Abstract: The invention relates to a blister for charging an inhaler with a pharmaceutical preparation, characterised in that the blister is at least partially manufactured from a dehydrating plastics material. The invention also relates to blisters according to the invention which are filled with a pharmaceutical preparation.

Abstract: The invention relates to substituted 2-alkylsulfanyl-3-(arylsulfonyl)-cycloalkyl[e and d]pyrazolo[1,5-a]pyrimidines, to serotonin 5-HT6 receptor antagonists, to novel drug substances and pharmaceutical compositions, comprising the said conpounds as active ingredients, to novel medicaments and methods for treatment and prophylaxis of CNS diseases of humans and warm blooded animals pathogenesis of which is associated with 5-HT6 receptors. In general formulas 1 and 2 R1 represents hydrogen or C1-C3 alkyl; R2 represents C1-C3 alkyl; R3 represents hydrogen, one or more optionally identical halogens, C1-C3 alkyl or hydroxyl optionally substituted with C1-C3 alkyl; n represents the whole numbers 1, 2 or 3.

Abstract: A child-resistant and senior-friendly package comprising one or more blister cards housed within a hollow molded plastic sleeve is provided. The sleeve is assembled from a pair of identical molded plastic body sections. Each body section has a latch and an unlocking tab and the blister card has a latch-catcher for cooperating with the latch to automatically lock the blister card in a storage position within the sleeve. The sleeve has a pair of opposite spaced-apart tabs in the side edges thereof that must be simultaneously pressed to unlatch the latches from the latch-catchers to permit the blister card to be slid from the storage position to a dispensing position. When pressed, the tabs flex the blister card off adjacent latches. An embodiment including a pair of separate blister cards is provided in which the blister cards are dispensed through opposite dispensing ends of the sleeve.

Abstract: The present invention pertains to a method for lyophilising particles comprising frozen liquid having a pharmaceutical compound contained therein, comprising providing a heat conducting container having a bottom and side walls, filling the container with a bed of the particles, the bed comprising multiple layers of the particles and having an aspect ratio of not less than 1, providing a heat source above a top layer of the particles, the heat source having a surface directed to a top layer of the bed, which surface has an emissivity coefficient of at least 0.4, subjecting the particles filled in the container to a reduced pressure, heating at least the bottom of the container and the said surface to provide heat to the particles to support sublimation of the frozen liquid at the reduced pressure, and after the frozen liquid is sublimated, stopping the provision of heat to the particles.

Abstract: A stable solid oral pharmaceutical composition comprising carvedilol or a pharmaceutically acceptable salt thereof, which is packed using a suitable packaging material along with a desiccant. A process for manufacturing a stable solid oral dosage form containing carvedilol or a pharmaceutically acceptable salt thereof, which is packed in the packaging configuration comprising moisture permeation inhibitory packaging. A method of preparing a stable solid oral pharmaceutical dosage form, said method comprising, encasing a pharmaceutical dosage form comprising carvedilol or pharmaceutically acceptable salt thereof in a container comprising a desiccant. A pharmaceutical kit comprising a container impervious to moisture, wherein said container comprises a desiccant; and a solid oral pharmaceutical dosage form comprising carvedilol or a pharmaceutically acceptable salt thereof, wherein said pharmaceutical dosage form is encased in said container.

Abstract: A product package includes a spine, a plurality of blister cards, and a coupler mechanism. Each blister card includes a plurality of individual cells. Each individual cell includes a blister for containing at least one product. The coupler mechanism is attached to the spine and re-attachably couples the plurality of blister cards within the product package.

Abstract: A child-resistant multi-step tear-access blister package having at least one product well containing a product. The product is accessed by tearing the blister package from a peripheral edge toward the product well. A step in addition to tearing is required to access the product, thereby elevating the cognitive skill necessary to access the product above those of a typical small child. In the disclosed exemplary embodiment, the additional step involves weakening a tear-resistant channel blocking a tear path from the peripheral edge of the package to the product well. More particularly, initial tearing of the package toward the product well is interfered with by the presence of the tear-resistant channel interrupting the tear path. The tear-resistant channel may be bent or snapped to permit tearing therethrough and to permit continued tearing of the blister package toward the product well to access the product.

