Abstract: The invention relates to a package (1) made of cardboard, comprising a sleeve (2) and an insert (3), the sleeve (2) being provided with at least one catch tab (10) located on the inside of the sleeve and provided with at least one projection (10b), so that the catch tab (10) forms an angle with the upper wall (2a) of the sleeve (2). At least one locking tab (11) is provided on the insert (3), which is arranged so as to be at least in part inserted between the catch tab (10) and the upper wall (2a). At least one operating tab (6) is provided, in addition to which the sleeve (2) is provided with at least one cutout (7) next to the operating tab (6), the operating tab (6) being arranged so as to be pressed by a user against the locking tab (11), movement of the insert (3) in the sliding direction (S) towards the opening (4) being made possible.

Abstract: A child resistant blister pack holder is described that includes (a.) a main housing receiving pocket having an open end for insertion and removal of blister pack; (b.) a locking mechanism adapted to lock onto and hold a blister pack in the main housing to prevent removal thereof; and, (c.) a release mechanism. The release mechanism, which is connected to the locking mechanism, has a first position wherein the locking mechanism is locked onto the blister pack, and a second position wherein the locking mechanism is unlocked from the blister pack. The release mechanism is located, at least in part, on an outside area of the main housing to permit manual movement thereof from the first position to the second position. A spring biases the release mechanism to its first position. In some embodiments, the invention is a system which includes the child resistant blister pack holder and a blister pack that contains a lock engaging section in the form of an orifice, recession or protrusion.

Abstract: A blister pack for dispensing pills that is childproof yet senior-friendly. The blister pack includes a substantially tear-resistant housing that encloses one or more blisters contained on a blister sheet and surrounded by criss-cross grain material to provide cut or tear resistance in multiple directions. In one embodiment, the cavities of the blisters are positioned such that the pills are aligned at an angle with respect to the corresponding dispensing slots on the housing in their normal position. The blisters are detachably attached to a zipper strip on the blister sheet to prevent undesired rotation of the blisters. Upon removal of the zipper strip, the blisters may be twisted until their pills are substantially aligned with their respective dispensing slot. The blisters may then be depressed to remove the pills from the cavities of the blisters by pushing the pills through the foil sheet that covers the slots.

Abstract: Pharmaceutical kits are provided that reduce or prevent oxidative degradation of oxygen-sensitive pharmaceutically active ingredients in solid unit dosage forms that are supplied in oxygen permeable containers. Stabilization of the active ingredient is accomplished by incorporating an oxygen absorber into a sealed oxygen permeable container.

Abstract: The invention relates to a dispensing container and a method of using the dispensing container that makes it possible to remove liquid, suspended, viscous or pasty contents from the container such that there is no excess of air within the container during storage and removal of the container contents and so that contact with the surrounding atmosphere is minimized. The dispensing container includes a hollow body, sealed at one end by a sliding element and at the other end by a membrane fastened on the hollow body. During the removal of the contents through the membrane, the sliding element is displaced toward the membrane by a vacuum generated by removal of some of the contents from the container.

Abstract: A sample container, having a lid and a base, is configured to secure at least one card to an inner or out surface of the container. At least one of the lid and the base forms an inner volume for holding a sample item.

Abstract: A personal medication in storage dispensing unit is provided for receiving and storing medication, vitamins, minerals, phytochemicals, pills capsules, gel tablets and the like in a manner which is easily accessible and which is conducive to inclusion within a medication regimen system. A medication regimen monitor can be included in this system in order to be programmed to signal proper medication dosage times. The monitor preferably provides non-compliance information, preferably information which persists and which designates which portion of the medication regimen was not complied with. The system also can include a holder for multiple storing and dispensing units in an ordered fashion consistent with daily requirements of the medication regimen.

Abstract: A molded product dispenser with a resistant clip adapted to secure the dispenser to another article is provided. The molded product dispenser includes a first and second body portion forming a compartment therebetween from reception of a product such as confection, tablets, mints, pills or the like.

Abstract: A packaging substrate is formed that has at least the following elements. A main panel with at least one gate formed on the main panel to assist with removing contents from a package cell. At least one cell flap secured to the main panel. The cell flap has at least one aperture dimensioned and aligned to fit over a package cell. At least one tab flap secured to the main panel on an opposite end from the cell flap. The tab flap further comprises at least one peel away tab and at least one glue tab. The peel away tab is aligned and dimensioned so that when properly folded it will substantially overlap the gate or gates of the main panel.

