Abstract: Capsule shells for use in multi-part dosage forms have generally cylindrical shell members with a snap fit component on an interior surface adjacent an open end, for connection to a linker part of the dosage form. The shell member also has a plurality of spaced apart integrally formed thin (relative to circumferentially adjacent shell member portions) panels located adjacent a closed shell member end, for preferential dissolution and release of pharmaceutical compositions from the shell member interior. The ratio of the thickness of the panels to the thickness of the shell member ranges from about 0.2 to about 0.6. The panels can be integrally formed together with the shell member as reliefs or depressions on the inner surface of the shell member by injection molding, and panel thicknesses as thin as about 0.

Abstract: A linker for multicomponent dosage form has a preformed drug substance tablet and an injection molded jacket including one or both axial jacket ends open for dispensing the preformed drug substances. The jacket has snap-fit connection elements on the outer surface adjacent each end for engagement with complementary snap-fit element on capsule-type and cap-type dosage form units. Another multicomponent drug form linker is injection molded with a raised circumferential band and snap-fit elements between the band and respective ends engageable with complementary snap-fit elements on dosage form units to provide compressive abutting contact between ends of the units and the band. The band can have an axially tapered outer surface to accommodate dosage form units of different diameters. Still another multicomponent dosage form linker has separable male and female parts each engageable with, and separately sealing, respective dosage form units to be linked.

Abstract: A method of manufacturing a linker of the type having an injection molded jacket radially confining a preformed tablet. The method includes grasping the tablet about the outer surface with a plurality of pincers and positioning the grasped tablet and the pincers with respect to a molding apparatus. The method also includes supporting the tablet via the pincers and injecting jacket material to cover the outer tablet surface and the pincers. The method further includes extracting the jacketed tablet from the molding apparatus and removing the pincers from the jacketed tablet. The method may also include supporting and longitudinally positioning the tablet within the mold via a plurality of additional pincers.

Abstract: Methods and systems for operating multiple web pages in a single browser window. The methods and systems include providing tabbed browsing whereby a user may select a tab to open a web page associated to it. A set of tabs and buttons are located on a tab band within the browser window. The functionality of tabbed browsing is compatible with existing browser features and applications. The computer software for tabbed browsing is created as a plug-in to the browser.

Abstract: A flux-switching machine stator comprising two or more C-cores, each C-core having two legs and a back portion joining the legs, and a permanent magnet arranged between legs of adjacent C-cores. Each leg has a main portion and a tip portion further from the back portion characterized in that the tip portion of each leg is angled relative to the main portion of the respective leg.

Abstract: The present invention discloses a process for the preparation of a stabilized polyester that is low in the generation of aldehydes which comprises reacting one or more diacids with one or more diols in an esterification process, and/or one or more diesters with one or more diols in a transesterification process in the presence of an effective amount of a stabilizer selected from the group consisting of (a) a polyhydric alcohol which is for example poly(ethylene-co-vinyl alcohol), poly(styrene-co-allyl alcohol), maltitol, isomalt, sorbitol, xylitol, sucrose, mucic acid dibutylester, mucic acid di(phenyl-1-ethyl)ester, pentaerythritol or dipentaerythritol; (b) a compound of the formula II which is for example di-iso-octyl-phosphinic acid; (c) a sterically hindered amine which is for example Tinuvin 123 or Tinuvin 622; (d) a polyacrylamide, an anionic acrylic polymer or a cationic acrylamide copolymer; or (e) a hydroxylamine and/or a nitrone.

Abstract: A system for mixing powdered materials includes a cannula and an actuator adapted to vibrate the cannula. An optional fluid delivery system is operable to add fluid to the powdered mixture through the cannula. The cannula can be extended into a powder bed and vibrated by the actuator to mix the powder bed. Fluid can be added to the powder bed through the cannula. The systems and methods are suitable for preparing relatively small quantities of candidate mixtures for high-throughput screening. Sample mixtures prepared by the mixing system can be pressed into tablets that are substantially devoid of foreign objects used to mix the samples. The sample mixtures can be subjected to one or more tests, such as an accelerated aging or forced degradation test, to assess one or more characteristics of the sample mixtures.

Abstract: A ground anchor (10) comprising an anchor shaft (11) and an anchoring screw (13) moulded onto the anchoring shaft adjacent the lower end thereof. The anchoring shaft (11) is of a rectangular cross-section with four side walls (12). The anchoring shaft (11) is configured at its bottom end (15) for ground penetration. The upper end (19) of the anchor shaft (11) is configured to receive torque applied thereto. The anchoring screw (13) comprises a hub (21) and a screw flight (23) on the hub. The anchoring screw (13) is moulded onto the anchor shaft (11), and the hub (21) is keyed to the anchor shaft. The anchoring screw (13) is so constructed that the spiral flight (23) is rigid yet has some resilient flexibility which allows the flight to deflect laterally in the direction of the screw axis. Specifically, the screw flight (23) has sufficient rigidity to allow it to penetrate the ground in which it is intended to be used when torque is applied to the anchor shaft (11).

Abstract: A reinforced matrix composite containment duct for gas turbine engines comprising a reinforced matrix composite containment duct having high strength integral flanges and pre-stressed reinforcing fibers, the reinforced matrix composite having uniform distribution of matrix material; and the reinforced matrix composite having less than or equal to 2.5% void space.

