Candy, Candy Coated Or Chewing Gum Patents (Class 424/440)
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Patent number: 4879108Abstract: A chewable delivery system for actives comprising:(a) an active pre-coated with at least one material selected from the group consisting of lecithin, polyoxyalkylenes having chain lengths of about 4 carbons or less, glycerides having a melting point of 100.degree. C. or less, polyalkyleneglycols having a molecular weight of 3,700 or less, synthetic and natural waxes and mixtures thereof; and(b) a confectionery matrix comprising a binder system comprising gelatin and a humectant material selected from the group consisting of glycerin and its lower alkyl (C.sub.2-7) ester derivatives; a sweetener; and about 1% to about 30% by weight water.Type: GrantFiled: October 14, 1988Date of Patent: November 7, 1989Assignee: Warner-Lambert CompanyInventors: Robert K. Yang, Shri C. Sharma, Shan-Shan Sheu, James J. Shaw
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Patent number: 4873085Abstract: A melt spinnable carrier agent such as sugar is combined with a cosmetic then converted into fiber form by melt spinning with "cotton candy" fabricating equipment. The as-spun product is converted to compacted individual dosage units. Examples are presented for topical application. All applications utilize the extraordinarily rapid entry of the fiber form mass into solution upon contact with a solvent. When lactose is used it absorbs moisture from the air which is then either transferred to the hair or skin to maintain the moisture content of the latter or it prevents the hair or skin from drying out.Type: GrantFiled: March 18, 1988Date of Patent: October 10, 1989Assignee: Fuisz Pharmaceutical Ltd.Inventor: Richard C. Fuisz
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Patent number: 4867989Abstract: A chewable mineral supplement which comprises: a chewing gum composition coated with an outer shell containing layers of a mineral compound and a coating syrup and wherein the mineral compound has an average a particle size of about 5 to about 75 microns to impart good "mouthfeel" to the chewable mineral supplement.Type: GrantFiled: September 9, 1986Date of Patent: September 19, 1989Assignee: Warner-Lambert CompanyInventors: Jose N. Silva, Jose F. Zamudio-Tena, Robert J. Huzinec
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Patent number: 4863737Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored confectionary base and to compress or otherwise attach the solid confectionary mixture onto an appliance or holder. Employing the present invention, the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods. The present invention achieves these advantages by incorporating the drug into a compressed powder "candy " matrix.Type: GrantFiled: June 8, 1987Date of Patent: September 5, 1989Assignee: University of UtahInventors: Theodore H. Stanley, Brian Hague
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Patent number: 4857333Abstract: An animal food product for administering medication to animals is a formed, chewable food treat with at least one pre-formed pocket therein opening to an outer surface of the treat and sized to retain a medicant therein.Type: GrantFiled: May 12, 1988Date of Patent: August 15, 1989Inventor: Robert G. Harold
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Patent number: 4857331Abstract: A sugarless ingestible gel confectionary delivery system which includes a pectin gel component, an algin gel component and a polymer network gel component in amounts sufficient to form a gel confectionery unit. The inventive gel confectionery unit has reduced intrinsic viscosity prior to gelation which permits the inclusion of an edible insoluble solid in an amount sufficient to strengthen the internal combination pectin-algin gel network and to bind internal moisture sufficiently to enhance mold removal capabilities. The delivery system also includes hydrogenated starch hydrolysates. The delivery system may also include a further active ingredient such as a drug, medicament, or nutritional supplement. The product and method of the present invention also includes a composition in which the gel delivery system can be molded directly in the receptacle which is used to dispense the confectionery unit to the consumer.Type: GrantFiled: March 31, 1988Date of Patent: August 15, 1989Assignee: Warner-Lambert CompanyInventors: James J. Shaw, Frank J. Bunick
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Patent number: 4857335Abstract: Liquid, controlled release formulations are provided by emulisifying an aqueous active ingredient-polymer complex, an organic solution of a film-forming polymer and an organic solvent, and a surfactant to form a first emulsion. An aqueous solution of a surfactant is emulsified with the first emulsion to produce a second emulsion and the organic solvent is subsequently removed to produce a liquid controlled release formulation. The formulation so produced includes an aqueous dispersion of microcapsules having permeable shells of the film-forming polymer and aqueous cores of the aqueous active ingredient-polymer complex.Type: GrantFiled: March 27, 1987Date of Patent: August 15, 1989Assignee: Lim Technology Laboratories, Inc.Inventor: Howard A. Bohm
