Patents Issued in November 28, 2019
  • Publication number: 20190360965
    Abstract: This magnetic body inspection apparatus (100, 200, 300, 400) includes a magnetic field application unit (1) configured to apply a magnetic field in advance to a steel wire rope (W) and to adjust a magnetization direction of the steel wire rope (W), and is configured to detect a magnetic field change by a detector (2).
    Type: Application
    Filed: January 26, 2017
    Publication date: November 28, 2019
    Applicant: Shimadzu Corporation
    Inventor: Kenji Iijima
  • Publication number: 20190360966
    Abstract: System and method for measuring a gas concentration are provided. A ball sensor generates a collimated beam of a surface acoustic wave including fundamental wave of first frequency and harmonic wave of second frequency, which propagates through a orbital path on piezoelectric ball while passing through sensitive film to adsorb a target gas. Temperature control unit controls ball temperature of the ball sensor. Signal processing unit transmits a burst signal to sensor electrode of the ball sensor to excite the collimated beam, receives burst signals after the collimated beam has propagated a predetermined number of turns around the piezoelectric ball, and calculates the gas concentration and the ball temperature by first and second relative changes in delay times of the first and second frequencies, respectively, using waveform data of the burst signals.
    Type: Application
    Filed: November 6, 2017
    Publication date: November 28, 2019
    Applicant: Ball Wave Inc.
    Inventors: Kazushi YAMANAKA, Shingo AKAO, Nobuo TAKEDA, Toshihiro TSUJI, Toru OIZUMI, Yusuke TSUKAHARA
  • Publication number: 20190360967
    Abstract: A water hardness mitigation or treatment evaluation system includes a first quartz crystal microbalance cell and a fluid coupling adapted to be fluidly coupled to a pre-treated water to be flowed over a first quartz crystal. A second quartz crystal microbalance cell and a fluid coupling are adapted to be fluidly coupled to a post-treated water to be flowed over a second quartz crystal. A computer processor receives a first frequency data from the first quartz crystal and a second frequency data from the second quartz crystal and based on a difference of frequency over time between the first frequency data and the second frequency data, provides an indication of an effectiveness of a water hardness mitigation or treatment component or system. A method to evaluate and effectiveness of a water hardness mitigation or treatment evaluation system is also described.
    Type: Application
    Filed: May 21, 2019
    Publication date: November 28, 2019
    Inventors: Dorian Cauceglia, Thomas R. Whiteside, Pamela Eldridge, Nicholas J. Pusateri
  • Publication number: 20190360968
    Abstract: A gas sensor includes: a main elongate gas chamber with a supply opening arranged on a first end of the main gas chamber and a discharge opening positioned opposite the supply opening and arranged on a second end of the main gas chamber, to permit gas to flow through the main gas chamber; a magnetic field device providing a magnetic field in the main gas chamber; and an ultrasonic transmitter and receiver sensor arranged on either the first or second end of the main elongate gas chamber for directing an ultrasonic wave along a longitudinal axis of the main elongate gas chamber, an opposite end of the main elongate gas chamber being reflective for an ultrasonic wave, or an ultrasonic transmitter sensor arranged on a first end of the main elongate gas chamber and an ultrasonic receiver sensor arranged on a second end of the main elongate gas chamber.
    Type: Application
    Filed: December 20, 2017
    Publication date: November 28, 2019
    Inventors: Alan MASSEY, Yogesh SHINDE
  • Publication number: 20190360969
    Abstract: A method for nondestructively testing a part comprising an elongate microstructure is disclosed.
    Type: Application
    Filed: January 23, 2018
    Publication date: November 28, 2019
    Applicants: SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Aurélien Baelde, Frédéric Jenson, Mathias Fink, Jérôme Laurent, Claire Prada
  • Publication number: 20190360970
    Abstract: The ultrasound diagnostic apparatus acquires an ultrasound image for examining an inspection object using an ultrasonic beam, and includes a sound velocity determiner configured to determine a sound velocity in the inspection object, and a sound velocity searching range setting section configured to set a range in which a sound velocity is searched by the sound velocity determiner. The sound velocity searching range setting section sets a sound velocity searching range using a sound velocity calculated in a predetermined range with respect to at least one of space and time.
