Abstract: A device is provided for monitoring the delivery and taking of medication pills by detecting both the passage of a pill and the covering of a pill outlet region, which is indicative of an active operation of the user to remove the pill from the pill outlet region. In this way, pill delivery can be monitored as well as an indication of actual pill taking.

Abstract: An aerosol delivery system is disclosed that is a single-use (disposable) continuous nebulizer system designed for use with mechanically ventilated patients to aerosolize medications for inhalation with a general purpose nebulizer, or for connection with devices usable in endoscopic procedures. The system separates the liquid reservoir from the nebulization process taking place either at the adapter hub, where it fits into an endotracheal tube (ETT), or a gas humidifier, where the aerosol may treat a gas used in an endoscopic procedure, with a multi-lumen tube configured to nebulize liquid and air at its distal end. The refillable liquid reservoir is mounted away from the immediate treatment zone, avoiding orientation issues associated with other types of nebulizers having a self-contained reservoir. The system can produce aerosols having a wide range of droplet sizes, depending upon central lumen diameter, with values of MMAD that range from 4 to 30 ?m.

Abstract: An improved aerosol dispensing apparatus includes an aerosol container, a discharge piece movably mounted to the aerosol container, a flow control valve mounted within the discharge piece, a battery, and an electronically controlled metering valve electronically connected to the battery and in fluid communication with the flow control valve. The flow control valve is movable between an open position wherein a volume of an aerosol formulation is directed from the aerosol container through the flow control valve to the metering valve, and a closed position, wherein the metering valve is configured to precisely control a flow of the aerosol formulation outward of the discharge piece. A solenoid is electronically connected to the battery and is movable between an actuated position wherein the solenoid urges the flow control valve into the open position, and an un-actuated position wherein the flow control valve remains in the closed position.

Abstract: A handheld portable recreational vaporizer has a rechargeable battery and a vaporizing chamber held within a unitary body. The vaporizing chamber is exposed on one end. A mouthpiece is attached over the chamber and held in place using magnets. The mouthpiece includes a removable screen bracket that holds a screen flush against the vaporizing chamber. When the mouthpiece is detached from the body, the screen bracket may be removed and cleaned using harsh chemicals and/or other sterilization procedures. This allows the screen to be cleaned more thoroughly than other components of the device. Indicator lights signal which predetermined temperature ranges the device currently operates at.

Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.

Abstract: A disposable cartridge is disclosed for use with an electronic device for producing an aerosol for inhalation by a person. The cartridge comprises a liquid container containing a liquid which when aerosolized is intended for inhalation by a person; and a transducer that, when actuated, causes the liquid from the container to be aerosolized such that the aerosol may be inhaled by a person. In various embodiments, the liquid comprises: a liposomal carrier; a liquid mixture having an active agent entrapped by liposomes; and a liquid mixture comprising a nanodispersion. The liquid may include nicotine, tetrahydrocannabinol, cannabidiol, or nanoparticles formed by an oil droplet covered by a monolayer of phosphatidylcholine. The transducer preferably comprises a mesh material with the transducer and the mesh material forming a piezo mesh disk for aerosolizing the liquid.

Abstract: Provided is a system and method for multi-modal dosing of a product. The system provides a control base for coupling to one of a plurality of different cartridges containing product, at least two cartridges having different modalities of delivery—the coupled control base and selected cartridge providing a dosing device. Each cartridge has at least a unique identifier, which may be read by the control base and correlated through a database to confirm that the user is authorized to use the cartridge, and use of the cartridge for a dose of product will not conflict with other products received by the user and known to the system. Cartridges that are not coupled to the control base are non-functional and cannot dispense product as intended with the system. An associated method of use is also provided.

Abstract: Provided is a system and method for multi-modal dosing of a product. The system provides a control base for coupling to one of a plurality of different cartridges containing product, at least two cartridges having different modalities of delivery—the coupled control base and selected cartridge providing a dosing device. Each cartridge has at least a unique identifier, which may be read by the control base and correlated through a database to confirm that the user is authorized to use the cartridge, and use of the cartridge for a dose of product will not conflict with other products received by the user and known to the system. Cartridges that are not coupled to the control base are non-functional and cannot dispense product as intended with the system. An associated method of use is also provided.

