Abstract: A novel strain Trichosporon Kashiwayama, a culture product or culture liquid of said strain, sterile liquid, sterile filtrate, sterile supernatant of said culture liquid, or concentrate or dry product thereof, processes for preparations thereof, a dermatic medicament having curative effect of skin disorder or a cosmetic consisting solely of or comprising as a main ingredient the above product, liquid, filtrate, supernatant, concentrate or dry product.

Abstract: Novel antibiotics didemnins A, B and C (didemnins), and nordidemnins A, B and C (nordidemnins) which can be obtained from a marine organism. These antibiotics are active against a variety of DNA and RNA viruses; thus, they can be used in various environments to control or eradicate these viruses. Further, these antibiotics can be used to treat animals and humans hosting a neoplastic disease.

Abstract: New fermentation products useful in the treatment of tardive dyskinesia by inhibition of choline oxidase are produced by fermentation of a nutrient medium with a microorganism, Streptomyces hygroscopicus.

Abstract: A method for extracting large quantities of an active biological factor that restores contact inhibition of growth to malignant cell types of different mammalian species.

Abstract: A novel proteinous substance KUP-PC, which is produced by culturing proteinous substance KUD-PC producing organisms belonging to the genus Streptosporangium. KUD-PC increases the antitumor activity of the anti-tumor substance, sporamycin.

Abstract: Antibiotic albicidin, a non-peptide antibiotic, is produced by culturing chlorosis-inducing strains of Xanthomonas albilineans isolated from diseased sugarcane, and mutants thereof. The antibiotic is isolated from the culture medium by adsorption on resin and is purified by gel filtration and HPLC.

Abstract: The mixture, Antibiotics-859A and the production thereof is described. The Antibiotics-859A are produced by the controlled aerobic cultivation of Streptomyces griseoruber, ATCC 39068 in an aqueous nutrient medium. The Antibiotics-859A exhibit activity both in vitro and in vivo against gram negative and gram positive organisms including the genera: Diplococcus, Staphylococcus, Streptococcus, Pseudomonas and Salmonella.

Abstract: A strain (ATCC 31918) of Rothia dentocariosa which, upon fermentation, produces an antibiotic--staphylocidin--which is selectively effective against staphylococci, particularly those with S. aureus and S. epidermidis; and a process for producing such antibiotic by cultivation of the strain under aerobic conditions. Staphylocidin-containing products comprising the cell murein from the fermentation product are also disclosed.

Abstract: A novel strain Trichosporon kashiwayama, a culture product or culture liquid of said strain, sterile liquid, sterile filtrate, sterile supernatant of said culture liquid, or concentrate or dry product thereof, processes for preparations thereof, a dermatic medicament having curative effect of skin disorder or a cosmetic consisting solely of or comprising as a main ingredient the above product, liquid, filtrate, supernatant, concentrate or dry product.

Abstract: The present invention provides a method for inhibiting the synthesis and release of toxins from bacteria which comprises contacting the bacteria with an antitoxic prostaglandin.

Abstract: Orally administered compositions for altering lipid metabolism are described herein, these compositions containing an effective dose of endomycin. Also the method of altering lipid metabolism including reducing and controlling the blood cholesterol level, is described herein.

Abstract: The present invention is directed to novel anticoccidial compositions and methods of employing the same to control coccidiosis in poultry. These compositions comprise a polyether antibiotic and a second component which is a selected carbanilide.

Abstract: The Antibiotics-875A are obtained from the controlled aerobic cultivation of Streptomyces hygroscopicus ATCC 39067. The Antibiotics-875A show in vitro and in vivo activity against gram positive and gram negative organisms including the genera; Staphylococcus, Streptococcus, Aerobacter, Escherichia, Klebsiella, Parlacolobactrum, Pseudomonas and Salmonella.

Abstract: The substance naturally present in milk (referred to as Milk Factor or MF) which is capable of inhibiting mammalian synthesis of cholesterol is produced by a fermentation process using a culture of Pseudomonas fluorescens loitokitok or other Milk Factor--producing strain of P. fluorescens in a culture medium containing glutaconic acid. The process may be used to increase the Milk Factor content of milk, yogurt, or similar dairy product, or the Milk Factor may be recovered from a culture medium and concentrated, crystallized and used as a food additive.

Abstract: Compositions of polyether antibiotic rumen propionate enhancers and glycopeptide rumen propionate enhancers are effective in increasing the efficiency of feed utilization in ruminants. A method for increasing rumen propionate production in ruminants having a developed rumen function is provided. Such increase in rumen propionate production is synonymous with increased efficiency of feed utilization.

