Abstract: Wide-field fluorescent imaging on a mobile device having a camera is accomplished with a compact, light-weight and inexpensive optical components that are mechanically secured to the mobile device in a removable housing. Battery powered light-emitting diodes (LEDs) contained in the housing pump the sample of interest from the side using butt-coupling, where the pump light is guided within the sample holder to uniformly excite the specimen. The fluorescent emission from the sample is then imaged using an additional lens that is positioned adjacent to the existing lens of the mobile device. A color filter is sufficient to create the dark-field background required for fluorescent imaging, without the need for expensive thin-film interference filters.

Abstract: The invention relates to a method for determining the presence of an analyte by means of a distribution of small magnetic particles. According to said method, the magnetisations of the small particles are oriented in relation to each other by means of an outer magnetic focusing field; once the focussing field has been terminated, the magnetisations of the small particles are rotated asynchronously to the magnetic field by means of an outer magnetic field of suitable field intensity and rotational frequency, which rotates about a longitudinal axis (z); the temporal course of the superpositioned transverse magnetisation of the set of particles is detected; and the presence of the analyte is deduced from the detected temporal course. The invention also relates to a corresponding device (1).

Abstract: Washing efficacy test apparatus (2) is provided which includes a holder (4) and a test soil device (6) for location with said holder (4). The test soil device (6) is in the form of sheet material with a test soil substance (34) provided thereon. The holder in one example includes two members (8, 10) between which the test soil device (6) is detachably attached so that the device (6) can be easily removed for inspection and maintained in a required orientation in the washing apparatus (2) in use.

Abstract: The present invention relates to a method for functionalising fluid lines (1b) in a micromechanical device, the walls of which include an opaque layer. For this purpose, the invention provides a method for functionalising a micromechanical device provided with a fluid line including a peripheral wall (5) having a surface (2) outside the line and an inner surface (3) defining a space (1b) in which a fluid can circulate, the peripheral wall at least partially including a silicon layer (5a).

Abstract: This invention provides a sample analyzing device and sample analyzing method designed to suppress nonuniform capture of magnetic particles (10) and detect a desired substance with higher accuracy.

Abstract: [Object] It is an object of the invention to provide a sensor area which can suppress a decrease in assay signal and an increase in assay blank in an SPFS measurement. [Solution] An SPFS sensor chip of the invention includes a purification area and a sensor area arranged upstream and downstream, respectively, relative to each other along a flow direction in a channel for surface plasmon-field enhanced fluorescence spectroscopy [SPFS].

Abstract: The present invention provides an immunoassay analyzer capable of discriminating between normal coloring due to a specific immunoreaction and abnormal coloring due to a cause other than the specific immunoreaction in a measurement region of a sample analysis tool. An immunoassay analyzer 1 of the present invention includes an optical detection unit 4 and a determination unit 5. The optical detection unit 4 includes an optical signal measurement unit for measuring an optical signal at each of two or more different wavelengths including a main wavelength for detecting color change due to the specific immunoreaction and a sub-wavelength(s) other than the main wavelength. The determination unit 5 includes a discrimination unit for comparing the respective optical signals at the two or more different wavelengths and discriminating between the color change due to the specific immunoreaction and color change due to a cause other than the specific immunoreaction based on a comparison criterion determined previously.

Abstract: The present invention relates to the field of laboratory diagnostics. Specifically, means and methods for determining the risk of mortality in a patient based on homoarginine and to reduce the risk of mortality by administration of homoarginine are disclosed. Moreover, the present invention relates to the use of homoarginine for the preparation of a medicament for the treatment of a patient having an increased risk of mortality caused by stroke or a cardiac cause. Furthermore, the present application relates to a pharmaceutical composition comprising homoarginine and a composition for foodstuff supplement comprising homoarginine.

Abstract: A chemical agent detection system is provided that includes a fluid sampling collector suitable for the collecting, concentrating, filtering and storing of chemical agents. Preferably a solid phase extraction syringe is coupled to an adaptor via an injection port. The adaptor forms an outer surface of a sample containment reservoir that allows the fluid sampling collector to associate with a chemical agent detector such as the M256A2 chemical agent detector. The inventive chemical agent detection system allows rapid, low level on-site detection of chemical agents such as nerve agents in fluid media.