Abstract: A collapsible joint for use with a nebulizer includes a housing connected to the source of carrier gas flow, an extensible and flexible airway and an extension connected to a patient applicator. A swivel joint for use with a nebulizer includes a swivel housing, a rotating airway pivoted in the swivel housing about a first axis of rotation; and an airway base coupling coupled to the swivel housing rotatable with respect to the swivel housing about a second axis of rotation. The first and second axes of rotation are mutually orthogonal at least in part to each other.

Abstract: An aerosol-generating device may comprise an electrical power supply, a housing defining a cavity for receiving an aerosol-generating article, at least one electrical heater within the cavity, and a controller configured to control a supply of electrical power from the electrical power supply to the at least one electrical heater. The controller is configured to activate the at least one electrical heater for a total time period when an aerosol-generating article is received within the cavity. The aerosol-generating device may also comprise a segmented visual feedback device, wherein a plurality of segments of the segmented visual feedback device each correspond to a portion of the total time period. Each of the plurality of segments is configured to provide visual feedback when an aerosol-generating article is received within the cavity and when the corresponding portion of the total time period has elapsed.

Abstract: Configuration technologies for apportioning resources and communicating indications of potential or actual incentives based on one or more measurements or other objective indications that therapeutic components have been administered to an individual, other attributes of the therapeutic components or the individual, or other such determinants. Techniques for apportioning resources cost-effectively (between providers and other parties, e.g.) and for facilitating or handling implementations thereof or output therefrom.

Abstract: An improved medicant delivery system is disclosed wherein the carrier for the medicant is a fluid that can be atomized or vaporized by exposure to heat. The system provides for repeatable dose of medicant, can be stored in any orientation, and/or has an ability to maximize energy efficiency.

Abstract: A nasal applicator for nasally applying medicinal active ingredients, comprising a dispensing pin which is introduced into a nostril, a active ingredient store arranged in an applicator housing, and a dispensing metering device. A transmitting device is designed to be engageable and disengageable between an actuation button and the dispensing metering device such that when the transmitting device is disengaged, the actuation button is moved in the open passage without a transmission to the dispensing metering device. A movement sensor is provided for detecting movements of the operating button, and a coupling switch is provided for engaging the transmitting device depending on a signal of the movement sensor. To generate a consistent spray pattern, the dispensing metering device comprises a pretensioning mechanism which is tensioned or released to actuate a metering conveyor with a defined pretensioning force, wherein the engaged transmitting device can tension or release the pretensioning mechanism.

Abstract: A compact wearable modular multifunctional inhalation device of the present invention. In the illustrative embodiment, the device includes a housing with at least one port; a removable cartridge module adapted to seat within the housing, the cartridge including: a source of inhalant mounted within the cartridge for providing inhalant into the port and a heating element mounted within the cartridge for heating the inhalant; a removable modular electronic circuit adapted to seat within the housing to provide electrical current to the heating element; and a mechanism coupled to the housing for wearing the device. The electronic circuit may include a processor and memory. A removable modular electronic display is adapted to seat within the housing and connect electrically with the circuit. Software is stored in the memory for execution by the processor for activating the heating element. The software includes code for monitoring the status of the inhalant and/or the source of electrical potential.

Abstract: The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.

Abstract: A system comprising a vaporizing device and a central server is described. The vaporizing device includes a housing and a cartridge, received within the housing, the cartridge including a predefined quantity of concentrate and an identification code associated with the concentrate. The vaporizing device further includes a control unit configured to read the identification code. The vaporizing device further includes a communication unit configured to transmit the identification code to a computing device of a user. The central server includes a database. The central server is configured to receive the identification code from the computing device and retrieve concentrate information corresponding to the identification code from the database. The central server is configured to transmit the concentrate information to the computing device for displaying to the user.

Abstract: Some embodiments are directed to a compliance monitor for monitoring patient usage of a medicament inhaler, the medicament inhaler including a store of medicament, a first housing for housing the store of medicament, a medicament dispenser for delivering a dose of medicament, a mouthpiece for directing the dose of medicament into the mouth of the patient, and a removable and replaceable cap for the mouthpiece. The compliance monitor includes a cap detector, such as a switch, for determining when the cap is covering the mouthpiece and/or for determining that the cap is being removed or replaced, with respect to the mouthpiece. The compliance monitor may also include a dose detector, such as a switch, for determining that a dose of medicament has been dispensed. Furthermore the cap is attached to the first housing by a tether or hinge.

