Abstract: A method and apparatus (10) for facilitating the shaving of large body surfaces. The method employs a skin lubricating unit (12) in the form of a shaving gel (41) impregnated with a luminous agent such as “Luminal” that will penetrate the user's body hairs wherever the foaming gel (41) is applied such that a razor blade member (20) equipped with a black light element (30) disposed in proximity to the shaving blade cartridge (24) will cause any body hairs missed in the shaving process to glow under the combined effects of the “Luminal” and the black light to insure that the selected body surfaces are completely shaved.

Abstract: A method and composition for treating a bacterial infection in humans and animals is disclosed. The composition contains an anti-bacterial agent that inhibits or kills a variety of Gram-negative and Gram-positive pathogenic bacteria, including several previously shown to be drug-resistant. In particular, the anti-bacterial agent comprises an antibiotic produced by members of the Alcaligenes genus. For instance, in one embodiment, the antibiotic is produced by the M3A strain of Alcaligenes faecalis. The antibiotic of the present invention can be administered parenterally or via a mucosal route.

Abstract: Antibiotic 10381a1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing the novel microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C1 to C3 alkyl ester of antibiotic 10381a1, are also disclosed along with the pharmaceutically acceptable salts of both the native and esterified forms. Antibiotic 10381a1 inhibits the growth of selected species of yeast, fungi and bacteria. This invention also relates to a novel process for the preparation of the antibiotics 10381b and to a method of using antibiotics 10381b to promote growth in meat-producing animals. These antibiotics are also obtained by the fermentation of a nutrient medium with the novel microorganism Streptomyces arginensis and are active against selected species of bacteria.

Abstract: A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.

Abstract: Provided are termite phagostimulatory compositions extracted from fungi coexisting with subterranean termites. In a preferred embodiment, a subterranean termite feeding stimulant is obtained from extracts of fungi coexisting with Reticulitermes hesperus. Termite feeding stimulants in accordance with the present invention may be incorporated into termiticide-treated bait-based systems and methods to selectively target and enhance control of subterranean termites. Also provided are compositions which deter feeding of subterranean termites. These phagodeterrent compositions may be obtained from non-polar extracts of subterranean termite-associated fungus-colonized filter paper. They may also find useful application in termite control strategies, for example, by deterring subterranean termites from colonizing or feeding on particular substrates and structures.

Abstract: A protein extract from Chilo iridescent virus or the whole virus controls insects, particularly the cotton boll weevil and the cotton aphid, respectively. These compositions/agents may be used to directly control insects or genes for active proteins may be cloned into vectors for transformation of plants or plant colonizing microorganism, thereby providing a method for controlling insect infestation.

Abstract: This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating Actinoplanes sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocylic lactone compound from the fermentation broth. The compounds produced by this process include a compound of the following formula: The present invention also relates to a pharmaceutical composition comprising the same, which is useful as immunosuppressive, antimycotic, antitumor agent or the like.

Abstract: A remedy for tragomaschalia characterized in that it conntains an effective amount of adrenocorticosteroid and from 1 to 10% by weight of an extraction product from lactic acid fermentation based on one gram of a base. The extraction product from lactic acid fermentation has a metabolism product of lactic acid bacteria and ingredients of bacterial cells of lactic acid bacteria together. By inhibition of the secretion itself of a odoriferous steroid which is the cause of tragomaschalia, remetabolism and generation of such a steroid compound by tragomaschalia bacteria are completely eliminated, and there is little fear of adverse drug reactions by the adrenocorticosteroid used for that purpose.

Abstract: A method for preparing the high protein nutrient from oilseed-based material is provided. The modified oilseed-based material produced by the process can be utilized in a wide variety of applications, including the preparation of fermentation media. The oilseed-based product typically includes at least about 55 wt. % protein (dry basis), low levels of soluble sugars, such as raffinose, stachyose and saccharose and has a FAN content of at least about 15 mg/g. Fermentation media and aqueous nutrient solutions derived from the modified oilseed material are also provided.

Abstract: The invention relates to low-molecular, metabolism-activating mixtures of active ingredients from yeast fungi of the order Saccharomycetes and is characterized in that they are obtained from yeasts of the said order of Saccharomycetes, which are cultivated for some hours at temperatures starting at 37.degree. C., are heated to a maximum of 45.degree. C. and, following cooling, are subsequently processed in a manner known per se.

