Abstract: A system to prepare an antimicrobial solution by the electrolysis of brine is presented where the antimicrobial solution is a solution comprising HOCl that contains a HOCl concentration of 100 ppm or more at a pH of approximately 6.5. The system includes an electrolysis cell that is provided with a constant current by a digital DC power supply controlled by a microprocessor and a controlled brine concentration at a controlled rate, which can also be controlled by the microprocessor to deliver a fluid that is continuously observed by a pH probe and an ORP probe that provides input to the microprocessor to adjust voltage, pump rate and/or flow rate in a programmed manner by the microprocessor. A method to produce the antimicrobial solution, including a sporicidal solution, by the novel system is presented.

Abstract: The present invention provides a preservative composition for protecting ophthalmic solutions from microbial attack comprising a combination of benzalkonium ion and An oxy-chlorite moiety, e.g. purite wherein the combined concentrations of benzalkonium ion and An oxy-chlorite moiety, e.g. purite in said composition is sufficient to provide protection against microbial attack when said composition is added to an ophthalmic solution as compared to said ophthalmic solution having the same concentration of benzalkonium ion and An oxy-chlorite moiety, e.g. purite, alone.

Abstract: The invention relates to an aqueous composition for inactivating sporulated and/or non-sporulated Coccidia parasites comprising 15 to 115 ppm chlorine dioxide and 0.01 to 1 wt-% of an anionic surfactant having one or more C6 to C18 alkyl groups and one or more aryl groups. The invention further relates to a method for preparing the composition and to a method for inactivating sporulated and/or non-sporulated Coccidia by applying the composition.

Abstract: The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood immune cell activation before and after therapy.

Abstract: The invention provides methods and systems for treating or preventing viral infection. In one embodiment, the invention provides a method of treating or preventing viral infection in an individual, the method comprising: administering to the individual, via at least one nasal cavity, nebulized ECAW containing a quantity of hypochlorous acid (HOCI) and a quantity of hypochlorite ion (OCI).

Abstract: There is provided a method of inhibiting the development of a biofilm adjacent a surface, the method comprising intermittently applying a biofilm inhibiting substance to a collection of microorganisms having biofilm developing potential. Other embodiments are also described.

Abstract: A two-part disinfecting systems, as well as disinfecting compositions and methods for making and using the same. The two-part disinfecting system contains a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition, wherein the first part comprises a chlorite and the second part comprises an acid, and wherein the first part, the second part, or both the first and second parts comprise an olefin compound.

Abstract: A solid composition in the form of a tablet that generates and releases a biocidal solution comprising at least chlorine dioxide with an enhanced weight percent yield is presented. The composition comprises reactants capable of in-situ generation of chlorine dioxide comprising a chlorite donor that is coated with a gel-forming material that slows the rate of dissolution of the high solubility chlorite donor, a free halogen donor, and an acid source, resulting in an unexpectedly high weight percent yield and providing a controlled release of biocidal solution. The compositions of the invention show improved environmental stability which can reduce the cost of packaging and significantly increase the utility of the composition. The controlled release allows the use in multi-tablet chemical dispensers which may otherwise induce potentially explosive conditions or allow rapid release of the biocidal solution thereby inducing a spike in chemical concentration rather than a controlled and sustained release.

Abstract: This invention relates to a formulation for use in personal care products, cleaning products and the like. Ideally, the formulation is a natural preservative and disinfectant formulation comprising activated water and grapefruit seed extract.

Abstract: The invention includes a method of preparing hypochlorite-activated solutions of hypobromous acid and/or hypobromite ion. The method includes the steps of mixing a solution of a source of bromide ion with a solution of a source of hypochlorite ion to activate the bromide ion, allowing sufficient time to maximize the activation of the bromide ion, and storing the solution before use. The invention also includes a method of using the solution to wash meat and poultry carcasses, trim, and offal to reduce pathogenic microorganisms. The solutions may also be used to reduce pathogenic microorganisms in industrial cooling water and on food contact hard surfaces and equipment. The solutions may be stored for up to about three hours before use and are stable for that period of time.