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Patent number: 4853212Abstract: This invention relates to reduced base-content chewing gum compositions containing an anesthetic active. These compositions release sufficient amounts of the anesthetic to provide an anesthetic effect in the mount and throat areas without significant bitterness or off-note taste. Hexylresourcinol is the preferred anesthetic.Type: GrantFiled: July 13, 1987Date of Patent: August 1, 1989Assignee: Warner-Lambert CompanyInventors: Steven M. Faust, Subraman R. Cherukuri
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Patent number: 4851431Abstract: A composition useful in a method for treating a mammal in order to induce memory enhancement, analgesia, sleep regulation and(or) inhibition of the symptoms of senility, comprises from about 13.0 to about 27.5% by weight of linolenic acid, balance linoleic acid. Physiologically hydrolyzable and pharmacologically acceptable derivatives of these acids may also be used. The specified combination of acids may be administered as pharmaceutical formulations or nutritional compositions.Type: GrantFiled: November 16, 1987Date of Patent: July 25, 1989Assignee: Bar Ilan UniversityInventor: Shlomo Yehuda
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Patent number: 4847090Abstract: A confection piece having two or more discrete parts, each part being different from another in respect of at least one of its physical and/or chemical properties such as in respect of at least one or a combination of its coloration, material composition or texture. The confection piece can be used to combine diverse confections to provide new and unique organoleptic response for the user and its also can be used as a vehicle for oral administration of nutrients and medicinal compositions and particularly where same include interactive components which should be kept separated until the confection piece is dissolved in the user's mouth. A method for making the confection piece also is disclosed.Type: GrantFiled: November 7, 1986Date of Patent: July 11, 1989Assignee: Warner-Lambert CompanyInventors: Joseph A. Della Posta, Anthony P. Piano
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Patent number: 4837255Abstract: A gel formation for oral administration having improved palatability comprising an effective hypocholesterolaemic amount of a uniform gelled dispersion of(a) between about 8 and about 20 percent by weight of a particulate, pharmaceutically acceptable, sparingly crosslinked non-digestible quaternary ammonium substituted polysytrene anion exchange resin having an average particle size below about 100 microns;(b) between about 4 and about 16 percent by weight of a pharmaceutically acceptable gelatin;(c) between about 0.015 and about 10 percent by weight of a natural or synthetic pharmaceutically acceptable sweetener;(d) between about 0.05 and about 2 percent by weight of a pharmaceutically acceptable organic acidulent;(e) between about 0.05 and about 5 percent by weight of one or more pharmaceutically acceptable flavoring or coloring agents or mixtures thereof; and(f) the remainder water.Type: GrantFiled: March 10, 1987Date of Patent: June 6, 1989Assignee: Ciba-Geigy CorporationInventor: Frederick J. Dechow
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Patent number: 4832994Abstract: Anti-smoking oral preparations are provided containing a silver compound as the anti-smoking agent and a sweetener in which the silver compound is present in amounts of from 0.1 mg. to 2.5 mg. and the ratio of sweetness intensity based on sucrose to silver compound content is from 100:1 to 2500:1.Type: GrantFiled: September 2, 1987Date of Patent: May 23, 1989Inventor: Michael S. Fey
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Patent number: 4830853Abstract: The oxidation--and color-stability of certain ace inhibitors is optimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.Type: GrantFiled: October 20, 1986Date of Patent: May 16, 1989Assignee: Warner-Lambert CompanyInventors: Kuchi S. Murthy, Michael R. Harris, Gerard C. Hokanson, Robert G. Reisch, Jr., Mahdi B. Fawzi, Frank Waldman
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Patent number: 4831022Abstract: A novel EPA/CD inclusion compound and a food product containing the same are disclosed. The undesirable odor of EPA is masked by including it into such EPA/CD inclusion compound. Gamma-CD is most favorable because it includes much more EPA, and highly stabilizes it. The EPA/CD inclusion compound is advantageously usable in perorally- or parenterally-usable products directed to the promotion or maintenance of health.Type: GrantFiled: September 15, 1988Date of Patent: May 16, 1989Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Hiromi Hijiya, Masakazu Mitsuhashi, Toshi Miyake
