Candy, Candy Coated Or Chewing Gum Patents (Class 424/440)
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Patent number: 6004538Abstract: An oral composition in the form of a toothpaste, powder, liquid dentifrice, mouthwash, denture cleaner, chewing gum, or candy comprising one or more oral composition components selected from abrasives, binders, humectants, surfactants, fluoride ion sources, anticalculus agents and sweetners and additionally comprising: a dimethicone copolyol selected from alkyl- and alkoxy-dimethicone copolyols having formula (I).Type: GrantFiled: October 28, 1997Date of Patent: December 21, 1999Assignee: The Procter & Gamble CompanyInventors: Iain Allan Hughes, Mark Ieuan Edwards
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Patent number: 5997862Abstract: The present invention relates to an oral delivery system containing a group c streptococcal phage associated lysin enzyme for the prophylactic and therapeutic treatment of Streptococcal A throat infections, commonly known as strep throat.Type: GrantFiled: October 31, 1997Date of Patent: December 7, 1999Assignee: New Horizons Diagnostics CorporationInventors: Vincent Fischetti, Lawrence Loomis
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Patent number: 5985271Abstract: The present invention relates to an oral delivery system containing a group c streptococcal phage associated lysin enzyme for the prophylactic and therapeutic treatment of Streptococcal A throat infections, commonly known as strep throat.Type: GrantFiled: February 25, 1999Date of Patent: November 16, 1999Assignee: New Horizons Diagnostics Corp.Inventors: Vincent Fischetti, Lawrence Loomis
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Patent number: 5985329Abstract: A coated product in the form of solid particles of a food or pharmaceutical wherein the particles are each coated with a water-soluble hemicellulose. The water-soluble hemicellulose has a viscosity in the range of from 50 to 1,000 mPa.multidot.s at 25.degree. C. when dissolved in water in an amount of 10% by weight and has a reducing sugar content of 5% by weight or less and an amino acid content, as measured by assay with 2,4,6-trinitrobenezene sulfonic acid, of 1.0% by weight or less.Type: GrantFiled: September 4, 1996Date of Patent: November 16, 1999Assignees: Freund Industrial Co., Ltd., Fuji Oil Co., Ltd.Inventors: Masanori Ogawa, Takehiko Ito, Chikako Ishigai, Hirokazu Maeda, Hitoshi Furuta, Mitsuo Hattori
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Patent number: 5972374Abstract: A new chewing gum with teeth whitener for helping whiten and brighten teeth while helping freshen the breath. The inventive device includes an elongate gum member having a central bore extending along its longitudinal axis. Extending through the central bore to substantially fill the central bore is a whitening gel which includes a whitening agent for whitening teeth while chewing the gum. The elongate gum member is divided along its length into a plurality of separable chewing portions such that each chewing portion includes portion of the gum member and a portion of the whitening gel member.Type: GrantFiled: April 2, 1998Date of Patent: October 26, 1999Inventor: Thomas Theisen
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Patent number: 5962009Abstract: Controlled release powder insufflation formulations are disclosed. The powder formulation includes cohesive composites of particles containing a medicament and a controlled release carrier which preferably includes one or more polysaccharide gums of natural origin.Type: GrantFiled: December 30, 1996Date of Patent: October 5, 1999Assignee: Edward Mendell Co., Inc.Inventors: Anand Baichwal, John N. Staniforth
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Patent number: 5958445Abstract: This invention discloses organoleptically acceptable formulations containing non-solubilized S(+) 1,8-diethyl-1,3,4,9-tetrahydropyrano?3,4-b!indole-1-acetic acid, preferably with an acidic component, also known as S(+)etodolic acid or S(+)etodolac.Type: GrantFiled: January 14, 1998Date of Patent: September 28, 1999Assignee: American Home Products CorporationInventors: Leslie G. Humber, Gerald L. Reuter
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Patent number: 5958380Abstract: This invention relates to a stable, single-part chewing gum product and methods of using same to effect remineralization of subsurface lesions in teeth and/or mineralization of exposed dentinal tubules. The chewing gum product contains a water-soluble cationic portion, a water-soluble anionic portion and a stabilizing component which substantially inhibits reaction between the cationic and anionic portions during storage of the chewing gum product but which allows the cationic and anionic portions to be simultaneously released at a substantially equal rate from the product when the product is chewed in the presence of saliva and/or water. The cationic portion is composed of at least one water-soluble calcium salt, and the anionic portion contains at least one water-soluble phosphate and, optionally, at least one water-soluble fluoride salt.Type: GrantFiled: July 7, 1997Date of Patent: September 28, 1999Assignee: Enamelon, Inc.Inventors: Anthony E. Winston, Norman Usen