Abstract: A solid composition in the form of a tablet that generates and releases a biocidal solution comprising at least chlorine dioxide with an enhanced weight percent yield is presented. The composition comprises reactants capable of in-situ generation of chlorine dioxide comprising a chlorite donor that is coated with a gel-forming material that slows the rate of dissolution of the high solubility chlorite donor, a free halogen donor, and an acid source, resulting in an unexpectedly high weight percent yield and providing a controlled release of biocidal solution. The compositions of the invention show improved environmental stability which can reduce the cost of packaging and significantly increase the utility of the composition. The controlled release allows the use in multi-tablet chemical dispensers which may otherwise induce potentially explosive conditions or allow rapid release of the biocidal solution thereby inducing a spike in chemical concentration rather than a controlled and sustained release.

Abstract: The invention relates to a non-thermal plasma for treatment of a surface, particularly for the treatment of a wound (1), wherein the plasma comprises a partially ionized carrier gas and at least one additive, which preferably has a sterilizing effect on the treated surface and/or improves the healing of the wound (1). Further, the invention relates to a corresponding apparatus and method.

Abstract: Nutritional compositions, formulations, and intermediates are provided which may be utilized to formulate various sweeteners and other products. The formulations described herein are made from constituents found in soils or fossilized soils.

Abstract: A massive body, e.g., a tablet, for producing a thickened solution of chlorine dioxide when the massive body is added to liquid water is disclosed. The massive body comprises a metal chlorite, an acid source and a thickener (incorporated directly into the massive body or added as a component separate from the massive body) and optionally a source of free halogen. The concentration of free chlorine in the solution will be: (a) less than the concentration of chlorine dioxide in said solution on a weight basis and the ratio of the concentration of chlorine dioxide to the sum of the concentrations of chlorine dioxide and chlorite anion in said solution is at least 0.25:1 by weight; or (b) equal to or greater than the concentration of chlorine dioxide in said solution on a weight basis and the ratio of the concentration of chlorine dioxide to the sum of the concentrations of chlorine dioxide and chlorite anion in said solution is at least 0.50:1 by weight.

Abstract: A cleaning medium or formulation that contains a sporicidal composition is described. The composition includes about 0.1-20% weight/weight of a germinant agent, about 0.01-75% w/w of an antimicrobial agent, in terms of dry or wet total weight, and which is admixed with water to generate a solution with a pH of 3.5-9.5. The composition can help trigger the germination of spores, in particular C. difficile, and subsequently deactivate or kill the spores. A means of applying the cleaning formulation in a medium and process for cleaning are also described.

Abstract: Chlorine dioxide generation systems and methods are disclosed. One or more reactants, such as sodium hypochlorite, may be electrolytically generated on-site for delivery to a reaction column. Low concentration reactants may be used to generate chlorine dioxide as part of a mixed oxy-chloro product stream containing free available chlorine. In at least one embodiment, an optical analyzer may be positioned along a reactant feed line to measure a concentration of reactant supplied to a reaction column. A controller may adjust a flow rate of the reactant in response to information provided by the optical analyzer. The controller may also perform pH control within the system. In some embodiments, the chlorine dioxide generator may be incorporated in an all-liquid water disinfection system.

Abstract: Disclosed is a process for preparing an adjuvant for agricultural applications, characterized in that a polyhydric alcohol, polyol, saccharide, or polysaccharide is reacted with a sulfonating agent, such as sulphamic acid.

Abstract: Disclosure is provided for imidazole-triazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.

Abstract: Methods for determining chlorine demand in water are provided. One method comprises (a) providing a test water sample containing at least one contaminant and a source of chlorine and a source of bromide; (b) heating the test water sample for a suitable time and temperature sufficient to substantially oxidize the at least one contaminant in the test water sample; and (c) determining the content of residual chlorine present in the test water sample.

Abstract: The invention provides methods and kits for screening a test agent for antiviral activity against Norovirus. The methods are effective in terms of determining the amount of intact Norovirus while decreasing the amount of interfering RNA and PCR inhibitors within the test sample.

Abstract: Compositions comprising a mixture of (a) a major amount of solid halogen-containing sanitizer material and (b) a minor amount of calcium oxide modified particulate boric acid, the amount of calcium oxide modified particulate boric acid being sufficient to enable the composition to be classified as a class 1 or class 2 NFPA oxidizer are described. Also described is particulate boric acid at least a portion of the particles thereof having on their surface at least a partial coating of calcium oxide, and a method for preparing such coated particulate boric acid.

Abstract: Methods of using a stabilized chlorite solution to inhibit antigen-specific immune responses are disclosed. The stabilized chlorite solution, when administered to a mammal in need thereof, can prevent the presentation of antigens by antigen presenting cells. The stabilized chlorite solution therefore is useful in treating, inter alia, auto-immune diseases, treating diseases caused by an inappropriate immune response, treating lymphoproliferative disease and in inhibiting rejection in transplant patients.

