Abstract: A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ≧14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and Helicobacter pylori.

Abstract: An oral composition in the form of a toothpaste, powder, liquid dentifrice, mouthwash, denture cleanser, chewing gum or candy comprising a lipophilic compound selected from flavorants, physiological cooling agents and antimicrobial compounds and a dimethicone copolyol selected from alkyl- and alkoxy-dimethicone copolyols having the formula (I): wherein X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, Y is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms, n is from about 0 to about 200, m is from about 1 to about 40, q is from about 1 to about 100, the molecular weight of the residue (C2H4O—)x(C3H6O—)yX is from about 50 to about 2000, and x and y are such that the weight ratio of oxyethylene:oxypropylene is from about 100:0 to about 0:100.

Abstract: A method for manufacturing an antidotal food product containing activated charcoal is provided to combine a binder, a filler composition, water, flavoring and sweetener compositions with an activated charcoal to form wafers having a consistency emulating that of a baked cookie. The activated charcoal (110), binder (112), filler (114), water (116), and flavoring and sweetener compositions (118) are combined in a mixer (210) to form a slurry. The slurry is then processed in a spray dryer (220) to form granules. The granules are combined with a lubricant (122) in a blender (230). The dry mixture from blender (230) is then formed into wafers by a tableting type machine in a compression molding step (240). The wafers formed in the compression molding step (240) are then coated in an anti-dusting coating step (250). A sweet creme filling is applied between pairs of the wafers in a cookie sandwich assembly step (270).

Abstract: A non-toxic, edible, enteric film coating, dry powder composition for use in making an aqueous enteric suspension which may be used in coating pharmaceutical tablets comprises a) an acrylic resin, said resin comprising i) from 20 to 85 percent by weight of at least one alkyl acrylate or alkyl methacrylate moiety, ii) from 80 to 15 percent by weight of at least one vinyl or vinylidene moiety having a carboxylic acid group capable of salt formation, and iii) from 0 to 30 percent by weight of at least one other vinyl or vinylidene moiety copolymerizable with i) and ii), b) an alkalizing agent capable of reacting with the acrylic resin such that, after reaction, 0.1 to 10 mole percent of the acidic groups in 1a-ii) are present in the salt form, and c) a detacktifier.

Abstract: The present invention provides compositions comprising complexes of &bgr;-lactoglobulin with particular lipophilic nutrients, in particular vitamin E and vitamin K1. Preferably, bioselective absorption is employed to isolate &bgr;-Lg for use as a carrier protein. Also provided are food compositions and topical compositions comprising complexes of &bgr;-lactoglobulin and a lipophilic nutrient.

Abstract: Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.

Abstract: A method of inhibiting blood platelet aggregation in humans which comprises administering an extract blend of the fruit of the Emblica officinalis plant to control said aggregation, suitably in a dose amount of about 50-500 mg/day.

Abstract: A composition for the control of smoking which comprises: (a) a flavonoid in the form of an extract from Eupatorium purpurem preferably euparani; (b) a cytochrome P45C inhibitor (c) a sugar; (d) a source of phosphate; and, optionally, (e) one or more pharmaceutically acceptable carriers.

Abstract: A method for smoking cessation therapy is described that utilizing an improved nicotine lozenge to satisfy transient craving. The lozenge contains nicotine, a nonnutritive sweetener and an absorbent excipient.

Abstract: A throat drop comprises from 60 to 95% of a candy shell and from 5 to 40% of an aqueous filling, by weight of the drop. The filling comprises, by weight, by 8 to 20% water, from 50 to 85% bulk sweetener, and sufficient emulsifier to provide a contact angle of from 90° to 120°, the filling having a contact angle of greater than 120° in the absence of the emulsifier. The reduction in contact angle relative to a composition without the emulsifier provides an improved perception of liquidity of the filling.

Abstract: An pharmacological element, generally configured in the shape of a tablet, for the transmucosal administration of nicotine is made to effect the equivalent physiological and psychological responses of smoking a cigarette. The element is made by placing between 0.5 mg and 5 mg of nicotine in a layer upon a non-nicotine containing matrix. The nicotine containing layer rapidly dissolves by the warmth and saliva in the mouth. The nicotine is then rapidly absorbed by the intra-oral mucosal surfaces of the mouth, and then felt as a sharp pulse in the brain in a period of less than two minutes, but usually in less than 30 seconds. A multi-layered element is also provided where the nicotine is placed in a plurality of layers separated by one or more layers that are essentially free of nicotine to support the nicotine containing layers, and, to provide a time delay between the sharp pulses produced by the nicotine containing layers.