    Type: Application
    Filed: August 7, 2019
    Publication date: November 28, 2019
    Applicant: FUJIFILM Corporation
    Inventor: Hiroaki YAMAMOTO
  • Publication number: 20190360971
    Abstract: The present invention discloses an apparatus and a method for evaluating properties of a temporary plugging agent based on acoustic emission, wherein the apparatus includes a fracturing machine, an acoustic emission sensor and an acoustic emission analyzer, wherein the fracturing machine is configured to load a sample when oil pressure is stable and remains unchanged in a fracture of the sample, a real fracturing condition being simulated for the sample, and oil being pumped in and a temporary plugging agent being placed into the fracture; the acoustic emission sensor is configured to detect an acoustic wave signal emitted by the sample when the fracturing machine loads the sample; and the acoustic emission analyzer is connected to the acoustic emission sensor and configured to determine that the temporary plugging agent is fractured when a fracture signal occurs in the acoustic wave signal.
    Type: Application
    Filed: November 27, 2018
    Publication date: November 28, 2019
    Inventors: Guangqing Zhang, Xuejing Han
  • Publication number: 20190360972
    Abstract: A sensor for a gas turbine includes a sensor element, including or consisting of a polymer-derived ceramic, and a pre-stressing device that is designed to pre-stress the sensor element against a surface. A method for producing a sensor for a gas turbine includes the following steps: providing a sensor element including or consisting of a polymer-derived ceramic, and providing a pre-stressing device that is designed to pre-stress the sensor element against a surface.
    Type: Application
    Filed: May 7, 2019
    Publication date: November 28, 2019
    Inventors: Linbo TANG, Felix ROSENBURG, Roland WERTHSCHUETZKY, Ralf RIEDEL
  • Publication number: 20190360973
    Abstract: Systems and methods are provided for ultrasonic inspection. One embodiment is a method for ultrasonic inspection. The method includes selecting an ultrasonic probe having an array of transducers arranged in an arc, placing the ultrasonic probe atop a surface of a part having a first radius of curvature, dynamically aligning the transducers of the array with respect to the surface, forming an ultrasonically conductive pathway between the transducers and the part, and inspecting the part via ultrasonic waves transmitted from the transducers.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 28, 2019
    Inventors: Fred D. Young, Hien Thuong Bui
  • Publication number: 20190360974
    Abstract: A sensor for ultrasonically measuring a portion of a structure having a temperature significantly above room-temperature, the sensor comprising: a high-temperature portion for intimate contact with the structure, the high-temperature portion comprising at least: at least one transducer for converting a first signal to an ultrasonic transmit signal, and for converting an ultrasonic reflected signal to a second signal; a low-temperature portion comprising at least: at least one digital sensor interface (DSI) to which the transducer is electrically connected, the DSI being configured to transmit the first electrical signal and receive the second electrical signal, and to generate an A-scan signal based on the first and second electrical signals; a wireless interface for transmitting a digital signal based directly or indirectly on at least said A-scan signal; and a battery for powering the DSI and the wireless interface; and an elongated member containing one or more electrical conductors for conducting the firs
    Type: Application
    Filed: January 9, 2018
    Publication date: November 28, 2019
    Inventors: James BARSHINGER, Mark FEYDO, Jeffrey ANDERSON
  • Publication number: 20190360975
    Abstract: A photoacoustic gas sensor includes a hermetically sealed housing filled with a reference gas. The photoacoustic gas sensor furthermore includes a microphone arranged in the housing and configured to generate a microphone signal as a function of a sound wave based on light incident in the housing. Furthermore, the photoacoustic gas sensor includes a controllable heat source arranged in the housing and configured to selectively thermoacoustically excite the reference gas in order to generate a thermoacoustic sound wave phase-shifted with respect to the sound wave.
