Abstract: Systems, methods, and devices are disclosed herein for developing a cell design. Operations of a plurality of electrical cells are simulated to collect a plurality of electrical parameters. A machine learning model is trained using the plurality of electrical parameters. The trained machine learning model receives data having cell layout design constraints. The trained machine learning model determines a cell layout for the received data based on the plurality of electrical parameters. The cell layout is provided for further characterization of electrical performance within the cell layout design constraints.

Abstract: A semiconductor device includes an edge active cell, an inner active cell and a middle active cell. The edge active cell is located near an edge of the semiconductor device. The edge active cell includes a plurality of fingers. The inner active cell is adjacent to the edge active cell toward a central portion of the semiconductor device. The inner active cell includes a plurality of fingers and at least one of the plurality of fingers of the edge active cell is electrically connected to at least one of the plurality of fingers of the inner active cell. The middle active cell is located near the central portion of the semiconductor device. The middle active cell includes a plurality of fingers and each of the fingers of the middle active cell is electrically connected to each other.

Abstract: The objective of the invention is to provide a visual rhythmic guide device for swimming training capable of emitting rhythmical flashlights with a given frequency to lead the tempo of movements such as arm stroking and leg kicking for a swimmer. To achieve the objective, the device comprises a waterproof body to house components including a control circuit board, a timer, a gravity sensor (G-Sensor), a LED light source, a screen, a battery, a connection port and a set of input keys. When the device is given a frequency by a swimmer through the input keys, the LED light source will be driven to emit rhythmical flashlights in accordance with the given frequency. The swimmer is able to wear the device on anywhere of the body as long as the rhythmical flashlights can be sensed to adjust and practice the tempo of swimming movements.

Abstract: A limb motion measurement device for swimming training includes a sense glove and a sense shoe able to measure and collect the states of moving hands and feet of a swimmer in a training practice, including strength, displacement, velocity, bearing angle, number of times, frequency and time parameters, and to generate a serial of limb motion data of arm stroking and leg kicking motions. These organized and quantified limb motion data can be transmitted outwards to an external computer for the swimmer to study and to produce useful information of more efficient movements and tempos of swimming techniques. Accordingly, the limb motion measurement device for swimming training can be applied to improve swimming techniques in a scientific way.

Abstract: A semiconductor device and a method for manufacturing the semiconductor device are provided. The semiconductor device includes an insulating layer, a semiconductor layer, a plurality of isolation structures, a transistor, a first contact, a plurality of silicide layers, and a protective layer. The semiconductor layer is disposed on a front side of the insulating layer. The plurality of isolation structures are disposed in the semiconductor layer. The transistor is disposed on the semiconductor layer. The first contact is disposed beside the transistor and passes through one of the plurality of isolation structures and the insulating layer therebelow. The plurality of silicide layers are respectively disposed on a bottom surface of the first contact and disposed on a source, a drain, and a gate of the transistor. The protective layer is disposed between the first contact and the insulating layer.

Abstract: The present disclosure provides oligomeric compound comprising a modified oligonucleotide having a central region comprising one or more modifications. In certain embodiments, the present disclosure provides oligomeric compounds having an improved therapeutic index or an increased maximum tolerated dose.

Abstract: The present disclosure describes a method for replacing a device with a cell structure having a plurality of uni-gates. An exemplary method includes receiving a circuit diagram that includes the device, determining the cell structure wherein a cumulative effective gate length of the plurality of uni-gates is equal to a gate length of the device, generating, based on the cell structure and the device, a floor plan that includes an arrangement of a plurality of placeholders that match an arrangement of the cell structure and an arrangement of the device in the circuit diagram, and generating a circuit layout based on the floor plan, the cell structure, and the circuit diagram. The plurality of placeholders is replaced by the cell structure and the cell structure is connectable to other parts of the circuit diagram based on the circuit diagram.

Abstract: A method for fabricating a semiconductor structure is provided. The method includes assigning a set of parameter values to a set of size parameters of a unit cell of the integrated circuit in a unit cell schematic of the unit cell according to a predetermined criterion, wherein the unit cell characterized by the set of parameter values has a circuit characteristic meeting the predetermined criterion; generating a unit cell layout of the unit cell according to the unit cell schematic; generating a circuit layout comprising a plurality of replicas of the unit cell layout, the replicas of the unit cell layout being arranged in correspondence with circuit blocks in a circuit floorplan of the integrated circuit, respectively; and fabricating the integrated circuit according to the circuit layout.

Abstract: A method for fabricating a semiconductor structure is provided. The method includes assigning a set of parameter values to a set of size parameters of a unit cell of the integrated circuit in a unit cell schematic of the unit cell according to a predetermined criterion, wherein the unit cell characterized by the set of parameter values has a circuit characteristic meeting the predetermined criterion; generating a unit cell layout of the unit cell according to the unit cell schematic; generating a circuit layout comprising a plurality of replicas of the unit cell layout, the replicas of the unit cell layout being arranged in correspondence with circuit blocks in a circuit floorplan of the integrated circuit, respectively; and fabricating the integrated circuit according to the circuit layout.

