Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. Deep learning techniques are brought to bear on the camera output to increase speed, accuracy and reliability.

Abstract: Systems and methods for wireless location are disclosed. In one aspect, a method for wireless location includes collecting signal strength values from one or more nodes (e.g., mobile devices) in an area over a time interval. The nodes receive wireless signals from one or more other transmitting nodes, where the signal strength values are representative of the signal strengths of the wireless signals. The method further includes normalizing the collected signal strength values and evaluating respective locations within the area of the nodes based on the normalized signal, strength values. In a further aspect, the, evaluated locations of the nodes may be used to execute an automated light show over the area, by instructing the nodes to display certain color or pattern at their locations in the area.

Abstract: Methods of optically marking and sorting adherent cells are provided. The methods include providing a plurality of adherent cells attached to a substrate, each adherent cell of the plurality of adherent cells having an optical marker. The methods also include selectively applying light energy to a subset of the plurality of adherent cells, and detaching the plurality of adherent cells from the substrate. These methods also provide the sorting of the plurality of adherent cells.

Abstract: A method enabling the quantitative analysis of acrylic acid in an acrylic adhesive resin includes: measuring, by means of a moisture analyzer for solid samples (MASS), moisture content generated through a ring forming reaction, in a high-temperature environment, of an acrylic polymer having a carboxyl group; and analyzing the acrylic acid content on the basis of the measured moisture content and the amount of the sample that is used.

Abstract: A detection chip, a detection method using the same and a manufacturing method thereof are provided. The detection chip includes: a detection baseplate including a first substrate and at least one photoresistor disposed on the first substrate; at least one cantilever beam configured to correspond to the at least one a photoresistor, wherein an orthographic projection of the cantilever beam on the detection baseplate is located within a region where the corresponding photoresistor is located, the cantilever beam has a free end that is separated from the photoresistor by a predetermined distance and that is movable relative to the photoresistor.

Abstract: An ellipsometer includes: a gantry; a polarization generator and a polarization analyzer mounted in the gantry; and a focusing lens disposed on a sample on a stage, wherein the sample is an object to be measured, wherein a vertical section of the focusing lens is a semi-circle.

Abstract: A multi-resolution spectrometer, includes: an incident slit (10) configured to receive an incident light beam; a collimating device (20) configured to collimate the light beam from the incident slit; a dispersing device (30) configured to disperse the light beam collimated by the collimating device (20) so as to form a plurality of sub-beams (61, 62) having different wavelengths; an imaging device (40) and a photon detector array (50), the imaging device (40) being configured to image the plurality of sub-beams (61, 62) on the photon detector array (50) respectively, the photon detector array (50) being configured to convert light signals of the plurality of sub-beams (61, 62) imaged thereon into electrical signals for forming a spectrogram, wherein the incident slit (10) has a first slit portion (11) and a second slit portion (12), and the second slit portion (12) has a greater width than the first slit portion (11).

Abstract: In a starch concentration measurement, a liquid sample is conducted from a liquid sample such as pulp suspension or filtrate of a paper, board or tissue process. An iodine solution is added to the sample, and a light absorbance or transmittance of the sample is measured at a target wavelength. The measured absorbance or transmittance of the sample is then converted into the starch concentration of the sample.

Abstract: A processing system monitors and/or controls a surface modification process occurring on a substrate within a processing chamber. An optical processing module having a light emission submodule to output a generated light signal and an optical detection submodule to detect a resultant light signal, is connected via fiber optic cables to light illuminating and light receiving components located within the chamber. A processor determines an amount of atomic absorption by an atomic element encountered by a probing beam passing between the illuminating and receiving components, based on the intensity of the generated light signal, the intensity of the received light signal and optionally the spontaneous emission of the atomic element in the absence of illumination by a probing beam. Based on the determined amount, the system derives a plurality of parameters of the modified substrate, their spatial and temporal uniformity, and information about process conditions in the processing chamber.

Abstract: A gas sensor, a method of manufacturing a gas sensor, a method for fabricating a micro electro-mechanical system (MEMS) die for a heater or thermopile, and a micro electro-mechanical system (MEMS) die for a heater or thermopile. The gas sensor comprises a first micro electro-mechanical system (MEMS) die comprising a light source; a second MEMS die comprising a light detector; a sample chamber disposes in an optical path between the light source and the light detector; and a holder substrate; wherein the first and second MEMS dies are disposed on the holder substrate in a vertical orientation relative to the holder.

