Abstract: Wound dressing assemblies and methods of producing the wound dressing assemblies. The wound dressing assemblies various comprise individual layers of nanomaterials that have been formed according to an electrospinning process. Each of the layers can have different characteristics and qualities. The invention also provides guidance in selecting materials to form a wound dressing assembly, as well as possible adaptations to the electrospinning process to provide different characteristics for particular materials.

Abstract: This invention relates to antimicrobial lenses containing metals and methods for their production.

Abstract: There is described a method for the deposition of silver nanoparticles on the surface of natural or synthetic textile fibers.

Abstract: A pharmaceutical composition and method for topical wound treatment by topical treatment with gallium salts, preferably gallium nitrate. In a preferred embodiment, the gallium nitrate is in an aqueous form without coagulation inhibitors such as citrate. The aqueous gallium salt formulation may be administered by a variety of methods including spraying, topical lotions, topical foams, and/or bandages containing or packaged with breakable ampoules of aqueous gallium salt formulations, and liquid bandage formulations. The aqueous gallium salt formulation may additionally contain other active and inactive ingredients, such as viscosity modifying agents, foaming agents, antiseptics, antibiotics, enzymes, fibrinogen, fibrin, polymers and growth factors.

Abstract: An antiviral composition and a method of treating viral conditions comprising colloidal silver, silver nitrate, or both, and an antiviral natural herb or a natural herb from the Rutaceae family, such as Ruta graveolens, Myrtaceae family, such as Melaleuca alternifolia, Cupressaceae family, such as Thuja occidentalis, and the Moraceae family, such as fig, or any combination thereof.

Abstract: The invention provides methods and kits for screening a test agent for antiviral activity against Norovirus. The methods are effective in terms of determining the amount of intact Norovirus while decreasing the amount of interfering RNA and PCR inhibitors within the test sample.

Abstract: The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.

Abstract: Disclosed is a method for preparing an antimicrobial composition for making filament for brushes. The method comprises steps in the following order: (1) mechanically pulverizing a polymer to obtain a polymer powder; (2) blending the polymer powder obtained in step (1) with an antimicrobial agent comprising phosphate, or glass, micropowder loaded with silver, zinc, or a silver-zinc composite.

Abstract: A medical device having an antimicrobial coating. The device has a first coating layer having an antimicrobial agent over at least part of the outer surfaces of the device. The first coating has an outer surface. There is a second discontinuous polymeric coating containing an antimicrobial agent, which is on top of and covering part of the outer surface of the first coating. The second discontinuous coating has a microstructure.

Abstract: A sanitizing agent for maintaining a biocidal effective bacteria count in a body of water comprising a metal ion donor for donating a metal ion and a compound containing a hydantoin ring with the combination of the compound containing the hydantoin ring with the metal ion donor enhancing the effectiveness of the sanitizing agent to enable the sanitizing agent to maintain a biocidal effective bacteria count in the body of water.

Abstract: Goniochromatic/light reflecting cosmetic compositions well suited for making up the skin, lips, hair or integuments, contain (a) at least one goniochromatic coloring agent and (b) an amount of light reflective particles different from said at least one goniochromatic coloring agent and selected from the group consisting of (i) particles of a natural or synthetic substrate at least partially coated with at least one layer of at least one metal, (ii) particles of a synthetic substrate at least partially coated with at least one layer of at least one metallic compound, (iii) particles which comprise a stack of at least two layers of materials having different refractive indices, at least one of such layers optionally comprising a polymer, and (iv) metal oxide particles, formulated into (c) a topically applicable, physiologically acceptable medium therefor.

Abstract: This invention is directed to improved compositions for treatment of acne and related methods. In some embodiments, the present invention is directed to compositions comprising a topical vehicle, nanosilver, acne medicine and soothing agents, effective for treating acne without irritation.

Abstract: The invention relates to a composite material, a precursor for forming the composite material and a method of forming the composite material from the precursor. The invention also relates to the use of said composite material and in particular to its use as an antibacterial or antimicrobial agent.