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Patent number: 5955099Abstract: A lollipop storage assembly is provided including a housing being selectably opened and closed. Also included is a sucking drop having a stick coupled thereto and extending therefrom. The stick is slidably connected to the housing.Type: GrantFiled: April 16, 1998Date of Patent: September 21, 1999Inventor: Wendy A. White
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Patent number: 5928664Abstract: The present invention provides consumable, gummy delivery systems and methods of making the same. The gummy delivery systems include an active ingredient admixed with a glycerylated gelatin matrix prepared by heating an aqueous solution of gelatin and glycerin to a temperature and for a time sufficient to remove some of the moisture content of the initial aqueous solution. The active ingredient can be delivered from a shearform matrix carrier.Type: GrantFiled: February 11, 1998Date of Patent: July 27, 1999Assignee: Fuisz Technologies Ltd.Inventors: Robert K. Yang, T. Victor Oh
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Patent number: 5922346Abstract: A composition for reducing free radical damage induced by tobacco products and environmental pollutants. The composition includes reduced glutathione and a source of selenium. The composition can be administered orally in the form of a gel, lozenge, tablet or gum.Type: GrantFiled: December 1, 1997Date of Patent: July 13, 1999Assignee: Thione International, Inc.Inventor: Theodore Hersh
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Patent number: 5922347Abstract: The invention relates to stable, pharmaceutically usable chewing gum formulations which contain acetylsalicylic acid (ASA) as the active compound, and to a process for their preparation.Type: GrantFiled: January 29, 1993Date of Patent: July 13, 1999Assignee: Bayer AktiengesellschaftInventors: Franz Hausler, Joachim Maasz, Thomas Valeri
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Patent number: 5912007Abstract: The present invention pertains to delivery systems for the localized administration of a medicament to the upper respiratory tract. The delivery system comprises:(a) a safe and effective amount of a medicament useful for treating the upper respiratory tract,(b) an ionic polysaccharide, and,(c) a cross-linking agent.This invention also pertains to the medicated compositions containing the targeted delivery system in a pharmaceutically acceptable carrier. The invention further pertains to methods for preparing and using the delivery systems and medicated compositions.Type: GrantFiled: December 6, 1996Date of Patent: June 15, 1999Assignee: Warner-Lambert CompanyInventors: Pauline C. Pan, Shan Shan Sheu, Shiuh J. Luo
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Patent number: 5910312Abstract: The acne treatment composition of the present invention includes an effective amount of acne treatment medication selected from the group consisting of benzoyl peroxide and salicylic acid, and effective amount of a vasoconstrictor and an inert carrier. The acne treatment medication is therapeutic to acne conditions by acting as an antibacterial agent. The vasoconstrictor removes the redness normally associated with acne conditions as well as additional redness which may be caused by the benzoyl peroxide itself. The carrier is simply an inert flowing carrier to permit application of the active ingredients to the skin. In preferred embodiments about 1 to 15% of the acne treatment medication based on the total weight of the composition is included. The preferred acne treatment medication is benzoyl peroxide and the preferred vasoconstrictor is tetrahydrozoline hydrochloride or a combination of tetrahydrozoline hydrochloride and zinc sulfate.Type: GrantFiled: October 9, 1996Date of Patent: June 8, 1999Assignee: Ideal Ideas, Inc.Inventor: Karen G. Fried
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Patent number: 5908614Abstract: A peroxidase-activating oral care composition, in accordance with an embodiment of the invention, includes a non-enzymatic, water-soluble hydrogen peroxide precursor and a pH-adjusting agent capable of producing a selected pH in an aqueous solution. The composition facilitates the rapid release of hydrogen peroxide and results in the activation of a peroxidase enzyme in an oral cavity A process for manufacturing the oral care composition including obtaining the precursor, dispersing it in a non-hygroscopic material so as to coat or encapsulate it, obtaining and associating the coated or encapsulated particles with a pH-adjusting agent, and formulating the particles into an oral care composition is provided in another embodiment.Type: GrantFiled: August 15, 1996Date of Patent: June 1, 1999Inventor: Robert Eric Montgomery
