sub.8, OR.sub.8, SR.sub.8, or NR.sub.9 R.sub.10 (where R.sub.8 is hydrogen, lower alkyl, aryl, or aralkyl; and R.sub.9 and R.sub.10 are, independently, hydrogen, lower alkyl, or aryl);A is O, NR.sub.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: June 12, 1984
    Assignee: American Home Products Corporation
    Inventors: Dong H. Kim, Ronald J. McCaully
  • Patent number: 4449005
    Abstract: Aliphatic and cycloaliphatic halogen compounds containing a halogen atom and a hydrogen atom attached to adjacent carbon atoms are dehydrohalogenated to the corresponding unsaturated compounds by contact with a quaternary ammonium fluoride or quaternary phosphonium fluoride.
    Type: Grant
    Filed: August 6, 1982
    Date of Patent: May 15, 1984
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: William R. Hydro, George T. Davis, deceased
  • Patent number: 4448727
    Abstract: Thermally stable, color-stabilized halobisphenolethylene polycarbonates comprising halobisphenolethylene polycarbonates containing an effective amount of a stabilizing organophosphite are described. The stabilized halobisphenolethylene polycarbonates can be molded or formed into films, sheets, fibers, laminates or other molded articles including reinforced articles by conventional molding techniques.
    Type: Grant
    Filed: September 2, 1981
    Date of Patent: May 15, 1984
    Assignee: General Electric Company
    Inventors: Arnold Factor, Keith N. Sannes
  • Patent number: 4449006
    Abstract: A process is provided for the manufacture of methyl mercaptan with substantial reduction of by-product methane by intimate mixture of carbon oxide, sulfur or hydrogen sulfide and hydrogen at elevated temperature and pressure with a single-phase, solid catalyst system comprising a porous alumina-containing support upon which is deposited a mixture of manganese sulfide and alkali metal sulfide.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: May 15, 1984
    Assignee: Pennwalt Corporation
    Inventor: Paul G. Haines
  • Patent number: 4439229
    Abstract: Compounds of the formula: ##STR1## wherein A is O or S, halo is chloro, bromo or fluoro; X' is --CH.sub.2 --, O or S; X is hydrogen or halo; R.sup.1 and R.sup.2 are the same or different radicals selected from hydrogen or lower alkyl; and Z can be a variety of substituents and agronomically acceptable salts, esters and amides as well as other heterocyclic benzenes are disclosed as selective herbicides.
    Type: Grant
    Filed: May 6, 1982
    Date of Patent: March 27, 1984
    Assignee: Rohm and Haas Company
    Inventor: Colin Swithenbank
  • Patent number: 4439228
    Abstract: Oxime derivatives of the formula (I) ##STR1## wherein n is 0, 1 or 2 and m is 0 or 1, and Ar is a phenyl radical ##STR2## a naphthyl radical substituted by R.sub.2 and R.sub.3, a 5- to 10-membered heterocyclic radical which contains not more than 3 identical or different heteroatoms N, O and/or S and which is substituted by R.sub.2, R.sub.3 and R.sub.4 and can be substituted by oxo or thiono, or if m is O, Ar is a radical R--CO, wherein R is a radical --OR.sub.5, in which R.sub.5 is an aliphatic group containing not more than 8 carbon atoms or is an araliphatic group containing not more than 15 carbon atoms or is a cycloaliphatic or aromatic group, each containing not more than 10 carbon atoms, while the possible substituents of the aromatic radicals or of the cycloaliphatic radical are halogen, --CN, --NO.sub.2, lower alkyl, lower alkoxy, haloalkyl; or R is a radical --NH--CO--NH--R.sub.7 or a radical --N(R.sub.6)(R.sub.7), wherein R.sub.6 is hydrogen or lower alkyl and R.sub.
    Type: Grant
    Filed: July 14, 1982
    Date of Patent: March 27, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Fory, Henry Martin, Georg Pissiotas
  • Patent number: 4439230
    Abstract: Oxime derivatives of the following formula are described: ##STR1## wherein R.sub.1 is hydrogen or halogen, and R.sub.8 is phthalimido, 4, 5, 6, 7-tetrahydrophthalimido or 3a, 4, 7, 7a-tetrahydrophthalimido attached at the nitrogen atom to the remainder of the molecule. These compounds are used for protecting plant crops from the action of aggressive agricultural chemicals.