Abstract: The availability of supplemental dietary choline to animals with a developed rumen is increased by co-administering choline or choline compounds with a propionate-enhancing antibiotic compound.

Abstract: A method for treating Dutch elm disease by treatment of an elm tree with a microorganism comprising P. syringae or equivalent. The method includes the step of applying the microorganism to an elm tree early in the growing seaons and wherein no more than 10% of the crown of the tree is infected with the disease.

Abstract: Antibiotic A-32724 complex, comprising microbiologically-active, related factors A, B and C, is produced by submerged, aerobic fermentation of a strain of Chaetomella raphigera Swift NRRL 12331. The A-32724 antibiotics are closely related antibiotics. The individual A-32724 factors are separated by chromatography. In addition to their antibacterial activity, the A-32724 factors inhibit certain enzymes and exhibit antihypertensive properties.

Abstract: Combinations of a polyether antibiotic and a 2,4-dinitro-N-[4-(fluoroalkoxy)phenyl]-6-(trifluoromethyl)benzenamine are synergistic in controlling coccidiosis in animals.

Abstract: Antibiotic A-7413 complex, comprising a major microbiologically active factor A, and minor active factors B, C, and D, is produced by fermentation of Actinoplanes sp. NRRL 8122. The individual factors are isolated and separated by extraction and chromatography. The A-7413 antibiotics are antibacterial agents. The A-7413 complex and A-7413 antibiotic compounds are also useful as growth-promoting agents and in the control of dental caries and acne.

Abstract: A colony stimulating factor effective in treating human granulocytopenia is produced by cultivating monocytes and macrophages isolated from the human peripheral blood in a synthetic medium for tissue culture containing a glycoprotein isolated from human urine and capable of stimulating the formation of human granulocytes or mouse macrophages and granulocytes.

Abstract: A novel method for treating Dutch elm disease by use of a certain type of P. syringae. This method includes the step of applying this microorganism to an elm tree early in the growing season. Also disclosed is a process for isolating an antimycotic substance formed by an exemplary strain of this type of microorganism, and a process for isolating a high molecular weight antibiotic also formed by this exemplary strain. In addition, the high molecular weight antibiotic is disclosed, as well as methods for treating Dutch elm disease using either the high molecular weight antibiotic or the antimycotic substance.

Abstract: Inhibitor for the glycoside hydrolases of the digestive tract, more particularly of the pancreatic .alpha.-amylase produced by fermentation of the specific microorganism Streptomyces tendae, strain 4158, as well as the variants and mutants thereof, the microbe strain per se and processes for the isolation of the inhibitor and for its purification.

Abstract: A piece of internal tissue of the sclerotium of Poria cocos (Fr.) Wolf is transplanted into an artificial culture medium to subject it to pure culture of hyphae of said microorganism, thereby obtaining mycelia, and the thus obtained mycelia are extracted with at least one medium selected from the group consisting of water and water-soluble organic media. The resultant substance has an excellent ani-tumor activity and is low in toxicity.

Abstract: Milk production in lactating ruminants is improved by the oral administration of an antibiotic selected from the virginiamycin or elfamycin families of antibiotics.

Abstract: Phthalides enhance propionate production and inhibit methane production in the rumen and are thus useful for improving feed utilization efficiency in ruminant animals.

Abstract: Antibiotic A-21978 complexes, in particular the A-21978C complex, comprising microbiologically active, related factors, C.sub.0, C.sub.1, C.sub.2, C.sub.3, C.sub.4, and C.sub.5. A-21978 complex and A-21978C complex are produced by submerged aerobic fermentation of Streptomyces roseosporus NRRL 11379. The individual A-29178C factors are separated and isolated by chromatography. The A-21978 and A-21978C complexes, the A-21978C factors, and pharmaceutically acceptable salts thereof are antibacterial agents and improve growth promotion in poultry.

Abstract: Antibiotic Actinomadura-L-31 A has the characteristics as the hydrochloride salt:appearance: white or pale yellow powdermelting point: non-clear melting pointspecific rotation: [.alpha.].sub.D.sup.25 -34.degree. (C: 0.5, pH: 7.5 water)elementary analysis: (found) C: 51.71%; H: 6.23%; O: 21.03%; N: 13.94%; S: 5.82%; Cl: 1.17%constitutive aminoacids: aspartic acid; glutamic acid; glycin; valine; phenylalanine; histidine; leucine; tryptophanultraviolet absorption spectrum: FIG. 1, maximum absorption:280 nm: E.sub.1 cm.sup.1% =45.2290 nm: shoulder E.sub.1 cm.sup.1% =38infrared spectrum: FIG. 2, absorption (cm.sup.-1) 3350, 3050, 2950, 1660, 1530, 1430, 1395, 1340, 1255, 1235, 1100, 745, 700Antibiotic Actinomadura-L-31 B has the characteristics as the hydrochloride salt:appearance: white to pale yellow powdermelting point: non-clear melting pointspecific rotation: [.alpha.].sub.D.sup.25 -26.degree. (C: 0.5; pH: 7.5 water)elementary analysis: (found) C: 51.10%; H: 6.34%; O: 20.75% N: 14.81%; S: 5.91%; Cl: 1.