    Type: Application
    Filed: May 10, 2019
    Publication date: November 28, 2019
    Inventors: Matthias Eberl, Thomas Albrecht
  • Publication number: 20190360976
    Abstract: Pipeline inspection systems are provided. In one embodiment, a pipeline inspection system can include at least one sensor module having a module body and a plurality of sensor holders mounted to the module body. Each sensor holder can include a holder body with a first body end, a second body end, and a plurality of sensors positioned therebetween, and a plurality of rotational guides that can be coupled to the holder body and configured to be biased towards an interior surface of the pipeline wall so as to define a standoff distance between each sensor and the interior surface of the pipeline wall. Each sensor holder can be at least partially pivotable about a longitudinal axis of the holder body extending between the first body end and the second body end. Methods of inspecting a pipeline are also provided.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 28, 2019
    Inventors: Volker Frueh, Heiko Witte
  • Publication number: 20190360977
    Abstract: A fluid network controls a gaseous flow, the fluid network having several pre-concentration units including at least one first series in which the pre-concentration units are linked in series and each defined by a rank j in the series, with j ranging from 1 to m and m being greater than or equal to 2. Each pre-concentration unit of the network includes a cavity filled with an adsorbent material, at least one first fluid pathway emerging in the cavity, at least one second fluid pathway emerging in the cavity. Finally, each pre-concentration unit includes a component for heating the cavity.
    Type: Application
    Filed: May 24, 2019
    Publication date: November 28, 2019
    Applicant: Commissariat A L'Energie Atomique et aux Energies Alternatives
    Inventor: Bertrand BOURLON
  • Publication number: 20190360978
    Abstract: The objective of the present invention is to provide a more accurate method and system for analyzing a sample containing an optical isomer. This method is characterized in that, with reference to results of chromatography, fractions for which complete separation from one or a plurality of chromatograph peaks corresponding to one or a plurality of other components has been achieved, from the time at which the peak starts to rise from the baseline until the peak has completely returned to the baseline, are successively fractionated separately, and if complete separation cannot be achieved for a single component, the fractionated fraction is subjected to additional chromatography, and if complete separation is achieved, the fractionated fraction is subjected to chiral chromatography.
    Type: Application
    Filed: November 15, 2017
    Publication date: November 28, 2019
    Applicant: SHISEIDO COMPANY, LTD.
    Inventors: Kenji HAMASE, Reiko KOGA, Masashi MITA
  • Publication number: 20190360979
    Abstract: A gas chromatographic (GC) column using a zwitterionic compound and methods of use thereof are disclosed herein. The volatile free acids were observed to strongly retain on these zwitterionic compounds-based columns with excellent peak symmetry. By carefully tuning the structures of these zwitterionic compounds, different selectivity toward volatile free acids was demonstrated. These stationary phases possess a wide working range with thermal stabilities at higher temperatures.
    Type: Application
    Filed: December 21, 2018
    Publication date: November 28, 2019
    Inventors: Jared L. Anderson, Kosuke Kuroda, He Nan
  • Publication number: 20190360980
    Abstract: Disclosed are methods for detecting protein sequence variants and evaluating the probability of generating protein sequence variants in biological product manufacturing.
    Type: Application
    Filed: February 2, 2018
    Publication date: November 28, 2019
    Applicants: LONZA LTD, LONZA LTD
    Inventor: James GRAHAM
  • Publication number: 20190360981
    Abstract: For improving sensitivity, dynamic range, and specificity of GC-MS analysis there are disclosed embodiments of novel apparatuses based on improved characteristics of semi-open source with electron impact ionization, providing much higher brightness compared to known open EI sources. In an implementation, the source becomes compatible with multi-reflecting TOF analyzers for higher resolution analysis for improving detection limit. With improved schemes of spatial and temporal refocusing there are proposed various tandem TOF-TOF spectrometers with PSD, CID, and SID fragmentation and using either singly reflecting TOF or MR-TOF analyzers.
    Type: Application
    Filed: August 7, 2019
    Publication date: November 28, 2019
    Inventor: Anatoly N. Verenchikov
  • Publication number: 20190360982
    Abstract: A chromatography analyzer system (10) for analyzing a sample (12) includes a MIR analyzer (34) for spectrally analyzing a sample fraction (12A) while the sample fraction (12A) is flowing in the MIR analyzer (34). The MIR analyzer (34) includes (i) a MIR flow cell (35C) that receives the flowing sample fraction (12A), (ii) a MIR laser source (35A) that directs a MIR beam (35B) in a MIR wavelength range at the sample fraction (12A) in the MIR flow cell (35C), and (iii) a MIR detector (35D) that receives light from the sample fraction (12A) in the MIR flow cell (35C) and generates MIR data of the sample fraction (12A) for a portion of the MIR wavelength range.