Abstract: Provided are a biosensor, an apparatus and a method for detecting a biomolecule using the biosensor. The biosensor may include a supporting substrate, a semiconductor layer spaced apart from a top surface of the supporting substrate by supporting patterns, and a nano-motor array formed on a top surface of the semiconductor layer. The nano-motor array may include a plurality of nano-metal rods configured to exhibit an autonomous propulsion in a fluid.

Abstract: The present invention relates to a method of detecting rupture of fetal membranes and to a device for implementing said method. In particular, a method of in-vitro detection of a rupture of fetal membranes comprising a step of simultaneously searching, within a specimen of vaginal or cervical secretions, for the alpha fetal protein (AFP) and for the insulinomimetic growth factor-binding protein 1 (IGFBP-1). The present invention finds, in particular, an application in the medical field, especially in the obstetric field.

Abstract: A device, system, and method for detecting or separating target molecules allowing efficient detection even when only a small amount of target molecules or target cells are included in a sample involving the use of a target molecule linkage portion, a signal production portion, and first and second separation portions.

Abstract: A system for managing the inventory of reagents for a laboratory automation system. The system for managing the inventory of reagents comprises a controller, software for the controller, and a refrigerator capable of refrigerating reagents, detecting the presence or absence of reagents in the refrigerator, and detecting the location of reagents in the refrigerator. The system for managing the inventory of reagents is connected to a laboratory automation system. The laboratory automation system comprises at least one clinical analyzer. A typical system for managing inventories of reagents includes an operator interface for the loading of boxes of reagents and other supplies, radio frequency identification system for identification of inventory and tracking, robotic mechanisms for loading containers onto the track system and removing containers from the track system, de-capping equipment, refrigeration equipment, and information technology connections to laboratory analyzers and vendors.

Abstract: A method of screening aircraft passengers and/or cargo comprising loading an aircraft with passengers, cargo or both, circulating air within the aircraft so that the air is in contact with the passengers and/or cargo, expelling some of the circulated air from the aircraft, diverting a portion of the air being expelled from the aircraft through a chemical filter configured to retained evidence of a target substance, and analyzing the chemical filter to detect the presence of a target substance within the aircraft.

Abstract: The invention relates to a device (10) for capturing odor- and/or taste-generating substances present in water flowing continuously in a water distribution network via a pipe (12). In characteristic manner, the device comprises: capture means (22) for capturing said substances; at least one chamber (18) containing said capture means (22) and suitable for having network water flow therethrough; and hydraulic link and connection means (14; 42) between said chamber (18) and said pipe (12). The invention is applicable to networks for distributing drinking water.

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

Abstract: Biological samples of mammary fluid or components thereof are obtained using a breast pump device coupled with an absorbent paper or membrane, optionally facilitated by administering oxytocin to the subject. The breast pump device stimulates expression of mammary fluid and provides for collection of diagnostic samples on the absorbent paper or membrane to evaluate breast disease, including cancer. The biological sample may include fluid containing one or more of cells or cellular components, proteins, glycoproteins, peptides, nucleotides or other desired constituents comprising a breast disease marker. Absorbent paper or membrane, and methods relating to the paper or membrane, and a breast pump device are also provided.

Abstract: A method and device for detecting an analyte in a solution or compound mixture use colorimetric detection to detect the quantity of an analyte in the solution or compound. The analyte sensor demonstrates a clear change in peak light absorption wavelength as a function of the stoichiometric relationship between the analyte sensor and the analyte. The method involves combining the analyte sensor and the analyte in solution and observing a color change of the mixture. Additionally, predefined amounts of the analyte sensor can be added until color change is detected and the quantity of analyte can be determined as a function of the total amount of analyte sensor in the mixture. Alternatively, a device having multiple wells or compartments, each with a different concentration of the analyte sensor.

Abstract: The present invention relates to a method for detecting and quantifying an analyte present in a liquid of interest using a solid support, the surface of which comprises at least one active area on which at least one probe capable of binding said analyte is immobilized and a solution containing at least one secondary reagent capable of binding to the analyte, said method comprising a step consisting of recycling said solution in order to put it back into contact with the surface and notably with the active area at least one additional time. The present invention also relates to a device which may be applied within the scope of such a method.

Abstract: The present invention provides methods, devices, compositions (e.g., capture complexes), and kits useful for enhancing the detection of antibodies in a test sample. The methods, devices, and compositions utilize detectable Fc-binding molecules such as Protein A, Protein G, and/or an Fc-specific antibody to amplify the signal of a detected antibody in immunoassays, such as lateral flow assays.