Abstract: The present disclosure relates to systems, methods, and devices that may be used to incentivize inhaler use.

Abstract: A housing for an inhalation device and an inhalation device. The inhalation device includes a container unit having a medium container and an outlet stub. The outlet stub is displaceable relative to the medium container for a delivery operation. The housing includes a main housing having a first end forming a mouthpiece, a second end angled in an L-shaped manner with respect to the first end and forming an air inlet, and an attachment piece. The attachment piece has a duct with an attachment opening receiving the outlet stub of the container unit, a nozzle opening, and a pressure chamber arranged between the attachment opening and the nozzle opening. The housing also includes a sensing device for recording a delivery operation, and a diaphragm reversibly deformable depending on a pressure in the pressure chamber. The diaphragm cooperates with the sensing device for actuation thereof.

Abstract: A spacer may improve the effectiveness of medication delivery by an inhaler. The spacer may be configured to store the inhaler to improve compactness and/or portability of the spacer and inhaler. The inhaler may be coupled to a retaining device, inhaler container, and/or the like that restricts movement of the inhaler to predetermined positions and/or orientations. A user may be able to transition the inhaler between a stored position and an active position by moving the inhaler translationally and/or rotationally. The inhaler may be able to remain coupled to the retaining device and/or inhaler container, and the retaining device and/or inhaler container may be able to remain coupled to the spacer during transition from the stored position to the active position. The spacer may be sized to fit in a pants pocket in an embodiment.

Abstract: The invention relates to a plug for placing on a connection element (1) of a medical syringe, which is connectable to the connection element (1), the plug (2) comprising a through-duct (3) and being formed free of further connectivity or connection elements.

Abstract: In one embodiment, the present disclosure provides a portable nebulizer comprising a housing, a mouthpiece, a reservoir, a disk having multiple pores, and a unit that is configured to cause the disk to vibrate, wherein the vibration of the disk creates a pressure differential that causes a fluid from the reservoir to move through the disk to create an aerosol for delivery. In one embodiment, the mouthpiece may be held in place with at least one metal plate imbedded in the mouthpiece and at least one magnet imbedded in the housing. In one embodiment, the reservoir may have a non-cylindrical shape. In one embodiment, the nebulizer may comprise a battery and a USB port for charging the battery.

Abstract: A compact wearable inhaler, vaporizer and/or atomizer is addressed by the wearable multifunctional inhaler, vaporizer and smartwatch of the present invention. In the best mode, the invention includes a housing with a chamber having at least port; a lid adapted to engage the housing and open the chamber in a first position and close the chamber in a second position; a source of inhalant mounted within the housing for sourcing inhalant into the chamber via the ports; and an mechanism coupled to the housing for wearing the device. The source of inhalant may be a vaporizer, pipe, inhaler or atomizer.

Abstract: An ultrasonic nebulizer includes a tank unit configured to be detachable with respect to a main body. The tank unit includes a working tank in which an ultrasonic vibrator is incorporated, a medicine tank, and a medicine tank cover, which are arranged overlaid in the stated order. The output of an oscillation circuit in the main body is applied to the ultrasonic vibrator through a main body-side contact electrode and a tank-side contact electrode when the tank unit is mounted on the main body. The main body includes an air fan that blows air into the medicine tank through an air duct of the medicine tank cover, and a medicine tank cover detection unit that detects whether or not the air duct of the medicine tank cover is adjacent to the main body so as to detect whether or not the tank unit is mounted on the main body.

Abstract: The present invention relates to a system and method for dispensing medication through a time controlled device linked to a web platform. The system includes a dispensing device in wireless communication with a computing device. A web platform on the computing device can be used to program the dispensing device with parameters such as the dosage number, minimum time period between dosages, and the like. Based on the programmed parameters, a solenoid in the dispensing device will lock or unlock based on dosages administered and the time between dosages.

Abstract: An atomizer for an inhaler includes a housing, a gasket, a liquid absorbing sheet, a wick, and an atomizing element. The housing includes a first housing and a second housing, the first housing and the second housing form a liquid reservoir therebetween for storing liquid. The gasket is sleeved on the first housing, the gasket defines a liquid conducting hole in communication with the liquid reservoir. The liquid absorbing sheet is sleeved on the first housing in contact with the gasket, the liquid absorbing sheet is configured to absorb the liquid in the liquid reservoir via the liquid conducting hole. The wick is in contact with the liquid absorbing sheet and configured to draw the liquid from the liquid absorbing sheet. The atomizing element is fixed to the wick and configured to atomize the liquid in the wick.