Abstract: A film container (FIG. 4) comprises two rectangular films (5) joined together at their periphery to form a receiving chamber (6) for a filling (7), particularly a pharmaceutical formulation of an active substance, at least one of said films (5) being provided, for the purpose of tearing it open, with a marking (13) formed within the connecting region, which is exposed after the films (5) have been bent. The marking (13) extends centrally between two opposing outer edges (11) of the film container (1).

Abstract: A child-resistant medicate container includes a housing having a top segment fixedly attached to and extending from a bottom segment. Each of the bottom segment and the top segment include a generally flat first sidewall and an opposing generally flat second sidewall that define the storage cavity. Each sidewall defines a plane and each plane extends generally parallel with respect to the remaining planes. The planes defined by the first and second sidewalls of the bottom segment are spaced-apart a greater distance than a distance between the planes defined by the first and second sidewalls of the top segment. A cover is movably attached to the housing and surrounds at least a portion of the first and second sidewalls of the top segment of the housing. One of the cover and the top segment of the housing include an aperture formed in a sidewall thereof.

Abstract: A multiple serving container shaped to incorporate an opening dimensionally sized to fit within the opening of the typical plastic liquid containers used for bottling water, fruit juice and soda. The serving container fitting inside an opening into the liquid container allows transfer of contents without spillage.

Abstract: A process for making a detergent composition, the detergent composition comprising: a) from about 0.1% to about 50% by weight of the composition of a polymer in particulate form comprising: i) a carboxylic acid monomer; ii) more than about 5% by weight of the polymer of a sulfonic acid monomer; and iii) optionally a non-ionic monomer; and b) from about 0.01% to about 10% by weight of the composition of a hydrophobic silica the process comprising the steps of: a) pre-mixing the polymer with the hydrophobic silica to obtain a polymer/silica premix; and b) mixing polymer/silica premix with any additional detergent components.

Abstract: A novel combination therapy for cardiovascular diseases or conditions, including administering a synergistic combination of at least one inhibitor of neutral endopeptidase, at least one inhibitor of the endogenous endothelin producing system and at least one diuretic, preferably a thiazide diuretic or an adenosine A1 antagonist.

Abstract: The invention relates to an apparatus, system and method for managing medication. In particular, the invention relates to adaptable pill organizer. The adaptable pill organizer comprises of at least one or more rectangular units for containing pills. Individual units and/or rows of seven units, wherein one unit corresponds to the days of the week, attach and detach from one another in order to create a custom pill organizer. The adaptable pill organizer further employs electronic capabilities which: allow user to input, store and display information on the pill organizer; provide lighting means for the device; provide various automatic and/or commanded physical responses to usage of the device such as the lighting of a unit, or the opening and closing of a unit; provide programmed alarms; communicate data messages and usage information with third party devices; and store and provide access to user medication and medication schedule information.

Abstract: A blister pack and a method for packaging a blister in the blister pack are proposed. The blister pack 10 in this case comprises a base field 14 with at least one recess 16 or perforation 18 for removal of at least one product arranged in a blister 36. A bottom field 26 is connected to the base field 14. A closure field 30 is connected to the bottom field 26. The blister pack 10 is distinguished by a fixing tab 22 which is mounted on the base field 14 for the purpose of fixing at least one blister 36 that is to be packaged in the blister pack 10.

Abstract: A package includes a slide card that is received in an outer sleeve having a false end wall. The false end wall extends between a top wall and a bottom wall to enhance the structural integrity of the outer sleeve. The false end wall provides child resistance in that it prevents a user from manipulating the outer sleeve to inadvertently disengage a locking feature that lockably retains a slide card in the outer sleeve. The false end wall also prevents a user from accessing the slide card through an opening that is created by removing an end wall.

Abstract: Systems and methods to dispense toothpaste include toothpaste beads positioned onto a dispensing medium. The toothpaste beads may be individually stored and accessed for use on a toothbrush.