Abstract: A method to determine the likelihood that a patient with cystic fibrosis will respond to treatment with an alginate oligomer. The method is based on analyzing the IR absorbance values and/or transmittance values, in particular a Fourier transform infrared spectroscopy (FTIR) spectrum, of a mucus sample from the respiratory system of a CF patient at certain specific wavenumbers.

Abstract: An optical component for terahertz waves includes a resin member that includes a powder containing cellulose. A content ratio of the powder in the resin member is 60 wt % or less.

Abstract: A system includes a detector and a computing device communicatively coupled to the detector. The detector detects spatial or temporal spectral features of a light beam after transmission of the light beam through a turbulent or aberrated medium and generate a measurement signal indicative of the spectral feature. The computing device receives the measurement signal and a comparative signal indicative of a spectral feature of the light beam prior to or after transmission of the light beam through the medium. The computing device compares the measurement signal and the comparative signal and determines, based on the comparison of the measurement signal and the comparative signal, one or more values related to variations in refractive indices of the medium.

Abstract: An apparatus comprising: including a plurality of light sources configured to emit light for reflection from tissue of a user wearing the apparatus, at least one light detector configured to detect light that enters the light detector to produce a detected signal for a physiological measurement, and a light-conducting element configured to conduct light to the light detector, wherein the apparatus is configured to allow light reflected from the tissue of the user to enter the light-conducting element at a plurality of spatially separated locations.

Abstract: A method for identifying fragmented red blood cells comprising: acquiring side scatter light signals and fluorescence signals of cell particles in a sample liquid; and distinguishing and identifying a fragmented red blood cell population from the cell particles according to the side scatter light signals and the fluorescence signals of the cell particles. The fragmented red blood cell population can be identified from the cell particles by processing and analyzing the side scatter light signals and fluorescence signals of the sample liquid. The present application further provides a device for identifying fragmented red blood cells, a blood cell analyzer and an analysis method. Fragmented red blood cells can be identified according to the fluorescence that characterizes a nucleic acid content in a cell particle and the side scatter light, thus reducing errors in identification and counting.

Abstract: Systems and methods for increasing the accuracy of a turbidity sensor are disclosed. The systems include a turbidity sensor and a flow module with a specialized flow path, with the turbidity sensor engaging with the flow module such that a measurement zone of the turbidity sensor is disposed within a flow path of the flow module and a bypass path of the flow module does not pass through the measurement zone. The methods include flowing a fluid containing bubbles into a system that separates the fluid in the flow module into a first stream of fluid containing relatively more bubbles and a second stream of fluid containing relatively fewer bubbles, the first stream flowing through a bypass path that does not pass through the measurement zone, and the second stream flowing through the measurement zone of the turbidity sensor.

Abstract: The optical cell of an elongated shape has an inner space into which gas is introduced and includes: a cell main body forming the inner space; a manifold member being separably connected to an outer surface of the cell main body extending in a longitudinal direction; and a heating mechanism heating the manifold member, in which the cell main body has a through hole penetrating from the outer surface into the inner space, and the manifold member has a gas introduction path extending along the longitudinal direction and guiding the gas, which has been taken in from the outside, from one side to another side in the longitudinal direction and then guiding the gas to the inner space through the through hole.

Abstract: A system in an embodiment can comprise an optical assembly, an SPR light source, and an SPR camera. The optical assembly in this embodiment can comprise a hemispherical prism comprising a planar top surface configured to support a surface-plasmon-resonance (SPR) sensor; a high numerical aperture (NA) lens; and a housing configured to mount the hemispherical prism and the high NA lens the such that the high NA lens is located distal from the planar top surface of the hemispherical prism. The SPR light source in this embodiment can be configured to emit a low-coherent monochromatic light beam for SPR imaging toward the high NA lens. The SPR camera in this embodiment can be configured to capture an SPR image formed after the low-coherent monochromatic light beam is incident upon and reflected by a metal-coated sample contacting surface of the SPR sensor.