Abstract: The present disclosure relates to detection of the presence or absence of cerebrospinal fluid (CSF) in a sample by the detection of one or more antigens that are enriched in CSF compared to their levels in other bodily fluids. The devices and methods are suitable for the detection of the presence or absence of cerebrospinal fluid in samples of mixed bodily fluids from a wide variety of human populations crossing ethnicity, age, gender, health status and genetic variability.

Abstract: The disclosure provides probes for one or more target molecules. In particular examples, the probes include a molecular linker and first and second functional groups linked and spaced by the molecular linker, wherein the functional groups are capable of interacting with one another or with the target biomolecule in a predetermined reaction, and wherein the molecular linker maintains the first and second functional groups sufficiently spaced from one another such that the functional groups do not substantially interact in an absence of the target biomolecule. In the presence of the target biomolecule the functional groups interact (with each other, with the target biomolecule, or both), and in some examples a detectable signal is produced. In some examples, the functional groups can detect or modify a target molecule. Also provided are methods of using the probes, for example to detect or modify a target molecule.

Abstract: The present invention relates to the identification and use of diagnostic markers for ischemic stroke of the lacunar subtype. The invention relates to devices and kits for performing these methods.

Abstract: A method is provided for preparing electrically conductive polymer and cellulose nanocomposite particles and nanocomposite materials. Cellulose microparticles coated with a conductive polymer are added to an acid solution for initiating an acid hydrolysis reaction for a prescribed time interval to form conductive polymer coated cellulose nanoparticles. After quenching the acid hydrolysis reaction, the nanoparticles are separated to obtain a colloidal solution of conductive nanoparticles. The conductive nanoparticles may be subsequently formed into a solid nanocomposite material such as a conductive film. Transparent conductive films may be prepared by forming thin layers having a thickness on a micron or submicron scale.

Abstract: A panel for monitoring levels of biomarkers, including an assay having at least one inflammation monitoring test, at least one oxidative stress monitoring test, and at least one antioxidant activity monitoring test. A method of monitoring an individual's health, by collecting a sample from the individual, applying the sample to an assay panel, performing at least one inflammation monitoring test, at least one oxidative stress monitoring test, and at least one antioxidant activity monitoring test in the panel, and determining levels of biomarkers related to inflammation, oxidative stress, and antioxidant activity and therefore providing information regarding the individual's relative health and/or risk of developing one or more diseases.

Abstract: The disclosed magnetic immunoassay device, which performs magnetic immunoassays using antigen-antibody reactions, can perform speedy immunoassays without bound/free separation in the test samples. The device is also practical, being capable of stable magnetism measurement without magnetic shielding. The disclosed magnetic immunoassay device is provided with: an excitation coil that uses an AC magnetic field to magnetize a test sample containing a magnetic marker; a magnetism sensor that measures magnetism in the test sample and outputs a magnetism signal; and a displacement sensor for detecting changes in the distance between the test sample and the magnetism sensor.

Abstract: In order to improve the detection accuracy of a reflection spectrum, a detection device for intermolecular interaction is provided with a detector (10) which has a ligand (16), a white light source (20) which emits white light, a spectroscope (30) which detects the spectral intensity of received light, a light transmission unit (40) which has a first light transmission path (41) for transmitting the white light from the white light source to the detector, a second light transmission path (42) for transmitting reflected light of the white light from the detector to the spectroscope, and a third light transmission path (43) for transmitting the white light from the white light source to the spectroscope, a switching unit (80) which performs switching between a reflected light receiving state in which the transmission of the reflected light of the white light in the detector to the spectroscope via the first and second light transmission paths is enabled and a white light receiving state in which the transmissio

Abstract: A method of chemical and/or biological analysis including: providing a container delimited by a wall including an inner surface on which there is deposited an active component intended to make possible a chemical and/or biological reaction with a solution disposed in the container; filling the container with a liquid solution containing an analyte which is to be detected; and in applying to the liquid a succession of movements of aspirating/discharging a volume in the container at a suitable frequency to bring about resonance of the liquid so as to deform the free surface thereof and to result in a preferential distribution of the fluid along the inner surface of the wall of the container.

Abstract: Provided are kits for determining a nucleotide sequence of a target nucleic acid, the kit including at least one sequence specific binding protein and a detectable tag. In accordance with a kit for determining a nucleotide sequence of a target nucleic acid according to one exemplary embodiment and a method and device for determining a nucleotide sequence of a target nucleic acid, the nucleotide sequence of the target nucleic acid may be more efficiently determined.