Abstract: A method or protocol for reducing the spread of bacterial infections such as MRSA among a population includes identifying a group of individuals at risk of carrying or becoming carriers of a bacterial infection that colonizes in the nose, determining whether any individuals can be excluded from treatment due to reasons relating to the individual's other activities or precautions taken, designating an individual or group of individuals who will receive treatment, providing a strip, the strip having an effective amount of antimicrobial agent capable of being delivered transdermally, the strip is exteriorly applied to the nose of the designated individual or group of individuals so to allow the antimicrobial agent to pass through the nose to interact with the colony to suppress the colonization, or altogether eradicate the colony.

Abstract: The present application discusses techniques and structures that incorporate calcium salts in the luminal surface of grafts. In an embodiment, a graft, stent-graft or TIPS may incorporate bio-compatible calcium salt, which is essentially non-osteoinductive in nature, on the surfaces of the implantable device.

Abstract: The present invention is directed to a method for preparing colloidal dispersions of precious metal nanoparticles selected from the group consisting of Pt, Au, Pd, Ag, Rh, Ru and mixtures or alloys thereof, and to a method for isolating such precious metal nanoparticles from these colloidal dispersions. The colloidal dispersions are prepared by reducing suitable precious metal precursor compounds in aqueous alkaline solutions at reaction temperatures between 40 and 70° C. and a pH?12.0 in the presence of polysaccharides with average molecular weights (Mw) in the range of 300,000 to 1,000,000. The precious metal nanoparticles are isolated after decomposing the polysaccharide by heating the colloidal dispersions to temperatures >80° C. The nanoparticles can be used for the manufacture of core/shell-type catalyst materials and for electronic, decorative and medical applications.

Abstract: In one embodiment, an antibacterial material includes at least one microparticles selected from tungsten oxide microparticles and tungsten oxide complex microparticles. The microparticles, which are undergone a test to evaluate viable cell count by inoculating in a test piece, to which the microparticles are adhered in a range of 0.02 mg/cm2 or more and 40 mg/cm2 or less, at least one bacterium selected from among Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, and enterohemorrhagic Escherichia coli, and storing for 24 hours, have an antibacterial activity value R of 0.1 or more expressed by the following: R=log(B1/C1) where, B1 denotes an average value (number) of viable cell count after storing an untreated test piece for 24 hours, and C1 denotes an average value (number) of viable cell count after storing the test piece on which the microparticles are coated for 24 hours.

Abstract: A method for controlling protozoa trophozoites and cysts wherein one or more biocides or non-biocidal agents are encapsulated within a micro-capsule or nano-capsule and then introduced into an aqueous system. The micro-capsule or nano-capsule has an exterior composition adapted for digestion by the protozoa. A vesicle for controlling protozoa trophozoites and cysts is also provided.

Abstract: A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms.

Abstract: The invention relates to a method for making a composite material including a porous polymer matrix containing HEMA monomers and in which silver nanoparticles are dispersed, and to the use thereof as an anti-microbial material.

Abstract: An embodiment relates to a composition comprising a noble-metal containing nanoparticle and a polymer located on a surface of the nanoparticle, wherein the polymer is a polycondensation product of a halogenated monomer. Other embodiments relate to the method of making a composition and providing antimicrobial treatment using the composition.

Abstract: Textile materials for management of skin health complications associated with skin folds, as well as adhesives for attaching the materials to the skin of a subject. The adhesive can be supplied separately from the material, for application post-production, or can be applied to the material during production.

Abstract: Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of loading them with silver compounds are described. The silver-containing biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more anti-infective agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.

Abstract: A system and method for using nanoparticles for antimicrobial activity. An antimicrobial coating can be provided, which can include a plurality of discrete first particles that can have an average diameter of less than approximately 400 nanometers and, in a preferred embodiment, 10 nanometers or less. The plurality of discrete first particles can include pure silver metal. In an embodiment, the plurality of discrete first particles can also include a physiologically inert stabilizer. The antimicrobial coating can also include a polymeric film, in which the plurality of discrete first particles can be directly embedded therein.

