Ammonia, Amine, Or Derivative Thereof (e.g., Urea, Etc.) Patents (Class 424/54)
  • Compositions containing a stain removing complex, and methods of making and using the same
    Publication number: 20080317681
    Abstract: A composition in the form of a chewing gum composition, a confectionery composition or consumable film composition containing a stain removing complex including a stain removing agent having therapeutic properties and a cyclodextrin compound and methods of preparing and using the same to remove stains from dental material including teeth.
    Type: Application
    Filed: March 7, 2008
    Publication date: December 25, 2008
    Inventors: Petros Gebreselassie, Shiuh John Luo, Navroz Boghani
  • ENHANCED DELIVERY OF CERTAIN FRAGRANCE COMPONENTS FROM PERSONAL CARE COMPOSITIONS
    Publication number: 20080299053
    Abstract: A personal care composition is provided having a fragrance which incorporates limonene, gamma terpinene, ethylene brassylate or combinations thereof in conjunction with a quaternary ammonium salt. The salt has a structure AB, wherein A is a cationic charge component, B is an anionic charge component, and A has one quaternized nitrogen atom, at least two hydroxyl groups and a molecular weight no higher than about 250. The quaternary ammonium salt functions as a scent boosting agent to enhance volatilization of the fragrance components when the personal care composition is first applied to skin or hair of the human body.
    Type: Application
    Filed: May 30, 2007
    Publication date: December 4, 2008
    Applicant: CONOPCO, INC., D/B/A UNILEVER
    Inventors: Lin Yang, Prem Chandar
  • PERSONAL CARE COMPOSITIONS WITH ENHANCED FRAGRANCE DELIVERY
    Publication number: 20080299054
    Abstract: A personal care product is provided which includes a fragrance, a substituted urea and a quaternary ammonium salt. The substituted urea and quaternary ammonium salt operate together as a scent boosting system to enhance volatilization of fragrance components upon the personal care composition being first applied to human skin or hair.
    Type: Application
    Filed: May 30, 2007
    Publication date: December 4, 2008
    Applicant: CONOPCO, INC., d/b/a UNILEVER
    Inventors: Prem Chandar, Lin Yang
  • Method of Preventing Oral Staining
    Publication number: 20080286215
    Abstract: A cosmetic method of preventing or decreasing oral staining, comprising the step of exposing the oral cavity to a morpholino compound having the general formula (I) wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 22, 2006
    Publication date: November 20, 2008
    Inventor: Rolf Valter Attstrom
  • N-Phenyl-N-Pyridinyl-Benzamides and Benzenesulfonamides Having Cooling Properties
    Publication number: 20080253974
    Abstract: Used as cooling agents are the compounds of formula (I), wherein Y is carbonyl (C(?O)) or sulfonyl (SO2—); and X is O CH3, CN, C(?O)NHR, C(?O)OR, or halogen; and R is hydrogen or C1-C4 alkyl.
    Type: Application
    Filed: October 23, 2006
    Publication date: October 16, 2008
    Inventors: Christophe C. Galopin, Lori W. Tigani, Jay Patrick Slack, Pablo Victor Krawec, Lucienne Cole
  • AMIDE COMPOUND OR SALT THEREOF, AND BIOFILM REMOVER CONTAINING THE SAME
    Publication number: 20080241081
    Abstract: The present invention provides a biofilm stripping agent for removing biofilms already formed. The biofilm stripping agent of the present invention contains, as an active ingredient, an amide compound or salt thereof denoted by General Formula (1), wherein R is a C1-11 alkyl group, and Q is a substituent denoted by the following Formulas (Q1), (Q2) or (Q3), wherein, in Formula (Q1), n is an integer ranging from 0 to 4; in Formula (Q2), R1 is a C1-4 alkyl group, and R2 is a hydroxyl group or carbamoyl group; in Formula (Q3), R3 is a hydrogen atom, hydroxyl group or carbamoyl group.