Abstract: Prodn. of FR-900129 comprises culturing a Streptomyces n. 4012 category which is analogous to Streptomyces misakiensis and Steptomyces aburaviensis, i.e. Streptomyces avellaneus No. 4012, at 25.degree. C. to 30.degree. C. during 50 to 100 hours in a culture medium which consists of a carbon source (e.g. glucose, fructose, glycerin, starch, galactose, maltose, dextrin), an organic or inorganic nitrogen source (e.g. yeast extract, peptone, cottonseed cake, soyabean powder, cornsteep liquor, dry yeast, ammonium nitrate, ammonium sulphate, ammonium phosphate, urea and amino acid) and an inorganic salt (e.g. calcium carbonate, sodium phosphate, potassium phosphate, sodium chloride, potassium chloride, magnesium salt and copper salt). The produced FR-900129 is isolated by a collecting step, a purifying step, a vacuum condensation step, a freeze-drying step, a pH adjusting step, a cationic, anionic or nonionic resin treating step, an active carbon adsorption step and a crystallizing and recrystallizing step.

Abstract: Described herein is a method for the extraction of an active biochemical factor that restores contact inhibition of growth to malignant cell types of different mammalian species.

Abstract: A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragilis Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.

Abstract: A method of treating inflammation comprising topical administration to mammals suffering from an inflammatory condition not associated with amicrobial component, employing selected antibiotics as the anti-inflammatory agent.

Abstract: Antibiotic A-39183 complex, comprising microbiologically active, related factors A, B, C, D, and E, is produced by submerged, aerobic fermentation of a new microorganism Streptomyces sp., NRRL 12049. The A-39183 antibiotics are closely related antibiotics. The individual A-39183 factors are separated by chromatography. The A-39183 factors are antibacterial agents which have activity against Staphylococcus and Streptococcus species that are penicillin resistant. The A-39183 factors are also active against both gram-positive and gram-negative anaerobic bacteria, and are ionophores.

Abstract: Inhibitor for the glycoside hydrolases of the digestive tract, more particularly of the pancreatic .alpha.-amylase produced by fermentation of the specific microorganism Streptomyces tendae, strain 4158, as well as the variants and mutants thereof, the microbe strain per se and processes for the isolation of the inhibitor and for its purification.

Abstract: A glucocorticoid sparing factor (GSF) which amplifies liver enzyme induction which is caused in glucocorticoid and a process for the production of GSF are disclosed. GSF can be isolated from the culture broth of a microorganism of the Family Enterobacteriaceae.

Abstract: A novel method for treating Dutch elm disease by use of a certain strain of Pseudomonas syringae. This method includes the step of injecting this microorganism into an elm tree. Also disclosed is a process for isolating the antimycotic substance formed by the microorganism and the antimycotic substance itself.

Abstract: Novel rifamycin compounds, designated P, Q, R and U, produced by the fermentation of mutant strains of Streptomyces mediterranei.

Abstract: On feeding both of the antibiotic A3823 complex monensin and the phosphate ester ronnel, i.e., 0,0-dimethyl 0-(2,4,5-trichlorophenyl)phosphorothioate, to livestock and poultry selected from cloven hoof ruminant animals, swine and poultry substantially every day for at least about 3 to about 28 days depending on the animal, and more preferably for a longer period through growth and/or fattening feeding cycles or during maintenance periods, in respective amounts in an effective amount in the range of about 0.14 to about 2.3 milligrams of the antibiotic and about 0.5 to about 4 milligrams of ronnel per kilogram (mg/kg) of body weight per day, the growth of the livestock and poultry takes place at an increased rate; fiber production, such as wool in sheep, is increased; the production of milk in lactating animals is increased; and, in particular, the feed conversion efficiency of the animal is markedly improved compared to the response obtained on providing either of the antibiotic or ronnel alone.

Abstract: This invention relates to a method of biologically controlling plant diseases caused by sclerotia of sporidesmium susceptible plant pathogenic fungi.

Abstract: A glucocorticoid sparing factor (GSF) which amplifies to liver enzyme induction which is caused in glucocorticoid and a process for the production of GSF are disclosed. GSF can be isolated from the culture broth of a microorganism of the Family Enterobacteriaceae.