Abstract: The present invention relates to a novel antibiotic-producing and metabolite-producing Bacillus subtilis strain that exhibits insecticidal, antifungal and antibacterial activity. The supernatant of this novel strain contains effective insecticidal, antifungal and antibacterial agents. Also included in the invention is a solvent extractable, small molecular weight (<10,000 daltons) corn rootworm-active metabolite produced in the supernatant. Also included in the invention are methods of protecting or treating plants from fungal and bacterial infections and corn rootworm infestations comprising the step of applying to the plant an effective amount of the antibiotic/metabolite-producing novel Bacillus subtilis strain, the antibiotic/metabolite produced by the novel Bacillus subtilis strain or a combination thereof, optionally further comprising another antibiotic-producing bacterial strain and/or a chemical pesticide.

Abstract: The present invention relates to a novel antibiotic-producing and metabolite-producing Bacillus subtilis strain that exhibits insecticidal, antifungal and antibacterial activity. The supernatant of this novel strain contains effective insecticidal, antifungal and antibacterial agents. Also included in the invention is a solvent extractable, small molecular weight (<10,000 daltons) corn rootworm-active metabolite produced in the supernatant. Also included in the invention are methods of protecting or treating plants from fungal and bacterial infections and corn rootworm infestations comprising the step of applying to the plant an effective amount of the antibiotic/metabolite-producing novel Bacillus subtilis strain, the antibiotic/metabolite produced by the novel Bacillus subtilis strain or a combination thereof, optionally further comprising another antibiotic-producing bacterial strain and/or a chemical pesticide.

Abstract: Secretion of gastric acid and development of ulcers can be inhibited by administering to a patient in need thereof an effective amount of a hot water extract of the cultivated mycelia of Cordyceps sinensis.

Abstract: An imperfect fungus such as a microorganism belonging to the genus Curvularia in a culture medium containing nutrients utilizable for normal microorganisms and isolating MK7634 substance of a molecular formula: C.sub.8 H.sub.15 N.sub.3 O.sub.4 from the culture by, for example, solvent extraction, ion exchange resin technique or gel filtration chromatography. The MK7634 substance can be used as an active ingredient of drugs. In particular, the MK7634 substance is a novel anthelmintic substance and expected to be used as an active ingredient of anthelmintics.

Abstract: The present invention is directed to a unique strain of Bacillus subtilis for inhibiting growth of plant pathogenic fungi and bacteria and methods for treating or protecting plants from fingal and bacterial infections.

Abstract: Disclosed are a deterioration inhibitor for an emulsion-type processing oil comprising, as an active ingredient, a culture of a bacterial species selected from the group consisting of Aerococcus viridans BC-A-4 (Acceptance No. FERM BP-5042), Bacillus brevis BC-A-69 (Acceptance No. FERM BP-5041) and Bacillus brevis BC-A-3124 (Acceptance No. FERM BP-5043) and a method for inhibiting deterioration of an emulsion-type processing oil comprising adding such deterioration inhibitor to the emulsion-type processing oil and then allowing the bacteria contained in the deterioration inhibitor to proliferate. Since the propagation of the putrefying bacteria in the emulsion-type processing oils can be suppressed by the proliferation of the bacteria contained in the deterioration inhibitor, the working life of the emulsion-type processing oil can be prolonged.

Abstract: Antibiotic 10381a.sub.1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing the novel microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C.sub.1 to C.sub.3 alkyl ester of antibiotic 10381a.sub.1, are also disclosed along with the pharmaceutically acceptable salts of both the native and esterified forms. Antibiotic 10381a.sub.1 inhibits the growth of selected species of yeast, fungi and bacteria. This invention also relates to a novel process for the preparation of the antibiotics 10381b and to a method of using antibiotics 10381b to promote growth in meat-producing animals. These antibiotics are also obtained by the fermentation of a nutrient medium with the novel microorganism Streptomyces arginensis and are active against selected species of bacteria.

Abstract: A method for producing a novel yeast and mold inhibiting products (FIC) from a Lactobacillus, particularly a Lactobacillus casei having the yeast and mold producing characteristics of Lactobacillus casei var. rhamnosus NRRL-B-15972 is described. The products (FIC) are particularly useful in retarding yeast and mold growth in foods and other materials in need thereof.

Abstract: Taxol is produced from taxol-producing microorganisms. Methods of obtaining he taxol-producing microorganisms are described. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol and for the treatment of leukemia and cancer cells are described.