Abstract: A computer-based system for monitoring medication compliance. The system can include one or more processors configured to process and manage data. Additionally, the system can also include one or more one or more medication packagings comprising a machine-readable medium. Notably, the machine-readable medium can comprise medication information among other types of information. The one or more processors can be configured to receiving the medication information of the machine-readable medium. The machine-readable medium and corresponding medication information can be adjustable based on a dispensing of a medication from the one or more medication packagings.

Abstract: The disclosure relates to a package comprising a sleeve and an insert, the insert being adapted to be movably received in said sleeve, wherein the package further comprises a locking mechanism adapted to limit unintentional movement of the insert in relation to the sleeve, the insert being provided with a grip portion being accessible to a user, wherein the grip portion is separable from the insert, and wherein the grip portion is adapted to be separated from the insert or made inoperable by application of a first force, wherein the locking mechanism is adapted to withstand said movement of the insert against application of a second force, and wherein the second force is greater than the first force. The disclosure further relates to an insert adapted to form part of a package of the above kind.

Abstract: An improved medication organizing system for allowing patients to rapidly and easily prepare hermetically sealed dosage packages to set up their medication regime for a week, month, or longer period of time. The device includes seven hoppers to allow the patient to prepare a set of hermetically sealed medication packages for a given time for each day of the week. After being filled, each package in the set of seven packages is hermetically sealed simultaneously by simply loading the set into a sealing unit and pulling a lever. Sealing of the packages does not require manual manipulation of the individual packages by the user, such as would be required for medication organizers utilizing individual packages with zip-lock seals. The medication organizing system allows patients who lack manual dexterity, such as elderly patients, to easily prepare medication dosages for an extended period of time.

Abstract: A seal for a pill dispenser having a body including a plurality of recesses formed in a surface of the body, each recess having an open mouth bounded by a surrounding portion of the body surface, the seal comprising a cover film defining a plurality of apertures to provide access to the open mouths of the recesses, each aperture being cut in the cover film so as to be smaller than the open mouth of the corresponding recess and being closed by a liner cut from a liner film, the liner being larger than the aperture and being adhered to the cover film around the entire periphery of the aperture, the seal in use being adhered to the body surface of the pill dispenser so that the liners are located between the cover film and the open mouths of the corresponding recesses and each liner is removable.

Abstract: Methods of treating diseases such as diabetes are disclosed. Methods of modulating elevated fructosamine levels, elevated HbA1c levels, impaired glucose tolerance, and impaired fasting glucose are also disclosed. In some embodiments, methods include co-administration of a bile acid sequestrant and two or more additional compounds selected from the group consisting of a biguanide, a sulfonylurea and insulin, or pharmaceutically acceptable salts thereof. Drug products including a bile acid sequestrant and two or more additional compounds selected from the group consisting of a biguanide, a sulfonylurea and insulin, or pharmaceutically acceptable salts thereof, in combination are also disclosed.

Abstract: A childproof package consists of a rectangular folding box of cardboard with at least one strip-like blister pack inside, which can be pulled out from one of the short, narrow sides of the folding box. The folding box is designed so that it can be reclosed in such a way as to be childproof again, and the folding box and the blister pack have cooperating means, which are designed so that the blister pack cannot be pulled completely out of the folding box.

Abstract: An air freshener device includes an open-cell, polyurethane foam body having a scent material interspersed in the foam body that is capable of diffusing out of the foam, and a flexible cover surrounding and conforming to the foam body having at least one hole in the cover to facilitate the release of scent. The foam body can be flexible and compressible, and also resilient and returnable to its original configuration. The flexible cover can have a fabric shell that is soothing to the touch, and may also have a non-porous inner liner to contain the scent material and prevent it from migrating out of the foam body. In addition, the air freshener can have a freestanding, self-supported, three-dimensional shape, and can be fashioned into the shape of a common sports ball, such as a baseball.

Abstract: Taught herein is a package for holding and securing various types of portable items. An inner slide card with integral tray (12) is loaded with items, and inserted into an outer sleeve (200). Receiving apertures (38) and securing tabs (40) hold and secure the items in the tray. An engaging element (42), integral to the slide card or tray cooperatively engages locking elements and stopping elements (240, 216) integral to the outer sleeve. The cooperative engagement of the elements provides an optional child-resistant feature and an optional spill-resistant feature. A release button (224) integral to the outer sleeve disengages the child-resistant feature.