Abstract: The present invention provides an atomizing system and device having a single authentication mechanism. The system includes at least one atomizing drug container and an atomizing device. The at least one atomized medicine container associates with an authentication code carrier and contains the atomized medicine. The atomizing device includes an atomizing module, a first power module, a control unit, an antenna module and an authentication module. The authentication module is configured to perform an authentication operation associated with the authentication code carrier to determine the authenticity of the at least one atomized medicine container or the atomized medicine and to generate an authentication result signal correspondingly.

Abstract: The present invention provides an atomizing method having an authentication mechanism, including the following steps: placing an atomized medicine contained in at least one atomized medicine container into an accommodating portion of an atomizing device; configuring an authentication module of an atomizing device to perform an authentication operation related to the authentication code carrier associated with the at least one atomized medicine container to determine the authenticity of the at least one atomized medicine container, and generate the authentication result signal correspondingly; and configuring the control unit of the atomization device to determine to determine whether to control the first power module connected to the atomization module to output a first driving voltage according to the authentication result signal.

Abstract: An e-vaping case includes a housing, a guide structure, a cartridge receiving portion connected to the guide structure, and an electronics system in the housing. The cartridge receiving portion is configured to be moved along the guide structure between a first surface and a second surface of the housing. The electronics system includes a power supply that is configured to initiate a transfer of power to an electrical contact structure if the cartridge receiving portion is moved towards the first surface of the housing to at least a first position of the housing. The electronics system is configured to interrupt the transfer of power to the electrical contact structure if the cartridge receiving portion is moved towards the second surface of the housing. An electronic vaping device may include a cartridge detachably coupled to the cartridge receiving portion.

Abstract: Various embodiments provide a pack for holding and re-charging an e-cigarette. The pack includes a pack battery; a body portion including a tube for receiving an e-cigarette; a re-charging mechanism for re-charging the e-cigarette received into the tube using the pack battery, wherein the e-cigarette can be re-charged in the tube without disassembly of the e-cigarette; and a dual activation mechanism comprising two separate triggers for causing the re-charging mechanism to begin re-charging the e-cigarette received into the tube using the pack battery. The re-charging begins only in response to the direct activation by a user of both of the separate triggers.

Abstract: A fluid dispenser device comprising a body (10) that supports, in stationary manner, a reservoir (20) containing fluid, a dispenser head (30) being assembled on said body (10) so as to be axially movable relative to said reservoir (20), said dispenser head (30) being provided with a dispenser orifice (31), said dispenser head (30) including a proximal bearing surface (35) that, during actuation, receives at least one, and typically two, of the user's fingers, and said body (10) including a distal bearing surface (15) that, during actuation, is suitable for receiving one of the user's fingers, and typically the thumb, said device including a removable actuator member (40) that is fastened in removable manner on said body (10) at said distal bearing surface (15), said removable actuator member (40) having a radial dimension that is greater than the radial dimension of said bearing surface (15).

Abstract: A system for delivering an agent to be taken up by a user's lungs and for simultaneously monitoring the user's lung health includes an inhalant-flow detection system and a computer-executable medium. The inhalant-flow detection system includes a flow sensor arranged to intercept a portion of inhalant flowing through the system and to provide detection signals regarding inhalant speed as a function of time. The computer-executable medium includes non-transient computer code, which when executed on a computer, causes the computer to receive the detection signals from the flow sensor, receive information about a quantity and type of agent provided by the agent delivery device for the inhalant during the inhalation time period, and calculate a delivered dose of the agent based on at least the detection signals received, the information received about the quantity and type of agent, and information concerning physiology of the user.

Abstract: An ultrasonic nebulizer includes: a working tank in which an ultrasonic vibrator is incorporated and in which a working liquid is stored facing the ultrasonic vibrator; a medicine tank that stores a medicinal liquid, at least a bottom portion thereof being dipped in the working liquid; and a main body that includes an oscillation circuit that is to drive the ultrasonic vibrator. The medicine tank is configured to be detachable with respect to the working tank. The working tank is configured to be detachable with respect to the main body.

