Abstract: The present invention relates to a series of quinazolinone compounds and applications thereof as PI3K? inhibitors. In particular, the present invention relates to a compound shown in formula (I) and a tautomer or pharmaceutically acceptable salt thereof.

Abstract: A semiconductor device includes an active area having source and drain regions and a channel region between the source and drain regions, an isolation structure surrounding the active area, and a gate structure over the channel region of the active area and over the isolation structure, wherein the isolation structure has a first portion under the gate structure and a second portion free from coverage by the gate structure, and a top of the first portion of the isolation structure is lower than a top of the second portion of the isolation structure.

Abstract: The present invention relates to a process for preparing a coatings composition with an open time additive comprising the steps of a) contacting an aqueous dispersion of alkali swellable polymer particles with a rheology modifier and a binder to form a coatings composition with a VOC of less than 50 g/L; and b) neutralizing the alkali swellable particles with a non-volatile base after or upon contact with the rheology modifier and the binder to form swelled multi-staged polymer particles; wherein the alkali swellable polymer particles comprise a shell having a Tg of not greater than 25° C. and an acid functionalized core; and wherein the core-to-shell ratio is in the range of from 1:3.2 to 1:10. The composition arising from the process of the present invention is useful for improving open time, especially for low VOC coatings applications.

Abstract: Disclosed is a real-time object detection method deployed on a platform with limited computing resources, which belongs to the field of deep learning and image processing. In the present invention, YOLO-v3-tiny neural network is improved, Tinier-YOLO reserves the front five convolutional layers and pooling layers of YOLO-v3-tiny and makes prediction at two different scales. Fire modules in SqueezeNet, 1×1 bottleneck layers, and dense connection are introduced, so that the structure is used to achieve smaller, faster, and more lightweight network that can be run in real time on an embedded AI platform. The model size of Tinier-YOLO in the present invention is only 7.9 MB, which is only ¼ of 34.9 MB of YOLO-v3-tiny, and ? of YOLO-v2-tiny. The reduction in the model size of Tinier-YOLO does not affect real-time performance and accuracy of Tinier-YOLO. Real-time performance of Tinier-YOLO in the present invention is 21.8% higher than that of YOLO-v3-tiny and 70.8% higher than that of YOLO-v2-tiny.

Abstract: A manufacturing method of a semiconductor device includes the following steps. A first inter-metal dielectric (IMD) layer is formed on a substrate. A cap layer is formed on the first IMD layer. A connection structure is formed on the substrate and penetrates the cap layer and the first IMD layer. A magnetic tunnel junction (MTJ) stack is formed on the connection structure and the cap layer. A patterning process is performed to the MTJ stack for forming a MTJ structure on the connection structure and removing the cap layer. A second IMD layer is formed on the first IMD layer and surrounds the MTJ structure. The semiconductor device includes the substrate, the connection structure, the first IMD layer, the MTJ structure, and the second IMD layer. The dielectric constant of the first IMD layer is lower than the dielectric constant of the second IMD layer.

Abstract: An exemplary embodiment of the present invention provides an optical communication system. The optical communication system can comprise a self-powered sensor and an optical array. The self-powered sensor can be configured to receive a mechanical input and generate an electrical signal corresponding to the mechanical input. The optical array can be configured to receive the electrical signal and generate an optical output. The optical output can correspond to the mechanical input.

Abstract: A random copolymer, a preparation method of the random copolymer, a drilling fluid containing the random copolymer. The random copolymer contains structural unit (A) represented by formula (1), structural unit (B) represented by formula (2), structural unit (C) represented by formula (3), and structural unit (D) represented by formula (4) or (5): wherein X is halogen. When the random copolymer is used as a filter loss reducer in a high-calcium drilling fluid, the filter loss of the high-calcium drilling fluid can be reduced.

Abstract: Disclosed in the present invention is a type of indole substituted piperidine compounds as an estrogen receptor down-regulator. Specifically disclosed are a compound as shown in formula (I), a pharmaceutically acceptable salt, hydrate or prodrug thereof, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof as an estrogen receptor down-regulator in the treatment of estrogen receptor positive breast cancers.

Abstract: Disclosed is a cosmetic composition comprising: a) a particulate material comprising a shell and a core, where said shell comprises a water-insoluble material having refractive index (ns) of 1.2 to 2.0 at 25° C. and wavelength of 589 nm and core comprises a fluid having refractive index (n) of at least 1.0 at 25° C. and wavelength of 589 nm and where oil absorption capacity of said particulate material is at least 300 g/100 g measured by ASTM D281-95 by Spatula Rub-out using linseed oil; and, b) particulate silicone elastomer having average particle diameter of 0.1 to 100 ?m. wherein ratio of the amount of said particulate material to that of said particulate silicone elastomer is 1:3.5 to 3.5:1 parts by weight.

Abstract: A medical macromolecular microsphere adsorbent for a blood perfusion apparatus and a preparation method thereof are provided. The polystyrene-divinylbenzene microspheres are graded by different pore sizes and specific surface areas, medically purified, and grafted by a bioactivity-controlled grafting technology. In the microsphere adsorbent, the volume ratio of microspheres with pore sizes of 1-10 ?m, 10-100 ?m and 100 ?m is 1:(1-10):(1-20), the content of residual monomers in the microsphere has O.D190-400 nm?0.03. The microsphere adsorbent not only can adsorb harmful micromolecules in blood but also can effectively adsorb harmful medium-molecules and macromolecules in blood, thereby meeting clinical application demands.

