Candy, Candy Coated Or Chewing Gum Patents (Class 424/440)
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Patent number: 5738865Abstract: Controlled release powder insufflation formulations are disclosed. The powder formulation includes cohesive composites of particles containing a medicament and a controlled release carrier which preferably includes one or more polysaccharide gums of natural origin.Type: GrantFiled: December 30, 1996Date of Patent: April 14, 1998Assignee: Edward Mendell Co., Inc.Inventors: Anand Baichwal, John N. Staniforth
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Patent number: 5733575Abstract: A non-toxic edible enteric film coating dry powder composition for use in making an aqueous enteric coating suspension which may be used in coating pharmaceutical tablets and the like comprises an enteric film forming polymer, a detackifier, a viscosity modifier, and an alkalizing/anti-coagulating agent. Advantageously, the inventive dry powder compositions may include a solid plasticizer, a lubricant, an anti-caking agent, a liquid plasticizer, and a pigment.Type: GrantFiled: October 7, 1994Date of Patent: March 31, 1998Assignee: BPSI Holdings, Inc.Inventors: Dev K. Mehra, Chittamuru Ramireddy, Li-Juan Tang, Stuart C. Porter
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Patent number: 5733577Abstract: The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.Type: GrantFiled: August 16, 1996Date of Patent: March 31, 1998Assignee: Fuisz Technologies Ltd.Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
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Patent number: 5728400Abstract: The present invention is a process for forming a low density compression dosage unit to provide increased strength. The process of the present invention includes compacting under bi-level compaction pressure to provide a continuous-volume dosage unit which has a first volume defining an edge portion of the unit and a density which is greater than a density of a second volume defining a non-edge portion of the unit. The present invention also includes the product resulting from the process and apparatus used to make such units.Type: GrantFiled: November 5, 1996Date of Patent: March 17, 1998Assignee: Fuisz Technologies Ltd.Inventors: Gerald E. Battist, B. Arlie Bogue, Garry L. Myers
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Patent number: 5725865Abstract: Coolant compositions, flavorant compositions and ingestible and topical compositions containing at least one coolant compound selected from monomenthyl succinate, alkali metal salts of monomenthyl succinate, alkaline earth metal salts of monomenthyl succinate and mixtures thereof. These compositions are found to provide a pleasant, long-lasting cooling effect without bitterness and the cooling effect manifests itself differently than the cooling effect of other known coolants. As a result, a complementary or synergistic effect can by obtained by combination with other coolants. Further, the succinate-based coolant compounds of the invention are found to enhance the sensation of alcohol in alcoholic beverages.Type: GrantFiled: August 29, 1995Date of Patent: March 10, 1998Assignee: V. MANE Fils S.A.Inventors: Jean M. Mane, Jean-Louis Ponge
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Patent number: 5723443Abstract: The invention concerns a low molecular weight proteinaceous agent which can be used to reduce body fat content by suppressing fat digestion and absorption thus reducing body fat and limiting excess fat accumulation. The proteinaceous material is a mixture of low molecular weight peptides. This mixture has about at least 50-67% of peptides having an average chain length of 3-4 amino acids. This material is administered to subjects in amounts of at least 0.1 to 50 weight percent relative to the amount of fat consumed by the subject.Type: GrantFiled: February 28, 1996Date of Patent: March 3, 1998Assignee: Hankyu-Kyoei Bussan Co. Ltd.Inventors: Kyoichi Kagawa, Takaya Kaneda, Tetsuo Tadokoro, Yoshikazu Matsumura
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Patent number: 5711961Abstract: Chewing gum tablets and their methods of preparation are disclosed. The gum tablets contain a mixture of chewing gum base and sugary microgranules with an additive agent and an active ingredient adsorbed onto their surface. A lacquer coating on the tablet contains cellulose and polyethlene glycols. The sugary microgranules are delayed release coated particles. The chewing gums act as vehicles for active ingredients. These active ingredients may be used alone or in combination in normal physical form in the form of coated microspheres.Type: GrantFiled: May 29, 1996Date of Patent: January 27, 1998Assignee: APR Applied Pharma Research S.A.Inventors: Alberto Reiner, Alessandro Seneci
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Patent number: 5705183Abstract: A system and a method are provided to spray sugar in fibrous form and compress the same and subsequently add medication to form a dose appropriate for ingestion by a patient. Alternatively, the sprayed sugar in fibrous form may include the medication when sprayed. The sprayed sugar in fibrous form is advanced on a conveyor system and compressed into a stream. The compressed stream may have medication added thereto if not provided in the sprayed sugar in fibrous form. The stream may be combined with a second stream and then cut into individual, uniform doses of medication.Type: GrantFiled: September 25, 1995Date of Patent: January 6, 1998Assignee: Phillips CompanyInventors: Jon Phillips, Troy W. Greenberg