Abstract: The invention relates to a pulverulent sorbitol, characterized in that it exhibits a hygroscopicity value, determined according to a test A, of less than 2%, preferably of less than 1.7%, and a specific surface, determined according to the BET method, at least equal to 2 m2/g, preferably at least equal to 2.2 m2/g, and also relates to its process of preparation. The invention also relates to compositions intended in particular for the food and pharmaceutical fields and to the use of the said pulverulent sorbitol in the preparation of tablets exhibiting a <<smooth in the mouth>> texture.

Abstract: The present invention relates to an oral care composition comprising a Cellulose Binding Domain and further ingredient conventionally used in oral care compositions, oral care products, and the use of CBDs for oral care purposes.

Abstract: The present invention relates to oral care chewing gum composition comprising at least a minimally effective amount of chlorite ion, wherein preferably the pH of the final composition in use is greater than 7 and level of chlorine dioxide or chlorous acid is less than about 50 ppm, preferably is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating breath malodor in humans or other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.

Abstract: The invention provides a method of making a chewing gum composition containing a water soluble bulk portion, a water insoluble chewing gum base portion, a flavoring agent, and bismuth-containing compounds. The invention provides a method of making a bismuth-containing gum which when chewed multiple times per day, over the period of two weeks, is effective in reducing peptic ulcers by eradicating H. pylori. The chewing gum is also effective in eliminating forms of halitosis. The chewing gum does not have undesirable side effects, unpleasant taste and poor chewing characteristics.

Abstract: The present disclosure relates to novel nutritional compositions containing linoleic acid and/or linolenic acid which optimize child neurological development and provide improved nutritional support for women prior to and during lactation. The nutritional compositions are intended for use by women to optimize infant neurological development and provide improved nutritional support for women prior to, during and after lactation.

Abstract: A food supplement and process for feeding a companion animal such as a dog or cat a diet containing an effective amount of lutein to enhance immune response and improve the overall health of the animal is provided. Preferably, the diet includes from about 1 to about 50 mg/day of lutein (from about 2 to about 315 mg lutein/kg diet). Such a diet provides sufficient lutein to be absorbed by the animal and supplied by the blood and blood leukocytes and neutrophils in the animal.

Abstract: The present invention provides improved confectionery compositions which have a substantial reduction in the unpleasant organoleptic sensations associated with the release of functional ingredients from the confection in the oral cavity. The confectionery composition comprises a confectionery base, a functional ingredient which is a botanical or a mineral or a mineral salt having an unpleasant mouthfeel, and from about 0.5% to about 5.0% by weight of the composition of one or more fats, said amount being effective to suppress the unpleasant mouthfeel of the functional ingredient. For botanicals the confectionery composition is a hard boiled candy composition or a hard gum composition and the fat is one or more partially hydrogenated vegetable oils or saturated fats. For minerals or their salts the confection is a hard boiled candy composition and the fat is one or more partially hydrogenated vegetable oils.

Abstract: A chewing gum which has a preventative effect against infection by influenza virus and inhibits dissemination of influenza virus. The chewing gum comprises adding at least 0.03 weight % of at least one tea polyphenol, for a chewing gum containing no organic acids; the chewing gum comprises at least 0.01 weight % of at least one tea polyphenol for a chewing gum containing at least one organic acid.

Abstract: A process is disclosed for producing vitreous molten mass from sweeteners by means of an extruder, in particular a double screw extruder. The sweetener is introduced into an inlet zone of the extruder, is extruded in a melting zone at an increased temperature, in a vacuum zone at a reduced pressure and increased temperature, and finally in a cooling zone at a reduced temperature, forming a vitreous molten mass.

Abstract: The present invention provides improved confectionery compositions which have a substantial reduction in the unpleasant organoleptic sensations associated with the release of functional ingredients from the confection in the oral cavity. The confectionery composition comprises a confectionery base, a functional ingredient which is a botanical or a mineral or a mineral salt having an unpleasant mouthfeel, and from about 0.5% to about 5.0% by weight of the composition of one or more fats, said amount being effective to suppress the unpleasant mouthfeel of the functional ingredient. For botanicals the confectionery composition is a hard boiled candy composition or a hard gum composition and the fat is one or more partially hydrogenated vegetable oils or saturated fats. For minerals or their salts the confection is a hard boiled candy composition and the fat is one or more partially hydrogenated vegetable oils.