    Type: Application
    Filed: August 9, 2019
    Publication date: November 28, 2019
    Inventors: Miles James Weida, Bruce Coy, David F. Arnone
  • Publication number: 20190360983
    Abstract: The present invention relates to a method for determining the origin of glutamic acid in a sample and, in a broader sense, relates to a method for determining the origin of an amino acid. The present invention makes it possible to measure the stable isotope ratio, with a considerably higher accuracy than that of conventional methods, by measuring the ?13C of glutamic acid (amino acid) by elemental analysis-stable isotope ratio mass spectrometry (EA-IRMS) and measuring the ?15N by gas chromatography-stable isotope ratio mass spectrometry (GC-IRMS). In addition, the present invention makes it possible to determine the origin of glutamic acid (amino acid) by comparing the stable isotope ratio of the glutamic acid (amino acid) whose origin is unclear with the stable isotope ratio of glutamic acid (amino acid) whose origin is clear.
    Type: Application
    Filed: January 31, 2018
    Publication date: November 28, 2019
    Inventors: Masaharu TANAKA, Yoichi YATSUKAWA, Kazuhiro KOBAYASHI, Soichi TANABE, Mitsuru TANAKA
  • Publication number: 20190360984
    Abstract: The present disclosure relates to an optical luminescence dual sensor comprising a polymerized form of a probe for sensing pH; a polymerized form of a probe for sensing oxygen; a polymerized form of an internal reference probe; and a matrix. The present disclosure also relates to methods of preparing an optical luminescence dual sensor and methods of using them.
    Type: Application
    Filed: January 19, 2018
    Publication date: November 28, 2019
    Inventors: Liqiang Zhang, Xiangxing Kong, Yanqing Tian, Deirdre Meldrum, Fengyu Su
  • Publication number: 20190360985
    Abstract: A combustion analyzer system includes an analyzer unit, a primary analysis probe and one or more remote probes. The analyzer unit includes a condensation removal unit and two or more electrochemical sensors to detect at least oxygen and carbon monoxide. The analyzer unit also includes a means for sealing or isolating the electrochemical sensor inputs to prevent oxidation of the reactive elements when the unit is not in use.
    Type: Application
    Filed: May 9, 2019
    Publication date: November 28, 2019
    Applicant: Fieldpiece Instruments, Inc.
    Inventor: Tinggui Hong
  • Publication number: 20190360986
    Abstract: The present invention relates to a method for the determination of processing influences on the quality of feedstuff raw materials and/or feedstuffs, in which the processing conditions indicator of the of feedstuff raw materials and/or feedstuffs is determined and the specific digestibility coefficient of an amino acid of a feedstuff raw material and/or feedstuff in an animal species is determined. The present invention also relates to a process for the optimization of feedstuffs considering the determined processing influences and the thus obtained and/or obtainable feedstuffs.
    Type: Application
    Filed: February 12, 2018
    Publication date: November 28, 2019
    Applicant: Evonik Degussa GmbH
    Inventors: Markus WILTAFSKY, Ingolf REIMANN, JOHANN FICKLER, Meike RADEMACHER-HEILSHORN
  • Publication number: 20190360987
    Abstract: Apparatus, methods and kits for detecting the contamination of a meat sample with another type of meat using parent-daughter ion transition monitoring that identifies peptides specific to a particular type of meat. The meat types detected can include pork, beef, lamb, chicken, duck and/or horse and one or more combinations thereof.
    Type: Application
    Filed: September 7, 2017
    Publication date: November 28, 2019
    Inventors: Lihai Guo, Huafen Liu, Stephen Lock, Si Mou, PeiBin Qin, Lei Xiong
  • Publication number: 20190360988
    Abstract: A chemical oxygen demand (COD) of a sample including water is determined. At least two test specimens are obtained. Each of the test specimens include a mixture of the sample and a standard solution including potassium hydrogen phthalate (KHP) in a known concentration. Each of the specimens include a same amount of the sample. Each of the specimens include different amounts of the standard solution. Each of the specimens is diluted with water. A COD of each of the specimens is measured. A COD of the sample is determined based on the measured CODs of the specimens.