Abstract: A manually operable tablet splitting device, including a base and a cover, pivotally attached to the base, and movable between a tablet loading position and a tablet splitting position. The cover includes a blade for splitting a tablet into two substantially equal portions. A disposable tray, having a tablet-receiving cavity, is installable in the base to fix the tablet in position for splitting and to retain the split portions. The base includes an inclined platform having upwardly projecting receptacle locators for holding the tray in place.

Abstract: A portable medication cartridge allows for both manual and automated dispensing of tablets or capsules of virtually all sizes through a radial dispensing apparatus. The cartridge may be sealed and encoded with medication and patient identification. A microprocessor controlled medication dispensing apparatus includes a cartridge magazine capable of holding a plurality of cartridges for the same or different patients. The portable medication dispensing apparatus and method detects patient identification data and activates a radial dispensing medication cartridge in response to verification of patient identification data. The radial dispensing medication cartridge may include, for example, a tablet carrier tape having a plurality of tablet packets with at least a partially open side. The tablet carrier tape accommodates different sizes and types of tablets or capsules and is sealed with a cover tape having an identification of the tablets.

Abstract: A product for application to skin includes a container having an open end, a non-flowable composition within the container including an application surface at the open end having a visual pattern, and a removable cap having a % opacity of less than 5%.

Abstract: There is provided a child resistant and senior friendly tamper evident package having a blister sheet with blister pockets for medicants, a rupturable foil sealed to a back side of the blister sheet, a layer of paper secured to a back side of the rupturable foil, and a reinforcing layer of a paperboard material being adhered to the paper layer with a portion of the reinforcing layer in registry with the blister pockets not being adhered thereto. There are provided tear strips and tab members to assist in removing the tear strips which delaminate.

Abstract: A package for storing an aerosolizable pharmaceutical formulation comprises a capsule adapted to contain the aerosolizable pharmaceutical formulation, and a moisture barrier around the capsule. The moisture barrier comprises a material that is resistant to moisture passage, whereby the moisture barrier reduces the amount of moisture in contact with the aerosolizable pharmaceutical formulation so that the aerosolizable pharmaceutical formulation may be aerosolized when the capsule is opened. In one version, the moisture barrier comprises a metal.

Abstract: A child-resistant container for holding an item includes a housing and a tray that is pivotably connected to the housing for pivotable movement between a closed position in which the tray is in the housing for preventing access to the item and an open position in which the tray extends out of the housing for exposing the item. A latch in the form of a flexible member is connected to the tray and is biased to engage the housing when the tray is in the closed position. A lock assembly is connected to the housing and is engageable with the tray when the tray is in the closed position. In use, the tray is secured in the closed position by the latch and the lock and is angularly displaceable from the closed position to the open position upon the simultaneous application of a first force to the latch, a second force to the lock and a torque to the tray.

Abstract: A process for increasing the stability during storage and/or application of light-sensitive therapeutic systems and/or components thereof, such as active ingredients or auxiliary substances, using light-stability agents absorbing or reflecting electromagnetic waves is characterized in that absorption or reflection agents are used whose absorption or reflection spectrum comprises that wavelength range which is responsible for the instability of the light-sensitive material or components thereof.

Abstract: A unit dose package formed from the combination of a flexible portion, preferably of paperboard, which houses unit dose materials, and a rigid molded plastic locking mechanism comprising a child resistant trigger release mechanism.

Abstract: The present invention provides apparatus for rapid pediatric resuscitation and/or emergency management. A standardized formulation of each commonly used resuscitation medication in a self-contained set-up along with commonly used medical equipment for use in resuscitation procedures is provided.

Abstract: Pharmaceutical kits are provided that reduce or prevent oxidative degradation of oxygen-sensitive pharmaceutically active ingredients in solid unit dosage forms that are supplied in oxygen permeable containers. Stabilization of the active ingredient is accomplished by incorporating an oxygen absorber into a sealed oxygen permeable container.

Abstract: A package for blister pack strips comprises a blister guide (11), a strip guide (12), a back cover (3) having a depression (10) accommodating blisters projecting through the blister guide (11), and a front cover (8). The package is made by folding a rectangular sheet (1) having appropriate cut outs forming blister guides (11) and strip guides (12) and being by folding lines (5, 7, 9) divided into three outer zones comprising an edge zone forming the front cover (8), an intermediary zone forming the strip guides (12), and an inner zone forming the blister guides (11), and a fourth zone forming the back cover (3).

