Abstract: Immunosensors according to present embodiments combine a sandwich bioassay with an electro-active, integrated optical waveguide (EA-IOW) for the detection of infectious pathogens and other analytes from a sample, whereby the electro-active waveguide surface is functionalized with a capture antibody capable of specific binding with a particular antigen. This functionalized arrangement then promotes the binding of a secondary, labeled antibody serving as a redox probe, which produces an analytical signal having unique spectral and electrochemical properties for the detection of virus antigens, pathogens, and other analytes that bind to proteins.

Abstract: The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the first probe is coupled to a detectable piece, the target is coupled to the first probe and the second probe, and the second probe is coupled to a solid support. Specific binding of the detectable piece to the target analyte can be distinguished from non-specific binding of the detectable piece by measuring the number of detectable pieces that leave their initial location after exposure to a disruptor that uncouples the detectable piece from the solid support.

Abstract: Methods and systems for identifying a protein within a sample are provided herein. A panel of antibodies are acquired, none of which are specific for a single protein or family of proteins. Additionally, the binding properties of the antibodies in the panel are determined. Further, the protein is iteratively exposed to a panel of antibodies. Additionally, a set of antibodies which bind the protein are determined. The identity of the protein is determined using one or more deconvolution methods based on the known binding properties of the antibodies to match the set of antibodies to a sequence of a protein.

Abstract: The present invention provides materials and methods for determining optimal dosage regimens for therapeutic agents. In particular, the invention relates to dosage regimens for therapeutic agents capable of targeting IL-2 receptor, preferably interleukin 2 (IL2)-based therapeutic agents. The methods of the invention allow general dosage regimens to be determined for new IL-2R targeted therapeutic agents but also specifically tailored dosage regimens to be achieved for individuals being treated with IL-2R targeted therapeutic agents.

Abstract: A use of a pentaxin-related protein 3 (PTX3) or a fragment thereof, in the preparation of a reagent for diagnosing an anti-citrulline polypeptide antibody-negative rheumatoid arthritis disease, is provided. 35 proteins as candidate ACPA-negative RA autoantigens were screened by hybridizing high density protein chips with RA serum. 4 protein antigens were identified as having high sensitivity and specificity in the ACPA-negative serum of RA, and all were newly discovered autoantigens (DOHH, DUSP11, PTX3, and PAGE5). The invention indicates that DOHH, DUSP11, PTX3, and PAGE5 can be used as ACPA-negative RA diagnostic markers.

Abstract: A method for treating a respiratory conditions comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR2, CCR1, CCR3, CCR5, CXCR1, CXCR2 and/or CCR7 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR2, CCR1, CCR3, CCR5, CXCR1, CXCR2 and/or CCR7 expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.

Abstract: Assays, arrays, and methods for distinguishing a bacterial infection from a viral infection are disclosed. The antibiotic crisis is in part driven by over prescription of antibiotics. There is a tendency, particular in pediatrics, to give an antibiotic even for viral infections. Thus, embodiments herein are directed to the problem of distinguishing a bacterial infection from a viral infection to reduce unnecessary antibiotic usage.

Abstract: The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).

Abstract: Provided is an information providing method including the steps of acquiring a biological sample separated from a specimen, identifying concentration of a protein, TNF-related apoptosis-inducing ligand (TRAIL) in the cerebrospinal fluid from the said biological sample, comparing the concentration of the said identified TRAIL to a reference value, and providing information related to encephalitis disorder according to the said results of comparison.

Abstract: A method of screening for colorectal cancer, including testing a person's feces, blood or urine for indications of colorectal cancer; if the results of the testing are negative scanning the walls of the colon with an X-ray imaging capsule to identify signs of abnormal growths; or scanning the walls of the colon with an X-ray imaging capsule to identify signs of abnormal growths; if the results of the scanning are negative testing a person's feces for indications of colorectal cancer. Wherein if the results of either the testing or the scanning are positive recommending examining the person with a colonoscopy examination, otherwise recommending retesting in a few years.

Abstract: Methods and compositions are provided for detecting, diagnosing and evaluating presence of prostate cancer in a biological sample.