    Type: Application
    Filed: November 6, 2007
    Publication date: October 2, 2008
    Inventors: Hiroaki SUGA, Jun Igarashi
  • PEPTIDE-BASED ORAL CARE SURFACE REAGENTS FOR PERSONAL CARE
    Publication number: 20080152600
    Abstract: Peptides have been identified that bind to oral surfaces such as teeth and gums. Peptide based oral care reagents have been created by couple such peptides to oral care benefit agents such as whiteners.
    Type: Application
    Filed: January 10, 2008
    Publication date: June 26, 2008
    Inventors: Xueying Huang, John P. O'Brien, Hong Wang
  • METHOD OF INHIBITING BACTERIAL GROWTH AND BIOFILM FORMATION WITH NATURAL QUORUM SENSING PEPTIDES
    Publication number: 20080069782
    Abstract: Methods for selectively manipulating a growth rate of a selected bacterium comprising the step of contacting the selected bacterium with a predetermined amount of a quorum sensing molecule to affect a change in the growth rate of the selected bacterium, wherein the quorum sensing molecule is species specific, and the change in the growth rate is dependent on the amount of quorum sensing molecule in a dose-dependent fashion. Also provided are methods for treating or protecting against bacterial infections by utilizing the dose-dependent response of bacterial quorum sensing systems. The methods can be applied to a wide range of bacteria species including Streptococci, Staphylococci, and Bacilli. Compositions, medicaments and oral formulations for use with the methods are also disclosed.
    Type: Application
    Filed: November 17, 2006
    Publication date: March 20, 2008
    Inventors: Steven D. GOODMAN, Olga Kay, Wenyuan Shi, Fengxia Ql
  • ORAL COMPOSITIONS COMPRISING SILOXANE POLYMERS
    Publication number: 20070253919
    Abstract: Oral compositions are provided that comprise an active ingredient comprising a siloxane polymer having at least one hydrophilic region. The oral care composition comprises a siloxane polymer having a phosphorus-containing moiety. A source of fluoride ions and/or other oral care actives can be included in the oral care composition. Methods of making and using the oral compositions are also provided.
    Type: Application
    Filed: April 30, 2007
    Publication date: November 1, 2007
    Inventor: THOMAS J. BOYD
  • High-cleaning, low abrasion, high brightness silica materials for dentrifices
    Patent number: 7270803
    Abstract: Unique abrasive materials that are in situ generated compositions of precipitated silicas and silica gels are provided. Such compositions exhibit different beneficial, particularly simultaneously high pellicle film cleaning properties and moderate dentin abrasion levels. Such a result thus accords the user a dentifrice that effectively cleans tooth surfaces without detrimentally abrading such surfaces. Furthermore, the produced abrasive materials also exhibit very high and desirable brightness properties that permit easy incorporation and utilization within dentifrices for aesthetic purposes. Encompassed within this invention is a unique method for making such gel/precipitated silica composite materials for such a purpose, particularly under high shear conditions, as well as the different materials within the structure ranges described above and dentifrices comprising such.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: September 18, 2007
    Assignee: J.M. Huber Corporation
    Inventor: Patrick D. McGill
  • High-cleaning/low abrasive silica and materials and dentifrice containing such materials
    Patent number: 7267814
    Abstract: Unique abrasive and/or thickening materials that are in situ generated compositions of precipitated silicas and silica gels are provided. Such compositions exhibit different beneficial characteristics depending on the structure of the composite in situ generated material. With low structured composites (as measured via linseed oil absorption levels from 40 to 100 ml oil absorbed/100 g composite), simultaneously high pellicle film cleaning properties and moderate dentin abrasion levels are possible in order to accord the user a dentifrice that effectively cleans tooth surfaces without detrimentally abrading such surfaces. Increased amounts of high structure composite materials tend to accord greater viscosity build and thickening benefits together with such desirable abrasion and cleaning properties, albeit to a lesser extent than for the low structure types.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: September 11, 2007