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Patent number: 4828820Abstract: A chewable tooth cleaning composition which removes dental plaque from the chewing surfaces of the teeth has incorporated into a chewing gum formulation about 20% to about 40% by weight, based on the weight of the total composition, of a calcium carbonate abrasive having a specific particle size distribution.Type: GrantFiled: January 15, 1987Date of Patent: May 9, 1989Assignee: Warner-Lambert CompanyInventors: Michael Glass, Kenneth P. Bilka, Anthony Guzowski
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Patent number: 4822597Abstract: This invention relates to chewing gum compositions containing local anesthetics. These compositions readily release the anesthetic such that it is available to anesthetize the throat and mouth areas, thereby providing relief to irritated areas. Increased availability of the anesthetic is possible by the formation of a sweetener/anesthetic premix. The preferred anesthetic is hexylresourcinol.Type: GrantFiled: July 13, 1987Date of Patent: April 18, 1989Assignee: Warner-Lambert CompanyInventors: Steven M. Faust, Subraman R. Cherukuri
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Patent number: 4814354Abstract: Cholestyramine can be administered orally along with one or more other lipid regulating agent(s) and/or other beneficial agent(s) in compositions in which the cholestyramine has been suitably pretreated.Type: GrantFiled: September 26, 1986Date of Patent: March 21, 1989Assignee: Warner-Lambert CompanyInventors: Isaac Ghebre-Sellassie, Robert H. Gordon, Mahdi B. Fawzi
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Patent number: 4808410Abstract: Novel pharmaceutical compositions of matter are disclosed for use in eliciting a topical anesthetic and antimicrobial response, preferably for oral health care purposes, said compositions comprising dyclonine hydrochloride and phenol. When used in combination, dyclonine hydrochloride and phenol provide an improved antimicrobial response.Type: GrantFiled: December 16, 1987Date of Patent: February 28, 1989Assignee: Richardson-Vicks Inc.Inventors: James V. Sorrentino, William J. Kelleher, Jeanne O. Moye
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Patent number: 4806356Abstract: There is disclosed a nicotine containing lozenge prepared from a mixture of inert filler material, a binder and either pure nicotine or a nicotine containing substance by a technique not involving any application of heat. Cold compression in a conventional tablet making machine is preferred.Type: GrantFiled: April 3, 1987Date of Patent: February 21, 1989Inventor: Alec S. W. Shaw
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Patent number: 4803077Abstract: Disclosed is a novel process to prepare a solid product containing an oil-soluble substance (e.g. oil and fat, spice, flavor, vitamin, emulsifier, hormone, higher fatty acid, unsaponifiable substance and complex lipid), comprising adding to an oil-soluble liquid substance an aqueous maltose solution along with a maltose seed, and crystallizing beta-maltose hydrate to effect solidification of the mixture.Type: GrantFiled: June 29, 1987Date of Patent: February 7, 1989Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Masakazu Mitsuhashi, Shuzo Sakai, Toshio Miyake
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Patent number: 4793998Abstract: The cyclization and hydrolysis of certain ACE inhibitors is minimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.Type: GrantFiled: October 20, 1986Date of Patent: December 27, 1988Assignee: Warner-Lambert CompanyInventors: Kuchi S. Murthy, Michael R. Harris, Gerard C. Hokanson, Robert G. Reisch, Jr., Frank Waldman, Mahdi B. Fawzi
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Patent number: 4792449Abstract: This invention relates to a method for administering drugs. In particular a lipophilic drug is solubilized by a food, such as chocolate, and admixed with an oil-based carrier. The lipid soluble drug is thus conveyed to the gastrointestinal tract. Because this type of food is digested readily, the drug is absorbed as intended, and the dose is not subject to day-to-day variations.Type: GrantFiled: January 28, 1987Date of Patent: December 20, 1988Assignee: Baxter Travenol Laboratories, Inc.Inventors: Robert K. Ausman, Mark Adams, Gerado Caballero, Rahim Hamid, Norman E. Hoffman, Edward J. Quebbeman, William J. Schulte, Robert Thomson, Julie Whipple, Steven D. Weitman
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Patent number: 4778676Abstract: A chewable delivery system for actives comprising:(a) an active pre-coated with at least one material selected from the group consisting of lecithin, polyoxyalkylenes having chain lengths of about 4 carbons or less, glycerides having a melting point of 100.degree. C. or less, polyalkyleneglycols having a molecular weight of 3,700 or less, synthetic and natural waxes and mixtures thereof; and(b) a confectionery matrix comprising a binder system comprising gelatin and a humectant material selected from the group consisting of glycerin and its lower alkyl (C.sub.2-7) ester derivatives; a sweetener; and about 1% to about 30% by weight water.Type: GrantFiled: December 20, 1985Date of Patent: October 18, 1988Assignee: Warner-Lambert CompanyInventors: Robert K. Yang, Shri C. Sharma, Shan-Shan Sheu, James J. Shaw