Abstract: In one embodiment, a system for determining strain within a material includes a magnetostrictive sensor configured to be embedded within the material, a sensing unit configured to apply an excitation magnetic field to the material and the embedded sensor and to receive a response magnetic field that has passed through the material and the embedded sensor, wherein the sensing unit does not contact the material, and a device configured to determine a difference between the excitation magnetic field and the response magnetic field and to determine the strain within the material based upon that difference.

Abstract: A circuit for measuring a bandwidth of an amplifier includes first and second capacitors, first through third switches, and a pulse generator. First terminals of the capacitors are coupled to an amplifier input, and a second terminal of the second capacitor is coupled to an amplifier output. The first switch has a control terminal and terminals coupled to a first input node and a second terminal of the first capacitor. The second switch has a control terminal and terminals coupled to the amplifier input and output. The third switch has a control terminal, a first terminal, and a second terminal coupled to the second terminal of the first capacitor. The pulse generator has a first output coupled to the control terminal of the third switch, and is configured to vary a pulse width of a pulse signal supplied from the first output to the control terminal of the third switch.

Abstract: In certain embodiments, the present disclosure provides compounds and methods of increasing the amount or activity of a target protein in a cell. In certain embodiments, the compounds comprise a translation suppression element inhibitor. In certain embodiments, the translation suppression element inhibitor is a uORF inhibitor. In certain embodiments, the uORF inhibitor is an antisense compound.

Abstract: A semiconductor device includes transistors and a resistor. The transistors are connected in series between a power terminal and a ground terminal, and gate terminals of the transistors being connected together. The resistor is overlaid above the transistors. The resistor is connected between a source terminal of the transistors and the ground terminal.

Abstract: A sensor for detecting a target analyte in a sample includes a pair of conducting electrodes that are separated by a gap. An insulator is disposed in the gap between the electrodes. Plural wells are defined by one of the electrodes and the insulator, to expose the other of the electrodes. The wells are configured to receive a sample including a target analyte. The target analyte, when present in the sample received in the wells, modulates an impedance between the electrodes. The modulated impedance, which is measurable with an applied electrical voltage, is indicative of the concentration of the target analyte in the sample. The wells can include antibodies immobilized inside the wells, to bind the target analyte, which can be a cytokine. Also provided are a method for label-free sensing of a target analyte in a sample, and a transcutaneous impedance sensor for label-free, in-situ biomarker detection.

Abstract: In certain embodiments, the present disclosure provides methods comprising contacting a cell with a compound comprising a modified oligonucleotide complementary to a nucleic acid transcript. In certain such embodiments, the modified oligonucleotide does not interact or interacts poorly with a mRNP complex or granule. In certain such embodiments the modifications and/or motifs of the modified oligonucleotide do not promote interaction with a mRNP complex or granule. In certain embodiments, the present disclosure provides methods comprising contacting a cell with a compound comprising a modified oligonucleotide thereby reducing the size or amount of protein aggregation in the cell. In certain such embodiments, the protein aggregate is a mRNP granule. In certain such embodiments, the modifications and/or motifs of the modified oligonucleotide promote interaction with a protein aggregate, such as a mRNP granule, that results in disruption of the protein aggregate.

Abstract: A fingerprint identification apparatus including a touch and display integration circuit and a fingerprint identification device is provided. The touch and display integration circuit is configured to perform a touch and display function in each of a plurality of touch and display periods during a total contact time. An object touches a predetermined area of the display panel during the total contact time. The fingerprint identification device is configured to obtain a plurality of sample images of the object in each of a plurality of sensing periods during the total contact time. Two adjacent sensing periods have at least one of the touch and display periods therebetween. A fingerprint identification method of the fingerprint identification apparatus is also provided.

Abstract: A cell culture carrier module and a cell culture system having the same are provided. A cell tank and a culture medium module respectively communicate with the carrier module. The carrier module includes a reactor, a first fixer, a second fixer and a plurality of cell culture carriers. The reactor has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the reactor and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. Two ends of each cell culture carrier are fixed to the first fixer and the second fixer, respectively. The cell culture carriers are in an untwisted state or a twisted state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.

Abstract: A biodegradable sealant includes: a polyethylene glycol derivative; a photoinitiator; and a solvent, wherein the content of the polyethylene glycol derivative is about 10-75 wt % in the biodegradable sealant. The polyethylene glycol derivative is obtained by a substitution reaction, and in the substitution reaction, the polyethylene glycol is modified with methacrylic anhydride.

Abstract: An eye wearing device is provided, including a body, at least one reservoir and at least one microchannel. The body has a first surface, a second surface, a center, a first outer edge of the first surface and a second outer edge of the second surface. The reservoir is disposed in the body to load the drug. The microchannel is disposed near the first outer edge of the first surface and the second outer edge of the second surface. One end of the microchannel is connected to the reservoir for filling the drug into the reservoir. The other end of the microchannel is an opening facing an edge of the eye wearing device for contacting the cornea and/or the sclera, and the opening is connected to the first outer edge of the first surface and the second outer edge of the second surface.

Abstract: A biodegradable sealant includes: a polyethylene glycol derivative; a photoinitiator; and a solvent, wherein the content of the polyethylene glycol derivative is about 10-75 wt % in the biodegradable sealant. The polyethylene glycol derivative is obtained by a substitution reaction, and in the substitution reaction, the polyethylene glycol is modified with methacrylic anhydride.