    Assignee: J.M. Huber Corporation
    Inventors: Patrick D. McGill, William C. Fultz
  • Precipitated silica product, dentifrices containing same, and processes
    Patent number: 7255852
    Abstract: Precipitated silica comprising porous silica particles having a cumulative surface area for all pores having diameters greater than 500 ? of less than 8 m2/g, as measured by mercury intrusion, and a percentage cetylpyridinium chloride (% CPC) Compatibility of greater than about 55%. The precipitated silica product is especially well-adapted for use in dentifrices containing cetylpyridinium chloride, which do not attach to the low surface area silica product in a meaningful level and thus remain available for antimicrobial action. Processes for making the silica product are also provided.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: August 14, 2007
    Assignee: J.M. Huber Corporation
    Inventors: Karl W. Gallis, Mark E. Wozniak, John A. Kostinko
  • Enzyme containing oral composition having enhanced stability
    Patent number: 7220404
    Abstract: An oral care composition having enhanced oral hygiene and antiplaque properties which comprises an orally acceptable vehicle containing a combination of an enzyme, cetylpyridinium chloride and a reducing agent.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: May 22, 2007
    Assignee: Colgate-Palmolive Company
    Inventors: André M. Morgan, Lori H. Szeles, Malcolm Williams, Susan M. Herles, Chanda L. Macias, Robert D'Ambrogio, Thomas J. Boyd, James G. Masters
  • Alcohol free non-foaming mouthwash
    Patent number: 7195753
    Abstract: A non-foaming periodontic composition for treating gum diseases or used in bleaching teeth which are alcohol free. The composition is a mixture of an isoalkyl amine oxide and an antimicrobial betaine compound. The composition is useful for treating gum disease and whitening teeth.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: March 27, 2007
    Assignee: OraTec
    Inventors: David M. Hall, James R. Hunt
  • Compound delivery systems
    Patent number: 7192572
    Abstract: A composition comprising (a) from 0.005% to 0.5% by weight of a cooling compound; (b) from 0.1% to 10% by weight of an emulsifiable substance; (c) from 0.15% to 15% by weight of a surfactant; (d) optionally up to 5% by weight, preferably from 0.05% to 5% by weight of a cosurfactant.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: March 20, 2007
    Assignee: Conopco, Inc.
    Inventors: Ingrid Anne Marie Appelqvist, Mark Emmett Malone, Asish Nandi
  • Anhydrous dentrifice formulations for the delivery of incompatible ingredients
    Patent number: 7182937
    Abstract: A composition for reducing dentinal hypersensitivity and remineralizing exposed dentinal surface and open dentinal tubules, comprising a non-aqueous carrier and a desensitizing amount of a desensitizing/remineralizing agent which consists essentially of a water soluble calcium salt and an incompatible ingredient which would otherwise react with the calcium salt. Upon contact with saliva when applied to an oral cavity, the desensitizing/remineralizing is then formed in situ by the reaction between the calcium salt and the incompatible ingredient, thereby remineralizing exposed dentinal surface and open dentinal tubules.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: February 27, 2007
    Assignee: Block Drug Company, Inc.
    Inventors: Jin Xu, Stephen W. Mruphy, Bala Nayar, Michael E. Trama
  • Oral preparation
    Patent number: 7166272
    Abstract: An oral composition comprising 0.5 to 10% by weight of an abrasive precipitated silica having a 50 percentile (d50) of particle diameter being 5 ?m or less, a 90 percentile (d90) of particle diameter being 15 ?m or less and an RDA value of 120 or more, and 0.01 to 5% by weight of at least one of sulfosuccinate surfactants represented by general formula (1): [wherein either X1 or X2 is R1O—(AO)n— or the like and the other is M2O—; M1 and M2 are the same or different and each represent hydrogen, alkali metal, etc.; R1 is C8-22 alkyl, etc.; AO is C2-3 oxyalkylene and the average number of moles of AO addition polymerization, “n”, is 0 to 20; and B is —NH— etc.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: January 23, 2007
    Assignee: Sunstar Inc.