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Patent number: 5906833Abstract: A nutritional supplement contains plural parts. Each of the plural parts is chronologically appropriate for its scheduled time of consumption. The nutritional supplement is contained in a palatable base, for example, a food bar which masks any unpleasant taste or texture of the nutrient. The nutritional supplement may contain any one or several nutrients including drugs, vitamins, herbs, hormones, enzymes and/or other nutrients in chronologically appropriate dosages in each part or sub-part.Type: GrantFiled: May 22, 1995Date of Patent: May 25, 1999Inventor: Ronald M. Klatz
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Patent number: 5902797Abstract: A nutritional supplement comprising approximately from about 5 to about 25 grams carbohydrate; approximately from about 1 to about 25 grams protein; and approximately from about 1 to about 10 grams fat, for use in treating low appetite that may result in weight loss, is described.Type: GrantFiled: November 10, 1997Date of Patent: May 11, 1999Assignees: Beth Israel Deaconess Medical Center, Medical Foods, Inc.Inventors: Stacey J. Bell, R. Armour Forse, Bruce R. Bistrian, Robert C. Jones
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Patent number: 5900230Abstract: The dental products of this invention can be used to treat and prevent periodontal disease. They contain a synergistic mixture of poloxamers, and/or poloxamer congeners, plus xylitol. These active ingredients are present in specific amounts. It is also necessary to eliminate all irritants from the dental products of this invention. The dental products of this invention include a dentifrice paste or gel, powder, granules, disintegrable tablet, and a mouthwash, lozenge, and chewing gum.Type: GrantFiled: August 18, 1997Date of Patent: May 4, 1999Assignee: Squigle, Inc.Inventor: Edward T. Cutler
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Patent number: 5895664Abstract: The present invention is a method of preparing a comestible unit which disperses quickly in the mouth. The present invention also includes the product resulting from the method. The method includes initiating crystallization of shearform matrix and combining with an additive, either before or after initiating crystallization, to form flowable, compactible micro-particulates. The combination is then subjected to compacting to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.Type: GrantFiled: June 14, 1994Date of Patent: April 20, 1999Assignee: Fuisz Technologies Ltd.Inventors: Subraman R. Cherukuri, Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
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Patent number: 5885551Abstract: A method for treating dentinal hypersensitivity by administering a therapeutic amount of an alginate to a hypersensitive tooth.Type: GrantFiled: August 1, 1997Date of Patent: March 23, 1999Inventors: Alfred J. Smetana, Jon Hayes, Kuo-Chen Yeh, Laura McCulloch
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Patent number: 5879699Abstract: A hollow, consumable fillable dispenser having a filler tube for delivery of medication in a more palatable manner. The dispenser may be a hard or chewy confection and defines a hollow chamber which may be filled with a medication at time of use by means of the filler tube.Type: GrantFiled: June 3, 1997Date of Patent: March 9, 1999Inventor: Julie Beth Green Lerner
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Patent number: 5879698Abstract: A dietary supplement composition is disclosed which comprises a calcium salt, vitamin D and at least one mineral, preferably a boron compound. Other minerals may be present, in addition to, or instead of the boron compound, such as copper compounds, Magnesium compounds, manganese compounds and zinc compounds.Type: GrantFiled: April 3, 1997Date of Patent: March 9, 1999Assignee: American Cyanamid CompanyInventors: Leon Ellenbogen, Lisa C. Buono
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Patent number: 5869084Abstract: Multi-vitamin and mineral supplements for administration to lactating, non-lactating, and menopausal women, which comprise specific regimens of critical nutritional agents. The supplements are specifically tailored to meet nutritional requirements and maintain a woman's health during each stage of life.Type: GrantFiled: June 7, 1995Date of Patent: February 9, 1999Assignee: K-V Pharmaceuticals Co.Inventors: George N. Paradissis, R. Saul Levinson, Gary Heeter, Robert C. Cuca, Patrick Paul Vanek