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Patent number: 4777162Abstract: A novel EPA/CD inclusion compound and a food product containing the same are disclosed. The undesirable odor of EPA is masked by including it into such EPA/CD inclusion compound. Gamma-CD is most favorable because it includes much more EPA, and highly stabilizes it. The EPA/CD inclusion compound is advantageously usable in perorally- or parenterally-usable products directed to the promotion or maintenance of health.Type: GrantFiled: March 25, 1986Date of Patent: October 11, 1988Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Hiromi Hijiya, Masakazu Mitsuhashi, Toshio Miyake
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Patent number: 4764375Abstract: A drug delivery system in which a taste masked solid is suspended in a liquid carrier. The solid has been rendered hydrophillic and its density approximates that of the carrier liquid.Type: GrantFiled: September 11, 1985Date of Patent: August 16, 1988Assignee: KV Pharmaceutical CompanyInventor: George N. Paradissis
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Patent number: 4762719Abstract: A cough drop is provided comprising a hard candy outer shell and a powdered centerfill containing a rapidly-dissolving powder such as dextrose monohydrate and an active ingredient such as menthol and eucalyptus which is preferably in the form of a liquid blend and a spray-dried powder. The hard candy outer shell also contains menthol and eucalyptus as a liquid blend.When the outer shell is dissolved in the mouth or the centerfill is bitten into, the rapidly-dissolving powder acts to enhance the active-ingredient's activity in the mouth so that a discernible vaporization of active-ingredient is felt.Type: GrantFiled: August 7, 1986Date of Patent: August 9, 1988Inventor: Mark Forester
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Patent number: 4761274Abstract: A medicament adsorbate of analgesics and process for making same. The medicament adsorbate comprises a complex magnesium aluminum silicate having sorbed therein an analgesic. The complex magnesium aluminum silicate has the following typical chemical analysis:______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.Type: GrantFiled: October 16, 1987Date of Patent: August 2, 1988Assignee: Warner-Lambert CompanyInventors: John Denick, Jr., David Peters, Anil K. Talwar, Wei C. Liao
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Patent number: 4759923Abstract: It has been found that certain derivatives of poly(diallylmethylamine) are therapeutically effective serum cholesterol lowering agents.Type: GrantFiled: June 25, 1987Date of Patent: July 26, 1988Assignee: Hercules IncorporatedInventors: George A. Buntin, Bernard J. Scheve
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Patent number: 4758425Abstract: A medicament adsorbate of antiasthmatics and process for making same. The medicament adsorbate comprises a complex magnesium aluminum silicate having sorbed therein an antiasthmatic. The complex magnesium aluminum silicate has the following typical chemical analysis:______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.Type: GrantFiled: October 16, 1987Date of Patent: July 19, 1988Assignee: Warner-Lambert CompanyInventors: John Denick, Jr., David Peters, Anil K. Talwar, Wei C. Liao
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Patent number: 4758424Abstract: A medicament adsorbate of decongestants and process for making same. The medicament adsorbate comprises a complex magnesium aluminum silicate having sorbed therein a decongestant. The complex magnesium aluminum silicate has the following typical chemical analysis:______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.Type: GrantFiled: October 16, 1987Date of Patent: July 19, 1988Assignee: Warner-Lambert CompanyInventors: John Denick, Jr., David Peters, Anil K. Talwar, Wei C. Liao
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Patent number: 4753790Abstract: A process for producing a sorbitol coated comestible is disclosed. The process comprises applying to a substantially anhydrous edible core at least two coating solutions comprising sorbitol to coat the edible core,wherein the first coating solution comprises:(a) about 77 to about 81 wt % sorbitol solution comprising about 65 to about 75 wt % sorbitol;(b) about 9.5 to about 12.5 wt % crystalline sorbitol powder;(c) about 0.25 to about 1.5 wt % of at least one film-forming agent; and(d) about 0.1 to about 5.0 wt % of at least one crystallization retardant; andwherein the second coating solution comprises:(a) about 82 to about 92 wt % sorbitol solution comprising about 65 to about 75 wt % sorbitol;(b) about 1.0 to about 2.5 wt % crystalline sorbitol powder;(c) about 0.05 to about 2.0 wt % of at least one film-forming agent; and(d) about 0.1 to about 0.Type: GrantFiled: December 16, 1986Date of Patent: June 28, 1988Assignee: Warner-Lambert CompanyInventors: Jose N. Silva, Robert K. Yang, Jose F. Zamudio-Tena