    Inventor: Koichi Fujisawa
  • Tooth bleaching compositions
    Patent number: 7094393
    Abstract: The present invention relates to improved dental compositions and methods for bleaching teeth. More specifically, this invention is directed towards hydrogen peroxide-containing compounds that are maintained at a substantially constant pH range of 6.0–10.0 during the tooth-bleaching procedure in the presence of a calcium chelating agent.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: August 22, 2006
    Assignee: BriteSmile Professional, Inc.
    Inventor: Robert Eric Montgomery
  • Methods and compositions for controlling biofilm development
    Patent number: 7094394
    Abstract: A method of cleaning or protecting surfaces by treatment with compositions comprising N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) blocking compounds and/or N-butyryl-L-homoserine lactone (BHL) analogs, either in combination or separately.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: August 22, 2006
    Assignees: Montana State University, University of Rochester, University of Iowa Research Foundation
    Inventors: David G. Davies, John William Costerton
  • Toothpaste containing anticancer agents
    Patent number: 7087219
    Abstract: A novel dentifrice composition is provided for prevention or treatment of carcinoma of the oral cavity, caries and periodontal diseases of the oral cavity. The dentifrice composition contains a partially water-soluble calcium salt, a medicinal composition useful in the treatment of human neoplastic disease, and a hydrophilic or hydrophobic liquid vehicle. A preferred dentifrice composition is a toothpaste comprising gypsum, 3-N-phenylacetylamino-2,6-dione, gypsum, paraffin oil and a mixture of natural flavoring oils. The components of the dentifrice composition act advantageously to allow the composition to remove plaque, tartar, and oral disease-causing bacteria.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: August 8, 2006
    Inventors: Stanislaw R. Burzynski, Wojciech Gruszecki
  • Use of ectoine or ectoine derivatives for oral care
    Patent number: 7048910
    Abstract: The invention relates to the use of one or more compounds selected from compounds of formulae Ia and Ib, the physiologically compatible salts of compounds of formula Ia and Ib and the stereoisomer forms of compounds of formula La and Ib, wherein R1, R2, R3, R4 and n have the meaning cited in claim 1.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: May 23, 2006
    Assignee: Merck Patent GmbH
    Inventors: Joachim Buenger, Hansjuergen Driller, Olaf den Hollander
  • Methods of treating tumors
    Patent number: 6995164
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: February 7, 2006
    Assignee: Rhode Island Hospital
    Inventors: Paul Calabresi, James Darnowski
  • Precipitated silica product with low surface area, dentifrices containing same, and processes
    Patent number: 6946119
    Abstract: Precipitated silica product having low surface area and enhanced flavor compatibility. The precipitated silica product is especially well-adapted for use in dentifrices containing cetylpyridinium chloride, which do not attach to the low surface area silica product in a meaningful level and thus remain available for antimicrobial action. Processes for making the low surface area silica product are also provided.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: September 20, 2005
    Assignee: J.M. Huber Corporation
    Inventors: Karl W. Gallis, Fitzgerald A. Sinclair, Mark E. Wozniak, Jason T. Zapf, John A. Kostinko, Michael Simone
  • Cyclodextrins in dental products
    Patent number: 6942848
    Abstract: Oral rinse and dentifrice compositions, comprising a phenolic selected from the group consisting of menthol, eucalyptol, methyl salicylate, thymol, triclosan, and mixtures thereof; and a cyclodextrin selected from the group consisting of hydroxypropyl ?-cyclodextrin, hydroxyethyl ?-cyclodextrin, hydroxypropyl ?-cyclodextrin, hydroxyethyl ?-cyclodextrin, ?-cyclodextrin, methyl ?-cyclodextrin, and mixtures thereof. These compositions are useful in retarding the development of plaque, treating gingivitis, and in treating the presence of micro-organisms in the oral cavity.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: September 13, 2005
    Assignee: Warner-Lambert Company LLC
    Inventors: Dennis George Anthony Nelson, Craig Joseph Sheehan
  • Signal peptides, nucleic acid molecules and methods for treatment of caries
    Patent number: 6923962
    Abstract: The invention relates to a compound that competitively inhibits binding of CSP to S. mutans histidine kinase. The compound is preferably a peptide or an antibody. The compound is preferably a derivative of [SEQ ID NO:2], a fragment of [SEQ ID NO:2] or a derivative of a fragment of [SEQ ID NO:2].