Abstract: Actuators for an aerosol inhalation device containing a housing adapted to receive an aerosol canister containing a pressurized medicament formulation, a mouthpiece portion through which the user inhales, a nozzle block and an orifice and a tubular element extending in the mouthpiece portion from the orifice aperture in a longitudinal axis substantially aligned with a longitudinal axis of the mouthpiece portion provide a significant reduction in the non-respirable, coarse fraction of the emitted aerosol medicament via inertial impaction and retention in the actuator than in the oro-pharynx, with consequent less associated side effects and oral candidiasis in the patient. In addition the presence of the tubular element has minimal, negligible impact on the fine particle dose and on the particle size distribution (PSD) of the delivered particles having aerodynamic diameter lower than 9 ?m.

Abstract: A magazine (18) that stores a plurality of needles (56) configured to engage a medication pen (2) for medication delivery, the magazine (18) comprising a magazine housing (20) enclosing a removable array (26) having a plurality of hub chambers (22) each enclosing one of a plurality of needle hubs (50), a connector (28) in each of the plurality of hub chambers (22), each connector (28) engages one of the plurality of needle hubs (50), a plurality of peel tabs (30) each sealing one of the plurality of hub chambers (22), and an electronic indicator (62) to identify a status of the plurality of needle hubs (50), wherein the electronic indicator (62) identifies how many of the plurality of needle hubs (50) are unused.

Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.

Abstract: The invention relates to a handset (1) for delivering a pharmaceutical substance, with a housing (2) that exhibits a mouthpiece (8), wherein the mouthpiece (8) can be sealed with a cap (9), and the cap (9) is attached to the housing (2) by means of a spring (16), and can be swiveled around a swivel axis (x) to release the mouthpiece (8). In order to further improve a handset of the kind in question, in particular as relates to attaching the cap to the handset, it is proposed that the spring (16) have an angled progression in a top view, in which the swivel axis (x) is imaged as a line.

Abstract: A nebulizer is proposed which receives a container with a fluid and an indicator device. The indicator device stops further use of the container in a locked state when a predetermined number of uses has been reached or exceeded. In the locked state, a locking device locks the nebulizer against rotation in a partially tensioned state and, thus, against further use. After replacement of the container including the indicator device, the nebulizer can be used again.

Abstract: A container for an aerosol generating device comprises receiving means for receiving the aerosol generating device. One or more tanks are each arranged to retain a substance in use. For each tank, there is dispensing means for controllably transferring the substance from the tank to the aerosol generating device while the aerosol generating device is in the container.

Abstract: A bi-functional intubating and ventilating supraglottic airway includes a supraglottic bowl defining a distal end, a neck extending outward of the supraglottic bowl and defining a proximal end, and a longitudinally extending intubation conduit formed therethrough. The supraglottic bowl includes a cuff and defines a bowl surface, wherein the intubation conduit extends from the proximal end of the neck to an opening in the bowl surface, and wherein the intubation conduit is configured to have an endotracheal tube inserted therethrough. At least one fluid flow channel is formed longitudinally through a wall of the supraglottic airway, collaterally to the intubation conduit, from the proximal end to the bowl surface within the supraglottic bowl.

Abstract: An aerosol generator (100) has a vibratable plate (1) with apertures therein and an annular piezo (2) which causes movement of the vibratable plate (1). An annular support member (3) supports the piezo (2) and the vibratable plate (1). A first electrical power conducting pin (10) engages directly with a first, top, surface of the piezo (2). A second electrical power conducting pin (11) indirectly conducts electrical power to a second surface of the piezo (2), by contacting an extension tab (103) of the support member (20), also on its top side. There is a film of cured epoxy adhesive on the tab (103), providing excellent gripping force between the pin (11) and the support (3). The aerosol generator (100) avoids need for soldered joints for electrical contact, and the pins are conveniently mounted parallel to each on the on the same lateral and top side of the piezo and support member. The pins may have multi-point tips (50) for particularly effective electrical contact.

Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.