Abstract: A new, novel and useful disinfection and purification system comprised of organic compounds in synergistic action with selected metal ions and method of manufacture and use. One of the benefits that is derived from this system is the ability to quickly and easily treat a surface, fluid or medium for disinfection of bacteria, fungi, viruses, algae and protozoans, with a non-toxic, non-chlorinated mixture that effectively kills all such organisms in minutes or hours. The disinfection and purification system remains effective for long periods of time maintaining its disinfection capacity making it highly effective for stored or transported mediums such as potable drinking water. The disinfection and purification system may be incorporated with carbon block or membrane filters to disinfect filtered liquids such as water to render it potable.

Abstract: Robust polymeric hydrogels and a method to fabricate antimicrobial non-woven fibrous wound dressing with controlled silver release that may be used for anti-infective medical implants and anti-infective coating for implantable medical device. The hydrogels may be provided in non-woven fibrous wound dressing and anti-infective implantable medical devices, especially for reconstructive oral and bone surgery.

Abstract: The present invention relates to methods for removal of dead tissue from wounds or skin using topical nitric oxide donor devices and/or compositions. In one embodiment, the present invention relates to a transdermal patch device that is designed to deliver nitric oxide. In another embodiment, the present invention relates to one or more devices and/or compositions that are designed to deliver nitric oxide and optionally one or more other compounds, where such devices/compositions include, without limitation, bandages, layered bandages, adhesive bandages, transdermal patches, creams, ointments, or a any combination of two or more thereof.

Abstract: An antimicrobial coating composition consisting essentially of 70 to 80 wt. percent water; 5 to 10 wt. percent methyl alcohol; 3 to 8 wt. percent octadecyl dimethyl trimethoxy silylpropyl-ammonium chloride; 1 to 5 wt. percent chloropropyl trimethoxysilane; 0.5 to 1.5 wt. percent aminopropyltrialkoxysilane; 0.5 to 1.5 wt. percent of a surfactant; 1 to 1.5 wt. percent of an anti-microbial agent; and 0.5 to 2.5 wt. percent sulfuric acid.

Abstract: The present invention discloses the preparation of antimicrobial membranes by inclusion of low leaching, control release silver-based antimicrobial additives as described in claim 1 into the polymer matrix and forming this into a semipermeable membrane. The antimicrobial agents protect the membrane system against bacterial and/or algal decay and assist in maintaining a high efficiency of the membrane filtration process.

Abstract: A process for the production of an aqueous dispersion of metal nano particles comprising palladium is provided. The process comprises the admixture of a water soluble organic polymer, a palladium salt and a first reducing agent to an aqueous liquid. The first reducing agent is a metal-containing polymer which has reducing properties or a saccharide which has reducing properties. The nano particles can include a second metal. The dispersions can be used as catalysts for electroless plating, to produce heterogeneous catalysts and in the production of anti-microbial devices and compositions.

Abstract: The present invention relates to antimicrobial zeolite which comprises zeolite wherein a hardly soluble zinc salt is formed within fine pores present therein and an antimicrobial composition which comprises the foregoing antimicrobial zeolite in an amount ranging from 0.05 to 80% by mass. The antimicrobial zeolite according to the present invention can widely be applied, without causing any color change, even to the goods which undergo color changes with the elapse of time when the conventional antimicrobial zeolite is added.

Abstract: The invention relates to a medical implant made of a metallic material. After fulfilling its temporary support function, the implant is degraded by corrosion at a predetermined rate. Negative long-term effects are thus avoided.

Abstract: A topical formulation for application to exposed body tissue, the formulation comprising a silver(II) oxide and zinc oxide, intimately dispersed within a carrier medium.