Abstract: A locking container has a tray with sidewalls, a shelf and a bottom with an elongated opening. A sliding lock and a spring are formed in the bottom opening. A lock flap is hinged to the shelf. A cover has a base glued to the tray bottom, a spine end and a top panel. A latch extension extends form the flap through holes in the shelf and top panel. Sliding the lock with a finger or thumb and lifting with fingers both side sections of the flap releases the latch extension and allows raising of the top panel. Articles are held in bubbles of an inner laminate on the panel.

Abstract: A sealed glass container containing therein a stable, injectable, sterile, pyrogen-free doxorubicin anti-tumor composition in a solution which consists essentially of a physiologically acceptable salt of doxorubicin dissolved in a physiologically acceptable solvent therefor, wherein said solution has not been reconstituted from a lyophilizate, and wherein said solution has a pH of from 2.5-3.5 and a concentration of said doxorubicin of from 0.1 to 100 mg/ml.

Abstract: The present invention is to a container, particularly for moisture sensitive materials, having a container body of a substantially atmospheric moisture-impermeable material and incorporating a solid element which is made at least in part of a desiccating polymer and which is in contact with the atmosphere inside the container.

Abstract: A system and multiple methods are described for removing dissolved gases from a liquid either prior to or following filling into a container. Prior to filling, gas is removed by creating a pressure differential, by application of heat, by sonication, or by generating a liquid by combination of dry solute and de-gassed solvent. Alternatively, liquids may be highly concentrated with solute to force any dissolved gas out of solution and later diluted with de-gassed solvents. In other embodiments, gases are percolated into liquids to displace atmospheric gases, wherein these percolated gases separate from solution and diffuse out of sealed contained after filling either by nature of their molecular size or chemical reaction with materials constructed into the container.

Abstract: A solid, stable composition containing a meiosis activating substance can be prepared by adding a protein or a phosphoglycid in the presence of an atmosphere having a low content of oxygen, for example in vacuo.

Abstract: The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved in an inflammatory response. The present invention also relates to methods useful for identifying such compounds. The present invention also relates to the treatment of platelets for transfusion with metalloproteinase inhibitors to treat or prevent inflammation. The present invention also includes compositions and methods to treat injury and disease related to such biological processes.

Abstract: A pill dispenser comprises a lightweight container that carries a small number of doses (e.g., fewer than five and preferably one) of a medication to be taken during emergency or unexpected events. The device provides a symbolic indication of the nature of the event or condition for which the medication should be taken. The device may carry expiration date information for the medication. The device may also provide an environment proof closure to protect the medication, yet provide easy access to the medication when needed.

Abstract: The present invention provides a dispensing unit with a sealed enclosure containing a pill or pills which is provided by a cover attached to a flat base portion. The flat base portion is attached to a commonly used object using a first adhesive. The cover has a top bubble portion to provide space for the pill or pills and a bottom flange which is sealed to the flat base portion using a second adhesive. A tab portion of the cover is used to remove the cover from the base portion to access the pill enclosure. The pill or pills are attached to the top surface of the base portion using a third adhesive. The base portion is not displaced from the object when the cover is removed. The user can easily remove the pill or pills from the base portion by hand as the base portion remains attached to the object. A number of dispensing units can be made together on a larger base assembly with perforations to provide each individual base portion of a dispensing unit.

Abstract: A thin, credit card sized reusable pill case. A top half lid and bottom half base are joined by a living hinge on one side and a releasable lock on the other side. Individual dosages are secured within the pill case in pods, the pods being sized to fit a particular medication pill to be held therein. Each pod substantially encloses the individual pill while having a finger engagement opening to allow easy extraction of the pill without turning the pill case upside down. Transparent windows formed in the top half case are aligned over the pods to allow the inventory of the pill case to be assessed without opening the pill case. In an alternative embodiment, sawtooth edges are provided to perforate packaging around pre-packaged medications.

Abstract: The present invention relates to a disposable dispensing apparatus which provides optimal therapeutic support to humans and other animals by conveniently supplying a complex dosing regimen requiring simultaneous administration of storage-incompatible or unevenly dosed components in a shelf stable user-friendly format. The present invention is particularly useful for humans with special therapeutic needs, such as pregnant, lactating and/or menopausal women.

Abstract: The invention relates a combined sample dispenser and order form comprising a backing sheet that may be prepared from cardboard and a generally planar retaining member, such as a clear plastic sheet, attached to the backing sheet along at least a portion thereof. The retaining member or plastic sheet defines a distention or pocket along a portion of its broad surface, that may contain samples of the product being dispensed, such as sample medications provided to physicians by pharmaceutical manufacturers. The invention is also useful for the sale of certain consumable items, including hardware, where the order form may be used by the consumer to directly request additional quantities of the product.