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Patent number: 5866179Abstract: The present invention relates to a medicated chewing gum comprising a pharmaceutically active agent incorporated therein. The medicated gum is used as a means for administering the active agent to a subject. The invention also relates to a method of preparing the medicated chewing gum. The process involves the formation of a cyclodextrin-active agent inclusion complex, which is dried and mixed with a granulated gum base without adding water or other solvents. The process is carried out under controlled temperature and humidity and the blended components are cold-pressed to produce a final gum product.Type: GrantFiled: May 3, 1996Date of Patent: February 2, 1999Assignee: Avant-Garde Technologies & Products S.A.Inventor: Emilio Stefano Testa
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Patent number: 5861169Abstract: A candy is disclosed which neutralizes plaque and contains at least one acid neutralizing substance such as an ammonium salt and may further comprise an alkaline metal salt and an alkaline earth metal salt with sugar substitutes and other ingredients.Type: GrantFiled: December 20, 1996Date of Patent: January 19, 1999Assignee: Dibona Holding AGInventor: Konrad Kaufmann
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Patent number: 5858333Abstract: A two-part oral product capable of remineralizing subsurface lesions and/or mineralizing exposed dentinal tubules in teeth is composed of cationic and anionic discrete parts. The cationic discrete part contains at least one water-soluble calcium salt and, preferably, at least one non-toxic, water-soluble salt of a divalent metal other than calcium, and a first pharmaceutically acceptable carrier. The anionic discrete part contains at least one water-soluble phosphate salt and, preferably, at least one water-soluble fluoride salt, and a second pharmaceutically carrier. Preferably, one of the carriers is an aqueous carrier and the other of the carriers is a non-aqueous carrier. The cationic and anionic parts are simultaneously released from the product upon mixing of the product with water and/or saliva to form the mixed aqueous solution. In this way, calcium ions released by the calcium salt and phosphate ions released by the phosphate salt are simultaneously delivered to the tooth surfaces by the solution.Type: GrantFiled: August 7, 1998Date of Patent: January 12, 1999Assignee: Enamelon, Inc.Inventors: Anthony E. Winston, Norman Usen
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Patent number: 5855908Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to manufacturing techniques that enable therapeutic agents to be incorporated into nondissolvable drug containment matrixes which are capable of releasing the drug within a patient's mouth. An appliance or holder is preferably attached to the drug containment matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.Type: GrantFiled: November 15, 1994Date of Patent: January 5, 1999Assignee: University of Utah Research FoundationInventors: Theodore H. Stanley, Brian Hague
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Patent number: 5849324Abstract: A method is provided for reducing the incidence of otitis media in infants and young children by enterally administering indigestible fructooligosaccharides. More specifically, the present invention relates to a method for reducing the incidence of otitis media comprising administering to humans an indigestible fructooligosaccharide selected from the group consisting of 1-kestose, nystose and 1-.sup.F -B-fructofuranosyl nystose . The indigestible fructooligosaccharides can be produced through enzymatic synthesis, chemical techniques or isolated from plant materials and are administered in the form of a nutritional product, candy, tablets, chewing gums, lozenges, milk products, yogurts and the like. In a preferred embodiment of this invention, the fructooligosaccharides have a DP of 2 to 20 and still more preferably are the fructooligosaccharides FG.sub.2, GF.sub.3, and GF.sub.4.Type: GrantFiled: June 12, 1996Date of Patent: December 15, 1998Assignee: Abbott LaboratoriesInventors: Margaret Ione Halpin Dohnalek, Karin Margaret Ostrom, Milo Duane Hilty
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Patent number: 5846557Abstract: The present invention pertains to chewing gum compositions containing cough suppressing agents. The compositions include a taste-masking mixture containing a flavoring agent, an intense sweetening agent and menthol. This combination nullifies the taste or off-note of the cough suppressant. The present invention also pertains to a method preparing the chewing gum composition and methods of treatment which include administering the cough suppressant-containing chewing gum to a patient in need thereof.Type: GrantFiled: June 30, 1997Date of Patent: December 8, 1998Assignee: Cumberland Packing CorporationInventors: Barbara Eisenstadt, Penny A. Cash, Abraham I. Bakal
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Patent number: 5843471Abstract: The invention relates to edible oral cleansing and sanitizing compositions and the use of these compositions for reducing plaque and calculus deposition in the mouth and improving oral cleanliness and tooth smoothness. The active ingredients include surfactants, sequestrants, and protein precipitants; each present in a specified concentration range. In a preferred embodiment, the hard candies comprise between about 0.01 and 20% surfactant, especially a glyceride or alkyl sulfate, 0.01 and 10% sequestrant, especially citric acid, and 0.01% and 10% protein precipitant, especially tannic acid.Type: GrantFiled: November 6, 1997Date of Patent: December 1, 1998Inventor: Sterling Chaykin