Abstract: A chewable calcium composition and its associated method of manufacturing are disclosed. The chewable composition includes a lipid base and a micronized calcium salt substantially uniformly mixed with the lipid base such that the lipid base forms a continuous phase. The composition provides for a relatively large dose of calcium in a easy to take chocolate like, chewable form. The composition of the present invention is manufactured by providing the lipid base including a melting temperature. The lipid base is then heated to a temperature of approximately 120° F. such that the lipid base melts. After the lipid base melts, the micronized calcium salt is mixed with the lipid base to form a melted mixture such that the micronized calcium salt is substantially uniformly distributed in the melted lipid base.

Abstract: Compositions and methods for the prophylactic and therapeutic treatment of bacterial infections are disclosed which comprise administering to an individual an effective amount of a composition comprising an effective amount of lytic enzyme and a carrier for delivering the lytic enzyme. This method and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, burns, vaginal infections, eye infections, intestinal disorders and dental problems.

Abstract: A natural antioxidant blend in the form of an amphorous powder was obtained by extraction from Emblica officinalis fruit. In this process, the finely pulped fruit was treated with a dilute aqueous salt solution at hot water temperature to provide an extract-containing solution, which was filtered and dried to provide the desired antioxidant blend powder. A synergistically stabilized composition of ascorbic acid or its derivatives with the antioxidant composition of Emblica officinalis, is also described. Cosmetic, pharmaceutical and nutritional use formulations thereof also are described.

Abstract: Disclosed is an oral hygiene preparation which is plaque disrupting in the form of a chewing gum. The chewing gum comprises a core containing a carbonate and/or bicarbonate which is surrounded by a coating that contains an encapsulated edible acid. Upon mastication the chewing gum effervesces, thus promoting the cleansing and breath freshening properties of the preparation.

Abstract: A confectionery product, suitable for the relief of cough and cold like symptoms, includes from about 0.5% to about 80%, by weight, of a coolant composition and from about 20% to about 99.5%, by weight, of a flavour composition in separate, distinct and discrete regions thereof. The coolant and flavour compositions are adapted to provide different release profiles.

Abstract: A gel, paste, gum or lozenge composition for oral application to human gums to prevent and reduce symptoms of gum disease. The composition includes reduced glutathione and a source of selenium.

Abstract: The present invention relates to a compressed formulation containing 1,1-GPS (1-O-&agr;-D-glucopyranosyl-D-sorbitol) or a mixture of sweetening agents composed of 1,1-GPS, 6-0-&agr;-D-glucopyranosyl-D-sorbitol (1,6-GPS) and 1-0-&agr;-D-glucopyranosyl-D-mannitol (1,1 GPM).

Abstract: Cetyl pyridinium chloride and other amphiphilic substances may be mixed with flavorants or therapeutics in accompaniment with such as bulking agents or sweeteners in order to prolong their duration of action at the site of attachment, which is a mucin coated surface for the purpose of providing the consumer with a more efficacious product. It is the concept of delayed dispensing that is the invention, the product being dispensed is only an illustration of the best mode.

Abstract: This invention pertains to a malodor counteractant composition comprising a malodor counteractant agent in an oral vehicle. The malodor counteractant agent is selected from the group consisting of, in percentages by weight: (A) (a) geranyl propionate; (b) benzyl benzoate; and (c) neryl acetate; (B) (a) citronellyl acetate; (b) benzyl benzoate; and (c) neryl acetate; (C) (a) benzyl benzoate; (b) geranyl propionate; and (c) citronellyl acetate; (D) (a) geranyl propionate; (b) citronellyl acetate; and (c) benzyl benzoate; (E) (a) citronellyl acetate; and (b) geranyl propionate; (F) (a) benzyl benzoate; and (b) neryl acetate; (G) (a) benzyl benzoate; (b) neryl acetate; (c) trimethyl (2,6,6) vinyl(6) tetrahydropyran; (d) citronella oil; and (e) and ethyl alcohol; and (H) (a) benzyl benzoate; (b) neryl acetate; (c) citronella oil; (d) geranyl acetate; (e) alpha ionone; (f) geranyl propionate; (g) linalool; and (e) and ethyl alcohol.

