Abstract: A compound of the formula (I) wherein the variables X1, X2, B, D, R1 to R7 including R3?, p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.

Abstract: A method of transferring data using a Trivial File Transport Protocol (TFTP) comprises sending a request packet from a client to a server, the request packet comprising a first TFTP option requesting that a segment of a grouping of data be transferred, and if an option acknowledgment packet comprising a second TFTP option corresponding to the first TFTP option is received at the client from the server, transferring the segment of the group of data as indicated in the second TFTP option using TFTP.

Abstract: Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer compris

Abstract: The invention provides VEGFxxxb, or an agent which selectively promotes the expression of VEGFxxxb in preference to VEGFxxx in cells of a subject or in vitro, or an expression vector system which causes the expression of the VEGFxxxb in a host organism, for use in treating or preventing neuropathic and neurodegenerative disorders, or for use as a neuroprotective or neuroregenerative agent in vivo or in vitro. The VEGFxxxb is preferably VEGF165b.

Abstract: An engine lubricant, especially an SAE OW engine lubricant is described. The engine lubricant has at least 15 wt % of at least one monoester and not more than 15 wt % of additives, wherein said at least one monoester, or mixture of said monoesters if more than one is present, has a kinematic viscosity at 100° C. of not more than 3.3, a viscosity index of at least 130 and a Noack evaporation loss of not more than 15 wt %. The monoester is preferably the reaction product of a monohydric alcohol and a monocarboxylic acid wherein said monohydric alcohol is at least one saturated branched-chain aliphatic monohydric alcohol having between 16 and 36, carbon atoms and wherein said monocarboxylic acid is at least one saturated straight-chain aliphatic monocarboxylic acid having between 5 and 10, preferably 5 and 7, carbon atoms. In preferred lubricants, the monoester, or mixtures of monoesters, have a pour point of not more than ?30° C. and a non-polarity index of at least 80.

Abstract: A method of analysing an input signal, the method including the steps of: (a) dividing a first input signal into first and second orthogonal signal polarisation components; (b) dividing a second input signal into orthogonal first and second orthogonal local polarisation components; (c) mixing the first orthogonal signal component with the second orthogonal local polarisation component to provide a first mixed signal; (d) mixing the second orthogonal signal component with the first orthogonal local polarisation component to provide a second mixed signal; (e) analysing the first and second mixed signal to determine the polarisation or phase information in the input signal.

Abstract: A collapsible pushchair can be expanded into a deployed state for carrying a child and collapsed into a portable state for being carried as a piece of luggage. Transformation of the pushchair between its deployed and portable states is enabled by the use of rotationally mounted chair legs.

Abstract: A stop device comprises a rotatable shaft, a travelling nut mounted upon the shaft in such a manner that rotation of the shaft causes the nut to translate along the shaft, and a stop member mounted upon the shaft and operable to limit the length of the shaft along which the travelling nut can translate, wherein the stop member is adjustably mounted upon the shaft.

Abstract: A chocolate composition and a method for manufacturing the chocolate composition include a solid material, e.g., nutritive carbohydrate sweetener that has a particle size from about 50 to about 1000 nanometers. The solid material may comprise a sugar, such as but not limited to, sucrose. By including within the chocolate composition the solid material that has the particle size from about 50 to about 1000 nanometers, the chocolate composition has enhanced temperature resistance properties.

Abstract: The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.

Abstract: A fuel vapor recovery system and method for an automotive vehicle are disclosed. The vehicle fuel tank is vented to atmosphere via a passageway having a carbon canister to remove fuel vapors, a bladder, and a normally-closed isolation valve. When fueling the vehicle, the gases in the fuel tank displaced by entering fuel are introduced into the carbon canister where the fuel vapors are stored. The isolation valve is commanded to open to allow such flow through the carbon canister. When the vehicle is parked for a period of a day, it undergoes a diurnal temperature change which causes fuel to vaporize into the fuel system. According to an aspect of the present development, the isolation valve remains closed and the gases are contained within the bladder as it expands or contracts as the volume of gases increases or decreases in response to temperature changes.