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Patent number: 5840322Abstract: A non-food oral hygiene composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In a preferred embodiment the anti-aggregation fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight .gtoreq.14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; an NMR line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against both P fimbriated bacteria and oral bacteria.Type: GrantFiled: December 19, 1996Date of Patent: November 24, 1998Assignee: Ramot-University Authority For Applied Research & Industrial Devel. Ltd.Inventors: Ervin Weiss, Itzhak Ofek, Yoel Kashman, Janina Goldhar, Nathan Sharon
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Patent number: 5834002Abstract: The invention provides a chewing gum composition containing a water soluble bulk portion, a water insoluble chewing gum base portion, a flavoring agent, and bismuth-containing compounds. The invention provides a bismuth-containing gum which when chewed multiple times per day, over the period of two weeks, is effective in reducing peptic ulcers by eradicating H. pylori. The chewing gum is also effective in eliminating forms of halitosis. The chewing gum does not have undesirable side effects, unpleasant taste and poor chewing characteristics.Type: GrantFiled: November 1, 1996Date of Patent: November 10, 1998Assignee: Josman Laboratories, Inc.Inventor: Narayan K. Athanikar
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Patent number: 5830489Abstract: The present invention relates to a topical protein preparation to be used for the therapy of periodontitis and diseases of the teeth and of the tissues of the oral cavity, comprising a mixture of transferrin with at least one protein selected from albumins, lysozymes, protease inhibitors, and mixtures thereof.Type: GrantFiled: October 11, 1995Date of Patent: November 3, 1998Assignee: Pfizer Inc.Inventors: Piera Valenti, Giovanni Antonini
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Patent number: 5827527Abstract: A candy product includes a ring forming an annular handle, and having an outer diameter of at least 5 cm. A candy holder attached to the handle and adapted for carrying a lump of candy to be consumed by a child. The holder forms a paddle to pacify the child upon removal of the candy from the holder.Type: GrantFiled: March 24, 1997Date of Patent: October 27, 1998Inventor: Dana B. Leonard
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Patent number: 5827526Abstract: A method is provided for reducing the duration of diarrhea and recurrent episodes of diarrhea in humans by enterally administering indigestible oligosaccharides prophylactically. More specifically, the present invention relates to a method using indigestible oligosaccharides or fructooligosaccharides (FOS) to reduce the duration and recurrence of diarrhea in a human wherein between 0.5 grams and 5 grams of at least one FOS selected from the group consisting of 1-kestose, nystose, and 1.sup.F -.beta.-fructofuranosyl nystose is administered to said human per day. The indigestible oligosaccharides can be produced through enzymatic synthesis, chemical techniques or isolated from plant materials and are administered in the form of a nutritional product, candy, tablets, chewing gum, lozenges, milk, yogurts, fermented products and the like.Type: GrantFiled: June 12, 1996Date of Patent: October 27, 1998Assignee: Abbott LaboratoriesInventors: Margaret Ione Halpin Dohnalek, Karin Margaret Ostrom, Milo Duane Hilty
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Patent number: 5824334Abstract: The present invention relates generally to a cigarette substitute for administering a dose of nicotine. More specifically, the present invention is directed to a nicotine-containing dosage-form comprising a holder member which may be used as part of an effective smoking cessation program or in situations where smoking is undesirable or not permitted. The dosage form is configured as a dosage form having a nicotine-containing composition attached to a holder member. Nicotine is released from the dosage form and absorbed through the intra-oral mucosal surfaces as the nicotine-containing composition releases nicotine within a user's mouth. The holder member facilitates insertion and removal of the dosage form into and out of a user's mouth. The user can selectively insert and remove the dosage form as desired to selectively control the release of nicotine.Type: GrantFiled: April 19, 1996Date of Patent: October 20, 1998Assignee: University of Utah Research FoundationInventors: Theodore H. Stanley, Brian I. Hague