Abstract: Disclosed are diagnostic reagents having metal-organic frameworks and protection and enhancement of diagnostic reagents and materials using metal-organic frameworks.

Abstract: Provided is a position detection method and a position detection device for detecting a position of a sensor chip and obtaining relative positional information between a well member and a prism as for a well chip type sensor chip in which the well member is provided on a prism. By applying measurement light to the sensor chip while changing a distance between the sensor chip and a measurement light irradiation unit and detecting reflected light traveling in a predetermined direction out of the reflected light generated when the measurement light is reflected by the sensor chip, at least any one of the position of the sensor chip and the relative position between a dielectric member and a sample solution holding member is detected on the basis of a change in intensity of the detected reflected light.

Abstract: An airborne microorganism measurement device includes a housing including a first body and a second body, an air passage formed between the first body and the second body such that air containing airborne microorganisms pass therethrough, a charging part and a collecting part disposed in the air passage to charge and collect the airborne microorganisms, a high voltage generating device provided in the first body to supply a high voltage to the charging part and the collecting part, and a light emitting unit and a light receiving part provided in the second body to detect a fluorescent signal generated by irradiating the airborne microorganisms collected in the collecting unit with light.

Abstract: A system (100) for time-resolved fluoroimmunoassay detection is disclosed. The system (100) comprises a receptacle (110) with a sample volume adapted for receiving a sample (99) therein; a light source (120) adapted to emit pulsed excitation light (200); illumination optics (130) adapted to collect the pulsed excitation light (200) from the light source (120) and to deliver said pulsed excitation light (200) to the sample volume in the receptacle (110); a detection device (140) adapted for gated detection of fluorescence radiation (210) at least in a detection spectral range; detection optics (150) adapted to collect fluorescence radiation (210) from the receptacle (110) at least in the detection spectral range and deliver said fluorescence radiation (210) to the detection device (140); and an optical filter device (160) configured for the separation of excitation light (200) and detection light (210).

Abstract: A microsecond-scale stimulated Raman spectroscopic imaging system having a light source, such as a laser output that provides two femtosecond laser beams and a modulator to modulate the laser intensity at frequency between about 1 and about 100 megahertz. The system can further include a medium that chirps the two femtosecond beams to generate a spectral focus in a specimen, and a galvo mirror or resonant mirror pair to scan the two femtosecond beams in two dimension on the specimen. An objective lens can focus the two laser beams into a specimen or sample and a resonant delay scanner configured to produce an optical delay to the pair of chirped beams in said specimen and a tuned amplifier or lock-in amplifier can be used to extract the stimulated Raman-signal shift at the aforementioned modulation frequency.

Abstract: A method for detecting dust mite antigens includes the steps of collecting a dust sample, applying an extraction and cleanup procedure for dust mite antigens from the dust sample in order to obtain a sample solution ready for measurement, and placing the sample solution on a SERS chip without immunological modification and under a Raman spectrometer for SERS detection in order to identify whether any dust mite antigens exist in the sample solution.

Abstract: A system can include an exchangeable mounting structure having a visual marking or coloring and at least one physically associated sample introduction system component having an indicating mark or color matching the visual marking or coloring of the exchangeable mounting structure. The visual marking or colored corresponds to a sample analysis configuration for analyzing a particular sample type at an analytical instrument.

Abstract: Provided is a system for detecting abnormalities in underlying surface of a coated substrate that includes a housing blocking external sources of light from impinging on the coated substrate; an array of light sources, matched in bandwidth to the transmission spectrum of the coating, arranged to direct light upon the coated substrate; an optical imaging system matched to the wavelength range of the light source array and positioned to collect reflected and scattered light from the substrate and generate an image of the structural features including any abnormalities in the substrate; and an onboard embedded system, providing real-time image processing to correct spatial and temporal variations in the light source array intensity and optical imaging system sensitivity. The optical imaging system includes a focal plane array matched in bandwidth to the transmission spectrum of the coating, and a flat optical window configured to reduce the optical Narcissus effect.

