Abstract: An in vivo assay to evaluate topical delivery of a biologic agent from a formulation is provided. The assay comprises treating a skin area of a CD hairless rat with tape stripping to disrupt the stratum corneum in the skin area to define a treated skin area and topically applying a formulation to the treated skin area. The formulation, in one embodiment, comprises the biologic agent and a pharmaceutically acceptable carrier. Delivery of the biologic agent into the skin from the topically applied formulation is evaluated via in vitro or in vivo techniques.

Abstract: The present disclosure discloses a cutting structure and a sewing process for back wearing protective clothing. An eye gap is formed in the top of a cap cutting piece. An upper neck interface is formed in the bottom of the cap cutting piece. Cap top seams which are in left-right symmetry are formed in the two sides of the eye gap. Cap openings are formed in the two sides of the lower part of the cap cutting piece. An upper right sleeve seam is formed in the upper end of one side of an upper section cutting piece. A lower right sleeve seam is formed in the lower end of one side of the upper section cutting piece. An upper left sleeve seam is formed in the upper end of the other side of the upper section cutting piece. A lower left sleeve seam is formed in the lower end of the other side of the upper section cutting piece.

Abstract: Systems and methods for providing improved recommendations are disclosed. In some embodiments, the systems and methods may be used for vehicle recommendations. The system may include a server system configured to receive user historical vehicle preferences, user vehicle preferences, generate weighted feature data sets, and apply a similarity model to the generated weighted feature data set in order to determine a vehicle recommendation data set. A visual representation of the vehicle recommendation data set may then be provided to an interface associated with a user.

Abstract: Methods and formulations for promoting the healing of fracture nonunion sites under inflammatory conditions. The formulation includes a flexible biodegradable scaffold loaded with therapeutically effective amounts of CXCL12 and SPPI encapsulated in biodegradable microspheres. The method includes applying the formulation directly to a region of a fracture nonunion to effect sustained local release of the therapeutically effective amounts of CXCL12 and SPPI to the fracture nonunion region.

Abstract: In a method of manufacturing a semiconductor device, a fin structure having a bottom part and an upper part on the bottom part is formed over a substrate. The bottom part is trimmed so that a width of an uppermost portion of the bottom part is smaller than a width of the upper part. Bottom end corners of the upper part are trimmed to reduce a width of the upper part at a bottom of the upper part. An isolation insulating layer is formed so that the upper part protrudes from the isolation insulating layer. A dummy gate structure is formed. A source/drain structure is formed. An interlayer dielectric layer is formed over the dummy gate structure and the source/drain structure. The dummy gate structure is replaced with a metal gate structure.

Abstract: A method of forming a semiconductor device includes following steps. A semiconductor strip is formed extending above a semiconductor substrate. A shallow trench isolation (STI) region is formed over the semiconductor substrate. The semiconductor strip has a fin structure higher than a top surface of the STI region. The fin structure includes a channel portion and a source/drain (S/D) portion adjacent to the channel portion. A dummy gate stack is formed over the channel portion. The S/D portion is exposed by the dummy gate stack. A doping process is performed to a top of the S/D portion using first dopants. An epitaxy layer is formed around the top of the S/D portion. The epitaxy layer has second dopants. A conductivity type of the second dopants is different from a conductivity type of the first dopants. The dummy gate stack is replaced with a replacement gate stack.

Abstract: A semiconductor device includes a substrate; a fin structure formed on a substrate; and a gate feature formed over the fin structure, the gate feature comprising a gate dielectric layer, wherein the gate dielectric layer traverses the fin structure to overlay a central portion of the fin structure and opposite side portions of the fin structure that are located in respective undercuts formed in respective portions of a dielectric layer located adjacent to opposite sidewalls of the gate feature, wherein the undercuts extend beyond respective sidewalls of the gate feature and away from the central portion of the fin structure.

Abstract: There is provided a method of selectively patterning a device structure. A hollow shadow wall is formed on a substrate. The hollow shadow wall is formed of a base lying on a surface of the substrate, and one or more side walls connected to the base. The one or more side walls extend away from the surface of the substrate and around the base to define an internal cavity of the hollow shadow wall. A device structure supported by the substrate adjacent to the shadow wall is selectively patterned by using a deposition beam to selectively deposit a layer of deposition material on the device structure. The deposition beam has a non-zero angle of incidence relative to a normal to the surface of the substrate and an orientation in the plane of the substrate's surface, such that the shadow wall prevents deposition on a surface portion of the device structure within a shadow region defined by the shadow wall.