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Patent number: 5702687Abstract: The present invention provides a chewing gum product which has a content of two or more active ingredients for improved dental health. In one embodiment a present invention chewing gum product has a content of ingredients which include a gum base, dispersed particles of organic-encapsulated sodium bicarbonate, a bulking sweetener, a plaque-inhibiting ingredient, and a flavorant.Type: GrantFiled: October 3, 1995Date of Patent: December 30, 1997Assignee: Church & Dwight Co., Inc.Inventor: Regina M. Miskewitz
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Patent number: 5698215Abstract: This patent deals with a chewing gum which possesses fluoride and citric acid for improved dental health. The incorporation of fluoride and citric acid into our gum product is for the citric acid to provide a means by which fluoride can be absorbed into the tooth structure. The mechanism of action of this product is the following: citric acid is incorporated in this chewing gum to microscopically open up the pores (prism layers) of the enamel tooth structure. This opening of the pores, at the moth surface, enables greater contact and penetration of the fluoride to be absorbed into the enamel. The resultant effect is greater penetration of fluoride into the enamel and the underlying tooth structure (dentine). In addition to facilitating the penetration of fluoride into the tooth, there would be an added benefit from the dietary content of the citrus fruits. Moreover, this gum includes novel organoleptic properties as a result of natural sugars, together with enhanced flavor, for sweetness impact.Type: GrantFiled: December 17, 1996Date of Patent: December 16, 1997Inventors: Tom Kalili, Angelo A. Caputo
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Patent number: 5695749Abstract: Cholestyramine and starch containing, oil-free compositions with excellent organoleptic features are obtained by mixing cholestyramine and grain starch in a weight ratio of 1:1.8 to 2.9 with the addition of grain bran as a filler and optionally an aroma stuff with 10 to 35% by weight of water (calc. on the starting materials) into a homogenous moist mass, forming of the mass through extrusion into a string, whereby the temperature is 105.degree.-180.degree. C. (measured in the mass in the extrusion head) and the pressure is 30-70 bars (measured in the extrusion head), and subsequently drying at a temperature above 100.degree. C. to a remaining humidity of .ltoreq.3.5% by weight, whereby the extruded material before or after the drying is divided into bars or is grinded into a powder.Type: GrantFiled: May 25, 1994Date of Patent: December 9, 1997Assignee: Astra AktiebolagInventors: Stefan Friess, Harald Heckenmuller
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Patent number: 5693334Abstract: The present invention provides a chewing gum product which has a content of two or more active ingredients for improved dental health. In one embodiment a present invention chewing gum product has a content of ingredients which include a gum base, dispersed particles of organic-encapsulated sodium bicarbonate, a peroxygen compound, a bulking sweetener, and a flavorant.Type: GrantFiled: October 5, 1995Date of Patent: December 2, 1997Assignee: Church & Dwight Co., Inc.Inventor: Regina M. Miskewitz
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Patent number: 5688492Abstract: An oral hygiene composition comprises an effective amount of an antimicrobial agent in the form of a particulate non-ion-exchanging support material combined with a metal source providing antimicrobial metal ions in use. Preferably the antimicrobial agent is particulate titanium dioxide coated with silver chloride.Type: GrantFiled: July 22, 1996Date of Patent: November 18, 1997Assignee: The Boots Company PLC,Inventors: Edward Galley, Michael David Cooper
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Patent number: 5688521Abstract: Object of the invention is a single dose form of application for lactulose in the form of pastilles based on at least partially or completely water soluble natural and/or synthetic polymers selected from gums, alginates, carrageen, starch, pectin, and gelatin comprising lactulose as active substance, as well as a process to prepare the said pastilles.Type: GrantFiled: December 1, 1995Date of Patent: November 18, 1997Assignee: Bolder Arzneimittel GmbHInventors: Hermann-Josef Bolder, Faruk Imer
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Patent number: 5681577Abstract: A chewable cold/sinus preparation comprising a bitter tasting mixture of a decongestant such as pseudoephedrine and an antihistamine such as diphenhydramine and/or chlorpheniramine maleate is made with no bitter, metallic taste or unpleasant mouthfeel by adsorbing the active drug mixture using a wet granulation process onto a silicon dioxide carrier which comprises from about 50 to about 85% of total weight of the adsorbate composition. A truly multi-symptom relief formula is prepared through the optional addition of an antitussive such as dextromethorphan hydrobromide and/or an analgesic such as meclofenamic acid, aspirin or ibuprofen. Additional excipients such as flavors, sweeteners, lubricants and bulk fillers are added for better taste, improved mouthfeel and as an aid to the tabletting process.Type: GrantFiled: September 19, 1995Date of Patent: October 28, 1997Assignee: Warner-Lambert CompanyInventors: Stanley Lech, Alexander M. Schobel, John Denick, Jr.