Abstract: Provided is a detection system for detecting abnormalities in a coated substrate having a coating and a substrate, and including a detection device that includes a housing configured to block external sources of light from impinging on the coated substrate, a light source array including a plurality of light sources and configured to be arranged to direct light upon the coated substrate, an optical imaging system configured to capture a video data stream and still images of the coating and an underlying surface of the substrate including structure features comprising any abnormalities in the coated substrate, an on-board embedded system to control the light source array and the optical imaging system and perform real-time processing to correct spatial and temporal variations in intensity of the plurality of light sources of the light source array, and spatial and temporal variations in sensitivity and optical Narcissus effect of the optical imaging system.

Abstract: A learning procedure involves generating a non-defective product learning model by conducting machine learning using non-defective product data as teacher data, and generating a defective product learning model for each defect type by conducting machine learning for each defect type using defective product data as teacher data. A calculating procedure involves calculating the likelihood of a non-defective product from output data calculated using the non-defective product learning model to which target product data is input, and calculating the likelihood of a defective product for each defect type from output data calculated using the defective product learning model to which the target product data is input. A determining procedure involves determining that the target product data is data on a defective product having an unknown defect when the likelihood of a non-defective product and the likelihood of a defective product for each defect type satisfy a predetermined requirement.

Abstract: A method of inspecting for micro-cracks in a coated piece that includes a substrate and a coating, the method comprising generating a responsive spectral response from an area of inspection of the coated piece by irradiating at least a portion of the coated piece, the area of inspection being less than a predetermined nominal dimension of a micro-crack, and analyzing the responsive spectral response to determine whether a micro-crack exists in the coating, including by comparing the responsive spectral response to one or more predetermined spectral values to determine whether the responsive spectral response corresponds to a response associated with a substrate such as the substrate in the coated piece.

Abstract: This diagnosis support apparatus is a diagnosis support apparatus of a vacuum degassing tank having an immersion tube that extends downward, the diagnosis support apparatus including a camera that is configured to capture an image of an inner circumferential surface of an immersion tube seen from below at an angle in a state of being disposed outside the inner circumferential surface of the immersion tube in a plan view and acquire the image as data and an image processor that is configured to be connected to the camera and carry out image-processing of the data.

Abstract: Methods, systems, and apparatus for detection of a condition in a hole defined by a transparent material that is at least partially enclosed by one or more substantially opaque materials. The method may include positioning a light source in a first hole in the transparent material, directing light from the positioned light source through the transparent material and toward a second hole that is adjacent to the first hole. A prism may be positioned so that the light transmitted from the light source through the machined inner surface of the second hole is visible through a viewing face of the prism. By observing the transmitted light, a surface condition of the machined inner surface of the second hole may be determined.

Abstract: Embodiments of the disclosure include an extended length core sample scanning apparatus that enables the imaging of extended length core samples using medical-type CT scanners. The extended length core sample scanning apparatus has a frame that defines a U-shaped receptacle that receives core housing containing the core sample when the core sample is placed in a CT scanner. The extended length core sample scanning apparatus may have two or more rollers located in the U-shaped receptacle to enable translation of the extended length core sample through a CT scanner during scanning. The rollers may also provide for a minimum clearance between the core housing and the walls of the U-shaped receptacle. Methods of imaging an extended length core sample are also provided.

Abstract: A method of computed tomography includes illuminating an object with a cone of illumination, wherein the object is between a source of the cone of illumination and a two-dimensional photo-detector array. The method includes shielding the photodetector array from the collimator shield that includes a slit defined therethrough and moving the slit of the collimator shield across the photodetector array in a direction perpendicular to the slit to expose the photodetector array to the cone of illumination through the slit as the slit scans across the photodetector array to acquire a two-dimensional image of the object. The method includes rotating the object to a new rotational position and repeating movement of the slit to expose the photodetector and rotating the object along the axis until the object has been imaged from multiple rotational positions to form a three-dimensional model of the object.

Abstract: A method of analyzing fines migration in a multiphase flow in a sediment layer using X-ray computed tomography (CT) image includes, preparing an X-ray CT image analysis sample; analyzing an X-ray CT image during a depressurization process; calibrating and calculating a fines content; and estimating a fines migration analysis result.