    Type: Application
    Filed: May 22, 2018
    Publication date: November 28, 2019
    Inventors: Nasir Ullattumpoyil, Abdulaziz M. Rueshed
  • Publication number: 20190360989
    Abstract: A system, device, and method for detecting and quantifying an analyte in a liquid include a vial having one or more pre-dosed reagents disposed in the vial. The vial is configured to hold a volume of a liquid including an analyte. The one or more pre-dosed reagents are dissolvable in the volume of the liquid to form a sample liquid solution comprising chromophores or fluorophores. The analyte and the one or more pre-dosed reagents react to yield the chromophores or fluorophores. The system further includes a detection device including a chamber configured to retain the vial, the detection device configured to quantify the analyte in the sample liquid solution. A device and method may perform the functions of the system.
    Type: Application
    Filed: August 7, 2019
    Publication date: November 28, 2019
    Inventors: Christopher Lloyd, Andrew Duncan
  • Publication number: 20190360990
    Abstract: A method for determining properties of a hydrocarbon-containing gas mixture includes determining a thermal conductivity value, density measurement, viscosity measurement, and temperature and pressure. The method also includes determining a hydrogen content of the gas mixture on the basis of the thermal conductivity value and the temperature and pressure, determining a density measurement and associated temperature and pressure, and determining the mean molar mass or standard density on the basis of the density measurement and the temperature and pressure. The method further includes determining the mean molar mass or standard density of a hydrogen-free residual gas mixture based on the mean molar mass or standard density and the hydrogen fraction, determining the Wobbe index of the residual gas mixture based on the viscosity measurement and the temperature and pressure, and determining a calorific value based on the mean molar mass or standard density and the Wobbe index.
    Type: Application
    Filed: October 10, 2017
    Publication date: November 28, 2019
    Inventors: Christof Huber, Patrick Reith, Anastasios Badarlis
  • Publication number: 20190360991
    Abstract: Embodiments of the disclosure can include systems, methods, and devices for determining saturation pressure of an uncontaminated fluid. Downhole saturation pressure measurements and downhole OBM filtrate contamination of a contaminated fluid may be obtained and a relationship may be determined between the saturation pressure measurements and OBM filtrate contamination. The relationship may be extrapolated to zero OBM filtrate contamination to determine the saturation pressure of the uncontaminated fluid. In some embodiments, OBM filtrate contamination may be determined from downhole saturation pressure measurements during pumpout of a fluid.
    Type: Application
    Filed: August 5, 2019
    Publication date: November 28, 2019
    Inventors: Youxiang Zuo, Christopher Harrison, Adriaan Gisolf, Cosan Ayan, Michael Mallari Toribio, Chetankumar Natwarlal Desai, Oliver Clinton Mullins, Matthew T. Sullivan, Elizabeth Smythe
  • Publication number: 20190360992
    Abstract: A leather inspection apparatus is provided for detecting inconsistencies on both upper and lower surfaces of a hide. It includes a first camera assembly movably coupled to a support frame and capable of movement along the upper surface of the hide and a second camera assembly movably coupled to the support frame and capable of movement along the lower surface of the hide. A computing device is coupled to the first camera assembly and the second camera assembly, such that the first camera assembly detects the locations of inconsistencies in the upper surface of the hide and the second camera assembly detects the locations of inconsistencies in the lower surface of the hide. The computing device digitally stores the locations of the inconsistencies of the upper surface of the hide and the locations of the inconsistencies of the lower surface of the hide.
    Type: Application
    Filed: May 21, 2019
    Publication date: November 28, 2019
    Inventors: Ming-Ji Lee, Chin-Yi Lin, Chun-Yen Tseng
  • Publication number: 20190360993
    Abstract: The present technology generally relates to a method for modulating in situ production of energy by a biological tissue. The method comprises stimulating the biological tissue by exposing the biological tissue to a photostimulated biophotonic composition for a time sufficient to initiate the production of energy by the biological tissue.
    Type: Application
    Filed: February 8, 2018
    Publication date: November 28, 2019
    Inventors: Nikolaos LOUPIS, Remigio PIERGALLINI, David OHAYON, Lise HÉBERT, Giovanni SCAPAGNINI
  • Publication number: 20190360994
    Abstract: Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.
    Type: Application
    Filed: August 7, 2019
    Publication date: November 28, 2019
    Inventors: Daniel Levner, Christopher David Hinojosa, Andries D. van der Meer, Marinke van der Helm, Abhishek Jain, Donald Elliot Ingber, Marjon Zamani
  • Publication number: 20190360995
    Abstract: Disclosed herein is a microelectrode platform that may be used for multiple biosystem applications including cell culturing techniques and biosensing. Also disclosed are microfabrication techniques for inexpensively producing microelectrode platforms.