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Patent number: 5670138Abstract: The invention is directed to improved mouth care products comprising an amount of at least one copolymer of N-vinylpyrrolidone and acrylic acid, in a weight ratio of 60-95 to 40-5, suitable additives and carrier material.Type: GrantFiled: July 6, 1995Date of Patent: September 23, 1997Assignee: Sara Lee/DE N.V.Inventors: Franciscus Ties Venema, Christiena Jannie Timmer, Jolanda Douma, Stephanus Aloysius Gerardus Jochems
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Patent number: 5667797Abstract: An anti-diarrheic product comprises a foodstuff and an anti-rotaviral agent such as human defatted fat globule membranes, the human milk macromolecular fraction, skim milk, curd, whey, the milk mucin complex, the 46 Kd app.MW glycoprotein, a polypeptide having an amino acid sequence having the rotavirus binding specificity of the 46 Kd app.MW HMFG glycoprotein or mixtures thereof. An anti-diarrheal kit comprises the anti-rotaviral agent of this invention and instructions for its use, and optionally a foodstuff. A method for inhibiting or countering rotavirus infection in mammalian cells comprises contacting the cells with an anti-rotaviral amount of the agent of this invention.Type: GrantFiled: April 1, 1996Date of Patent: September 16, 1997Assignees: Cancer Research Fund of Contra Costa, Senomed, Inc., The Johns Hopkins University School of MedicineInventors: Jerry A. Peterson, David S. Newburg, Robert H. Yolken
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Patent number: 5667802Abstract: Antacids comprise a pharmaceutically acceptable gum coated with simethicone and a pharmaceutically acceptable antacid to provide prolonged antacid treatment to the stomach while preventing acid rebound. Compatible active ingredients can be included in the antacids, including analgesics, antibiotics, gold salts, and fluorine compounds.Type: GrantFiled: May 15, 1995Date of Patent: September 16, 1997Inventor: Georges Serge Grimberg
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Patent number: 5665376Abstract: A method for treating or reducing excess stomach acidity by ingesting a predetermined dose of a flour or meal made from dried fava beans. The predetermined dose may be incorporated into edible food products such as a chewable wafer, cookie, biscuit, drink mix etc. The minimum recommended dose is at least 1000 mg. The treatment of the present invention may be taken in anticipation of excess stomach acidity or after its occurrence.Type: GrantFiled: November 2, 1995Date of Patent: September 9, 1997Inventor: Ubaldo Russo
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Patent number: 5665385Abstract: There are disclosed compositions and methods for supplementing dietary intake of various metals in a warm-blooded animal. The compositions include highly water soluble metal chelidamate salts and metal arginine salts in combination with a pharmaceutically acceptable carrier or diluent. The methods include the administration of such metal chelidamate or arginine salts to prevent or alleviate conditions resulting from metal deficiency.Type: GrantFiled: December 9, 1994Date of Patent: September 9, 1997Assignee: Sound Nutrition, Inc.Inventors: Barry L. Johnson, Al. F. Czap
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Patent number: 5662920Abstract: A method for smoking cessation therapy is described that utilizing an improved nicotine lozenge to satisfy transient craving. The lozenge contains nicotine, a nonnutritive sweetener and an absorbent excipient.Type: GrantFiled: May 15, 1996Date of Patent: September 2, 1997Assignee: Pharmacia ABInventor: Gian Carlo Santus
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Patent number: 5660842Abstract: The present invention is directed to a method for inhibiting Helicobacter by administering C.sub.8 -C.sub.16 monoglycerides of fatty acids or lauric acid. The monoglycerides and/or lauric acid are conveniently administered via a nutritional composition.Type: GrantFiled: May 5, 1995Date of Patent: August 26, 1997Assignee: Bristol-Myers Squibb CompanyInventor: Bryon W. Petschow
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Patent number: 5656274Abstract: The present invention discloses the method of isolation and purification of the bioactive constituents cinnamophilin from Cinnamomum philippinense (Merr.), the same as Machilus acuminatissima (Hayata). Pharmacological evaluation showed that these compounds possess the activity to inhibit platelet aggregation and to produce relaxing effects of aortic vascular constriction.Type: GrantFiled: February 24, 1995Date of Patent: August 12, 1997Assignee: National Science Council of TaiwanInventors: Tian-Shung Wu, Che-Ming Teng, Sheu-Meei Yu