Abstract: A device for holding blister packs has first and second members, which are operable between an open condition to allow removal of products from the blister packs, and a closed condition to prevent this. The blister packs are not removable from the device. The blister packs may be retained by panels overlying their bases. The members can be retained in their closed conditions by a child-resistant closure.

Abstract: An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to selective vials, and a waste tube system for purging material from the vials. A purging operation can be selectively performed on one or more of the banks of vials. The multiple banks of valves provide an additional number of reagent choices while operating in a serial mode and faster reagent distribution while operating in a parallel mode. The plurality of vials are stored in the cartridge and are divided among individual banks wherein each bank of vials has a corresponding drain. There is at least one waste tube system for expelling the reagent solution from vials within a particular bank of vials when the waste tube system is coupled to the corresponding drain.

Abstract: A base and a plurality of containers is described. The base may have a plurality of receptacles, each of the plurality of receptacles having a first dimension. Each of the plurality of containers may correspond to one of the plurality of receptacles. Each container may have a first dimension which is about the same as the first dimension of its corresponding receptacle. The base may have a top surface and each of the plurality of receptacles may be comprised of a plurality of walls, each of which extends upward from the top surface of the base. Each of the plurality of containers may have a lid which can be sealed and unsealed. The plurality of receptacles can be arranged in a plurality of rows and columns. Each of the plurality of containers may have protrusion at its top and a recess at its bottom so that a first container can be stacked on a second container.

Abstract: The present invention is a protective system for a plurality of pills contained within a blisterpack. It includes a plurality of hollow modules formed of a non-flexible plastic material, each hollow module having a sufficient size and shape to fit over individual blister-contained pills in the blister pack, and a plurality of spacing bars connecting the plurality of modular hollow modules. The hollow modules may be arranged in predetermined geometric patterns linearly or in an x-axis, y-axis plane to coincide with the pattern of blisters of a blisterpack so as to fit over the blisterpack for packaging and shipping to prevent breakage and damage to the blisters and the pills contained therein.

Abstract: A flat pill pack container includes a main container body with a dispensing opening and an attachment mechanism for attaching a closed-biased, cover, and a defined dispensing chamber adjacent its dispensing opening. The closed-biased cover is attached at the dispensing opening in a first, closed position to prevent removal of pills from the main container body. The cover is movable to a second, open position to permit pill removal. The cover has a gate positioned in an open position when the cover is in its closed position, and the gate moves to a closed position when the cover is moved to its open position. A child resistant safety lock and/or a date indicator may also be included.

Abstract: The present invention provides methods and compositions for the safe, effective, and efficient storage and transport of microbial cultures and comprises a vial and cap combination wherein the cap comprises an immobilized desiccant and the vial comprises viable microorganisms lyophilized in a lyophlization medium. In particular, the present invention provides compositions and methods for the storage and transport of bacterial cultures. The present invention is suitable for use in circumstances where long-term storage of microbial cultures is desired.

Abstract: An ampule storage bag can store ampules for one patient and can engage a transfusion bottle for the same one patient. The ampule storage bag includes a nontransparent sheet and a transparent sheet bonded along the edge to the nontransparent sheet so as to define an opening along the edge. The bag is formed with two holes for engaging a neck of a transfusion bottle. The holes are provided symmetrically with respect to a fold line provided near the opening. Cushion members are provided in the bag to arrange ampules in order in the bag and to prevent breakage of the ampules.

Abstract: A packaging for goods, such as, for example, tablets, capsules or the like, is suggested which is simple to produce and can be handled without problem, comprising a packaging lower part and a cover film, wherein the goods are arranged individually between the packaging lower part and the cover film and enclosed by them, wherein the cover film comprises a pull-off layer and a push-through layer which are designed such that first of all the pull-off layer can be detached from the packaging in sections and the goods then removed individually by being pushed through the push-through layer, wherein the pull-off layer is peelably connected to the push-through layer, wherein the push-through layer is connected to the lower part by means of a sealing layer and wherein the push-through layer is produced on a polymer basis.

Abstract: A child-resistant blister package having a tray adapted to receive a blister card with at least one blister compartment is provided. The tray includes a first slide component. A cover having a top and a second slide component is provided. The second slide component is complementary to and slidingly engaged with the first slide component. The second slide component is connected to the top of the cover such that the cover can be slidably displaced relative to the tray between a first position, in which the top of the cover substantially overlies the tray and is adapted to prevent access to the blister card, and a second position, in which the cover is displaced at least partially from the tray such that the blister card is exposed. A tab is connected to the cover, and one of a locking projection and a slot is located on the tab.

