Abstract: The invention relates to ketolide compounds of Formula (I) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compounds of invention, wherein, T is —C*H(R1)—P-Q; R1 is hydrogen; unsubstituted or substituted lower alkyl, cycloalkyl or aryl; P is heteroaryl ring; Q is unsubstituted or substituted aryl or heteroaryl ring; and P is attached to Q via carbon-carbon link; and R3 is hydrogen or fluorine, With the provision that when R1 is hydrogen, R3 is fluorine.

Abstract: In one embodiment, a method includes accessing a first field of a first link capabilities register of a first device having a protocol stack including a transaction layer and a link layer according to a first communication protocol and a physical layer of the protocol stack having a physical unit of a second communication protocol, using the first field as a pointer value to a location in a second link capabilities register of the first device, and using information from the location in the second link capabilities register to perform a configuration operation for a physical link coupled to the device. Other embodiments are described and claimed.

Abstract: Systems and techniques are described for estimating optimal gate sizes in a circuit design using numerical delay models of cells and cell types in a technology library. Gate sizes are optimized in the circuit design in a reverse-levelized processing order. Gates that are at the same level in the reverse-levelized processing order, and whose inputs are electrically connected to the same driver output are optimized together. A closed-form expression is used to determine the optimized size for each gate in a set of gates that are optimized together. Some embodiments perform multiple optimization iterations, wherein in each optimization iteration all of the gates in the circuit design are processed in the reverse-levelized processing order. The iterative optimization process terminates when one or more termination conditions are met.

Abstract: Methods and apparatus for provision of a low power, low frequency squelch break protocol are described. In some embodiments, a fixed or variable time transmitter LFPS (Low Frequency Periodic Signaling) mechanism may be used that does not require a handshake and therefore much simpler in implementation than USB3 (Universal Serial Bus 3.0), for example. Also, an embodiment does not require a link common mode to be established and therefore may be optimized to support shorter durations for effecting exit from an electrical idle state that may be established via power-gating, for example. Other embodiments are also disclosed.

Abstract: Systems and techniques for optimizing a circuit design are described. Some embodiments reduce the number of gates in the library (e.g., by dynamically pruning the library) which are considered for optimization. Some embodiments create a linear delay model, and use the linear delay model instead of a non-linear delay model to substantially reduce the amount of computation required to check whether or not a particular replacement gate improves one or more metrics of the circuit design. Some embodiments determine an order for processing the gates in the library or for processing input pins of a gate to facilitate early rejection of a candidate gate in the library of gates. In some embodiments, the evaluation of the impact of a candidate gate transformation is done progressively and level-by-level only up to the point where the gate transformation degrades one or more metrics.

Abstract: Systems and techniques for incrementally updating Elmore pin-to-pin delays are described. During operation, an embodiment receives a representation of a physical topology of a routed net that electrically connects a driver pin to a set of load pins. The embodiment then computes a set of incremental Elmore delay coefficients based on the representation. Next, using the Elmore delay coefficients, the embodiment computes a set of delays based on the representation, wherein each delay in the set of delays corresponds to a delay between the driver pin and a corresponding load pin in the set of load pins. As load pin capacitances change during circuit optimization, the set of incremental Elmore delay coefficients can then be used to update the delays between the driver pin and the load pins in a very computationally efficient manner.

Abstract: Embodiments of apparatus, computer-implemented methods, systems, devices, and computer-readable media are described herein for tracking per-virtual machine (“VM”) resource usage independent of a virtual machine monitor (“VMM”). In various embodiments, a first logic unit may associate one or more virtual central processing units (“vCPUs”) operated by one or more physical processing units of a computing device with a first VM of a plurality of VMs operated by the computing device, and collect data about resources used by the one or more physical processing units to operate the one or more vCPUs associated with the first VM. In various embodiments, a second logic unit of the computing device may determine resource-usage by the first VM based on the collected data. In various embodiments, the first and second logic units may perform these functions independent of a VMM of the computing device.

Abstract: Full length MxA constructs and truncated MxA constructs produce human MxA protein in E. coli. The full length MxA and truncated MxA constructs are preferably E. coli codon-optimized to optimize the amount of protein made using the constructs. T5 or T7 promoters can each be used in combination with either the full length MxA or the truncated MxA constructs. In one preferred embodiment, the MxA protein produced by the full length MxA or truncated MxA constructs is used in a control prep or external control. In other preferred embodiments, the MxA protein is used as a therapeutic.

Abstract: Low frequency pulse-echo ultrasonic transducers are provided especially suited for use in downhole cement bond evaluation, but usable for various applications. One frequency pulse-echo ultrasonic transducer comprises a transducer stack having alternating layers of a piezoceramic element and an ultrasonic attenuating element that is preferably acoustic impedance matched to the piezoceramic elements in order to reduce the Q of the transducer stack. Another low frequency pulse-echo ultrasonic transducer comprises an assembly having the present transducer stack disposed on an acoustic attenuating backing and a front face. Yet another low frequency pulse-echo ultrasonic transducer comprises a transducer composite made from a lead metaniobate. Still another frequency pulse-echo ultrasonic transducer comprises a composite stack. A further low frequency pulse-echo ultrasonic transducer comprises a composite stack, wherein multiple drive elements allow driving individual elements at different times.

Abstract: Disclosed is an apparatus for synthesizing nitroalkanes by reaction of a hydrocarbon feedstock with aqueous nitric acid. The apparatus may be designed such that it can synthesize more than one nitroalkane using the same equipment.