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Patent number: 5656296Abstract: The present invention pertains to a dual control sustained release drug delivery system which comprises a core and a porous coating layer over the core, wherein the coated core comprises (A) a core comprising in percentages by weight of the core composition (a) a medicament present in an amount from about 60% to about 90%; (b) an edible material having a melting point from about 25.degree. C. to about 100.degree. C. selected from the group consisting of (i) fatty acids having an iodine value from about 1 to about 10, (ii) natural waxes, (iii) synthetic waxes, and (iv) mixtures thereof, present in an amount from about 5% to about 40%; and (B) a porous coating layer over the core comprising in percentages by weight of the coating layer composition (a) a pH-independent water-insoluble polymer present in an amount from about 40% to about 80%; and (b) a water-soluble film forming polymer present in an amount from about 20% to about 60%.Type: GrantFiled: June 7, 1995Date of Patent: August 12, 1997Assignee: Warner-Lambert CompanyInventors: Sadath U. Khan, Phyllis Ying, Russell U. Nesbitt, Mahdi B. Fawzi, Jay Weiss
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Patent number: 5653993Abstract: This disclosure is directed to preparation of individual taste-masked, high bioavailability, high payload, microcapsules by microencapsulation of water-insoluble NSAID drug materials in the substantial absence of microcapsule agglomerates. These taste-masked microcapsules contain a high payload, e.g., about 83+wt. % of said NSAID drug material having high bioavailability and can then be formulated into chewable tablets and liquid aqueous suspensions for medicinal use. Both cellulose acetate phthalate and gelatin are the microencapsulating polymer wall material.Type: GrantFiled: June 7, 1995Date of Patent: August 5, 1997Assignee: Eurand America, Inc.Inventors: Sambasiva Rao Ghanta, Robert Edmon Guisinger
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Patent number: 5654003Abstract: The present invention is a process for making edible units from compression and the products resulting therefrom. The method of the present invention includes compression of shearform matrix mass sufficiently to form a comestible compression unit such as a compression tablet.Type: GrantFiled: February 10, 1994Date of Patent: August 5, 1997Assignee: Fuisz Technologies Ltd.Inventors: Richard C. Fuisz, Subraman R. Cherukuri
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Patent number: 5648093Abstract: A fast dissolving, solid dosage form defined by a matrix containing gelatin, pectin and/or soy fiber protein and one or more amino acids having from about 2 to 12 carbon atoms is disclosed.Type: GrantFiled: May 22, 1995Date of Patent: July 15, 1997Assignee: Janssen Pharmaceutica Inc.Inventors: Dilip J. Gole, R. Saul Levinson, Paul K. Wilkinson, J. Desmond Davies
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Patent number: 5645853Abstract: This invention relates to chewing gum compositions and methods utilizing same which are useful to remineralize subsurface dental enamel. More specifically, this invention relates to stable, single-part chewing gum compositions containing calcium and phosphate salts which when applied to lesions in dental enamel result in remineralization of subsurface dental enamel and/or mineralization of tubules in dentin thereby counteracting caries and/or hypersensitivity.Type: GrantFiled: August 8, 1995Date of Patent: July 8, 1997Assignee: Enamelon Inc.Inventors: Anthony E. Winston, Norman Usen
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Patent number: 5639470Abstract: A deodorizer comprises a hydrophilic solvent extract of fruit-bodies of champignon mushroom or powder of the extract as an effective component. The extract of champignon mushroom used as an effective component can be prepared by a method which comprises the step of immersing the mushroom in a hydrophilic solvent at a temperature ranging from 60.degree. to 100.degree. C. for 15 minutes to 2 hours to perform extraction. The extract can further be treated to obtain the effective components in the form of powder.Type: GrantFiled: August 16, 1993Date of Patent: June 17, 1997Assignees: Ricom Corp, Zeria Pharmaceutical Co. Ltd., Mitsui & Co.Inventors: Sadami Ishibashi, Tadao Hamaya, Tadashi Imai, Masao Iijima