    Type: Application
    Filed: May 6, 2019
    Publication date: November 28, 2019
    Inventors: Swaminathan RAJARAMAN, Lei ZHAI, Avra KUNDU, Nilab AZIM
  • Publication number: 20190360996
    Abstract: Integrated circuits for sensing biological molecules are disclosed. The integrated circuits can be used to measure the impedance of a biological sample under test. The integrated circuits can be used to sequence polynucleotides using a cell array.
    Type: Application
    Filed: May 23, 2019
    Publication date: November 28, 2019
    Inventors: STEPHEN F. DREYER, PRIYANKA AGRAWAL, HUI TIAN
  • Publication number: 20190360997
    Abstract: The invention relates to devices and methods for nanopore sequencing. Methods for controlling translocation of through the nanopore are disclosed. The rate of transport of the template nucleic acids through the nanopore can be controlled using a translocating enzyme having two slow, or kinetically observable kinetic steps. The translocating enzyme and reaction conditions can be selected such that the translocating enzyme exhibits two kinetic steps wherein each of the kinetic steps has a rate constant, and the ratio of the rate constants of the kinetic steps is from 5:1 to 1:5. The invention also provides for using the signals from n-mers to provide sequence information, for example where the system has less than single base resolution. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS.
    Type: Application
    Filed: April 8, 2019
    Publication date: November 28, 2019
    Inventors: Stephen Turner, Benjamin Flusberg
  • Publication number: 20190360998
    Abstract: Hybrid nanopores, comprising a protein pore supported within a solid-state membrane, which combine the robust nature of solid-state membranes with the easily tunable and precise engineering of protein nanopores. In an embodiment, a lipid-free hybrid nanopore comprises a water soluble and stable, modified portal protein of the Thermus thermophilus bacteriophage G20c, electrokinetically inserted into a larger nanopore in a solid-state membrane. The hybrid pore is stable and easy to fabricate, and exhibits low peripheral leakage, allowing sensing and discrimination among different types of biomolecules.
    Type: Application
    Filed: May 17, 2019
    Publication date: November 28, 2019
    Inventors: Meni Wanunu, Alfred Antson, Sandra Greive, Benjamin Cressiot
  • Publication number: 20190360999
    Abstract: Disclosed are a method and an apparatus (2) for analyzing a body fluid sample from a sampler, the apparatus (2) comprising: a sampler bed (4) comprising a plurality of slots (10), each slot being configured to receive a sampler containing a body fluid sample; an analyzing unit configured to analyze body fluid samples; at least one inlet (6) configured to withdraw a body fluid sample from a sampler from any of the slots (10) for provision of the withdrawn body fluid sample to the analyzing unit; and at least one display unit comprising at least one display area (8); the apparatus being configured to display graphical information simultaneously within a plurality of primary zones (12) of the at least one display area, wherein the plurality of primary zones comprises a primary zone for each slot (10), and wherein each of the primary zones (12) individually faces a respective slot (10), and wherein the graphical information comprises a respective primary graphical information part within each primary zone, and wh
    Type: Application
    Filed: December 4, 2017
    Publication date: November 28, 2019
    Inventors: Kasper Nedergaard SØRENSEN, Frederik BUNDGAARD, Kristian HVIDTFELDT, Nina Pytter LAURSEN
  • Publication number: 20190361000
    Abstract: Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided.
    Type: Application
    Filed: August 7, 2019
    Publication date: November 28, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Ravinder J. Singh, Robert L. Taylor, Stefan K.G. Grebe
  • Publication number: 20190361001
    Abstract: The present invention relates to a sensor chip and more particularly to the sensor chip for detection of acetone. In one embodiment, the sensor chip comprising: a first layer having a nano-porous silicon fabricated on a P-type Si <100> substrate, a second layer having molybdenum trioxide (MoO3) in contact with the first layer and a third layer having chrome gold inter digitated electrodes in contact with the second layer.