Abstract: Nebulizer systems, apparatus, and methods are disclosed. The apparatus includes a body, a breathing gas inlet and outlet, and a barrier. The body is sized to be positioned within an adaptor of the nebulizer system. The breathing gas inlet and the breathing gas outlet are at opposite ends of the body. The barrier is coupled to the body. A plurality of holes are formed in the barrier. The plurality of holes open in a direction orthogonal to the breathing gas inlet. The system employs the apparatus in conjunction with a nebulizer and an adaptor. The method includes generating an aerosolized medicament, providing the aerosolized medicament to the adaptor, passing the aerosolized medicament through the barrier of the apparatus, providing a breathing gas to the apparatus, and flowing the aerosolized medicament and the breathing gas through the breathing gas outlet of the apparatus.

Abstract: In a method of manufacturing a cartridge of an electronic vaping device, wherein the cartridge includes a pre-vapor formulation storage element, an electrical inductor is formed from an electrical component, wherein the electrical inductor has an inductance indicative of a pre-vapor formulation substrate contained in the pre-vapor formulation storage element. The electrical inductor is then mounted to the cartridge.

Abstract: A device for generating a scented mist of an atomized liquid fragrance oil includes an atomizer complex, a reservoir assembly, a drainage tube, and a vacuum tube. The atomizer complex can atomize the liquid fragrance oil into a scented mist and deliver the scented mist to air outside of the atomizer complex, where the liquid fragrance oil the fragrance oil that is not atomized into the scented mist delivered to the air outside of the atomizer complex includes collected oil that is collected and drained to a reservoir assembly. A drainage tube extends from a bottom area of the atomizer complex into the liquid fragrance oil. The device can filter the liquid fragrance oil in the reservoir assembly and the collected oil from the atomizer complex that drained down the drainage tube. The vacuum tube can suction the filtered liquid fragrance oil and the collected oil into the atomizer complex for atomization.

Abstract: A method of purifying herbal extract(s) from an herbaceous plant composition includes heating the herbal extracts-containing composition to volatilize at least one of herbal extract(s) into a vapor and condensing the vapor on a substrate or wet extracting the herbal extract(s) by treatment of the herbaceous plant composition or a derivative thereof with a solvent for the herbal extract(s), separating the solution of herbal extract(s), forming a concentrate and casting the concentrate on the substrate to form a coating of the herbal extract(s) on the substrate. A corresponding delivery cartridge and delivery system can include a controllable heating element and the substrate coated with at least one of herbal extract(s). These are configured to allow passage of air over the substrate to volatilize or entrain the herbal extract(s) as a vapor, gas or aerosol for administration to a user.

Abstract: A system can include a nebulizer having a tip and a spray chamber configured to be in fluid communication with the nebulizer. The tip of the nebulizer and/or an interior of the spray chamber can have a treated surface. The nebulizer and/or the spray chamber can be treated using a physical abrasion technique, chemically etched, and so forth. In some embodiments, treated surfaces of the nebulizer and the spray chamber can be proximate to one another. The spray chamber can include a drain ridge, which can project into an interior of the spray chamber, be depressed away from an interior of the spray chamber, and/or include a treated surface. The spray chamber can also include an output port having a treated surface. In some embodiments, the output port can include an additional port so that rinse liquid can flow through the spray chamber (e.g., continuously and/or intermittently).

Abstract: A wearable drug delivery device has a needle assembly and a drug vial arranged side-by-side. This arrangement makes the device compact so that it can be easily worn around a user's wrist, for example. When the user triggers the device to inject a dose of medication like epinephrine, in an orchestrated sequence, a first spring drives the needle assembly downward and inserts a needle into the user while connecting the needle assembly to the drug vial. A second spring then delivers the dose from the drug vial through the needle and into the user. Advantageously, the small form factor encourages the user to wear the device and have lifesaving medication at the ready.

Abstract: Formulation comprising buprenorphine or a pharmaceutically acceptable salt thereof as the sole active ingredient, a viscosity enhancer, and a buffering agent in an amount to provide a pH of from 5.0 to 7.0 are useful for treating opioid withdrawal syndrome.

Abstract: An aerosol-generating system may include a liquid storage portion, a vaporizer, and a pump. The liquid storage portion may be configured to store a liquid aerosol-forming substrate. The vaporizer may be configured to volatilize the liquid aerosol-forming substrate. The pump may be configured to pump air into the liquid storage portion so as to push out a volume of the liquid aerosol-forming substrate from the liquid storage portion and to supply the volume of the liquid aerosol-forming substrate to the vaporizer. A method for generating an aerosol may be performed with the system.