Abstract: A system, a computer readable storage medium including instructions, and a computer-implemented method of pre-fetching in a network, are provided. In an example embodiment, computer-implemented method of pre-fetching in a network comprises receiving a request from a user device for a first network-accessible data item in the plurality of network-accessible data items; transmitting the first network-accessible data item to the user device; identifying a second network-accessible data item in the plurality of network-accessible data items; and transmitting the second network-accessible data item to the user device, the second network-accessible data item being transmitted before receiving a request for the second network-accessible data item from the user device. Pre-fetch logic may be embedded in the first network-accessible data item.

Abstract: Methods and apparatus for tunneling platform management messages through inter-processor interconnects. Platform management messages are received from a management entity such as a management engine (ME) at a management component of a first processor targeted for a managed device operatively coupled to a second processor. Management message content is encapsulated in a tunnel message that is tunneled from the first processor to a second management component in the second processor via a socket-to-socket interconnect link between the processors. Once received at the second management component the encapsulated management message content is extracted and the original management message is recreated. The recreated management message is then used to manage the targeted device in a manner similar to if the ME was directly connected to the second processor. The disclosed techniques enable management of platform devices operatively coupled to processors in a multi-processor platform via a single management entity.

Abstract: According to one aspect, the subject matter described herein includes a method for routing Diameter messages. The method includes steps occurring at a Diameter signaling router (DSR) comprising a plurality of Diameter message processors. The method also includes receiving, by a first of the plurality of Diameter message processors and from a first Diameter node, a Diameter message, wherein the Diameter message is received via a first Diameter connection. The method further includes determining, by the first Diameter message processor, a next-hop Diameter node for the Diameter message. The method further includes communicating, by the first of the plurality of Diameter message processors and to a second of the plurality of Diameter message processors, the Diameter message. The method further includes communicating, by the second Diameter message processor and to the next-hop Diameter node, the Diameter message, wherein the Diameter message is communicated via a second Diameter connection.

Abstract: Devices and methods incorporate lysis agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters a lysis agent. The lysis agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the initially lysis agent is localized between the sample application zone and the conjugate zone. The lysis agent is preferably soluble or miscible in the sample transport liquid, and the lysis agent is solubilized and activated upon contact with the sample transport liquid. The sample transport liquid then contains both lysis agent in solution or suspension and sample components in suspension. Any lysis-susceptible components in a sample, then being exposed in suspension to the lysis agent, are themselves lysed in situ. The running buffer then carries the analyte, including any lysis-freed components, to the detection zone.

Abstract: A mobile device tracks a relative pose between a camera and a target using Vision aided Inertial Navigation System (VINS), that includes a contribution from inertial sensor measurements and a contribution from vision based measurements. When the mobile device detects movement of the target, the contribution from the inertial sensor measurements to track the relative pose between the camera and the target is reduced or eliminated. Movement of the target may be detected by comparing vision only measurements from captured images and inertia based measurements to determine if a discrepancy exists indicating that the target has moved. Additionally or alternatively, movement of the target may be detected using projections of feature vectors extracted from captured images.

Abstract: Localisation of an electronic device is enabled by establishing a localisation environment wherein sources of visible light are configured to modulate onto emitted light a detectable signal, each signal bearing information identifying that light source, such that light incident on a device can be processed to identify particular sources of incident light and therefrom the location of the device.

Abstract: A process comprising: contacting a lower alkane feed comprising propane and ethane with an aromatization catalyst in a first stage under first stage reaction conditions to produce a first stage product stream comprising ethane and aromatics; separating the aromatics from the first stage product stream to form an aromatics product stream and a second stage feed; and contacting the second stage feed with an aromatization catalyst in a second stage under second stage reaction conditions to produce a second stage product stream comprising ethane and aromatics wherein the amount ethane in the first stage product stream is equal to from 80 to 300% of the amount of ethane in the lower alkane feed and the amount of ethane in the second stage product stream is 500 equal to at most 80% of the amount of ethane in the second stage feed is described.

Abstract: A mobile device compensates for a lack of a time stamp when an image frame is captured by estimating the frame time stamp latency. The mobile device captures images frames and time stamps each frame after the frame time stamp latency. A vision based rotation is determined from a pair of frames. A plurality of inertia based rotations is measured using time stamped signals from an inertial sensor in the mobile device based on different possible delays between time stamping each frame and time stamps on the signals from the inertial sensors. The determined rotations may be about the camera's optical axis. The vision based rotation is compared to the plurality of inertia based rotations to determine an estimated frame time stamp latency, which is used to correct the frame time stamp latency when time stamping subsequently captured frames. A median latency determined using different frame pairs may be used.

Abstract: A vise apparatus with a bending fixture is disclosed in which the bending fixture includes a collection of projections on an operative and substantially vertical front face of a holding arrangement of the vise apparatus. The bending fixture supports and enables gravity assisted bending of a workpiece. The vise apparatus promotes bending workpieces with reduced effort and minimizes manufacturing costs.

Abstract: The present disclosure relates to radiation detectors having a layer of a high Z material, such as tungsten or lead, disposed on a face of a photodetector layer or other underlying layer. In one embodiment, the layer of the high Z material substantially prevents radiation from reaching on or more electronics components or circuits, such as an analog-to-digital conversion ASIC or other circuit.