    Type: Application
    Filed: September 22, 2017
    Publication date: November 28, 2019
    Inventors: Saakshi DHANEKAR, Priyanka DWIVEDI, Samaresh DAS
  • Publication number: 20190361002
    Abstract: The present invention is related to the field of bio/chemical sensing, assays and applications. Particularly, the present invention is related to collecting a small amount of a vapor condensate sample (e.g. the exhaled breath condensate (EBC) from a subject of a volume as small as 10 fL (femto-Liter) in a single drop), preventing or significantly reducing an evaporation of the collected vapor condensate sample, analyzing the sample, analyzing the sample by mobile-phone, and performing such collection and analysis by a person without any professionals.
    Type: Application
    Filed: August 6, 2019
    Publication date: November 28, 2019
    Applicant: Essenlix Corporation
    Inventors: Stephen Y. CHOU, Wei DING
  • Publication number: 20190361003
    Abstract: The invention relates generally to systems and methods of bioenergetic profiling, uses thereof, and systems and devices relating thereto. In particular, methods of the invention are useful in assessing wellness, particularly in elderly subjects. Described are systems and methods of assessing likelihood of subject morbidity, life expectancy, positive clinical outcome, responsiveness to treatment, and certain disease states as well as of selecting treatment strategy, improving outcome to treatment strategy, and treating subjects with low bioenergetic profiles. Also described are devices and systems for measuring respiratory capacity.
    Type: Application
    Filed: April 5, 2019
    Publication date: November 28, 2019
    Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
    Inventors: Anthony J.A. Molina, Jeff Williamson, Stephen Kritchevsky
  • Publication number: 20190361004
    Abstract: A method of inhibiting an overactive fibroblast growth factor receptor 3 (FGFR3) in a cell by contacting the cell with a composition that contains an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Also disclosed is a method for treating a disorder associated with an overactive FGFR3 with a composition containing an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Further, a composition for treating a disorder associated with an overactive FGFR3 is described. The composition contains an ethanol extract of Amaranthus viridis.
    Type: Application
    Filed: February 8, 2018
    Publication date: November 28, 2019
    Applicants: ACADEMIA SINICA
    Inventors: Yuan-Tsong Chen, Yi-Ching Lee, Jer-Yuarn Wu, Hsiao-Jung Kao
  • Publication number: 20190361005
    Abstract: A method of identifying a subject having cancer who is likely to be responsive to a treatment compound, comprising administering the treatment compound to the subject having the cancer; obtaining a sample from the subject; determining the level of a biomarker in the sample from the subject; and diagnosing the subject as being likely to be responsive to the treatment compound if the level of the biomarker in the sample of the subject changes as compared to a reference level of the biomarker; wherein the treatment compound is Compound 1, Compound 2, or Compound 3.
    Type: Application
    Filed: May 22, 2019
    Publication date: November 28, 2019
    Inventors: Maria Soraya Carrancio Anton, Joshua Hansen, Courtney G. Havens, Antonia Lopez-Girona, Gang Lu, Daniel W. Pierce, Lilly L. Wong
  • Publication number: 20190361006
    Abstract: The invention provides methods of predicting responsiveness of an individual having a cancer to administration of an anticancer drug regimen using a tumor tissue culture capable of mimicking physiologically relevant signaling, where the prediction depends in part on an immune contexture phenotype in the tumor tissue culture.
    Type: Application
    Filed: February 7, 2018
    Publication date: November 28, 2019
    Inventors: Aaron GOLDMAN, Pradip K. MAJUMDER, Padhma D. RADHAKRISHNAN
  • Publication number: 20190361007
    Abstract: The invention relates to a bioassay of insulin peptide in oral formulations and low affinity insulin peptides in liquid formulations, by for quantifying phosphorylated Akt, thereby avoiding the interference of excipients in potency determination.
    Type: Application
    Filed: October 24, 2017
    Publication date: November 28, 2019
    Inventors: Louise Hjerrild Zeuthen, Jan Amstrup, Thomas Aaskov Pedersen
  • Publication number: 20190361008
    Abstract: Apparatus and method for separating whole cells from a mixture, e.g., including liquid, other cell types, nucleic acid material, or other components. Focused acoustic energy may be used to move whole cells in a chamber so that the cells exit the chamber via a first outlet rather than a second outlet. A filter may, or need not, be used to assist in separation.
    Type: Application
    Filed: May 22, 2019
    Publication date: November 28, 2019
    Applicant: Covaris, Inc.