Abstract: Provided is a microfluidic apparatus including: a microfluidic structure for providing spaces for receiving a fluid and for forming channels, through which the fluid flows; and valves for controlling the flow of fluid through the channels in the microfluidic apparatus. The microfluidic structure includes: a sample chamber; a sample separation unit receiving the sample from the sample chamber and separating a supernatant from the sample by using a centrifugal force; a testing unit receiving the supernatant from the sample separation unit for detecting a specimen from the supernatant using an antigen-antibody reaction, and a quality control chamber for identifying reliability of the test.

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

Abstract: A method for diagnosing a cardiac disorder by detecting levels of cardiac-specific membrane polypeptides in tissue samples.

Abstract: The invention generally relates to detection and analysis of biological materials. In particular; the invention relates to quantum dot-based optical, sensors and methods for rapid detection and quantitative analysis of various biomolecules and biological materials, such as nucleic acids, proteins, cells, etc.

Abstract: An integrated chromatography-immunoassay system for integrated chromatography-immunoassay system includes a chromatographic unit that receives labeled nano-structured probes comprising nano particles and antibodies attached to the nano particles, and a test membrane comprising coating antigens. The chromatographic unit allows the labeled nano-structured probes to diffuse there through and into the test membrane, wherein the antibodies on the nano particles are bound to the coating antigens. A laser device emits a laser light to illuminate the labeled nano-structured probes having the antibodies bound to the coating antigens on the test membrane. A spectral analyzer obtains a Raman spectrum from light scattered from the labeled nano-structured probes having the antibodies bound to the coating antigens on the test membrane, and to identify a spectral signature in the Raman spectrum associated with the antibody-antigen pair, which enables detection and identification of the antibody.

Abstract: The invention relates to sensors configured to include compositions disposed in specific regions of the sensor in order to provide the sensors with enhanced functional properties, for example faster start-up times. These compositions include, for example, hygroscopic compositions, gas generating compositions and gas solvating compositions. While typical embodiments of the invention pertain to glucose sensors, the systems, methods and materials disclosed herein can be adapted for use with a wide variety of sensors known in the art.

Abstract: The present invention related to a pregnancy test device that can selectively detect hyperglycosylated human chorionic gonadotropin (hCG-H) in a liquid sample. The sample can be deposited on a proximal portion of the device for transport to a distal portion of the device. The device can include a release medium formed of a first material and including a detectable label thereon and a capture medium, including a capture site, in fluid communication with the release medium and formed of a second, different material. At least one of the release medium and the capture medium includes a binding member that exhibits a moderate to high affinity for hCG-H and is selectively or preferentially reactive with hCG-H.

Abstract: Devices, methods and kits for rapid and simple determination of target molecules, including small molecules, polypeptides, proteins, cells and infectious disease agents in liquid samples that are capable of real-time measurement of these entities in fluid samples that are highly selective, highly sensitive, simple to operate, low cost, and portable. The devices, methods and kits also provide, in at least some embodiments, the use of MIPs in a flow through or lateral flow device.

Abstract: Disclosed are methods and apparatuses pertaining to measuring DNA damage due to exposure to ultraviolet light, as measured by formation of pyrimidine-pyrimidine dimers in a polynucleotide. The apparatuses can be in the form of a patch which can be particularly useful in measuring the effectiveness of a sunscreen. The apparatuses can further include a reporter agent for instant determination of the pyrimidine-pyrimidine dimer formation.

Abstract: The invention concerns a method and apparatus for determining one or more characterizing features of a macromolecule, in particular torque and/or twist of nucleic acids like DNA, using magnetic fields.

Abstract: Biomarkers for determining a kidney flare episode in systemic lupus erythematosus are described.

Abstract: A generation device and the like for generating long-life antibody chips which can be produced and held in stock is a generation device and the like for generating an antibody chip by binding antibody to a cup, including an antibody solution holder that holds antibody solution having antibody, a buffer solution holder that holds buffer solution, and an injector that injects solution into the cup. The injector has an inlet out of which solution is injected. The injector injects the buffer solution held by the buffer solution holder. The injector injects the antibody solution held by the antibody solution holder with the inlet in the buffer solution in the cup.