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Patent number: 5824291Abstract: A chewing gum composition for whitening teeth comprising a water insoluble gum base in admixture with a plasticizer, a flavorant, sweetener, filler, texturizer, color, stabilizer, surface active agent and the like, some of the foregoing being optional, and a safe and effective whitening amount of a water soluble alkali metal percarbonate, a safe and effective amount of neem oil, sodium bicarbonate and parsley extract.Type: GrantFiled: June 30, 1997Date of Patent: October 20, 1998Assignee: Media GroupInventor: Herman S. Howard
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Patent number: 5817330Abstract: Paraffin oil and lactulose-based jellied clear laxative emulsion containing from 75 to 85 parts by weight of liquid paraffin oil and from 25 to 15 parts by weight of an edulcorated lactulose aqueous solution. The invention also concerns a method for the preparation of said emulsion.Type: GrantFiled: February 4, 1997Date of Patent: October 6, 1998Inventor: Bernard Doat
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Patent number: 5814332Abstract: This disclosure is directed to preparation of individual taste-masked, high bioavailability, high payload, microcapsules by microencapsulation of water-insoluble NSAID drug materials in the substantial absence of microcapsule agglomerates. These taste-masked microcapsules contain a high payload, e.g., about 83+ wt. % of said NSAID drug material having high bioavailability and can then be formulated into chewable tablets and liquid aqueous suspensions for medicinal use. Both cellulose acetate phthalate and gelatin are the microencapsulating polymer wall material.Type: GrantFiled: February 20, 1997Date of Patent: September 29, 1998Assignee: Eurand America, Inc.Inventors: Sambasiva Rao Ghanta, Robert Edmon Guisinger
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Patent number: 5804210Abstract: A method of treating an animal to maintain or enhance the mineral content of the bones of the animal consists of administering to the animal a safe and effective amount of CLA. Compositions for use in the method are also disclosed.Type: GrantFiled: August 7, 1996Date of Patent: September 8, 1998Assignee: Wisconsin Alumni Research FoundationInventors: Mark E. Cook, Michael W. Pariza
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Patent number: 5800830Abstract: This invention relates to a bifidobacterium growth promotant comprising gluconic acid, a nontoxic salt thereof and/or glucono-.delta.-lactone as an active ingredient. The bifidobacterium growth promotant of this invention has selective bifidobacterial growth promoting-activity and, at the same time, inhibits growth of deleterious bacteria. Moreover, its rate of digestion and absorption in the upper alimentary tract is so low that the promotant has very satisfactory characteristics as a bifidus factor. Therefore, the bifidobacterium growth promotant of this invention can be used per se or as an additive for various foods and drink to provide functional foods and drinks, thus being of great value from the standpoint of health improvement.Type: GrantFiled: November 29, 1996Date of Patent: September 1, 1998Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Toshihiko Asano, Ryoko Kondo, Yasumi Mori, Seishi Takenawa, Motoko Yamochi, Kiyohiko Kunugita, Tsutomu Terachi
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Patent number: 5788982Abstract: A vehicle useful for delivery of capsaicin that is convenient, and acceptable to patients, and which insures sufficient exposure to the capsaicin to produce desensitization is the subject of this invention. The applicants have developed a candy vehicle for the delivery of capsaicin. Candies containing 5-9 ppm capsaicin were made by adding cayenne pepper to a standard candy carrier recipes.Type: GrantFiled: June 16, 1995Date of Patent: August 4, 1998Inventors: Wolffe Nadoolman, Linda M. Bartoshuk
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Patent number: 5785989Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored dissolvable matrix. An appliance or holder is preferably attached to the dissolvable matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.Type: GrantFiled: March 19, 1997Date of Patent: July 28, 1998Assignee: University Utah Research FoundationInventors: Theodore H. Stanley, Brian Hague
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Patent number: 5783207Abstract: The present invention relates to a selectively removable nicotine-containing dosage form for use in the transmucosal delivery of nicotine to a patient. More specifically, the present invention is directed to a nicotine-containing dosage-form comprising an attached holder member which may be used to manipulate the dosage form within the mouth of the patient as part of an effective smoking cessation program or in situations where smoking is undesirable or not permitted. Nicotine is released from a dosage form and absorbed through the intra-oral mucosal surfaces as the nicotine-containing matrix releases nicotine within the user's mouth. The user may selectively insert and remove the dosage form as desired to control the release of nicotine. In addition, the user may manipulate the dosage form by use of the holder means in such a manner to meet the user's psychological need or desire for ritualistic oral stimulation similar to cigarette smoking.Type: GrantFiled: February 4, 1997Date of Patent: July 21, 1998Assignee: University of Utah Research FoundationInventors: Theodore H. Stanley, Brian Hague