    Inventors: James A. Laugharn, JR., Carl BECKETT, Srikanth KAKUMANU
  • Publication number: 20190361009
    Abstract: Coating compositions are described that include one or more rare metal components, such as rare alkali metal components, as well as diagnostics test elements that incorporate the same. Methods also are described for determining an amount of a dried coating composition in a coat based upon the rare metal components.
    Type: Application
    Filed: March 29, 2019
    Publication date: November 28, 2019
    Applicant: Roche Diabetes Care, Inc.
    Inventors: Wolfgang Schick, Alexander Ibach, Yilmaz Isgören, Kai Küllmer
  • Publication number: 20190361010
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from one or more cells. Such polynucleotide processing may be useful for a variety of applications, including generation of labeled macromolecules, including major mistocompatability complex (MHC) molecules, dextramers, etc. Labeled macromolecules may be generated using an in vitro transcription reaction. Labeled macromolecules may be generated in one or more partitions.
    Type: Application
    Filed: April 4, 2019
    Publication date: November 28, 2019
    Inventors: Kamila Belhocine, Jason Bell, Zachary Bent, Rajiv Bharadwaj, Christopher Hindson, Mohammad Rahimi Lenji, Bill Kengli Lin, Anthony Makarewicz, Geoffrey McDermott, Elliott Meer, Francesca Meschi, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Michael Schnall-Levin, Sarah Taylor, Jessica Michele Terry, Tobias Daniel Wheeler, Yifeng Yin, Xinying Zheng, Solongo Batjargal Ziraldo, Eswar Prasad Ramachandran Iyer, Luigi Jhon Alvarado Martinez
  • Publication number: 20190361011
    Abstract: The compositions described herein include a substrate, wherein the substrate is a metal, metal oxide, metal nitride or a silicon containing material; a self-assembled monolayer (SAM) bonded to the substrate, wherein the self-assembled monolayer comprises: a surface binding unit bonded to the substrate, wherein the surface binding unit is selected from the group consisting of hydroxamates, phosphonates, catechols, halosilanes, alkoxysilanes, phosphonic acids, alkenes, alkynes, alcohols, 1,2-diols, and thiols; a separator unit bonded to the surface binding unit; a mass altering unit bonded to the separator unit; and a detector unit bonded to the separator unit.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 28, 2019
    Inventors: Bharat KUMAR, Sufi ZAFAR, Ali AFZALI-ARDAKANI
  • Publication number: 20190361012
    Abstract: This invention relates to a method of determining ligands of macromolecules, said method comprising or consisting of (a) subjecting a sample comprising (i) complexes formed by said macromolecules and said ligands and (ii) unbound ligands to a method which separates said complexes from said unbound ligands; (b) releasing ligands from complexes obtained in step (a); and (c) subjecting the released ligands obtained in step (b) to a chemical analysis method, thereby determining said ligands of said macromolecules.
    Type: Application
    Filed: May 29, 2017
    Publication date: November 28, 2019
    Inventors: Aleksandra SKIRYCZ, Sylwia KIERSZNIOWSKA, Daniel VEYEL, Lothar WILLMITZER, Monika CHODASIEWICZ
  • Publication number: 20190361013
    Abstract: The present invention refers to a method for determining the ability of an immunoglobulin to bind to a post-translationally modified target in an intracellular environment, which folds and it is post-translationally modified as a native protein intracellularly. The present invention also refers to antibodies obtained by the above method and uses thereof.
    Type: Application
    Filed: November 2, 2016
    Publication date: November 28, 2019
    Inventors: Antonino CATTANEO, Michele CHIRICHELLA
  • Publication number: 20190361014
    Abstract: A protein kinase that includes a donor molecule and an acceptor molecule, methods of making the protein kinase, and methods of using the protein kinase are described. Measurement of the conformation of the kinase can be obtained using intramolecular FRET. The protein kinase can be used to, for example, identify conformational changes involved in kinase regulation, that is, as an allostery sensor; to identify kinase-binding molecules including, for example, kinase inhibitors; to identify cancer therapeutics; or for high-throughput screening.
    Type: Application
    Filed: September 8, 2017
    Publication date: November 28, 2019
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Nicholas Mark Levinson, Emily Ruff, Joseph M. Muretta, David D. Thomas, Eric Lake