    Type: Grant
    Filed: July 14, 1982
    Date of Patent: March 27, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Fory, Henry Martin, Georg Pissiotas
  • Patent number: 4438282
    Abstract: Sulfides prepared by reacting a sulfoxide with a hydrazine or hydroxylamine derivative or a quaternary salt thereof are useful starting materials for the preparation of drugs, pesticides and dyes.
    Type: Grant
    Filed: June 23, 1982
    Date of Patent: March 20, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Hartmut Lardon, Guenther Seybold
  • Patent number: 4437879
    Abstract: Oxime derivatives of the formula (I) ##STR1## wherein n is 0, 1 or 2 and m is 0 or 1, andAr is a phenyl radical ##STR2## a naphthyl radical substituted by R.sub.2 and R.sub.3, a 5- to 10-membered heterocyclic radical which contains not more than 3 identical or different heteroatoms N, O and/or S and which is substituted by R.sub.2, R.sub.3 and R.sub.4 and can be substituted by oxo or thiono, or if m is O, Ar is a radical R--CO, wherein R is a radical --OR.sub.5, in which R.sub.5 is an aliphatic group containing not more than 8 carbon atoms or is an araliphatic group containing not more than 15 carbon atoms or is a cycloaliphatic or aromatic group, each containing not more than 10 carbon atoms, while the possible substituents of the aromatic radicals or of the cycloaliphatic radical are halogen, --CN, --NO.sub.2, lower alkyl, lower alkoxy, haloalkyl; or R is a radical --NH--CO--NH--R.sub.7 or a radical --N(R.sub.6)(R.sub.7), wherein R.sub.6 is hydrogen or lower alkyl and R.sub.
    Type: Grant
    Filed: July 14, 1982
    Date of Patent: March 20, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Fory, Henry Martin, Georg Pissiotas
  • Patent number: 4436668
    Abstract: Carbonates are prepared by reacting carbamic acid esters with alcohols at above 140.degree. C., the ammonia formed being stripped from the reaction mixture during the reaction by passing an inert gas or vapor therethrough.The carbonates obtainable by the process of the invention are valuable starting materials for the preparation of dyes, crop protection agents and plastics.
    Type: Grant
    Filed: May 28, 1981
    Date of Patent: March 13, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Harder, Franz Merger, Friedrich Towae
  • Patent number: 4433171
    Abstract: Sulphones useful for preparing polyenes have the formula: ##STR1## where the sulphonyl group replaces a hydrogen atom on carbon atom (a) or (b), R represents alkyl, aralkyl or aryl, optionally substituted, A and Q represent an optionally substituted hydrocarbon of 5n+1 carbon atoms (n is 1-5), methyl, optionally substituted by halogen, sulphide or sulphone, CH.sub.2 OH (or an ether or ester thereof), CHO (optionally protected), COOH (or an acid chloride, ester or nitrile thereof), with the proviso that when A represents a 2-(2,6,6-trimethylcyclohex-1-enyl) ethenyl radical, Q cannot represent --COOH or an ester thereof.
    Type: Grant
    Filed: February 4, 1982
    Date of Patent: February 21, 1984
    Assignee: Rhone-Poulenc S.A.
    Inventors: Pierre Chabardes, Marc Julia, Albert Menet
  • Patent number: 4431820
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.Claimed compounds include those of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined hereinafter.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: February 14, 1984
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Patent number: 4429162
    Abstract: The instant invention relates to compounds of the formula ##STR1## wherein each R.sub.f is independently straight or branched chain perfluoroalkyl of 2 to 18 carbon atoms or perfluoroalkoxy-perfluoroalkyl of 4 to 18 carbon atoms;each R.sub.1 is independently straight or branched chain alkylene of 1 to 12 carbon atoms, alkylenethioalkylene of 2 to 12 carbon atoms, alkyleneoxyalkylene of 2 to 12 carbon atoms, or alkyleneiminoalkylene of 2 to 12 carbon atoms where the imino nitrogen atom contains as a third substituent, hydrogen or alkyl of 1 to 6 carbon atoms;R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen, chloro, bromo, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, hydroxyalkyl of 1 to 6 carbon atoms or alkoxy of 1 to 6 carbon atoms, and R.sub.2 and R.sub.3 additionally may, together with the carbon atoms to which they are attached, form a fused benzo ring;R.sub.