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: August 2, 2005
    Inventors: Dennis Cvitkovitch, Peter C. Y. Lau, Yung Hua Li
  • Compositions and methods to inhibit tartar and microbes using denture adhesive compositions with colorants
    Patent number: 6905672
    Abstract: The present invention relates to compositions comprising: (a) from about 15% to about 70% by weight of the composition of a denture adhesive component; (b) a safe and effective amount of a colorant selected from the group consisting of xanthene dyes, fluorescein dyes, free acids and salts thereof, and mixtures thereof; and (c) a safe and effective amount of a non-aqueous denture adhesive carrier. The present invention further relates to a method of reducing, inhibiting and/or preventing, calculus, tartar, plaque, stain, and/or microbes in the oral cavity, by applying the above denture adhesive composition to the oral cavity of a denture wearer in need thereof. The present invention further relates to a method of providing improved antimicrobial effects in the oral cavity by applying the above denture adhesive composition to the oral cavity of a denture wearer in need thereof.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: June 14, 2005
    Assignee: The Procter & Gamble Company
    Inventors: Jayanth Rajaiah, Kimberly Ann Gilday-Weber, Lisa Catron Ernst, Timothy Sadley Owens, John E. Barnes, Nivedita Ramji
  • Oral composition comprising water and cyclic carbonate in two phase state
    Patent number: 6899865
    Abstract: An oral composition comprises water and a cyclic carbonate compound in a certain ratio. In this case, the ratio of the water and the cyclic carbonate compound is such that when the water and the cyclic carbonate compound are mixed together the mixture goes into a 2-phase state. Moreover, the oral composition may further comprise a polyol, and in this case the ratio of the water, the cyclic carbonate compound and the polyol is such that when the water, the cyclic carbonate compound and the polyol are mixed together the mixture goes into a 2-phase state. The oral composition has an excellent effect of removing accumulations on dental surfaces or between teeth through a physico-chemical action, rather than relying purely on a mechanical action.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: May 31, 2005
    Assignee: Kao Corporation
    Inventor: Yoshiyuki Eshita
  • Chlorhexidine-based collutory for oral hygiene
    Publication number: 20040265246
    Abstract: Collutory for oral hygiene comprising chlorhexidine and ascorbic acid, characterized in that it comprises also sodium metabisulphite and optionally also an alkali metal fluoride. The so prepared collutory, besides preventing the formation of dental plaque, avoids the drawback of the dark pigmentation thereof.
    Type: Application
    Filed: May 21, 2004
    Publication date: December 30, 2004
    Inventors: Restituta Castellaccio, Stefano Giovannardi
  • Oral rinse for treatment for prevention of bacterial and fungal infection
    Publication number: 20040253193
    Abstract: Disclosed is a mouthwash composition, and a related use and method, for the treatment or prevention of bacterial and fungal infection in the oral cavity, the mouthwash composition comprising an effective amount of metronidazole and nystatin, together with an orally-acceptable carrier.
    Type: Application
    Filed: August 12, 2004
    Publication date: December 16, 2004
    Inventors: Anne Bosy, Julian Geller
  • Cosmetic use of at least one polyorganosiloxane as a gelling agent and cosmetic composition containing it
    Patent number: 6814973
    Abstract: The present invention relates to the cosmetic use, as a gelling agent, of at least one linear or cyclic polyorganosiloxane which comprises at least two organosiloxy units and at least two side and/or end groups each capable of forming at least one hydrogen bond with one or more partner groups. The invention also relates to a cosmetic composition comprising at least one such polyorganosiloxane in a cosmetically acceptable medium. This cosmetic composition is intended to be used for making up and/or caring for the skin, including the skin of the eyelids, and also for the lips and superficial body growths.