Abstract: Systems and methods for packaging, identifying and dispensing medicines are described. The medicines may include homeopathic and other products. A package may include a container is having a port through which medicine is dispensed. A sleeve partially encloses the container and is slidable along a portion of a surface of the container between two positions. The port is accessible when the sleeve is in one of the two positions and inaccessible when the sleeve is in the other position. The sleeve may include a cover that prevents unassisted extraction of the objects from the container where the cover may be a semi-adhesive tape or similar. An identifier and color coding may be provided that distinguishes the contents from the contents of other packages.

Abstract: A child-resistant and senior-friendly unit dose package has a hollow container body, an internal divider, and at least first and second separate trays each carrying a plurality of tablets or like items for being dispensed from the container body. The container body has an end with an opening, and each tray can be slid to a retracted position in which the tray is located within the container body and a dispensing position in which the tray extends at least partially through the opening of the container body. The package includes a separate cap removably securable to the container body to seal the opening and prevent access to the trays. Multiple simultaneous manipulations are required to remove the cap from the container body thereby providing a child-resistant connection. A method of assembling a package with at least two separate blister cards and a divider is also disclosed.

Abstract: A pill receptacle has a number of recessed pill compartments formed therein. The method comprises the steps of providing a cover sheet member that has a sealing sheet with a top identification surface on which information can be printed and a bottom adhesive surface provided with an adhesive. The cover sheet member further has a protective sheet that removably overlays the sealing sheet on its adhesive surface. First weakness zones are provided on the cover sheet member, that extend transversely through the sealing sheet and the protective sheet in a registering fashion to define first cutaway lines on the cover sheet member. A fraction of the cover sheet member is separated from the rest of the cover sheet member along at least some of the first cutaway lines, including concurrently separating corresponding fractions of the sealing sheet and the protective sheet in registering fashion. The protective sheet fraction is peeled away from the sealing sheet fraction on the cover sheet member fraction.

Abstract: A multi-layered plastic body for containing, storing or conducting a medical, diagnostic, pharmaceutical, cosmetic or other product, the plastic body including a first layer made of a stress fracture resistant plastic material, and at least a second layer adjacent to the first layer and made of a plastic material exhibiting a lower resistance to stress fractures than the first plastic material. The invention encompasses a suitable method of making the body.

Abstract: An insert package includes an insert and a container. The container is formed by assembling an upper housing member and a lower housing member, thereby creating a void bound by side walls and a closed end. The container includes rails or channels, and an open end with an engageable cover. When the cover is open, the open end provides access to the void. An insert can be passed into container through the open end. The insert is a package for storing and dispensing items, such as a blister card. The insert includes wings and the wings can include lugs or detents. The wings are designed to interface with the rails, to align the insert with the container during storage and dispensing of the items. A retainer in the container, and a retainer receiver on the insert (or vice versa) can selectively immobilize the insert. A release can disengage the insert and allow slideable movement of the insert into and out of the container.

Abstract: A child resistant package for tablets is disclosed. The package includes an outer sleeve and a blister package. The blister package is designed to fit within the outer sleeve, and is capable of being slid from a closed position to an open position. The blister package includes a blister sheet and a lidding material sheet that is peeled from the blister sheet to access the tablets.

Abstract: There is described a package (10) of laminated multilayer material (PM) with at least two layers (17, 18) coupled to each other, for granular products, the package (10) consisting of a parallelepiped container including, in the position of use, a bottom wall (11), a top wall (12), a rear wall (14) and two side walls (15). The at least two layers (17, 18) of multilayer laminated material (PM) have areas of non-total coupling at the front (13), rear (14) and side (15) walls.

Abstract: A packaging includes a tray and a sheet. The tray has a series of spaced apart sections. Each spaced apart section is generally rectangular in shape and has a recessed compartment and an upper surface. The sheet is fixed in part to the upper surface of the tray and has a plurality of tab portions that are not fixed to the tray thereby creating a tab. Each tab portion corresponds to one of the spaced apart sections and has first and second ends. Each tab portion can be graduated in width from the first end to the second end. The first end can be positioned in a corner of the corresponding spaced apart section. The tab portion has a length measured parallel to the length of the corresponding spaced apart section and the second end is adjacent to the sealed portion of the sheet.