Abstract: Fucans with low molecular weight having anticoagulant, antithrombinic and antithrombotic activity.Fucan sulfates having molecular weight between 14000 and 29000 Dalton show a remarkable anticoagulant activity both in the global coagulation mechanism (APTT) and in the last phase of coagulation (antithrombinic activity). These compounds are useful also as antithrombotic drugs.

Abstract: This invention is a healthful composition comprising a hot-water extract of the cultivated mycelia of Cordyceps sinensis.The healthful composition of the invention is an oral healthful composition which is highly safe and has excellent cardiotonic, hypotensive, antitussive and anti-fatigue effects.

Abstract: Taxol is produced from taxol-producing microorganisms. Methods of obtaining he taxol-producing microorganisms are described. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol and for the treatment of leukemia and cancer cells are described.

Abstract: The invention relates to a new nutrient composition resulting from maize steeping. This composition comprises an inorganic phosphorous concentration to total phosphorus concentration ratio (Pi/Pt) of between 35 and 95%. The composition also comprises proteins in an amount which gives a value of less than or equal to 5 according to a C test. A process for producing a nutrient composition is also disclosed; wherein the process requires maize steepwater to be subjected to an enzymatic treatment with the aid of protease and phytase enzymes. Furthermore, the enzymatic treatment is performed on a steepwater whose dry matter content is between 5 and 50%, and pH between 3 and 5, at a temperature varying between 40.degree. and 60.degree. C. and for 4 to 16 hours.

Abstract: Methods and compositions for modulating the immune system of animals by activating macrophages to release cytokines and down-regulating their sensitivity to bacterial endotoxin and to conversion to cytotoxic phenotypes by the administration of stress response factors released by stressed bacteria.Methods and compositions for protecting the viability of liquid or dried cultures of bacteria by the administration of stress response factors released by stressed bacteria.

Abstract: A physiologically active agent for fish is provided which comprises metabolite of green sulfur bacteria as an effective component thereof. The physiologically active agent, which can be easily prepared by the mass culture of green sulfur bacteria, exhibits an excellent efficiency as a feed additive, can be preserved for a long time and hence is economical.

Abstract: A novel bacteriocin produced by Lactococcus lactis NRRL-B-18535 is described. The bacteriocin is useful in foods and other materials and has a wide spectrum of activity against Gram-positive bacteria in a pH range between 2 and 8.

Abstract: This invention relates to the extraction of biological compounds from plants and animals and to the preparation and tinctures and essences from the extracted materials. The materials are extracted using alcoholic and/or phosphate buffered saline solutions. The extraction step can be performed repeatedly on the residue from the previous step. The rich solution resulting from the extraction can be freeze dried for further use or employed as a fermentation feed. The fermenter product can be freeze dried for further use. The invention also makes use of the residues resulting from the extraction and fermentation reactions.

Abstract: The present invention relates to a novel strain antibiotic-producing Bacillus subtilis which is effective against plant fungal and bacterial infections. The invention also includes methods of protecting plants from fungal and bacterial infections comprising the step of applying to the plant an effective amount of the antibiotic-producing Bacillus subtilis, the antibiotic produced by the antibiotic-producing Bacillus subtilis or a combination thereof, optionally further comprising another antibiotic-producing bacterial strain and/or a chemical pesticide. The invention includes methods of treating fungal and bacterial infections using whole broth cultures or supernatants obtained from cultures of antibiotic-producing Bacillus subtilis cultures. The invention also includes treating plant infections using a combination of whole broth and/or supernatant obtained from the antibiotic-producing strain of Bacillus subtilis optionally in combination with chemical pesticides.

Abstract: A skin whitening composition includes acerola cherry fermentate. The composition can be topically applied to the human skin and can include one or more whitening agents in combination with acerola cherry fermentate to achieve enhanced whitening effect. A method of whitening human skin includes topically applying to the skin acerola cherry fermentate in an amount and for a period of time sufficient to visibly whiten the skin. The method includes incorporating acerola cherry fermentate with known whitening agents and applying to the skin in an amount and for a period of time sufficient to visibly whiten the skin.

Abstract: The invention discloses a bait for fishes and shellfishes characterized in that the bait comprises a matrix material containing a microorganically fermented product of a plant residue obtained by separating from a plant at least one liquid selected from the group consisting of vegetable juice, fruit juice, plant essential oil, juice extracted from a processed plant product, plant milk and mixtures thereof, or disintegrated product of said microorganically fermented product, wherein the matrix material has incorporated therein (A) an amino acid having 2 or 3 carbon atoms, and (B) amino acid having at least 4 carbon atoms in an (A)/(B) molar ratio of 1:1 to 40:1.