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Patent number: 5780046Abstract: This invention discloses organoleptically acceptable formulations containing S(+)-2-(p-isobutylphenyl)-propionic acid, also known as S(+) ibuprofen.Type: GrantFiled: June 10, 1996Date of Patent: July 14, 1998Assignee: American Home Products CorporationInventors: Leslie G. Humber, Gerald L. Reuter
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Patent number: 5776462Abstract: The attachment of H. influenzae to human cells such as oropharyngeal cells, is inhibited by aqueous extracts of the plants known as Pogostemon cablin and Agastache rugosa. The composition obtained from the aqueous extraction of the plants Pogostemon cablin, Agastache rugosa or mixtures thereof is also effective in preventing or treating Otitis media and sore throat. The plant extract may be contained in a liquid enteral product such as an infant formula or may be incorporated into lozenges, candies, chewing gums and the like. The plant extract may also be administered as a throat spray or nasally using drops or a spray. A process for the production of a medicinal product is also disclosed.Type: GrantFiled: December 10, 1996Date of Patent: July 7, 1998Assignee: Sage R&D, a partnershipInventors: Hsiu-Hsien Tsai, Shie-Ming Hwang
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Patent number: 5770215Abstract: The present invention relates to a vitamin supplement containing from 5% to 1000% of the RDA of vitamins and a therapeutically effective amount of a vascular occlusion inhibiting compound which is preferably aspirin (acetylsalicylic acid). The vitamins are selected from vitamins A, D; E, K, C, thiamin, riboflavin, niacin, niacinamide, B.sub.6, folate, B.sub.12, biotin, pantothenic acid and mixtures thereof. The composition can be in capsule or tablet form, may further contain minerals, herbal extracts, homeopathics or other therapeutic substances, and finds particular utility with regard to cardiac care patients.Type: GrantFiled: January 6, 1997Date of Patent: June 23, 1998Inventor: Emil Payman Moshyedi
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Patent number: 5766622Abstract: The present invention relates to a method for inhibiting an undesirable taste in oral compositions such as foods, beverages, and pharmaceuticals. The present invention also relates to oral and pharmaceutical compositions comprising undesirable tasting compounds wherein undesirable tastes are inhibited by the addition of a phosphorylated amino acid, such as phosphotyrosine, phosphoserine, phosphothreonine, and mixtures thereof, to said oral and pharmaceutical compositions.Type: GrantFiled: August 14, 1996Date of Patent: June 16, 1998Assignee: The Procter & Gamble CompanyInventor: Sandra Lynn Nelson
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Patent number: 5762963Abstract: Methods and compositions are provided for the oral delivery of temporally increasing concentrations of capsaicin, its derivatives, and analogs (collectively, "capsaicinoids"), to provide oral or pharyngeal analgesia while minimizing sensations of nausea and burning associated with the oral administration of capsaicinoids. The methods and compositions described herein soothe and relieve oral or pharynx pain. In one embodiment, one or more capsaicinoids are dispersed within a lollipop, with successively decreasing concentrations of capsaicin from the center out to the periphery, and administered to a patient in need of amelioration of oral pain. Alternatively, the capsaicinoid can be dispersed, with decreasing concentrations from the center to the periphery, in a tablet, caplet, lozenge, troche, pill, candy, or similar formulation.Type: GrantFiled: June 7, 1995Date of Patent: June 9, 1998Assignee: Emory UniversityInventor: Michael G. Byas-Smith
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Patent number: 5741507Abstract: The present invention deals with a ranitidine tablet containing at least 30% ranitidine chloride and having a hydroxypropylmethylcellulose containing coating characterized in that the coating comprises hydroxypropylmethylcellulose and ethylcellulose in a mutual ratio between 10:1 and 1:2 as well as a method for producing the desired coating when manufacturing such ranitidine tablets.Type: GrantFiled: January 15, 1997Date of Patent: April 21, 1998Assignee: A/S GEA Farmaceutisk FabrikInventors: S.o slashed.ren Bols Pedersen, Knud Erik Gebhard-Hansen, Helle Kann