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: November 9, 2004
    Assignee: L'Oreal
    Inventor: Jean Mondet
  • Bleeding control and healing aid compositions and methods of use
    Patent number: 6797260
    Abstract: A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral “gum” and other “skin” (epithelial) tissues. The composition is preferably in the form of a paste which promotes ease of application and use of the composition. A variety of instruments can be used in application and cleanup of the composition showing versatile unparalleled friendly usage. The composition preferably comprises aluminum chloride, ferric sulfate (subsulfate), regenerated oxidized cellulose, aluminum ammonium sulfate, absorbable gelatin and a solvent. The composition has many dental and medical procedure applications.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: September 28, 2004
    Inventor: Terence Prevendar
  • Dentrifice
    Publication number: 20040175332
    Abstract: A method for suppressing discoloration of a composition in which a discoloration suppressing amount of ethylenediaminetetraacetic acid or a salt thereof is incorporated into a composition containing an ascorbic acid derivative. Compositions that resist discoloration containing an ascorbic acid derivative and ethylenediaminetetraacetic acid or a salt thereof, and methods of making such compositions.
    Type: Application
    Filed: November 7, 2003
    Publication date: September 9, 2004
    Inventor: Horst Westenfelder
  • Non-foaming anti-infective periodontic compositions
    Patent number: 6770268
    Abstract: A non-foaming periodontic composition in a gel form or mouth wash for treating gum diseases or used in bleaching teeth which are alcohol free. The composition is a mixture of an isoalkyl amine oxide and an antimicrobial betaine compound. The composition is useful for treating gum disease and whitening teeth.
    Type: Grant
    Filed: May 21, 2003
    Date of Patent: August 3, 2004
    Assignee: Oratec Corp.
    Inventors: Dave Hall, James R. Hunt
  • Methods of treating periodontal disease
    Patent number: 6770267
    Abstract: The present invention relates to methods of treating periodontal disease.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: August 3, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Cynthia Holder Jurgensen, Michael Tolar Martin, Martin Howard Osterhout
  • Proteinaceous animal chew with dentally therapeutic cation
    Patent number: 6737077
    Abstract: This invention relates to chewable objects for animals which contain, as a dentally therapeutic ingredient, one or more cationic substances. The inventive therapeutic animal chews are of sufficient durability to allow for a chewing cycle long enough for the release of the aforementioned cationic substances into saliva. Furthermore, the inventive animal chews may contain an effective amount of a counter-ionic compound, such as an alkali metal salt, to allow for rapid solubilization of said cationic antimicrobial substance into the saliva of an animal chewing thereupon, especially when delivered or carried on a carrier having a negatively charged surface.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: May 18, 2004
    Assignee: Oraceutical Innovative Properties LLC
    Inventor: Robert E. Montgomery
  • Devices with coatings containing chlorhexidine gluconate, compositions and methods
    Patent number: 6733745
    Abstract: Devices, coating compositions and methods for making such compositions are provided, wherein the coatings deliver chlorhexidine gluconate from a stable non-aqueous system.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: May 11, 2004
    Assignee: 3M Innovative Properties Company
    Inventors: Sharon M. Rozzi, Robert A. Asmus, Brian R. Morrison
  • Calcified tissue facing preparation containing antimicrobial agent
    Patent number: 6726899
    Abstract: The present invention provides a calcified tissue facing preparation characterized by having a polymerizable resin, and an antimicrobial agent of the formula: where R1 is a hydrocarbon radical having between 1 and 16 carbon atoms, n is an integer between 1 and 8 inclusive and X is a halogen atom selected from fluorine, chlorine or bromine. It is appreciated that R1 includes unsaturated hydrocarbon radicals, as well as heteroatom containing radicals. Preferably, the molecule of Formula (I) is associated with an adduct species. At least one of glutaraldehyde or a chelating agent are added to enhance the preparation characteristics.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: April 27, 2004
    Assignee: Advantage Dental Products, Inc.