Abstract: The present invention is directed to a new antibiotic denominated antibiotic GE1655 complex, its factors antibiotic GE1655 factor A, antibiotic GE1655 factor B, and antibiotic GE1655 factor C, the pharmaceutical acceptable salts thereof, the pharmaceutical compositions thereof, and their use as medicaments against bacteria and fungi, particularly for the treatment of fungal infections in animals and human beings.

Abstract: A Bacillus licheniformis producing an antifungal principle active against a wide variety of plant pathogenic fungi has been isolated. The microorganism was obtained from the rhizosphere of perennial ryegrass (Lolium perenne L.). The type isolate, strain PR1-36a, is particularly antagonistic to filamentous fungi, including Rhizoctonia and Magnaporthe. The microorganism was shown to be effective as a biocontrol agent for control of Fusarium seedling blight in corn. The antifungal principle produced by the microorganism is diffusible and may be purified by acid precipitation of the culture fluid, followed by ethanol extraction. The antifungal principle is fungistatic against several diverse species of fungi, and shows particularly strong activity against filamentous fungi, many of which are serious plant pathogens.

Abstract: Prophylactic and therapeutic agents for the prevention and treatment of viral-induced tumors and, in particular, compositions derived from an Aspergillus fermentation extract, and the use thereof, either directly or to prepare a medicament, for the prevention and treatment of viral-induced tumors in mammals. Such tumors include papilloma-induced tumors. The composition is topically administered.

Abstract: Prophylactic and therapeutic agents for the prevention and treatment of viral-induced tumors and, in particular, compositions derived from an Aspergillus fermentation extract, and the use thereof, either directly or to prepare a medicament, for the prevention and treatment of viral-induced tumors in mammals. Such tumors include papilloma-induced tumors. The composition is topically administered.

Abstract: The present invention relates to novel bacterial isolates and to their use s agents, or source of agents, antagonistic to growth of rot causing organisms. Particularly the present invention provides novel isolates of bacteria of species Pseudomonas fluorescens, Serratia liquefaciens, Serratia plymuthica, Bacillus subtilis, Bacillus pumilis and Bacillus polymyxa which are particularly effective in inhibiting the growth of organisms of the post-harvest disease causing fungi Botrytis cinerea and Alternaria brassicicola. Further provided are antibiotics derived from the Bacillus species.

Abstract: The present invention relates to a method for the preparation of a melanic pigment by enzymatic bioconversion, implementing a melanin precursor substrate and plant cells, characterized in that: (a) poppy (Papaver somniferum) plant cells previously cultivated are separated from their culture medium and subcultured in a culture medium with a concentration from 10 to 100 g/l; (b) the cells are ground at least partially, before or at the end of the latency time, (c) the at least partially ground cells are placed in a bioconversion medium in the presence with a melanin precursor substrate selected amoung indol, indolin, dihydroxyphenylalanin, tyramin and tyrosin; (d) the precipitated melanic pigment is collected. The invention also relates to the utilization of such resulting pigments for the preparation of cosmetic compositions.

Abstract: The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these substances in the treatment of infectious diseases involving microorganisms susceptible to it.

Abstract: Prophylactic and therapeutic agents for the prevention and treatment of viral-induced tumors and, in particular, compositions derived from an Aspergillus fermentation extract, and the use thereof, either directly or to prepare a medicament, for the prevention and treatment of viral-induced tumors in mammals. Such tumors include papilloma-induced tumors. The composition is topically administered.

Abstract: The invention provides Form II dirithromycin, a novel polymorph of dirithromycin. Also disclosed are the acetone, 1-butanol, 1-propanol, and 2-propanol solvates of dirithromycin, which provide an efficient means for preparing and isolating Form II. Processes for preparing and isolating Form II dirithromycin from these solvates or from Form I dirithromycin are provided. A process for obtaining Form II dirithromycin from non-solvated dirithromycin is also provided. Another aspect of the invention is an improved tablet containing Form II dirithromycin as the active ingredient.