Abstract: A system for targeted email marketing includes one or more processors, and a memory storing instructions. When executed by the one or more processors, the instructions cause the system to perform operations including: generating email templates respectively corresponding to different customer marketing communications; sending first emails to first customers, in which each of the first emails includes one of the email templates in accordance with an initial allocation; compiling response information from the first customers and updating a bandit model in accordance with the response information, the bandit model for determining an allocation of the email templates to customers; determining, by the bandit model, a revised allocation of the email templates to second emails; and sending the second emails to second customers in accordance with the revised allocation.

Abstract: In a method of manufacturing a semiconductor device including a Fin FET, a fin structure, which has an upper fin structure made of SiGe and a bottom fin structure made of a different material than the upper fin structure, is formed, a cover layer is formed over the fin structure, a thermal operation is performed on the fin structure covered by the cover layer, and a source/drain epitaxial layer is formed in a source/drain region of the upper fin structure. The thermal operation changes a germanium distribution in the upper fin structure.

Abstract: The present disclosure provides, among other things, methods for using presenilin based gene therapy to treat neurodegenerative dementia including, but not limited to Alzheimers disease, frontotemporal dementia, frontotemporal lobar degeneration, Picks disease, Lewy body dementia, memory loss, and cognitive impairment including mild cognitive impairment (MCI).

Abstract: Disclosed embodiments provide systems and methods related to updating creatives generation models. The system may include at least one memory unit for storing instructions and at least one processor configured to execute the instructions to perform operations.

Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.

Abstract: A computer-implemented method may include predicting a first marketing indicator using a first module of an aggregate model; comparing the predicted first marketing indicator with a measured first marketing indicator; and based on the comparison of the predicted first marketing indicator with the measured first marketing indicator, adjusting the first module of the aggregate model. Additionally, the method may include predicting a second marketing indicator using a second module of the aggregate model; comparing the predicted second marketing indicator with a measured second marketing indicator; and based on the comparison of the predicted second marketing indicator with the measured second marketing indicator, adjusting the second module of the aggregate model. Further, the method may include determining a bid value based on the aggregate model.

Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof. The 4H-pyrazolo[1,5-alpha]benzimidazole compound has the structure of Compound 2.

Abstract: A computer-implemented method may include predicting a first marketing indicator using a first module of an aggregate model; comparing the predicted first marketing indicator with a measured first marketing indicator; and based on the comparison of the predicted first marketing indicator with the measured first marketing indicator, adjusting the first module of the aggregate model. Additionally, the method may include predicting a second marketing indicator using a second module of the aggregate model; comparing the predicted second marketing indicator with a measured second marketing indicator; and based on the comparison of the predicted second marketing indicator with the measured second marketing indicator, adjusting the second module of the aggregate model. Further, the method may include determining a bid value based on the aggregate model.

Abstract: A system may include an aggregate model comprising a plurality of modules, a monitoring dashboard in communication with the aggregate model, and a search-marketing campaign manager in communication with the aggregate model, the monitoring dashboard, and a search engine entity. Additionally, the system may include a bidding interface in communication with the aggregate model and a search engine entity and/or a monitoring dashboard configured to generate model adjustment data. The search-marketing campaign manager may be configured to determine trend data, measured marketing indicators, or both, from one or more of marketing data or historical data.

Abstract: A method for protecting a circuit is provided, wherein the circuit comprises a plurality of switch devices connected in series. The method comprises detecting a failure risk indicator of each switch device; determining whether each switch device has a failure risk based on the corresponding failure risk indicator; and making each of the switch device(s) having the failure risk in a constant on-state to eliminate the failure risk and prevent a failure of the switch device optionally if a number of the switch device(s) which have or had the failure risk is less than or equal to a preset value.

Abstract: A modular substation (10) for subsea applications includes a plurality of modular DC/AC converters (32) configured for converting DC electrical power transmitted along a DC transmission link (24) into AC electrical power for supplying to a plurality of subsea loads (56). The plurality of modular DC/AC converters (32) is configured to couple in series to the DC transmission link (24) and couple in parallel to an AC distribution network (52). At least a first modular DC/AC converter (32) is configured to be selectively electrically and mechanically disconnected from the DC transmission link (24) and the AC distribution network (52) to facilitate maintenance of the first modular DC/AC converters (32) while the AC distribution network (52) continues to supply AC electrical power to at least one of the plurality of subsea loads (56). The modular substation (10) also comprises protection and bypass circuits (26) intended to isolate faulty DC/AC converters (32) and to facilitate safe maintenance and repair.

Abstract: A semiconductor device includes a substrate; a fin structure formed on a substrate; and a gate feature formed over the fin structure, the gate feature comprising a gate dielectric layer, wherein the gate dielectric layer traverses the fin structure to overlay a central portion of the fin structure and opposite side portions of the fin structure that are located in respective undercuts formed in respective portions of a dielectric layer located adjacent to opposite sidewalls of the gate feature, wherein the undercuts extend beyond respective sidewalls of the gate feature and away from the central portion of the fin structure.