Abstract: A modular active test probe and removable tip module therefor. Within the scope of the invention, there is a probe tip module comprising a first probe tip adapted for probing a circuit under test to receive a signal therefrom. The probe tip module includes an amplifier having a first input solidly connected to the probe tip, an output connected to an output connector, and a housing for supporting the probe tip, the amplifier, and the output connector. A probe body is cooperatively adapted with the housing for repeatably removably receiving at least the output connector.

Abstract: Access is provided to network connection data for a user terminal. A query based on a request from a communications device to access the network connection data is received over a first network. The network connection data corresponding to the request is retrieved from a database based on the query. The database is populated with the network connection data and interfaces with a second network over which network connections are established with the user terminal. The network connection data retrieved from the database is forwarded for display at the communications device.

Abstract: Methods for forming thermal oxidative barrier coatings for organic matrix composites include applying a bond coat having nano-particles dispersed in a polyimide matrix to a hot side surface of a component and overlying the bond coat with a thermal barrier layer comprising a silsesquioxane or an inorganic polymer. The nano-particles may include clay platelets, graphite flakes or a polyhedral oligomeric silsesquioxane. The bond coat may be applied as a liquid. The thermal barrier layer may be applied as a liquid, film, prepreg, molding compound, or a spray.

Abstract: A tailorable polyimide resin system may be used to form an organic matrix composite (OMC) structure for use in high temperature applications. A thermal oxidative barrier coating on the OMC may include a bond coat comprising a tailorable polyimide resin system. The bond coat may include nano-particles such as clay platelets, graphite flakes or a polyhedral oligomeric silsesquioxane. The coating system may include a thermal barrier layer including a silsesquioxane or an inorganic polymer. The tailorable polyimide resin system includes first and second independent prepolymer components able to impart desired properties in the prepolymer blend or the crosslinked polyimide matrix.

Abstract: A thermal oxidative barrier coating for organic matrix composites includes a bond coat having nano-particles dispersed in a polyimide matrix and a thermal barrier layer comprising a silsesquioxane or an inorganic polymer. The nano-particles may include clay platelets, graphite flakes or a polyhedral oligomeric silsesquioxane. The coated article may be utilized in gas turbine engine applications, particularly for a flow path duct adapted for exposure to high temperature, oxygen-containing environments.

Abstract: A microcapsule comprising a lipid-based core that is encapsulated in an enteric polymer shell providing enhanced bioavailability of a sparingly water-soluble drug as well as modulated release of the drug, wherein the microcapsule is, in one embodiment, prepared by a centrifugal coextrusion process. The lipid-based core comprises lipidic carriers, either liquid or solid (melting point<1000C), that would provide adequate drug solubilization and is compatible with the enteric shell materials.

Abstract: A method and system for calculation of rotation dependent parameters in a system that senses shaft rotation of a toothed speed wheel. The method includes determining the passing edges of multiple gear teeth on a rotating speed wheel; calculating rotational speed of the rotating machine based on the passing edges of multiple gear teeth of the speed wheel; calculating a rotation independent tooth spacing correction factor for each gear tooth on the rotating wheel; and correcting the calculated rotational speed of the rotating machine using the tooth corrections.

Abstract: A method for forming a polyimide composite article utilizes a polyimide resin system including at least a first prepolymer component and a second prepolymer component. A preform structure is tackified with the first prepolymer component. Using resin infusion or resin transfer molding techniques, the tackified preform structure is contacted with the second prepolymer component. The polyimide resin system is cured under suitable cure conditions so that the first and second prepolymer components mix and react to produce the polyimide composite structure.

Abstract: A method for fabricating a turbine engine composite containment casing is provided. The method comprising impregnating a plurality of fiber-reinforced layers with a resin to form a preform, heating the preform to a first temperature, applying a vacuum to the preform, varying an amount of pressure applied to the preform when the temperature reaches the first temperature, heating the preform from the first temperature to a second temperature at a first temperature rate, and heating the preform from the second temperature to a third temperature at a second temperature rate to facilitate curing of the preform.

Abstract: Thin plies used to manufacture components having changes in contour and changes in thickness and in fabricating thin cross-sections utilizing scrims. A scrim is applied to the surface of a thin, high temperature CMC prepreg ply. The scrim assists in maintaining the integrity of the thin ply during handling and lay-up operations thereby preventing damage to the thin plies and the lay-up. The scrim is a thin supportive layer applied to the surface of a thin prepreg to improve its handling characteristics, such as by preventing wrinkling. The scrim can be a coarse or fine mesh of thin or heavy fiber applied as a reinforcement. The scrim can be a temporary removable structure or can be incorporated into the component as part of the thin ply. The structure and composition of the scrim will be dependent upon whether the scrim is a temporary removable structure or whether it is incorporated permanently into the component.

Abstract: Tailorable polyimide resin systems suitable for processing by resin transfer molding (RTM) and resin infusion (RI) methods. An exemplary resin system includes first and second prepolymer components present in respective amounts to provide the desired processibility. The cured polyimide system exhibits high glass transition temperature and other properties required for gas turbine engine applications. The first and second prepolymer components independently comprise a monomeric mixture or a reaction product of a diamine component, a dianhydride component, and an end group component.