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Patent number: 5637313Abstract: Disclosed is a soft, chewable dosage form, including a matrix of hydrogenated starch hydrolysate, a water soluble bulking agent, and a water insoluble bulking agent. The present invention also includes a method of preparing a soft, chewable dosage form, including the steps of mixing under high shear force, a hydrogenated starch hydrolysate, a water soluble bulking agent, and a water insoluble bulking agent until a uniformly blended matrix is obtained. Active ingredients may optionally be incorporated in the matrix.Type: GrantFiled: December 16, 1994Date of Patent: June 10, 1997Assignee: Watson Laboratories, Inc.Inventors: Tommy L. Chau, Nicholas A. La Bella, Jr.
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Patent number: 5633005Abstract: The invention concerns pastilles made from completely or partly water-soluble, natural and/or synthetic polymers selected from the group comprising gums, alginates, carrageen, starch, pectin and gelatin and containing polydimethylsiloxanes (dimeticon, simethicone). The invention also concerns a method of producing such pastilles.Type: GrantFiled: December 11, 1995Date of Patent: May 27, 1997Assignee: Bolder Arzneimittel GmbHInventor: Faruk Imer
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Patent number: 5629013Abstract: Chewable antacid tablet compositions comprising calcium carbonate sweetened with aspartame, and preferably also saccharin wherein said composition is in a solid unit dose form to be ingested by chewing.Type: GrantFiled: April 28, 1994Date of Patent: May 13, 1997Assignee: The Procter & Gamble CompanyInventors: James G. Upson, Carmelita M. Russell
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Patent number: 5616621Abstract: There is provided a pharmaceutically acceptable taste masking liquid excipient base for administration of relatively large amounts of unpleasant tasting medicines, said excipient base having higher than normal viscosities due to a combination of polyethylene glycol and cellulosic material.Type: GrantFiled: January 30, 1995Date of Patent: April 1, 1997Assignee: American Home Products CorporationInventors: Shankar D. Popli, Zenaida O. Go
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Patent number: 5616340Abstract: A hard-candy based lozenge containing an antacid is produced in a manner compatible with a continuous process method of manufacture. Sucrose solution, corn syrup, and a carbonate antacid are mixed, the mixture is heated, the mixture is further heated and exposed to a vacuum. The mixture is then mixed with cold-flow enhancers, flavorings, and colorings, and finally tempered and formed into lozenges of exceptional efficacy and taste. The lozenges thus formed contain 600 mg of calcium carbonate or magnesium carbonate.Type: GrantFiled: December 2, 1994Date of Patent: April 1, 1997Assignee: McNeill-PPC, Inc.Inventors: Thomas S. Ells, Joseph R. Luber
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Patent number: 5614207Abstract: The present invention relates to a dry mouth lozenge comprising a lozenge base, a demulcent, a humectant, and a pharmaceutically acceptable acidulent to stimulate the flow of saliva.Type: GrantFiled: June 30, 1995Date of Patent: March 25, 1997Assignee: McNeil-PPC, Inc.Inventors: Manoj N. Shah, Randall G. Goodreau
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Patent number: 5612053Abstract: Controlled release powder insufflation formulations are disclosed. The powder formulation includes cohesive composites of particles containing a medicament and a controlled release carrier which preferably includes one or more polysaccharide gums of natural origin.Type: GrantFiled: April 7, 1995Date of Patent: March 18, 1997Assignee: Edward Mendell Co., Inc.Inventors: Anand Baichwal, John N. Staniforth
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Patent number: 5605698Abstract: The present invention provides auxiliary food having the effects of decreasing food intake as an external factor by suppressing the sensibility to sweetness in eating food, and the effect of decreasing a desire for eating as an internal factor by increasing the number of times of chewing.The auxiliary food is used as chewing gum for helping diet and abstinence from drinking and preventing obesity, containing 0.3 to 130 mg of gymnemic acid as an effective ingredient.Type: GrantFiled: December 5, 1994Date of Patent: February 25, 1997Assignee: Dai-Nippon Meiji Sugar Co., Ltd.Inventor: Gaku Ueno