Abstract: A biochemical process for the aerobic thermophyllic fermentation of cotton gin waste is disclosed which converts a presently useless pest ridden agricultural waste product into a useful medium for the culture of horticultural and agronomic plants as well as microorganisms useful to man. By the aeration, water content and physical shape and size of the waste product, piles are so conditioned that by means of the resulting biodegradation processes plant pathogenic microorganisms, insects, viruses, spider mites and related pests are destroyed. Additionally, pesticidal residues, chemical plant growth regulators and certain harvest aid materials normally added to the growing cotton crop for production purposes are reduced to materials harmless to plant life. The resulting humus like material provides improved plant growth, nearly five times that of a good river loam soil, and contains a microbial population that prevents the spread of soil borne plant pathogenic microorganisms reintroduced into the medium.

Abstract: A species of Nocardia, designated Nocardia argentinensis Huang ATCC 31438, when subjected to aerobic submerged fermentation, produces an antibiotic complex containing as its major component antibiotic Compound 51,467. Methods for the recovery and purification of antibiotic Compound 51,467 and minor antibiotic components, Compounds 52,726 and 52,748, and some of their properties are outlined.

Abstract: The present invention is directed to novel anticoccidial compositions and methods of employing the same to control coccidiosis in poultry. These compositions comprise a polyether antibiotic and a second component selected from nicarbazin and 4,4'-dinitrocarbanilide.

Abstract: Antibiotic A-21978 complexes, in particular the A-21978C complex, comprising microbiologically active, related factors C.sub.0, C.sub.1, C.sub.2, C.sub.3, C.sub.4, and C.sub.5. A-21978 complex and A-21978C complex are produced by submerged aerobic fermentation of Streptomyces roseosporus NRRL 11379. The individual A-29178C factors are separated and isolated by chromatography. The A-21978 and A-21978C complexes; the A-21978C factors; and pharmaceutically acceptable salts thereof are antibacterial agents and improve growth promotion in poultry.

Abstract: The present invention relates to diacyloxyacids derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The diacyloxyacids derivatives of acid S of this invention are useful as antifungal and antibacterial agents.

Abstract: A Sarcoma 180 tumor growth inhibiting glycoprotein material produced extracellularly from Candida albicans is provided. The inhibitor material is effective to arrest Sarcoma 180 tumor angiogenesis thereby causing tumor regression. The preferred inhibitor material is an extracellular glycoprotein produced from Candida albicans SA#1 (CBS 5736) cultured in a glucose containing chemical medium with a filtrate of the growth medium precipitated with ethanol. Dosage innoculations of the precipitate into the peritoneal cavities of Sarcoma 180 tumor infected mice effect substantial tumor regression.

Abstract: The present invention refers to novel antibiotics, Bacileucines A and B and use thereof, which are effective as agricultural and horticultural fungicides. Bacileucines A and B are produced from the microorganism belonged to Genus Bacillus and are characterized by that they have no phytotoxicity of plant and no adverse effect on the human body, have an excellent control effect on diseases of plants such as rice plant, vegetables and green plants and cause no pollution on the environment.

Abstract: Antibiotic A-38533 complex, comprising microbiologically active, related factors A.sub.1, A.sub.2, B and C, is produced by submerged, aerobic fermentation of a new Streptomyces sp., NRRL 11298. The A-38533 antibiotics are closely related antibiotics. The individual A-38533 factors are separated by chromatography. The A-38533 factors are antibacterial agents which have a unique activity against Pseudomonas species.

Abstract: Antibiotic A-7413 complex, comprising a major microbiologically active factor A, and minor active factors B, C, and D, is produced by fermentation of Actinoplanes sp. NRRL 8122. The individual factors are isolated and separated by extraction and chromatography. The A-7413 antibiotics are antibacterial agents. The A-7413 complex and A-7413 antibiotic compounds are also useful as growth-promoting agents and in the control of dental caries and acne.

Abstract: A process for the conversion of the major antifungal antibiotic, acid S (ATCC No. 25532) isolated from the fermentation of Polyangium cellulosum var. fulvum into the minor antibiotic, acid F, from the same fermentation is described wherein acid S is methylated with diazomethane to provide acid S methyl ester which is then oxidized with silver carbonate on celite to obtain the corresponding keto ester S, which is subsequently reduced with sodium borohydride to give a mixture of acid S methyl ester and acid F methyl ester. These esters are readily separated by preparative thin layer chromatography and the acid F methyl ester is hydrolyzed with sodium hydroxide solution to provide acid F.