Abstract: A method and apparatus for neutron radiography is provided for the examination of elongate radioactive items, primarily nuclear fuel elements, and also for the non-destructive testing of irradiated and non-irradiated objects in order to determine the internal structure and material composition thereof. The method and apparatus include placing an object under examination into a protective container. A detection system includes a rotatable limb with a mounting seat for securing neutron detectors in a diametric groove. The limb being mounted to be rotatable by a set angle about an axis parallel to the axis of the object under examination and having a semi-circular recess therein for the passage of an elongate object as the limb rotates by an angle ±?i relative to the direction of a neutron beam.

Abstract: The present invention relates to an in-vitro method of detecting Mtb infection by using SAXS profile of hair sample. The invention is an approach to overcome the problem of non-invasively and cost-effectively yet reliably diagnosing presence of active tuberculosis in the patient. There would be no risk to the sample handlers getting infected from the sample, cross-contamination of samples, low cost and quick turn-around time of diagnosis.

Abstract: A multi-charged particle beam inspection apparatus includes a movable stage to place thereon an inspection substrate where plural dies each with the same pattern are arranged in a predetermined direction, a pitch acquisition circuit to acquire an arrangement pitch of plural dies, a magnification control circuit to control, when imaging the inspection substrate with multi-charged particle beams while continuously moving the stage, magnification of the multi-charged particle beams to be a controlled magnification such that the arrangement pitch of the plural dies becomes a natural number (2 or greater) multiple of an imaging region cycle in the predetermined direction of plural imaging regions to be individually imaged by each beam at each arrangement position of the multi-charged particle beams, and an acquisition mechanism to acquire inspection images of the plural dies on the inspection substrate, using the multi-charged particle beams whose magnification has been controlled to be the controlled magnificatio

Abstract: The present disclosure provides a method of measuring a percent solids content (PSC) of solids by mass in a slurry catalyst composition, where the solids include a catalyst. The method includes obtaining a first time domain (TD) 1H-nuclear magnetic resonance (NMR) spectrum using a time domain (TD)-NMR spectrometer and a test sample of the slurry catalyst composition from which a value of a voltage signal (a) that represents the slurry catalyst composition is determined. A second TD 1H-NMR spectrum using the TD NMR spectrometer is obtained for a neat sample of the suspension liquid for the solids of the slurry catalyst composition, where a value of a voltage signal (b) from the second TD 1H-NMR spectrum that represents the suspension liquid for the solids of the slurry catalyst composition is determined.

Abstract: The object of the invention is to provide a thermal conductivity measuring device that comprises a heat generator arranged in such a way as to come into contact with an object to be measured for thermal conductivity, a heat resistant material arranged in such a way as to come into contact with the heat generator, at least one pair of differential thermocouples for measuring a voltage value caused by the difference in temperature of two points of the heat resistant material, the temperature being generated by allowing heat to flow from the heat generator, and a calculating device for calculating the time rate of change of output voltage of the differential thermocouples and then calculating the thermal conductivity of the object to be measured on the basis of the calculated time rate of change.

Abstract: An information processing apparatus calculates a first temperature of a temperature surface when a heat density of each of a plurality of heating cells is set to a first heat density, calculates a second temperature when heat densities of the plurality of heating cells are set to a second heat density obtained by adding a constant value to each of first heat densities, calculates a change coefficient according to a temperature difference between the first and second temperatures, determines a third heat density so that a third temperature becomes a desired target temperature, based on the change coefficient, determines a width of each of the plurality of heating cells, based on the third heat density, and changes a shape of each of the plurality of heating cells, based on the width by using mesh morphing.

Abstract: A method for manufacturing a gas sensor may be provided, the method comprising the steps of: preparing a metal nanowire; manufacturing a thermoelectric composite by adding a polymer bead to the metal nanowire, and then mechanically mixing same; manufacturing a thermoelectric layer by hot-pressing the thermoelectric composite; forming a first electrode on the upper surface of the thermoelectric layer, and forming a second electrode on the lower surface of the thermoelectric layer; and disposing a heating catalyst layer on the first electrode.

Abstract: Embodiments of the present disclosure relate to a method and system for detecting a presence and/or quantity of lead within a section of buried piping, without excavation, by calculating electrical resistance of a section of the piping. At least one embodiment of the present disclosure comprises coupling source leads of wire and sensor leads of wire to separated locations of a section of piping buried in a field setting. After the source leads and sensor leads are coupled, electrical current flow may be delivered to the section of piping via the source leads. A voltage level between the sensor leads may be measured via a voltmeter connected to the sensor leads. Resistance of the section of piping, as a function of the electrical current flow and the measured voltage level, is calculated to determine whether at least a portion of the section of piping includes lead and/or quantity of lead.