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Patent number: 5605697Abstract: This invention relates to a bifidobacterium growth promotant comprising gluconic acid, a nontoxic salt thereof and/or glucono-.delta.-lactone as an active ingredient.The bifidobacterium growth promotant of this invention has selective bifidobacterial growth promoting-activity and, at the same time, inhibits growth of deleterious bacteria. Moreover, its rate of digestion and absorption in the upper alimentary tract is so low that the promotant has very satisfactory characteristics as a bifidus factor. Therefore, the bifidobacterium growth promotant of this invention can be used per se or as an additive for various foods and drink to provide functional foods and drinks, thus being of great value from the standpoint of health improvement.Type: GrantFiled: April 24, 1995Date of Patent: February 25, 1997Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Toshihiko Asano, Ryoko Kondo, Yasumi Mori, Seishi Takenawa, Motoko Yamochi, Kiyohiko Kunugita, Tsutomu Terachi
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Patent number: 5595753Abstract: A topical treatment for hemorrhoidal pain and for spasms of the sphincters and muscles located in the gastrointestinal (GI) tract is disclosed. The topical preparation includes the amino acid L-arginine in a pharmaceutically acceptable carrier substance, e.g., K-Y jelly, suppository, or ingestible formulation, and can be applied directly to the affected area. The topical preparation of the invention is effective for relieving the pain of hemorrhoids or for treating conditions resulting from spasms of sphincters of the GI tract including anal fissure, post operative rectal pain, hypertrophic pyloric stenosis, and pancreatitis, as well as conditions resulting from general spasm of the muscles of the GI tract.Type: GrantFiled: April 14, 1995Date of Patent: January 21, 1997Assignee: President and Fellows of Harvard CollegeInventor: Herbert B. Hechtman
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Patent number: 5593685Abstract: The present invention provides a chewable ranitidine tablet comprising ranitidine, or a physiologically acceptable salt thereof, a chewable base selected from sucrose, glucose, lactose, maltose, or a mixture thereof, a flavouring and, optionally, an intense sweetener and a process for its preparation.Type: GrantFiled: April 11, 1995Date of Patent: January 14, 1997Assignee: Glaxo Group LimitedInventors: Alan Bye, Jill Evans, Paul D. Huckle, Laurence F. Lacey, Peter J. Rue
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Patent number: 5585110Abstract: This patent deals with a chewing gum which possesses fluoride and citric acid for improved dental health. The incorporation of fluoride and citric acid into our gum product is for the citric acid to provide a means by which fluoride can be absorbed into the tooth structure. The mechanism of action of this product is the following: citric acid is incorporated in this chewing gum to microscopically open up the pores (prism layers) of the enamel tooth structure. This opening of the pores, at the tooth surface, enables greater contact and penetration of the fluoride to be absorbed into the enamel. The resultant effect is greater penetration of fluoride into the enamel and the underlying tooth structure (dentine). In addition to facilitating the penetration of fluoride into the tooth, there would be an added benefit from the dietary content of the citrus fruits. Moreover, this gum includes novel organoleptic properties as a result of natural sugars, together with enhanced flavor, for sweetness impact.Type: GrantFiled: May 26, 1995Date of Patent: December 17, 1996Inventors: Tom Kalili, Angelo A. Caputo
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Patent number: 5573774Abstract: A therapeutic method is provided to alleviate the tobacco withdrawal syndrome, the symptoms of nicotine withdrawal or the management of human body weight in nicotine-experienced or nicotine-naive individuals, comprising of administering an amount of nicotine metabolites or a pharmaceutically acceptable salts thereof to a human in need of such treatment, in an amount which is effective to reduce or eliminate at least one of the symptoms of the tobacco withdrawal syndrome, nicotine withdrawal or manage human body weight.Type: GrantFiled: June 6, 1995Date of Patent: November 12, 1996Inventor: Robert M. Keenan