Abstract: The subject invention pertains to methods and compositions for wound treatment. The methods and compositions provide for promoting and accelerating wound healing; provide for inhibition of microbial infection; provide for a protective scab-like covering on a wound; and/or for arresting the flow of blood or body fluids from an open wound. The methods and compositions can be used to increase granulation and epithelialization in a wound. In one embodiment, a substantially anhydrous compound of a salt ferrate and a cation exchange material is provided. Compositions of the invention can also include silver compounds. In use, compositions of the invention are preferably applied as a dry dressing to an exuding chronic wound site. If the chronic wound site is dry, the wound site may be wetted with a suitable liquid or aqueous media prior to applying the dressing in dry form.

Abstract: A delivery vehicle for a silver ion source such as silver nitrate and the like, suitable for use in the treatment of menorrhagia, comprises a plurality of physiologically inert beads bearing a tissue cauterizing amount of a silver ion source. Preferably the beads are made of a physiologically inert polymer, ceramic or stainless steel. The silver ion source preferably is silver nitrate and can be substantially pure silver nitrate, or can comprise silver nitrate in combination with a physiologically tolerable binder or a diluent. Suitable binders include physiologically tolerable synthetic polymeric binders, polysaccharide binders, and the like. Diluents can include other salt materials such as potassium nitrate. The beads are useful in treating menorrhagia of a mammalian uterus. The beads can be delivered to the uterus via a catheter, and are distributed throughout the uterine cavity by uterine massage or like expedient. Silver ions are delivered to the endometrium and cause necrosis of the endometrial tissue.

Abstract: A two part biocide composition containing metal ions and bromine donor for killing microorganisms in a body of water and a method of killing microorganisms in a body of water by placing both metal ions and a bromine in the body of water to allow use of lower concentrations of bromine than if bromine were used alone as a biocide.

Abstract: A long-lasting anti-microbial composition is provided, which includes one or more polymer or oligomer and a plurality of nanowires distributed therein, wherein the nanowires have an aspect ratio of more than 20 and the nanowires form a network-like structure. An anti-microbial film and spray including the composition are also provided.

Abstract: The present invention provides a coating comprising a bioactive material and an antimicrobial agent, wherein the concentration of said antimicrobial agent varies throughout the thickness of the coating.

Abstract: The present invention provides solution to the problem involved in preparation of metal nanosponges using templates and polymers. The instant invention is successful in providing a simple, template free single step process for the preparation of metal nanosponges having porous low density and high surface area. These metal nanosponges were found to be good self-supported substrates for surface-enhanced Raman spectroscopy (SERS) and have shown significant anti-bacterial activity.

Abstract: The present invention discloses a coating for a medical implant, wherein at least a part of said coating contains an osseointegration agent and the same and/or a different part of the coating contains an antimicrobial metal agent.

Abstract: The present invention relates to combinations of hydroxypyrion compounds, and silver compound which provide an improved biocidal effect. More particularly, the present invention relates to compositions comprising a combination of a hydroxypyrion compound selected from 1-hydroxy-2-pyridinone, ciclopirox, ciclopirox olamine, piroctone, piroctone olamine, rilopirox, or a salt thereof, together with one or more silver salts selected from silver acetate, silver alginate, silver azide, silver citrate, silver lactate, silver nitrate, silver perchlorate, silver sulfate, silver chloride, silver thiocyanate, silver-sodium-hydrogen-zirconium phosphate, silver sulfadiazine, silver cyclohexanediacetic acid and disilver 2,5-dichloro-3,6-dihydroxy-2,5-cyclohexadiene-1,4-dione in respective proportions to provide a synergistic biocidal effect.

Abstract: A washable device for personal use, in particular a hair removal device, such as an epilator and a shaver, a portion of which is coated with paraffin. The device, the paraffin, or both may include an antibacterial agent. A method of manufacturing components of a device for personal use can include dipping the components into a paraffin bath, spraying molten paraffin on the components, spraying a paraffin solution onto the components, applying solid paraffin by tumbling, and the like.