Abstract: The instant disclosure provides biomarkers and methods for identifying subjects at risk of developing cytokine release syndrome (CRS), neurotoxicity, or both after adoptive immunotherapy to guide preemptive intervention, modified therapy, or the like. For example, adverse event biomarkers may be measured in a subject before pre-conditioning chemotherapy, before immunotherapy (e.g., adoptive immunotherapy infusion comprising a chimeric antigen receptor (CAR) modified T cell), or shortly after pre-conditioning chemotherapy and/or immunotherapy. Exemplary biomarkers include temperature, cytokine levels and endothelial activation biomarkers, such as angiopoietin 2, von Willebrand factor (vWF), ratio of angiopoietin 2 to angiopoietin 1, and ratio of ADAMTS13 to vWF. Also provided are methods of treating subjects identified as at risk of developing cytokine release syndrome (CRS), neurotoxicity, or both to minimize such potential adverse events.

Abstract: The present disclosure relates generally to determining the risk of developing breast cancer. In particular, the present disclosure provides materials and methods for determining whether a subject diagnosed with a non-cancerous breast tumor will develop cancer based on expression of multiple oncogenic biomarkers in the non-cancerous breast tumor. The present disclosure also provides a cancer risk score to determine whether a subject has low risk, intermediate risk, or high risk of developing cancer, thereby permitting selection of appropriate therapies to treat the subject. The present disclosure addresses the need for improved diagnostic assessment of early hyperplastic lesions, the presence of which in a subject is a significant indicator that a subject will eventually develop invasive breast cancer.

Abstract: Uncomplexed neutrophil gelatinase associated lipocalin (NGAL) is present at increased levels in individuals with atypical ductal hyperplasia (ADH), a major risk factor for future breast cancer development; in individuals that have ovarian cancer; and in individuals that have breast cancer, both invasive and noninvasive. Accordingly, the present invention is directed to measuring uncomplexed NGAL levels in urine as a primary screen to determine if an individual is either at risk of developing, or has developed cancer, e.g., cancer of epithelial origin including breast and ovarian cancer.

Abstract: The object of the present invention is to provide insoluble carrier particles used for high-sensitivity rapid immunoassay, which allow visual observation and high-sensitivity apparatus measurement. The insoluble carrier particles are visible colored insoluble carrier particles labeled with a fluorescent dye, which are used for immunoassay, wherein absorption of fluorescence by the visible colored insoluble carrier particles is low within a wavelength range of fluorescence emitted by the fluorescent dye.

Abstract: The present invention relates to a kit for radiolabelling a targeting agent with gallium-68. The present invention also relates to the use of said kit for radiolabelling a targeting agent, a method for radiolabelling a targeting agent with gallium-68 using said kit, said kit and a method of preparation.

Abstract: Provided herein, in some embodiments, are methods and compositions for protein identification.

Abstract: Disclosed are various embodiments for automated drug assays. A command is sent to the mass spectrometer to analyze a blood sample to generate a mass spectrum. The mass spectrum is then received from the mass spectrometer. The mass spectrum is analyzed to determine an identity of a pharmaceutical compound present in the blood sample. Finally, a report for the blood sample is generated, the report containing the identity of the pharmaceutical compound present in the blood sample.

Abstract: Materials and methods for distinguishing agonistic anti-B7-H1 antibodies from antagonistic anti-B7-H1 antibodies, and for treating subjects diagnosed with clinical conditions such as cancer, pathogenic infection, or autoimmune disease.

Abstract: Methods for determining MHC class II binding activity of a preparation comprising lymphocyte activation gene-3 (LAG-3) protein, or a fragment, derivative, or analogue thereof, is described. The methods comprise determining binding of the LAG-3 protein, fragment, derivative, or analogue to MHC class II molecules using bio-layer interferometry (BLI). Such methods can be used as a quality control assay in good manufacturing practice (GMP) grade production of such compounds. Probes and kits for carrying out the methods are also described.

Abstract: The present invention relates generally to the field of implant related risk of revision, in particular implant related risk of revision not caused by an infection or metal on metal reaction. The present invention provides methods of diagnosing implant related risk of revision, use of kits for such diagnostic purposes and compositions for use in the treatment of implant related risk of revision, in particular implant related risk of revision not caused by an infection or metal on metal reaction.

Abstract: Provided herein are methods and kits for analyzing a biological sample obtained from a subject having, suspected of having, or being at risk for a disease associated with the contact activation system.

Abstract: The present invention relates to methods for quantifying subpopulations of exosomes and diagnostic and prognostic methods for neurodegenerative disorders (e.g., Alzheimer's disease). The invention also provides compositions for quantifying subpopulations of exosomes as well as compositions and methods useful for treating Alzheimer's disease and other neurodegenerative disorders.