Abstract: A process producing a pharmaceutical lozenge formulation comprising the steps of: 1) granulating a mixture of flurbiprofen and a bulking agent with a solution of a binding agent in a polar solvent to form granules; 2) melting a lozenge-forming composition; 3) mixing the granules with the molten lozenge-forming composition; 4) forming the resulting mixture into lozenges each containing a therapeutically effective amount of flurbiprofen.

Abstract: An oral composition in the form of a toothpaste, powder, liquid dentifrice, mouthwash, denture cleanser, chewing gum or candy comprising one or more oral composition components selected from abrasives, binders, humectants, surfactants, fluoride ion sources, anti-calculus agents and sweeteners and additionally comprising: i) an aminoalkylsilicone; and ii) a silicone surfactant having general formula (1) wherein X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, Y is CH3, q is 0, n is from about 1 to about 100, m is from about 1 to about 40, the molecular weight of the residue (C2H4O—)x(C3H6O—)yX is from about 50 to about 2000, and x and y are such that the weight ratio of oxyethylene:oxypropylene is from about 100:0 to about 0:100. The composition provides improved antiplaque and anti-bacterial activity together with excellent cleansing performance.

Abstract: A ready-to-use water dispersible pigment composition containing at least 5% by weight of water is provided. The composition comprises a stable dispersion of a water-insoluble and/or hydrophobic natural pigment such as a carotenoid, curcumin, a porphyrin pigment or vegetables carbon black in the form of bodies of an average size which is at the most 10 &mgr;m is provided. The pigment bodies are dispersed without the use of a surface active substance in an aqueous phase comprising a hydrocolloid. The natural pigment in compositions which are useful for coloring of food products and pharmaceuticals do not migrate in the products. The compositions are useful in coating compositions for tablets and dragees.

Abstract: The invention relates to chewing gum containing 1.1-GPS (1-O-&agr;-D-glucopyranosyl-D-sorbitol), especially a sweetening agent mixture of 6-O-&agr;- D-glucopyranosyl-D-sorbitol (1.6-GPS), 1-O-&agr;-D-glucopyranosyl-D-sorbitol (1.1-GPS) and 1-O-&agr;-D-glucopranosyl-D-mannitol (1.1-GPM).

Abstract: The present invention relates to a solid oral anticariogenic composition in the form of a sucking tablet for cleaning the oral cavity and the teeth, and to a process for producing such composition.

Abstract: The present invention anti-cariogenic activity of erythritol. The invention further discloses the use of erythritol in food preparations as an at least partial replacer of sugar or other cariogenic sweetening agent. Erythritol is used in combination with normally employed sweetening agents and the favourable characteristics of the erythritol are preserved while the amount of erythritol used is much less than what would be needed to replace the sugar completely.

Abstract: A chewing gum composition for instant and extended release breath freshening has a gum base, at least one wetting agent, at least one immediate release flavor ingredient, and at least on encapsulation. The encapsulations include flavor encapsulations, metallic ion encapsulations, and organic substance encapsulations.

Abstract: A drug delivery system comprising a dissolvable solid portion (10) having an outer (12) and inner surface (14) and a cavity (16) for receiving fluid. The cavity (16) is surrounded by, and contained within, the solid portion (10). Both the solid portion (10) and the cavity (16) are supported by a handle (20). A method of administering a drug is also disclosed.

Abstract: A polyol composition useful for the production of tablets for consumption. The polyol is obtained by co-spray drying or co-fluidized bed granulating at least two polyols, one of which is a non-hygroscopic polyol, and the non-hygroscopic polyol is present in an amount of at least 80% by weight. An optional binder may be present. An active medicament may be present.

Abstract: An oral lubricant having particular usefulness for alleviating the symptoms of xerostomia based on a beta-glucan polymer in an orally acceptable carrier or vehicle.

Abstract: A drug or other medication is incorporated into a candy and is molded onto a lollipop stick. A medicated lollipop is safely and conveniently stored by mounting the end of the lollipop stick remote from the medicated candy to the inner surface of a childproof cap. The lollipop then is inserted into a container, and the childproof cap is releasably locked with the open top of the container. The medicated lollipop can be accessed as needed merely by opening the container. Additionally, the medicated lollipop can be temporarily stored away from the container merely by converting the cap, and supporting the medicated lollipop by the cap.