Abstract: A novel strain of Bacillus cereus, designated AS4-12, has been isolated from the environment. The strain AS4-12 is one of a number of B. cereus strains which are useful as biocontrol agents to combat fungal damping off disease in field crop plants, and strain AS4-12 has exhibited the best performance among a large number of natural isolates in fostering the emergence and growth of alfalfa plants under normal field conditions in the upper midwestern U.S.

Abstract: The invention is directed toward strains of Escherichia coli which produce a colicin effective in inhibiting the growth of pathogenic Enterobacteriaceae including E. coli strain 0157:H7, and the colicin derived from those strains of E. coli. The invention also provides methods of using the colicin to inhibit the growth of pathogenic Enteriobacteriaceae in food substances and on hard surfaces.

Abstract: A method for suppressing the viscosity of a calcium exotoxin slurry is disclosed. The method comprises adding to the slurry a viscosity-suppressing amount of a copolymer of a vinyl-based monomer and 2-acrylamide-2-methylpropane sulfonic acid or its sodium salt. The copolymer has a weight average molecular weight of from about 1,000 to about 10,000. A slurry comprising calcium exotoxin and about 0.25 to about 2.5 percent by weight of such copolymer is also disclosed.

Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270 factor C.sub.2a, the addition salts thereof, the pharmaceutical compositions thereof and its use as medicament, particularly in the treatment of infectious diseases involving microorganisms susceptible to it and its use as animal growth promoter.

Abstract: Prophylactic and therapeutic agents for the prevention and treatment of viral-induced tumors and, in particular, compositions derived from an Aspergillus fermentation extract, and the use thereof, either directly or to prepare a medicament, for the prevention and treatment of viral-induced tumors in mammals. Such tumors include papilloma-induced tumors. The composition is topically administered.

Abstract: A novel trehalase inhibitor having the following physicochemical properties:(1) Activity: a specific inhibitory activity to trehalase;(2) Form: white powder, water-soluble;(3) Somogy-Nelson test: negative(4) Rydon-Smith test: positive(5) Optical rotation [.alpha.].sub.D.sup.23 : 113.8.degree. (C, 0.1, H.sub.2 O)(6) Molecular weight: 335 ([M+H].sup.+ =336)(7) Ultraviolet absorption spectrum: 258.5 nm (max.)(8) .sup.13 C-NMR(ppm): 28.9, 41.0, 56.9, 58.4, 64.3, 65.0, 71.3, 74.0, 75.2, 75.8, 76.0, 77.1, 123.0, 144.

Abstract: There are described a novel protein derived from Clostridium perfringens FERM BP-4584 method of obtaining the same and use thereof as an effective ingredient for treating wounds and ulcers. The protein has a molecular weight of 420,000.+-.40,000 by a GPC, isoelectric point of 4.8, and consists of a single subunit having a molecular weight of 130,000.+-.20,000 by a SDS-polyacrylamide gel electrophoresis, and shows cell growth-stimulating activity as well as macrophage chemotactic action. The protein can be extracted and separated by conventional techniques for obtaining a protein from general microorganisms, by taking an inhibition of decomposition into consideration, since the protein is not so stable.

Abstract: The invention relates to various methodologies for diagnosing Kawasaki syndrome. Various bacteria, including TSST-1 producing Staphylococcus aureus, and SPEB and SPEC producing streptococcus have been found to be indicative of the pathological condition. Also described is a Kawasaki syndrome implicated isolate of S. aureus, and therapeutic methodologies for preventing treating the condition. These involve the administration of anti-TSST-1 agents which are not gamma globulin.

Abstract: The present invention relates to the discovery of a new bacteria of the genus Alteromonas which has been found to attract oyster larvae by the production of compounds involved in melanin synthesis. More specifically, the present invention contemplates a method for inducing the settlement and metamorphosis of Crassostrea virginica larvae by induction with certain metabolic substances produced by the present bacteria and its altered variants. Furthermore, the present invention is directed to other and derivative metabolic products which can be employed for their desired utility and application. In accordance with the present invention, it has been discovered that ammonia (NH.sub.3) initiates settlement and metamorphosis of the oyster larvae in the same manner as the natural phenomena.

Abstract: The use of biomasses obtained in the fermentative production of lipase inhibitors, especially lipstatin, for the preparation of foodstuffs, feedstuffs, food additives, feed additives, feed supplements, medicinal feed premixes or medicaments for oral administration, are described.

Abstract: By carrying out the fermentation of Streptomyces avermitilis ATCC 55278, a dried mycelium is obtained which, orally administered to animals, particularly to ovines, has an antiparasitic activity.