Abstract: A folding box for packing articles in which the folding box has a one-piece parallelepiped body. An insert for the articles and a compartment for a package leaflet is disposed in the body. The one-piece blank of the folding box is embodied such that the folding box can be produced with only a few folding operations. This is attained by a special disposition of an insert on a longitudinal gluing flap.

Abstract: The invention is a child resistant and easy to use blister package for containing a solid medicament that utilizes a dual compartment cavity assist mechanism as an opening feature. The multi-section blister card package has an opening feature comprising a pre-formed dual compartment cavity in the blister container sheet which is adjacent to the cavity containing the product and a corresponding weakened area such as perforation or score in the backing closure sheet in the area covering the dual compartment cavity. The blister is opened by applying pressure on the dual compartment cavity at the underside of the backing score line. The pre-formed second cavity assists in forming a pull tab on the opposite side of the blister, allowing for easy access to separate and pull the backing material towards the product cavity and thus exposing the product cavity for product removal.

Abstract: A health improvement device for modifying a daily behavior by reminding a person to take medication includes a generally vertically upstanding housing. The housing includes first and second adjoining sections. The first section is provided to removably hold an instrument, such as a toothbrush, for use in a daily activity. The second section is provided for holding a material, such as medication, to be taken by the person. When a person reaches to use the toothbrush, for example, the person is reminded to take the medication due to its proximity in the second section.

Abstract: A stretched PCTFE (polychlorotrifluoroethylene) film is provided with a good moisture-proofness (low moisture permeability) even at a relatively small thickness and at a small crystallinity The film is characterized by a crystallinity A (%) of 15-75% and a moisture permeability B (mg/m.sup.2.day) at a film thickness of 20 .mu.m, satisfying a relationship of B/(100-A).ltoreq.3.0. The film may suitably be produced through a process characterized by a sequence of a relatively low-temperature melt-extrusion and a low temperature stretching. The film is suitably used for constituting moisture-proof packaged products, such as an EL device or a packaged drug product.

Abstract: There is provided a skin lotion composition with non-greasy skin feel, capable of being stably encapsulated within a softgel, and which may preferably include tocopheryl acetate and/or vitamin A palmitate and methods for making and using the same.

Abstract: A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube with a penetration in a receptacle containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprise the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be in the form of a cartridge containing a plurality of receptacles formed in a continuous web. The cartridge may be reciprocated relative to the feed tube and a separate piercing mechanism in order to sequentially piercing the receptacle and thereafter couple the feed tube through the resulting penetration for extracting the powder. Alternatively, penetration(s) through the receptacle may be formed as the feed tube is coupled, or some penetrations formed prior to coupling with other penetrations formed at the time of coupling.

Abstract: In a preferred embodiment, the improved vial holder apparatus comprises a body portion having two pairs of outwardly extending arms and top and bottom outwardly extending supports. The outwardly extending arms and supports together define a central cavity for releasably securing therein a vial. The top support preferably includes an aperture for receiving a ring therein such that the vial holder apparatus may be secured to a necklace or to a key ring along with a set of keys. Accordingly, the vial holder apparatus permits a vial to be securely held within the holder thereby lessening the chance of damage to the vial. The holder also permits the vial to be releasably secured to a necklace or a key chain thereby lessening the chance of loss of the vial.

Abstract: Disclosed herein are a divided package of a medicinal adsorbent for internal use, comprising a divided package bag and an adsorbent for internal use which releases air ranging from 1.3 to 10 ml based on one gram of the adsorbent on heating from 10.degree. C. to 30.degree. C. and is packed therein, and having a volume expansion coefficient ranging from 0 to 0.064 ml/.degree.C..multidot.g (adsorbent for internal use) at a temperature of from 10.degree. to 30.degree. C., and a process for producing the same.

Abstract: A vial holder is provided which is easily loaded with a vial, retains the vial in a rigid manner and permits the vial to be discharged in a simple manner. The vial holder can also exhibit two vial retention sections for simultaneously rigidly holding two vials.

Abstract: A health improvement device for modifying a daily behavior by reminding a person to take medication includes a generally vertically upstanding housing. The housing includes first and second adjoining sections. The first section is provided to removably hold an instrument, such as a toothbrush, for use in a daily activity. The second section is provided for holding a material, such as medication, to be taken by the person. When a person reaches to use the toothbrush, for example, the person is reminded to take the medication due to its proximity in the second section.