Abstract: A display method and an electronic device are provided. The display method comprises: displaying a source panorama; based on a viewing angle during displaying the source panorama, determining an initial viewing angle of the destination panorama; and in response to switching from the source panorama to the destination panorama, displaying an image of the destination panorama at the initial viewing angle.

Abstract: A rehabilitation robot comprises an upper limb rehabilitation device comprising a shoulder width adjusting device for adjusting a shoulder width of the rehabilitation robot, a right arm device and a left arm device, the right arm device and the left arm device are disposed at two sides of the shoulder width adjusting device, respectively; and a lower limb rehabilitation device connected to the upper limb rehabilitation device.

Abstract: An ion pulse generator (100) includes a triboelectric generator (110), an ion emitter (132) and a conductive surface (134). The triboelectric generator (110) includes a first electrode (114), a spaced apart second electrode (120) and a first triboelectric layer (116). The triboelectric generator (110) generates a predetermined amount of charge as a result of relative movement of the first triboelectric layer (116). The ion emitter (132) is electrically coupled to the first electrode (114). The conductive surface (134) is electrically coupled to the second electrode (120) and is spaced apart from the ion emitter (132) at a predetermined distance. Generation of the predetermined amount of charge causes formation of ions between the ion emitter (132) and the conductive surface (134).

Abstract: A semiconductor device preferably includes a metal-oxide semiconductor (MOS) transistor disposed on a substrate, an interlayer dielectric (ILD) layer disposed on the MOS transistor, and a magnetic tunneling junction (MTJ) disposed on the ILD layer. Preferably, a top surface of the MTJ includes a reverse V-shape while the top surface of the MTJ is also electrically connected to a source/drain region of the MOS transistor.

Abstract: A backplane connector includes a shielded design that has wafers with signal terminals supported as edge-coupled terminal pairs for differential signaling. A ground shield is mounted on each wafer and provides a U-channel that partially shields each terminal pair. The wafers omit a ground terminal between adjacent terminal pairs. An insert can be provided to help connect the ground shield to a U-shield to provide U-shaped shielding structure substantially the entire way from a tail to a contact.

Abstract: The present invention discloses a method for improving the blood compatibility of a material surface by using a controllable grafting technique. The method involves placing a monomer NVP, an RAFT reagent and a solvent acetonitrile in a container, adding an initiator AIBN, mixing the same uniformly, removing oxygen with liquid nitrogen, making the same react in an oil bath; after polymerization, adding liquid nitrogen to quench and stop the reaction, thus obtaining PVP-COOH; mixing the PVP-COOH with DCC and NHS; adding dry dichloromethane to the mixture in a nitrogen atmosphere, adding mercaptoethylamine, and making the same react in darkness at room temperature; obtaining a crude sample; dissolving the crude sample in water, and performing dialysis with deoxygenated water in darkness, and then obtaining HS-PVP by freeze-drying. An Au—S bond chemisorption method is used to controllably graft an anti-protein high-molecular polymer onto an Au surface.

Abstract: Disclosed is a personal care composition comprising: a) a porous particle; b) a film forming polymer; and c) a cosmetically acceptable carrier which is a water and oil emulsion; wherein the porous particle has oil absorption value in the range of 50g/100g to 1500g/100g; wherein the porous particle is selected from porous silica, cellulose, acrylic polymer, nylon and ethylene/methacylate copolymer hollow sphere coated with porous silica; wherein the film forming polymer is selected from an acrylate polymer, a methacrylate polymer, a urethane polymer or co-polymers thereof; and wherein the composition comprises whitening pigment in an amount of from 0.001 to 2 wt %.

Abstract: An automatic dishwashing composition is provided including a builder selected from the group consisting of carbonate, bicarbonate, citrate, silicate and mixtures thereof; a nonionic surfactant; and a dispersant polymer comprising: (a) 5 to 75 wt % of structural units of itaconic acid; (b) 10 to 85 wt % of structural units having formula I wherein each R3 is independently selected from a hydrogen and a —C(O)CH3 group; and (c) 10 to 65 wt % of structural units of (meth)acrylic acid; wherein the dispersant polymer has a lactone end group and wherein the dispersant polymer has a weight average molecular weight of 1,500 to 6,000.

Abstract: The present disclosure relates to a welding quality detecting field, and specifically relates to a quality detection device. The quality detection device includes an integrated probe set, a driving module and a collecting module. The integrated probe set includes a plurality of integrated probe assemblies. The integrated probe assemblies are disposed in pairs and each integrated probe assembly includes a driving end and a collecting end. The driving end of one integrated probe assembly is matched with the driving end of another integrated probe assembly disposed in pairs with the one integrated probe assembly. The collecting end of one integrated probe assembly is matched with the collecting end of another integrated probe assembly disposed in pairs with the one integrated probe assembly.

Abstract: Disclosed are a crystal form of an estrogen receptor inhibitor and a preparation method therefor, in particular disclosed are a crystal form A of a compound of formula (I) and a preparation method therefor, and the use of the crystal form in the preparation of a drug for treating breast cancer.