Abstract: The disposable pill counting device is a tray formed of a disposable material and includes a sidewall to define areas for holding and dispensing pills. The disposable tray may be substantially U-shaped with a folding sidewall and can be used with a disposable spatula.

Abstract: A container with child-resistant fastening means, the container comprising base (31), a lid (32), and a hinge (33) connecting the base (31) to the lid (32) and about which the lid (32) is movable between an open position and a closed position, the fastening means comprising first interlocking means (31A, 32A) for resisting opening movement of the lid (31) in a first direction (D) relative to the base portion (31) and which is releasable upon relative movement between the lid (32) and base (31) in a second direction (B), and second interlocking means (31B) which resist relative movement of the lid (32) and base (31) in the second direction (B) and which is releasable upon pressure (C) being applied to release means (42A, 42B) in two spaced apart locations.

Abstract: A dispensing system (300) includes a packaging structure (200) and a blank (100) that is constructed to enclose the packaging structure (200). The dispensing system (300) includes a top panel (110) and a bottom panel (112) that define a tubular structure (310) and includes side flaps (120a, 120b) that are configured to extend into the tubular structure (310). The side flaps (120a, 120b) close the open sides of the tubular structure (310).

Abstract: The present invention relates to a new pharmaceutical blister with reduced permeability to water vapor and gas. It is proposed according to the invention to coat conventional blisters with a silicon oxide-containing functional layer to protect against gases, water vapor and organic molecules.

Abstract: The present invention relates to a new pharmaceutical blister with reduced permeability to water vapor and gas. It is proposed according to the invention to coat conventional blisters with a silicon oxide-containing functional layer to protect against gases, water vapor and organic molecules.

Abstract: A package (1) for pharmaceutical, medical or similar products, particularly pesticides or plant protection products, comprising a substantially flat element (2) for supporting indications (T) prescribed for a pharmaceutical, medical or similar product, particularly a pesticide or plant protection product, a first receptacle (3) for containing a container (4) of the product which is formed in the substantially flat element (2), and first means (5) for connecting the container (4) and the substantially flat element (2).

Abstract: A system for storing and opening encased articles, such as those wrapped in a protective seal, provides a combined container and seal cutting apparatus. The container is configured to store at least one removable article encased within a protective seal. The seal cutting apparatus includes a receiving channel and a cutting member which extends into the receiving channel. The receiving channel is configured to receive at least a portion of the seal while the cutting member is configured to cooperatively cut the seal portion as it is inserted into and translated along the channel. The cutting apparatus may be permanently or temporarily attached to the container.

Abstract: A package comprises an outer package (2) having two members (20, 21) connected to one another via a flexible web portion (22). Each member (20, 21) comprises a base panel (200, 210) and two opposite side wall panels (201, 202, 211, 212). One of the side wall panels (201, 211) has an attachment (204, 214) portion extending towards the opposite side wall panel (202, 212). An inner package comprises blister pack members (3) comprising an edge portion (304, 314) attached to the attachment portion (204,214) of the outer package member (20, 21) such, that in a closed state the goods carried by the blister pack member are facing towards the base panel (200,210). The members (20,21) are folded towards each other via the flexible web portion (22). In an open state the outer package members (20, 21) are unfolded and the members (3) can be accessed by folding the blister pack member (30, 31) away from the opposite side (202, 212) wall panel.

Abstract: A freezable unit dosage delivery system, method of preparation, a solid unit dosage, method of treating symptoms and conditions, and kit is disclosed. The freezable unit dosage delivery system includes a composition, preferably containing one or more medicinal ingredients, having a freezing point less than 5° C.; a storage container comprising one or more cavity, each configured to receive a unit dosage quantity of the composition; and a sealing sheet for sealing engagement with the storage container. Upon freezing, the unit dosage quantity solidifies into a solid unit dosage that may be administered one of orally, rectally or vaginally for the local or systemic treatment of symptoms and conditions in a human.