    Type: Grant
    Filed: February 1, 1982
    Date of Patent: January 31, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Thomas W. Cooke, Robert A. Falk
  • Patent number: 4427441
    Abstract: This invention discloses novel herbicidal chemical compounds of the formula ##STR1## wherein X is halogen or trifluoromethyl; Y is selected from the group consisting of hydrogen, halogen, nitro and cyano; R is selected from the group consisting of nitro, alkylthio, halogen and cyano; Z is selected from the group consisting of alkyl, halogen and nitro; and n is an integer from 0 to 4.
    Type: Grant
    Filed: August 23, 1982
    Date of Patent: January 24, 1984
    Assignee: Velsicol Chemical Corporation
    Inventors: Frank Wu, Leonard J. Stach
  • Patent number: 4423228
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Patent number: 4423230
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.Included is a process for the preparation of an intermediate compound of the formula ##STR1## wherein R.sub.2, R.sub.3 and R.sub.4 are as defined hereinafter.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Patent number: 4423232
    Abstract: Tricyclic isoindole derivatives characterized by having a 1,2,3,4,6,10b-hexahydropyrazino]2,1-a]isoindole or 1,3,4,10b-tetrahydropyrimido[6,1-a]isoindol-6(2H)-one nucleus are disclosed. The foregoing compounds are useful antihypertensive agents.Claimed compounds include those of the formula ##STR1## in which R.sup.3 and R.sup.4 each is hydrogen, lower alkoxy, lower alkyl, trifluoromethyl, halo or hydroxy, or R.sup.3 and R.sup.4 together form an OCH.sub.2 O chain; and R.sup.14 and R.sup.15 each is hydrogen or lower alkyl.
    Type: Grant
    Filed: February 19, 1981
    Date of Patent: December 27, 1983
    Assignee: American Home Products Corporation
    Inventors: Christopher A. Demerson, Leslie G. Humber, Jean-Marie Ferland
  • Patent number: 4420327
    Abstract: .DELTA.'-Tetrahydrophthalimides having a substituted oxy group at 3-position and a halogen atom at 4-position if necessary, a halogen atom at 2-position of phenyl group as N-substituent have excellent herbicidal activity and are useful as selective herbicides.
    Type: Grant
    Filed: October 5, 1981
    Date of Patent: December 13, 1983
    Assignee: Mitsubishi Chemical Industries Ltd.
    Inventors: Tetsuo Jikihara, Masatsugu Oda, Kazuyuki Ushinohama, Hisao Watanabe, Seiichi Suzuki
  • Patent number: 4420488
    Abstract: Quaternary 1,1-diphenyl-4-pyrrolidinium-2-butyne salts corresponding to the following general formula ##STR1## in which R represents methyl or ethyl and X is a chlorine or bromine atom, are described. These compounds are distinguished by improved spasmolytic and broncholytic activity.
    Type: Grant
    Filed: March 13, 1981
    Date of Patent: December 13, 1983
    Assignee: Ludwig Heumann & Co. GmbH
    Inventors: Walter Liebenow, Hans Liedtke
  • Patent number: 4419519
    Abstract: A process for the continuous preparation of phthalimide by reacting phthalic anhydride with ammonia in about the stoichiometric ratio, in a mixing apparatus and subsequently in a reaction tube at a particular flow velocity and a particular temperature.The phthalimide obtainable by the process of the invention is a valuable starting material for the preparation of dyes, pesticides and pigments, especially copper phthalocyanines.
    Type: Grant
    Filed: June 29, 1981
    Date of Patent: December 6, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerhard Kilpper, Johannes Grimmer