    Inventor: Joseph J. Pellerin
  • Oral care compositions comprising diglycerol
    Patent number: 6723304
    Abstract: The invention relates to oral care compositions such as toothpaste, gels, tooth powders, mouthwashes, mouth rinses, gums, mouth sprays and lozenges comprising diglycerol. The diglycerol is used as a humectant in the compositions. The compositions may further comprise water, flavoring agents, active compounds, emulsifier, alcohol, sweeteners, thickening agents, surfactants, suspending agents, astringent and toning drug extracts, flavor correctants, abrasives or polishes, deodorizing agents, preservatives, flavoring buffers, whitening agents, wound-healing and inflammation inhibiting substances, colorants, dyes, pigments, abrasives, polishes, antimicrobial agents, pH buffers and other additives and fillers.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: April 20, 2004
    Assignee: Noville, Inc.
    Inventor: Roger E. Stier
  • Anti-microbial breath freshening mouthrinse
    Patent number: 6723305
    Abstract: It has been found that a mouthrinse comprising CPC and zinc ions is a very effective mouthrinse. It has an antibacterial effect that removes odor creating bacteria from the oral cavity. The CPC and zinc ions preferably are used in combination with an ionone terpene such as alpha ionone or a beta ionone.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: April 20, 2004
    Assignee: Colgate Palmolive Company
    Inventors: Karen J. DePierro, Lisa Christina-Beck, Hollandra P. Niles, Nuran Nabi, Alexander J. Simone, John P. Curtis
  • Systems for delivering a cosmetic and/or therapeutic active to oral surfaces using an integral carrier
    Patent number: 6719995
    Abstract: Systems for delivering cosmetic and therapeutic actives to the oral cavity employ a strip comprising a first layer of material, a second layer comprising polybutene with a molecular weight of about 300 to about 3000, and a cosmetic or therapeutic active included within the second layer. Therapeutic and cosmetic actives in compositions comprising polybutene inhibit or prevent gingivitis, caries, staining, fungi, bacteria and plaque build-up in the oral cavity by means of the delivery system.
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: April 13, 2004
    Assignee: The Procter & Gamble Company
    Inventors: Jayanth Rajaiah, Lisa Catron Ernst, Ann Maria Case, Thinh Nguyen Ha, William Michael Glandorf, Christopher Robert Mayer
  • Methods for regulating bud-hypha transitions and cAMP levels by the adenylate cyclase-associated protein gene, CAP1
    Patent number: 6706688
    Abstract: The infection of a mammalian host by a microorganism can be prevented or treated through the disruption of the C. albicans homologue of adenylate cyclase-associated protein gene. These methods may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: March 16, 2004
    Inventor: Paula Sundstrom
  • Denture adhesive compositions with antimicrobial agents
    Patent number: 6706781
    Abstract: The present invention relates to methods and compositions for reducing, inhibiting, and/or preventing, calculus, tartar, plaque, and/or microbes, in the oral cavity, comprising from about 15% to about 70% of an alkyl vinyl ether maleic copolymer or terpolymer denture adhesive component, an effective amount of a quaternary ammonium antimicrobial agent selected from the group consisting of cetylpyridinium chloride, domiphen bromide, and mixtures thereof, and a non-aqueous vehicle. A denture wearer in need thereof applies the composition to the oral cavity and/or the denture prosthesis and thereafter secures the denture to the oral cavity.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: March 16, 2004
    Assignee: The Procter & Gamble Company
    Inventors: Jayanth Rajaiah, Kimberly Ann Gilday-Weber, Lisa Catron Ernst, Thinh Nguyen Ha, John E. Barnes, Nivedita Ramji, Ann Maria Kneipp
  • Confectionery compositions
    Patent number: 6703000
    Abstract: A confectionery composition comprising: (i) an effective amount of a natural plant extract selected from tea, gold thread, honeysuckle, magnolia extracts and mixtures thereof; (ii) an oral care active selected from the group consisting of anti-calculus agents; anti-plaque agents; fluoride ion source; desensitising agents; oral malodour control agents; H2 antagonists; and mixtures thereof; (iii) less than about 10% water; and (iv) a suitable confectionery carrier material.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: March 9, 2004
    Assignee: The Procter & Gamble Co.