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Patent number: 5573777Abstract: The invention relates to a relatively pure pulverulent mannitol, having a moderate and not excessive friability of between 40 and 80% in a Test I, a low apparent density of between 300 and 525 g/l for a particle size cut of between 100 and 200 microns and, additionally, a specific particle size in the sense that it contains less than 30% of particles with a size of less than 75 microns. This pulverulent mannitol possesses remarkable functional properties which make its use particularly recommended as sweetening agent, texturizing agent or additive excipient or vehicle in the food and pharmaceutical industries.Type: GrantFiled: September 26, 1994Date of Patent: November 12, 1996Assignee: Roquette FreresInventors: Michel Serpelloni, Jean-Philippe Boonaert
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Patent number: 5571528Abstract: The present invention is a pilocarpine containing chewing gum for stimulating salivation. The invention contains 0.13-0.20 weight % of pilocarpine as well as normal gum base that includes sweetening agents and flavors. It can improve oral hygiene by stimulating parasympathetic innervation in salivary glands with pilocarpine solubilized in the oral cavity.Type: GrantFiled: June 28, 1995Date of Patent: November 5, 1996Inventors: Sung-Woo Lee, Hong-Ryeol Ryu
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Patent number: 5567439Abstract: The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.Type: GrantFiled: November 4, 1994Date of Patent: October 22, 1996Assignee: Fuisz Technologies Ltd.Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
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Patent number: 5560921Abstract: The present invention relates to immediate release compositions comprising a pre-complex comprising a polymeric polycarboxylate and an aminophenylalkanol vasoconstrictor in a solid chewable matrix of pharmaceutically-acceptable carrier ingredients wherein the aminophenylalkanol vasoconstrictor and polymeric polycarboxylate are in a weight ratio of from about 5:1 to about 1:10 and wherein the pre-complex is dissociable at a pH of from about 4.5 to about 6.8, releasing the aminophenylalkanol vasoconstrictor.Type: GrantFiled: April 28, 1995Date of Patent: October 1, 1996Assignee: The Procter & Gamble CompanyInventors: Nalinkant C. Damani, Rita Vienhues
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Patent number: 5554380Abstract: A solid or semi-solid bioadherent, orally ingestible drug delivery system containing a water-in-oil system having at least two phases, one phase comprises from about 25% to about 75% by volume of an internal hydrophilic phase and the other phase comprises from about 25% to about 75% by volume of an external hydrophobic phase and wherein the external hydrophobic phase is comprised of three components, a) an emulsifier, b) a glyceride ester and c) a wax material.Type: GrantFiled: May 15, 1995Date of Patent: September 10, 1996Assignee: KV Pharmaceutical CompanyInventors: Robert C. Cuca, Keith S. Lienhop, Thomas C. Riley, Jr., R. Saul Levinson, Mitchell I. Kirschner
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Patent number: 5549906Abstract: A method for smoking cessation therapy is described that utilizing an improved nicotine lozenge to satisfy transient craving. The lozenge contains nicotine, a nonnutritive sweetener and an absorbent excipient.Type: GrantFiled: July 26, 1993Date of Patent: August 27, 1996Assignee: Pharmacia ABInventor: Gian C. Santus
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Patent number: 5545410Abstract: A composition of carbohydrates having an edible coating is disclosed, whereby the coated carbohydrate, when orally ingested, causes a time delay release of the carbohydrate into the digestive system. The method of administering carbohydrates in this manner may be useful in the treatment of diseases such as diabetes and exercise programs calling for sustained effort.Type: GrantFiled: October 31, 1994Date of Patent: August 13, 1996Assignee: The Estee CorporationInventors: J. Gary Fox, Darlene Allen
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Patent number: 5536156Abstract: A composition of carbohydrates having an edible coating is disclosed, whereby the coated carbohydrate, when orally ingested, causes a time delay release of the carbohydrate into the digestive system. The method of administering carbohydrates in this manner may be useful in the treatment of diseases such as diabetes and exercise programs calling for sustained effort.Type: GrantFiled: October 17, 1994Date of Patent: July 16, 1996Assignee: The Estee CorporationInventors: J. Gary Fox, Darlene Allen