Abstract: A sealed bag containing a reference fluid for the calibration and/or quality control of a creatine and/or creatinine sensor, the bag comprising: an inner polymer layer and an outer polymer layer; and an aluminium oxide gas barrier layer there between; and wherein the inner polymer layer is in contact with the reference fluid.

Abstract: The present invention relates to a method of identifying a compound that binds to or modulates the activity of one or more polypeptides encoding one or more receptors that are involved in the detection and perception of fatty acids.

Abstract: Methods for measuring and analyzing parathyroid hormone-related peptide (PTHrP) using LC-MS/MS, including applications of the methods thereof, are disclosed and discussed. Such methods can include, along with the use of an isotope-labeled internal standard, purifying PTHrP from a biological sample, proteolytically digesting the PTHrP, and measuring specific digestion products using the using LC-MS/MS.

Abstract: An automated analyzer capable of continuously performing supply of consumables is realized while continuing measurement is performed, by a simple and small amount of mechanism. An automated analyzer includes a unit that executes processing necessary for sample analysis; a consumable supply unit that supplies consumables necessary for the sample analysis to the unit; and a control device that controls operations of the unit and the consumable supply unit, in which the consumable supply unit includes a consumable container holding portion that holds a consumable storage container in which consumables is aligned and accommodated, a preliminary storage portion that temporarily holds the consumables taken out from the consumable storage container, and a transport mechanism that transports the consumables to the unit, and in which the control device transports and stores at least a portion of the consumables taken out from the consumable storage container in the preliminary storage portion.

Abstract: An automatic analyzer (100) includes: a storage unit (21b) that stores various parameters of the automatic analyzer (100) in association with each of elevations used in the automatic analyzers (100), the parameters being optimized for each of the elevations; an input unit (21d) that acquires information of an elevation at which the automatic analyzer (100) is provided; and a controller (21a) that reads the parameters stored in the storage unit (21b) and sets the read parameters to the automatic analyzer (100) based on the elevation acquired by the input unit (21d). As a result, various parameters can be easily adjusted according to a usage environment of the device.

Abstract: A turbo rotation sensor, which is configured to be mounted on a turbocharger provided with a compressor including a rotary driven compressor wheel housed in a compressor housing, to detect rotation speed of the compressor wheel, is composed of a magnet rotatable integrally with the compressor wheel and having a plurality of magnetic poles in a circumferential direction of the compressor wheel, and a sensor section attached to the compressor housing and including first and second magnetic detection elements capable of detecting a magnetic field in a radial direction of the compressor wheel due to the magnet. The first and second magnetic detection elements are arranged side by side in the radial direction of the compressor wheel. The rotation speed of the compressor wheel can be measured based on a difference between detection results of the first and second magnetic detection elements resulting from a difference between their respective distances from the magnet.

Abstract: A system for measuring the distance of an obstacle, in which an optical flow is measured radially while rotating along a circle in a plane intersecting the obstacle; and the distance of the obstacle is determined according to the amplitude of the optical flow, the radius of the circle, and the speed of rotation.

Abstract: A microelectromechanical system (MEMS) sensor includes a substrate having a piezoelectric layer thereon; a MEMS piezoelectric resonator including a reference electrode on a first side of the piezoelectric layer, a first port (port 1) including a capacitor coupling electrode on a side of the piezoelectric layer opposite the first side, and a second port (port 2) for excitation signal coupling including another electrode on the side opposite the first side. The MEMS piezoelectric resonator has a natural resonant frequency. A variable capacitor on the substrate is positioned lateral to the MEMS piezoelectric resonator having a first and a second plate are connected to port 1. An antenna or an oscillator circuit is connected to port 2. Responsive to a physical parameter a capacitance of the variable capacitor changes which changes a frequency of the MEMS piezoelectric resonator relative to the natural resonant frequency to generate a frequency shift.

Abstract: Disclosed is a method for determining malignant melanoma by a scanning probe microscope system with a cantilever, which includes: setting locations of a plurality of measurement points to be measured in a sample tissue; applying force in a predetermined range to each measurement point on the sample tissue through the cantilever and acquiring information on a distance between a probe and the sample tissue depending on force for each measurement point; generating a force-distance graph of measurement points based on distance information depending on the force acquired at the plurality of measurement points; and determining whether the sample tissue is malignant melanoma based on characteristics information of the sample tissue extracted from the force-distance graph.