    Inventors: Ji Ning, Thomas Mark Lawlor, Zhu Long
  • Enzyme containing oral composition having enhanced stability
    Patent number: 6692726
    Abstract: An oral care composition having enhanced oral hygiene and antiplaque properties which comprises an orally acceptable vehicle containing a combination of an enzyme, cetylpyridinium chloride and a reducing agent.
    Type: Grant
    Filed: February 11, 2003
    Date of Patent: February 17, 2004
    Assignee: Colgate Palmolive Company
    Inventors: André M. Morgan, Lori H. Szeles, Malcolm Williams, Susan M. Herles, Chanda L. Macias, Robert D'Ambrogio, Thomas J. Boyd, James G. Masters
  • Irrigation solution and methods for use
    Publication number: 20030235804
    Abstract: Methods and solutions are provided for removal of the smear layer on prepared tooth and bone surfaces, especially in endodontic environments.
    Type: Application
    Filed: January 21, 2003
    Publication date: December 25, 2003
    Inventors: Mahmoud Torabinejad, William B. Johnson
  • Biological methods of use of 4-amino-3-mercapto-triazoles
    Publication number: 20030225148
    Abstract: This invention claims the utility of two structural variants of functionalized 4-amino-3-mercapto-1,2,4-triazoles as inhibitors of nitric oxide synthase (NOS) and as inhibitors of malignant cell growth. This fundamental molecular construct operates as a heterocyclic mimic of the open-chain N-aminoarginines (or N-aminoguanidines) previously established as NOS inhibitors. A convenient bioassay method, using PAM 212 keratinocytes for detection and quantification of relative NOS inhibition potential in a series of candidate drugs, is described as is a bioassay for growth inhibition.
    Type: Application
    Filed: September 17, 2002
    Publication date: December 4, 2003
    Inventors: Ned H. Heindel, Jeffrey D. Laskin, Diane E. Heck, Christophe Guillon, Robert D. Rapp
  • Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
    Publication number: 20030219387
    Abstract: The present invention relates to compositions and methods of treating periodontal disease and related disorders utilizing a sustained, controlled release targeted delivery method to effectively disrupt and inhibit bacterial biofilms at periodontal treatment sites.
    Type: Application
    Filed: June 6, 2003
    Publication date: November 27, 2003
    Inventor: Gary R. Jernberg
  • Bleeding control and healing aid compositions and methods of use
    Patent number: 6652840
    Abstract: A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral “gum” and other “skin” (epithelial) tissues. The composition is preferably in the form of a paste which promotes ease of application and use of the composition. A variety of instruments can be used in application and cleanup of the composition showing versatile unparalleled friendly usage. The composition preferably comprises aluminum chloride, ferric sulfate (subsulfate), regenerated oxidized cellulose, aluminum ammonium sulfate, absorbable gelatin and a solvent. The composition has many dental and medical procedure applications.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: November 25, 2003
    Inventor: Terence Prevendar
  • Method of treating glutathione deficient mammals
    Patent number: RE39705
    Abstract: Glutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intra-cellularly either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate), by way of inhibition of synthesis, or by subjecting cells to oxidant stress. Most cells, except for epithelia cells, do not have a direct transport capacity for intact GSH. Non-epithelial cells must either transport precursor substrates for GSH synthesis or salvage amino acids from circulating GSH for reuse in intracellular resynthesis. Dietary cysteine is a rate limiting substrate for the synthesis of glutathione and also inhibits GSH efflux. Although GSH is synthesized from precursors in virtually all cells, the liver is the main source of plasma GSH. Protection and support of liver function is paramount to elevating GSH levels.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: June 26, 2007
    Assignee: Vit-Immune, L.C.
    Inventors: Robert H. Keller, David Kirchenbaum
  • Preventing and reversing advanced glycosylation endproducts
    Patent number: RE38330
    Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reversing, the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: November 25, 2003
    Assignee: Alteon Inc.
    Inventors: Anthony Cerami, Peter C. Ulrich, Dilip R. Wagle, San-Bao Hwang, Sara Vasan, John J. Egan