Abstract: A portable biosensor system includes at least one capillary tube extending longitudinally along a major axis between a proximal inlet end and a distal end. The at least one capillary tube has an interior surface coated with a capture material and forms a waveguide. At least one collimated light emitting diode is disposed proximate and perpendicular to the major axis of the at least one capillary tube and is positioned relative to the at least one capillary tube so that energy enters the at least one capillary tube from its exterior along the entire length of the at least one capillary tube to project a line of energy along substantially the entire longitudinal extent of the at least one capillary tube. A photosensor is disposed proximate the distal end of the at least one capillary tube for receiving emissive radiation therefrom. The photosensor generates an output voltage (or, optical output) representative of the emissive radiation, and a means for measuring the output voltage is provided.

Abstract: A sensor system is provided to detect the mass of a compound in a liquid solution, the system including a sensor including a plurality of pillars extending from a substrate and having a given height, the pillars having a free end opposite to the substrate, and including a lateral surface connecting said free end to the substrate. The free end defining a surface and the surface is functionalized in order to bind with the compound to be detected, and the lateral surface is hydrophobic. The distance between any two nearest neighbors pillars of the plurality satisfies the following equation height ? ? of ? ? any ? ? of ? ? the ? ? two ? ? n . n . ? pillars maximum ? ? distance ? ? between ? ? the ? ? two ? ? n . n . ? pillars > 1. The system also includes a detection device to detect the oscillations of said pillars.

Abstract: The described embodiments may provide a method of fabricating a chemical detection device. The method may comprise forming a microwell above a CMOS device. The microwell may comprise a bottom surface and sidewalls. The method may further comprise applying a first chemical to be selectively attached to the bottom surface of the microwell, forming a metal oxide layer on the sidewalls of the microwell, and applying a second chemical to be selectively attached to the sidewalls of the microwell. The second chemical may lack an affinity to the first chemical.

Abstract: Disclosed is a test instrument for measuring an analyte in a liquid sample by a noble metal colloid aggregation measurement method. The test instrument involves a reaction chamber in which at least the liquid sample is to be reacted with a reagent, wherein the reagent is adhered on at least a part of a surface constituting the reaction chamber in a dried state, and the reagent enables the measurement of the analyte by a noble metal colloid aggregation measurement method.

Abstract: A system, apparatus and method evaluates samples or analytes using a point-of-care device. A test selection is received from the user interface. A determination is made whether a test cartridge connected to the test cartridge interface matches the test selection. Properties of the sample or the analyte are detected using detector(s) or sensor(s) in the POC device. A test results data based on the properties is generated. A report based on an analysis of the test results data is generated and the report is provided to the user interface of the POC device. The POC device also includes memory, communication interface(s), test cartridge interface, and processor(s).

Abstract: A sensor for fluorescence measurement comprising: a light source arranged for emitting light to a sample region, wherein the light source intensity is modulatable; an indicator system located at the sample region, said indicator system comprising: a receptor for an analyte; and a fluorophore associated with said receptor, wherein the fluorophore has a fluorescence lifetime that changes in response to the presence of analyte at the receptor; a single photon avalanche diode arranged to receive fluorescence light emitted from said sample region in response to the light incident on the sample region from the light source, and to generate an output signal; a driver arranged to modulate the light source intensity at a first frequency; a bias voltage source arranged to apply a bias voltage to the single photon avalanche diode, wherein the bias voltage is modulated at a second frequency, different from the first frequency, and wherein the bias voltage is above the breakdown voltage of the single photon avalanche diod

Abstract: The present invention provides for increasing fluorescence detection in surface assay systems while increasing kinetics of a bioreaction therein by providing low-power microwaves to irradiate metallic materials within the system in an amount sufficient to increase heat thereby affecting the kinetics of a bioreaction therein.

Abstract: The invention relates to a microfluidic device that utilizes nucleic acid-based detection and a detection system containing the same, as well as a process for preparing the micro fluidic device and for using the same to detect the presence of a target nucleic acid molecule in a sample.

Abstract: A surface plasmon-field enhanced fluorescence spectroscopy [SPFS] sensor chip may include a transparent support, a metal thin film formed on one surface of the transparent support, a self-assembled monolayer [SAM] formed on a surface of the metal thin film, said surface not being in contact with the transparent support, a solid phase layer formed on a surface of the SAM and having a three-dimensional structure, said surface not being in contact with the metal thin film, and a ligand immobilized in the solid phase layer. A fluctuation ratio represented by the following formula is not less than 0% but not more than 30%: {half-width (?)?half-width (?)}/half-width (?)×100.