Abstract: A test apparatus for testing electronic device comprises a lower base, an upper base and a pressing force generating module disposed between the upper and lower bases. The lower base having a chip socket for receiving a plurality of probes, and a test socket plate having a first guiding device, each of the probes has a spring force stored therein. The upper base having a second guiding device coupled to the first guiding device. When an electronic device is placed in the chip socket, and the upper base is slidably moved with respect to the lower base by the cooperative actions between the first and second guiding devices, so that the pressing force generating module is in alignment with the electronic device for applying a pressing force on the electronic device, and the pressing force being greater than the sum of the spring forces generated by the plurality of probes.

Abstract: A probe includes a pedestal and at least one feature extending from the pedestal to engage a surface of a corresponding contact at a position offset from a central longitudinal axis of the contact.

Abstract: A probe pin is provided with a plate-like movable pin including: a flexible part configured to extend and contract lengthwise; a first contact part and a second contact part each provided at an end of the flexible part lengthwise; and a conduction-path forming element overlapping the movable pin along the thickness thereof. The conduction-path forming element includes a first contact surface and a second contact surface at lengthwise ends configured to contact the first contact part and second contact part; the movable pin and the conduction-path forming element are arranged to allow the first contact part to remain in contact with the first contact surface and the second contact part to remain in contact with the second contact surface while allowing relative movement of the movable pin and the conduction-path forming element lengthwise.

Abstract: A probe card of a testing apparatus of electronic devices comprises a testing head, which houses a plurality of contact elements extending along a longitudinal axis between a first end portion and a second end portion, a support plate, onto which the first end portion is adapted to abut, and a flexible membrane. Suitably, the testing head is arranged between the support plate and a first portion of the flexible membrane, which is connected to the support plate through a second portion thereof, the probe card further comprising a plurality of contact tips arranged on a first face of the flexible membrane at the first portion thereof, the second end portion of each contact element being apt to abut onto a second face of the flexible membrane, opposite to the first face, the number and distribution of the contact elements being different to the number and distribution of the contact tips.

Abstract: A probe card for a testing apparatus of electronic devices comprises a testing head, which houses a plurality of contact elements extending along a longitudinal axis (H-H) between a first end portion and a second end portion, a support plate, onto which the first end portion is adapted to abut, and a flexible membrane which comprises a first face and a second and opposite face.

Abstract: A voltage detector includes a voltage division circuit which outputs a divided voltage based on an input voltage, a comparison circuit which compares the divided voltage and a reference voltage to output a detection signal and a release signal, and a voltage limiting circuit which limits the divided voltage to a preset voltage.

Abstract: A power conversion device of the present invention includes a power conversion circuit configured to convert power; a conductor configured to transmit a current to the power conversion circuit; and a coreless current sensor configured to detect the current, in which the coreless current sensor includes: a magnetic field detection portion configured to detect a magnetic field of the current; and a shield portion that faces the magnetic field detection portion, the conductor includes: a first conductor portion that passes through a space between the magnetic field detection portion and the shield portion; and a second conductor portion connected to the first conductor portion via a first bent portion, and the first bent portion is formed such that the space between the magnetic field detection portion and the shield portion is not disposed in a direction perpendicular to a face of the second conductor portion closest to the shield portion.

Abstract: A current sensor includes a substrate, a first bus bar, and a second bus bar. The first bus bar has a first detection recess recessed in a square U-shape upstream in the extending direction (in the Y-direction) and a first adjustment recess downstream, with a first intermediate portion therebetween. The bottom surface of the first detection recess is a first bottom surface. The first sensitive axis of a first magneto-electric conversion element, if extended toward the second bus bar, abuts the body of the second bus bar at a portion where a second adjustment recess is provided.

Abstract: A current sensor includes a substrate, a first bus bar, and a second bus bar. The first bus bar includes a first terminal portion, a first rising portion, a first extending portion, a first cutout portion, and a first stepped portion. The second bus bar includes a second terminal portion, a second rising portion, a second extending portion, a second cutout portion, and a second stepped portion. The second stepped portion and the second rising portion are connected together. A second magneto-electric conversion element is mounted on the lower surface of the substrate. A first magneto-electric conversion elements is mounted on the upper surface of the substrate.