Abstract: A fuel vapor recovery system and method for an automotive vehicle are disclosed. The vehicle fuel tank is vented to atmosphere via a passageway having a carbon canister to remove fuel vapors, a bladder, and a normally-closed isolation valve. When fueling the vehicle, the gases in the fuel tank displaced by entering fuel are introduced into the carbon canister where the fuel vapors are stored. The isolation valve is commanded to open to allow such flow through the carbon canister. When the vehicle is parked for a period of a day, it undergoes a diurnal temperature change which causes fuel to vaporize into the fuel system. According to an aspect of the present development, the isolation valve remains closed and the gases are contained within the bladder as it expands or contracts as the volume of gases increases or decreases in response to temperature changes.

Abstract: A collapsible pushchair can be expanded into a deployed state for carrying a child and collapsed into a portable state for being carried as a piece of luggage. Transformation of the pushchair between its deployed and portable states is enabled by the use of rotationally mounted chair legs.

Abstract: Methods and a processing device are provided for restoring pixels damaged by artifacts caused by dust, or other particles, entering a digital image capturing device. A user interface may be provided for a user to indicate an approximate location of an artifact appearing in a digital image. Dust attenuation may be estimated and an inverse transformation, based on the estimated dust attenuation, may be applied to damaged pixels in order to recover an estimate of the underlying digital image. One or many candidate source patch may be selected based on having smallest pixel distances, with respect to a target patch area. The damaged pixels included in the target patch area may be considered when calculating the pixel distance with respect to candidate source patches. RGB values of corresponding pixels of source patches may be used to restore the damaged pixels included in the target patch area.

Abstract: Described herein are systems and methods for managing testing functionalities. One such method includes receiving, from a test tool, data indicative of a user-created test script, being a data-bound test script in the present example. The data-bound test script is created for testing a target application, and is bound to a predetermined data set. This received data is then processed, thereby to define data indicative of an unbound test script. A user interface is provided for allowing a user to associate the unbound test script with one or more data sets selected from a repository of stored data sets. Responsive to a user command, data indicative of a new data-bound test scripts is defined based on the association of the unbound test script with the selected one or more data sets. This new defined data-bound test script is executable via the test tool. For example, instructions are provided to the test tool such that those scripts are executed for the testing of the target application.

Abstract: A method of determining velocity of a shaft is provided. The method includes receiving a first shaft position signal and a second shaft position signal. Derivatives of each of the first shaft position signal and the second shaft position signal are computed, as are squares of each of the derivatives, a summation of the squares, and a square root of the summation. The velocity is output as a result of the square root.

Abstract: A delivery system and methods for generating droplets of liquid active materials, such as a perfume, air freshener, insecticide formulation, and volatile materials, to the atmosphere by means of a electromechanical transducer. The electromechanical transducer employs a first period of activation and a second period of deactivation to increase the distribution of volatile materials contained within the liquid active materials to the atmosphere and reduce the hedonic habituation of the user. The electromechanical transducer is configured to improve flow rate and decrease deposition of the droplets on to nearby surfaces.

Abstract: A stacked laminate component for a turbine engine that may be used as a replacement for one or more metal components is provided. The stacked laminate component can have a body formed by a process of stacking and laminating layers to define a radially inner surface along the hot gas path. The layers can be substantially orthogonal to the radially inner surface. The layers can be at least a first layer of a first material and a second layer of a second material. At least the first material is a ceramic matrix composite. The second material can have a higher thermal conductivity or a higher creep strength than the first material.

Abstract: An optical coupling device including: at least a first input port for delivering an optical input signal beam that includes a plurality of wavelength channels; at least a first optical output port for receiving an optical output signal beam; a wavelength dispersion element for spatially separating the plurality of wavelength channels in the optical input signal beam to form a plurality of spatially separated wavelength channel beams; an optical coupling device for independently modifying the phase of each of the spatially separated wavelength channel beams such that, for at least one wavelength channel beam, a selected fraction of the light is coupled to the first output port and a fraction of the light is coupled away from the first output port.

Abstract: Systems and methods for improved data transfers are provided. In one embodiment, a computer readable data storage device having computer executable code for a method for an accelerated file transfer protocol is provided. The method comprises: determining a number (N) of data blocks for accelerating a sending device ahead of a receiving device; transmitting an initial data block plus N additional data blocks to the receiving device without waiting for an acknowledgement (ACK) message from the receiving device; checking for receipt of an ACK message; when a correct ACK message is received, transmitting a next data block; and when a final data block is transmitted, verifying receipt of an ACK message for each of a last N transmitted data blocks.