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Patent number: 4753800Abstract: A medicament adsorbate and process for making same. The medicament adsorbate comprises a complex magnesium aluminum silicate having sorbed therein an edible wax and a medicament drug.Type: GrantFiled: October 4, 1985Date of Patent: June 28, 1988Assignee: Warner-Lambert CompanyInventor: Ronald F. Mozda
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Patent number: 4749575Abstract: Any orally administrable medicament is prepared into a dosage form which eliminates the unpleasant taste and mouth feel of the medicament and is easily and pleasantly ingested even by children, by microencapsulating the medicament into microcapsules of less than 300 microns diameter, and embedding the microcapsules into a soft, sweet, palatable matrix, such as chocolate.Type: GrantFiled: January 29, 1986Date of Patent: June 7, 1988Assignee: Bio-Dar Ltd.Inventor: Avner Rotman
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Patent number: 4743450Abstract: The cyclization, hydrolysis, and coloration of certain ACE inhibitors is minimized when they are formulated with a metal-containing stabilizer and a saccharide.Type: GrantFiled: February 24, 1987Date of Patent: May 10, 1988Assignee: Warner-Lambert CompanyInventors: Michael Harris, Gerard Hokanson, Kuchi Murthy, Robert Reisch, Frank Waldman
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Patent number: 4734283Abstract: A method of making a food composition and the composition containing at least 5 mg of inositoltriphosphate.Type: GrantFiled: October 18, 1985Date of Patent: March 29, 1988Inventor: Matti Siren
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Patent number: 4716033Abstract: A medicament adsorbate and process for making same. The medicament adsorbate comprises a complex magnesium aluminum, silicate having sorbed therein a medicament drug and a surfactant.Type: GrantFiled: March 27, 1986Date of Patent: December 29, 1987Assignee: Warner-Lambert CompanyInventor: John Denick, Jr.
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Patent number: 4704295Abstract: A non-toxic edible enteric film coating dry powder and aqueous enteric coating suspension for coating pharmaceutical tablets and the like; the enteric coated tablets; and methods of making the enteric coating dry powder, the aqueous coating suspension, and of coating the tablets.Type: GrantFiled: August 30, 1985Date of Patent: November 3, 1987Assignee: Colorcon, Inc.Inventors: Stuart C. Porter, Edward J. Woznicki, Susan M. Grillo, Louis F. D'Andrea
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Patent number: 4695463Abstract: A delivery system useful in chewing gum, confectionary and pharmaceutical products comprising:(a) an insolubolized active ingredient; and(b) a cross-linked hydrocolloid multivalent cation alginate or carageenenate matrix entrapping said insolubolized active ingredient.A process of preparation is also disclosed.Type: GrantFiled: May 24, 1985Date of Patent: September 22, 1987Assignee: Warner-Lambert CompanyInventors: Robert K. Yang, Shri C. Sharma
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Patent number: 4693888Abstract: A caries-preventive composition comprises an antibody obtained by immunizing a mammal with at least one antigen selected from the group consisting of Streptococcus mutans, its cell-wall fraction, fibrous substance fraction, glucosyltransferase fraction and protein antigen fraction, and a synergist selected from the group consisting of fluorine compounds, chlorhexidine and its salts, lytic enzymes, bacteriocins, glucosyltransferase inhibitors, proteases and dextranases.Type: GrantFiled: August 7, 1984Date of Patent: September 15, 1987Assignee: Lion CorporationInventors: Tsuneo Miyahara, Yoshihiro Harada, Katsuyuki Futakami, Yasukuni Nishida, Ryoko Konishi
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Patent number: 4671953Abstract: The present invention is directed to methods and compositions for noninvasively administering drugs having a sedative, analgesic, or anesthetic effect. A drug capable of absorption through mucosal tissues in incorporated into a candy matrix, which is then advantageously formed into a lollipop. A patient is put at ease when given the lollipop, and the drug rapidly enters the patient's bloodstream as the lollipop is sucked. When sedating or anesthetizing the patient, the physician can observe the patient's condition and remove the lollipop when it has had a desired effect on the patient. Alternatively, the physican can alter placement of the lollipop to slow the rate of the drug release for absorption into the patient's system. An analgesic-containing lollipop can be self-administrated by a patient in response to his own subjective experience of pain and to the patient's susceptibility to the particular drug utilized.Type: GrantFiled: May 1, 1985Date of Patent: June 9, 1987Assignee: University of Utah Research FoundationInventors: Theodore H. Stanley, Brian Haque