Abstract: Interface circuits that may utilize a limited number of pins to detect a presence of an accessory, determine whether the accessory can provide or receive power, communicate with the accessory regarding at least that transfer of power, and transfer power accordingly. One example may provide detection circuitry for a host that may detect the presence of a pull-down resistor on a data pin of an accessory. The pull-down may indicate that a power consuming accessory has been connected. This example may detect the presence of power on a power pin. The presence of the power on the power pin may indicate that a power providing accessory has been connected.

Abstract: A current detector includes a temperature sensor that detects a temperature that corrects variation in electric resistance of a shunt resistor caused by a temperature of the shunt resistor. The shunt resistor detects electric current. The temperature sensor includes a thermocouple. The thermocouple includes a pair of temperature detecting leads made of different types of metals, respectively. The pair of temperature detecting leads are connected to each other at a measurement point at front ends of the pair of temperature detecting leads. A measurement point of the thermocouple is electrically connected to the shunt resistor.

Abstract: Embodiments of the present invention disclose system for workload analyzing and optimization. The system includes one or more processors which are configured to capture, in real time, electrical signature data of one or more sub-systems running on a main system. The electrical signature is captured by one or more sensors coupled to a power controller. The captured electrical signature data into at least time domain or frequency domain. A volume of a workload of the one or more sub-systems is determined based on the converted data and a first threshold data. A type of the workload is determined based on the converted data and a second threshold data. A report is generated based on the determined volume and the type of workload.

Abstract: A method for determining a sense impedance of a guard-sense capacitive sensor operated in loading mode, the sensor having an electrically conductive sense electrode and an electrically conductive guard electrode. The method includes: providing a periodic guard voltage to the guard electrode; sequentially providing periodic reference voltages Vrefi via a reference impedance Zref, to the sense node; for each reference voltage, determining the value Imi of the current applied to the sense node; determining the sense reference voltage Vs to be provided to the sense node, which would lead to a current with an amplitude of zero; and calculating the unknown sense impedance Zx of the sense electrode, with reference to the sense reference voltage Vs, the periodic guard voltage Vg, and the reference impedance Zref.

Abstract: The present invention relates to a measurement of radio-frequency signals by a measurement arrangement comprising a radio-frequency lens for mapping a vertex of a reflector to a virtual vertex. Accordingly, measurement of radio-frequency signals may be performed either at the vertex of the reflector or the virtual vertex generated by means of the radio-frequency lens.

Abstract: A mapping probe provides real-time signal sampling and recovery from engineered electromagnetic interference and includes: a trigger voltage source that synchronizes transmission of primary electromagnetic waves; primary electromagnetic wave synthesizers that receive a trigger voltage signal and produce time-varying voltage signals; transmitters that receive time-varying voltage signals and synchronously transmit primary electromagnetic waves, such that the primary electromagnetic waves are subjected to scattering by a structural entity to produce scattered electromagnetic waves; receivers that receive scattered electromagnetic waves and produce receiver signals based on the scattered electromagnetic waves; a conversion stage that receives the receiver signals and the trigger voltage signal and produces converted data; and a render that receives the converted data and produces a map of the structural entity.

Abstract: A looped conductor (1) is opened at both ends, one end (1a) is connected to a conductor plate (2), and the other end (1b) is connected to a lead wire (5b). The conductor plate (2) is disposed parallel to a loop surface of the looped conductor (1) and has a shape covering the looped conductor (1). A lead wire (5a) is connected to the conductor plate (2), and outputs from the lead wire (5a) and the lead wire (5b) are specified as a measurement output of an electromagnetic field probe.

Abstract: An over-the-air test system is provided. The over-the-air test system comprises a test chamber, a device under test, measurement equipment for performing at least one wireless measurement with respect to the device under test, and a signaling unit. In this context, the signaling unit is configured to visually and/or acoustically indicate a status of the at least one wireless measurement.

Abstract: This application relates to a test chamber for testing a device under test (DUT), the test chamber comprising: a plurality of chamber walls defining an interior of the test chamber which are configured to provide an anechoic and shielded test chamber, an antenna arrangement which is arranged in the form of a plane-wave synthesizing array and which is configured to emit plane-waves into the interior of the test chamber, a receiving area for receiving the DUT, wherein in a test mode the receiving area forms a region of measurement of the DUT, wherein the receiving area is formed by a portion of a first wall of the test chamber and wherein the receiving area is configured such that during test mode heat from the DUT is transferred to the outside of the test chamber. The application further relates to a test system comprising such a test chamber.