Abstract: A child-resistant dispensing closure for a container may include one or the other or both of a dispensing cover non-removably securable to a container, or an outer cover non-removably securable and rotatable with respect to the inner cover and cooperable with the dispensing cover to render the closure child-resistant. According to another embodiment, an outer cover may include a flange to aid users in pushing and turning the outer cover with their fingers.

Abstract: Package system (2) for a powdery, granular, paste-like or liquid sterile product comprising a plastic outer tray (4) and a plastic inner tray (6). The inner tray (6) is to be sealed with a first plastic cover to form a sterile receptacle for the sterile product. The outer tray (4) is to be sealed with a second plastic cover to form a sterile receptacle for the inner tray (6). The inner tray (6) has a spout (40) for the application of the sterile product.

Abstract: A package is proposed, comprising a sleeve (2) of essentially parallelepipedal shape, and an insert ((3) which can be inserted into and withdrawn from the sleeve (2) in a sliding direction (S) through an opening (4) in the sleeve (2), the sleeve (2) comprising four longitudinal walls (2a, 2c) which are essentially parallel to the sliding direction (S). The package is characterized in that the sleeve is provided with a first stop tab (7) which extends from a first (2c) to a second (2a) of the longitudinal walls, the tab being at least partly separated from the first longitudinal wall (2c) and the second longitudinal wall (2a) in that the insert has a first locking edge (9a), the insert being prevented, upon contact of the first locking edge with the first stop tab (7a), from moving out of the sleeve, and in that the first locking edge (9a) can, by elastic deformation of a part of the insert (3) by means of maneuvering by a user, be moved so that its movement past the first stop tab (7a) is made possible.

Abstract: The invention herein relates to a method and apparatus for forming (or cold-forming) an embossed blister from a laminated film wherein an indicia is formed on the base of the blister. In particular, the invention involves a single pass process of combining the formation of a blister and the formation of an indicia (embossing) on the blister, wherein the blister-forming pin contains a face with an indicia and is adapted to controllably stretch the laminated film during blister formation to minimize stretching of the film at the base of the blister. The invention is particularly useful in manufacturing processes which involve the formation of blisters having laminated films which contain a metal foil and polymer layer, wherein improved control in the stretching of the laminate during blister formation is desirable.

Abstract: Package components for the radiochemical sterilization of medical devices contain paraformaldehyde as the precursor of the radiolytically generated, sterilizing dose of formaldehyde, premixed with a particulate solid dispersant of, preferably, polyethylene or silica gel, which facilitates the free passage of the formaldehyde to the package gaseous environment or additionally, absorbs trace amounts of moisture in the package, thus, facilitating the device manufacturing process and increasing shelf-stability.

Abstract: This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.

Abstract: A childproof package consists of a rectangular folding box of cardboard with at least one strip-like blister pack inside, which can be pulled out from one of the short, narrow sides of the folding box. The folding box is designed to be reclosed in such a way as to be childproof again, and the folding box and the blister pack have cooperating means, which are designed so that the blister pack cannot be pulled completely out of the folding box.

Abstract: A drug card having a tamper proof serrated pull tab on the back. The pull tab is partially removed from the back of the drug card to provide access to a plurality of individually sealed doses of medicine. A single dose of medicine is removed from the plurality of individually sealed doses of medicine, after which the remaining individually sealed doses of medicine are placed back in the card and the card resealed. The integrity of the drug card is thereby maintained while presenting a brand name of the product to the consumer at all times.

Abstract: The present invention relates to a multi-functional pharmaceutical package surface and a method of preparing a multi-functional pharmaceutical package surface. In particular, the present invention relates to a pharmaceutical package having a protein deterrent and lubricious surface and methods of preparing said surface by applying coatings directly to the pharmaceutical package that (a) reduce the adsorption of proteins onto pharmaceutical packaging while not affecting the activity of the protein solution and (b) provide a lubricious surface. The pharmaceutical package surface may also contain a barrier coating. Coatings can be deposited on a variety of pharmaceutical packaging materials and configurations by various methods.