Abstract: A fatty acid metal salt used for forming ultrafine metal particles satisfying at least one of that: (i) the water content is 200 ppm or less; (ii) the volume-cumulative particle diameter D90 is 80 ?m or smaller as measured by the particle size distribution measuring method of the laser diffraction/scattering type; or (iii) a metal of an atomic weight of 50 to 200 is contained, and the amount of the unreacted substance or the by-product is 4.0 mol % or less when the fatty acid metal salt is formed. The fatty acid metal salt can be favorably used for forming ultrafine metal particles in a resin, or for forming a resin composition, a coating, a dispersion solution or a molded article containing the ultrafine metal particles.

Abstract: A facial mask for use in decreasing the transmission of one or more than one human pathogen to and from a human wearer of the facial mask, the facial mask comprising a facepiece; where the facepiece comprises three or more than three layers; where one or more than one of the three or more than three layers comprises a fabric comprising one or more than one binding substance comprising one or more than one human pathogen binding group for chemically attaching the human pathogen to the binding substance; where the fabric further comprises one or more than one type of multivalent metallic ion or metallic salt; and where one or more than one of the three or more than three layers comprises a heat-moldable fabric.

Abstract: A blood pressure measurement cuff comprising an inflatable bladder, a source of fluidic pressure in fluidic communication with the inflatable bladder, a manometer in fluidic communication with the inflatable bladder, a cover at least partially covering the inflatable bladder and comprising an antimicrobial substance, and means to place the inflatable bladder sufficiently close to a limb of a living being to allow the measurement of the blood pressure of the living being. The source of fluidic pressure can be a pump that transforms human force into fluid pressure, such as a squeezable ball pump, or a canister of compressed fluid. The manometer can include a dial display or a digital display. The cuff can further comprise a tube providing fluidic communication between the manometer and the inflatable bladder, and the tube can be 1 foot or longer. The cover can be made of a fabric coated with an antimicrobial substance.

Abstract: The invention relates to a composition comprising a) silver and/or one or more silver compound and b) one or more biocidal active ingredients of the isothiazoline.

Abstract: The invention provides compositions, methods and devices relating to a silaceous oxide that generates a reduced heat of hydration upon contact with blood. By reducing the heat of hydration, the compositions provide a hemostatic agent that attenuates a tissue burning side effect of conventional hemostatic agents without adversely affecting the wound healing properties of the composition.

Abstract: There is provided a method for preparing a natural cellulose-AgO matrix having antimicrobial activity without leaching silver from the cellulose-AgO matrix. The method comprises: introducing silver ions (Ag+) into a natural cellulose matrix by dipping the natural cellulose matrix in an AgCl-dissolved NH4OH solution; and substituting hydrogen (H) of hydroxyl group (—OH) in natural cellulose with Ag+ by drying the silver ion-infused natural cellulose matrix, thus to form a natural cotton-AgO complex. The cellulose-AgO matrix prepared in the method may be useful to continuously maintain antimicrobial activity by maintaining an effective concentration of silver, which does not have cytotoxicity to human skin, and chemically bonded silver is not leached during the rehydration due to the chemical bond between the silver and the cellulose matrix.

Abstract: Microbiologically effective silver hydrosol is used to reduce the local level of microorganisms at the site of a dental procedure and to prevent or inhibit their growth during the healing that follows the procedure. Any gingival lesions created by a dental procedure are treated with silver hydrosol in an aqueous gel. Following the procedure the patient's mouth is periodically rinsed several times a day with a solution of silver hydrosol or, more preferably, with a combination of silver hydrosol and hydrogen peroxide. These steps result in a significant reduction in post operative pain and swelling. Overall healing is accelerated by this treatment.

Abstract: A system, method and apparatus provices an antimicrobial card, badge holder or token made from an antimicrobial polymereric material. The antimicrobial polymereric material includes one or more polymers and one or more antimicrobial agents that affect the growth of bacteria, fungi, virus or a combination thereof.