Abstract: Noncontact sensing components are provided herein, in an aspect, they can be for an electronic device. The noncontact sensing components can contain a semiconductor layer having a r-GO portion and a CNT portion. The noncontact sensing components can be used to detect the presence or movement of a humidity source in the vicinity of the noncontact sensing component. The resistance/humidity response of the component can be based on the combined contribution of carbon nanotube (positive resistance variation) and reduced-graphene oxide (negative resistance variation) behaviors.

Abstract: A method for manufacturing a gas sensor may be provided, the method comprising the steps of: preparing a porous base substrate; providing, on the porous base substarte, a source solution having graphene dispersed in a base solvent; manufacturing a graphene-impregnated base substrate by means of a driving process; and forming a first electrode and a second electrode on the graphene-impregnated base substrate.

Abstract: The present invention relates to a sensor for detecting one or more target analytes, the sensor comprising: at least one polymeric sensing element capable of selectively and reversibly binding to a target analyte; at least one working electrode having the polymeric sensing element disposed thereon; at least one reference electrode that is electrically communicated with said working electrode; and means for measuring a change in an electrical property across said working electrode and said reference electrode. In particular, the target analyte is Na+, urea or creatinine. Also disclosed is a multi-layered sensor, comprising at least one working electrode layer and at least one reference electrode layer, said working electrode layer and said reference electrode layer being separated by at least one electrically insulating layer.

Abstract: A method of detecting acetone in a gas sample, comprising, at an operation temperature of 50° C. or less, exposing the gas sample to a gas sensor comprising an electrode and a sensing material deposited on the electrode, wherein the sensing material comprises tungsten bronze, and a level of the acetone in the gas sample is detected by a change in resistivity of the sensing material.

Abstract: A gas sensor for detecting the concentration of a detection target gas in an atmosphere of interest is disposed on an electrically insulating member. The gas sensor includes an insulating porous layer formed of an electrically insulating porous material, a reference electrode, a solid electrolyte body, a detection electrode that are stacked in this order on the electrically insulating member, and a reference electrode lead disposed between the insulating member and the insulating porous layer. The insulating porous layer defines a through hole in a region sandwiched between the reference electrode lead and the reference electrode. An electrically conductive member formed of a material having electrical conductivity is disposed in the through hole so as to extend from an opening of the through hole at one end thereof to an opening of the through hole at the other end thereof.

Abstract: A measurement device including: an ion-sensitive element; a reference electrode disposed in a state in which a measurement subject is interposed between the reference electrode and the ion-sensitive element; and a controller configured to: establish a first state at a predetermined interval, the first state being a state in which a current flows at the ion-sensitive element, and establish a second state within each period after the first state has been established and before the first state is next established, the second state being a state in which a potential difference between the ion-sensitive element and the reference electrode is greater than a potential difference between the ion-sensitive element and the reference electrode in the first state.

Abstract: A sensor system configured to detect oxygen in an exhaust stream of an industrial process is provided. In one embodiment, the sensor system comprises a probe with an oxygen-detecting sensor, wherein the oxygen-detecting sensor detects a concentration of oxygen in the exhaust stream. The system may also comprise a catalytic converter located on the probe near the sensor, wherein the catalytic converter is configured to convert carbon monoxide to carbon dioxide. The system may also comprise a signal detector configured to detect a change in oxygen concentration indicative of a carbon monoxide breakthrough.

Abstract: A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet and an ion outlet, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and at least one ion steering channel controllable to selectively pass ions traveling through the single-pass drift tube into the multiple-pass drift tube via the ion inlet of the multiple-pass drift tube and to selectively pass ions traveling through the multiple-pass drift tube into the single-pass drift tube via the ion outlet of the multiple-pass drift tube. The single-pass drift tube separates in time ions traveling therethrough according to a first function of ion mobility, and the multiple-pass drift tube separates in time ions traveling one or more times therethrough according to the first or a second function of ion mobility.