Abstract: A dietary supplement which is useful for the promotion of healthy hair and pigment restoration in human subjects is provided. The dietary supplement supplies useful nutrients for hair growth, development, and pigmentation. In some instances, the use of the present dietary supplement can retard, prevent, suppress, and/or even reverse the graying of hair. Thus, at least for some already-turned gray individuals, the natural hair color can be restored, and maintained, naturally without the use of dyes, colorants, or the like. The dietary supplement contains, in effective amounts, a copper salt; para-aminobenzoic acid or salts thereof; pantothenic acid or salts thereof; and vitamin B6 in an appropriate carrier.

Abstract: The present invention relates generally to a complete nutritional product that provides soy protein and enhanced levels of isoflavones. Preferably, the soy protein comprises at least 0.7 mg isoflavones / gm soy protein and at least 0.5 mg genistein / gm soy protein. The product is fortified at 35% of the RDI for calcium and contains an antioxidant package. The invention also describes the method to produce a heat stable isoflavone-enriched soy protein complete nutritional.

Abstract: Sugar alcohol mixtures are used as antimicrobially active compounds.

Abstract: The present invention relates to oral compositions having enhanced organoleptic characteristics of fattiness, creaminess, soothing, satisfaction, and full mouthfeel, and comprises acylglycerol compounds having substituents R.sub.1, R.sub.2, and R.sub.3 attached at the positions of the OH.sup.- groups of a glycerol backbone. The substituents R.sub.1 and R.sub.2 are independently selected from conjugated polyunsaturated fatty acids having from 16 carbon atoms to 22 carbon atoms and R.sub.3 is selected from the group consisting of R.sub.1, OH, PO.sub.3 HR.sub.4, and C.sub.6 -C.sub.12 carboxylic acids, wherein R.sub.4 is selected from the group consisting of OH, choline, inositol, serine, and ethanolamine. The oral compositions of the present invention being substantially free of free conjugated polyunsaturated fatty acids.

Abstract: A natural antioxidant blend in the form of an amphorous powder was obtained by extraction from Emblica officinalis fruit. In this process, the finely pulped fruit was treated with a dilute aqueous salt solution at hot water temperature to provide an extract-containing solution, which was filtered and dried to provide the desired antioxidant blend powder. Cosmetic, pharmaceutical and nutritional use formulations thereof also are described.

Abstract: The present invention is a system which topically delivers pharmaceuticals to the buccal mucosa. Preferred pharmaceuticals include topical local anesthetics, such as tetracaine, which can be applied to the mucosa for rapid pain relief. The system comprises a hard candy matrix in which the pharmaceutical is dispersed. The hard candy matrix may be formed without the addition of dyes, synthetic flavoring agents, alcohols, or preservatives. Also, the candy may be mounted on a handle to form a lollipop, and the handle may be used to position the candy adjacent a particular site where the pharmaceutical is needed.

Abstract: A flavonol-containing dry composition derived from wine and useful as a food supplement is provided wherein at least 25% of the composition derived from wine includes polyphenols and at least 1.0% w/w of the composition is flavonol.

Abstract: The invention relates to edible oral cleansing and sanitizing compositions and the use of these compositions for reducing plaque and calculus deposition in the mouth and improving oral cleanliness and tooth smoothness. The active ingredients include surfactants, sequestrants, and protein precipitants; each present in a specified concentration range. In a preferred embodiment, the hard candies comprise between about 0.01 and 20% surfactant, especially a glyceride or alkyl sulfate, 0.01 and 10% sequestrant, especially citric acid, and 0.01% and 10% protein precipitant, especially tannic acid.

Abstract: A nicotine candy is provided for consumption in small volumes and in a cigarette shaped package. Each portion of the candy is obtained by removing it from a cigarette shaped package from the end. In a first embodiment, standard paper is used to wrap the a series of linearly disposed candy portions. In a second embodiment, the package is made of edible rice paper, and may be torn off of the end in a single piece. The formulation of the candy preferably uses a food grade Beta-pyridyl-alpha-N-methylpyrrolidine dissolved into any standard hard sugar candy. This material is water soluble and is admixed into the sugar candy composition during candy formation. Preferably, the candy composition is available in a range of strengths which further enables users to regulate their doses. One or two or three pieces can be ingested simultaneously to enable control of the intake, in addition to the availability of the composition in different strengths.