Abstract: Chlorine and Hydrogen Peroxide Medical Therapies including Ear Dropper Multiple Vile Medicine Mixing Cool Mist Vaporizer with detachable Inhalation Hose and Facemask Double Density Air Filter, 3-Speed Motor with On/Off Switch, Home and Hospital Models with Atomizer and an Orifice for attachment to and Oxygen Tank, Pre-Wrapped Bandages, Gauze Stick-On Strips or Squares or Strip-less Gauze Pads with Liquid or Gel, Chlorine or Hydrogen Peroxide also, Lotions for Skin Infections and Cancers, Chemical Injections and Patient Baths, and Wellness Therapies

Abstract: Antiseptic compounds that act as persistent and fast acting antiseptics and disinfectants. The base of these antiseptic actions is CaF2 as the persistent part, preventing the colonization of tissue and nonliving surfaces with microorganisms through the targeted on-demand release of fluorine ions. For fighting heavy contamination and invasion of transient microbes through new application of the solution, fast acting alcohols and toxic solutions have been added in small percentage. They act fast and evaporate fast, leaving the natural protection of skin undamaged and coated with a persistent antiseptic.

Abstract: A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms.

Abstract: A therapeutic agent for infectious skin and mucosal diseases to be applied to an infected area for ameliorating a symptom of the infected area caused by infection with a pathogenic microorganism includes: a chlorine dioxide solution including a dissolved chlorine dioxide gas.

Abstract: A method for controlling protozoa trophozoites and cysts wherein one or more biocides or non-biocidal agents are encapsulated within a micro-capsule or nano-capsule and then introduced into an aqueous system. The micro-capsule or nano-capsule has an exterior composition adapted for digestion by the protozoa. A vesicle for controlling protozoa trophozoites and cysts is also provided.

Abstract: A method for reducing pathogens in the gastrointestinal tract of a live animal comprising orally administering to the animal an effective amount of an aqueous antimicrobial solution, wherein the aqueous antimicrobial solution comprises from about 0.01% to about 0.1% by weight of a metal chlorite and a sufficient quantity of an acid having a first pKa of from about 2.0 to about 4.4 to adjust the pH of the aqueous antimicrobial solution to about 2.2 to about 4.5 and to maintain the chlorite ion concentration in the form of chlorous acid to not more than about 35% by weight of the total chlorite ion present in the aqueous antimicrobial solution, is disclosed.

Abstract: Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis. An iontophoretic preparation for treatment of breast cancer and/or mastitis containing, as an active ingredient, a nonsteroidal anti-inflammatory analgesic agent and/or an anticancer agent, wherein an electrolyte is topically administered through the nipple part into the mammary gland; subsequently, a donor is applied to the nipple part; and the active ingredient is topically administered through the nipple part into the mammary gland by application of current.

Abstract: The present invention provides a photosensitising composition comprising a mixture of at least one oxygen carrier, at least one oxidising agent and at least one surfactant, and its uses. The ratio of the at least one oxygen carrier to the at least one oxidising agent to the at least one surfactant may be in the range of 50:40:10 to 80:19.8:0.2. The photosensitising composition may be used for treating and/or preventing conditions caused by microorganisms.

Abstract: Disclosed is a method of making a non-aqueous chlorine dioxide solution by combining a chlorite salt and a non-aqueous carboxylic acid and the non-aqueous chlorine dioxide solution made by this method. Also disclosed are methods of disinfecting an object by applying the non-aqueous chlorine dioxide solution to the object and methods of disinfecting a liquid by adding the non-aqueous chlorine dioxide solution to the liquid.

Abstract: There are provided a chlorine dioxide solution composition whose solute includes dissolved chlorine dioxide and chlorite; and a solution composition encapsulating body including a glass vessel or enameled vessel and the chlorine dioxide solution composition hermetically sealed therein.

Abstract: A composition and method are described for suppressing or preventing fibrous adhesion formation using a multicomponent aqueous oxychlorine composition. Fibrous adhesions typically form during healing of tissue, for example following a surgical procedure. A multicomponent oxychlorine composition is provided for irrigating the tissue which minimizes post-surgical adhesion formation, the composition containing both chlorine dioxide and chlorite ion, and a complex ion thereof. The chlorine dioxide level generally is in an effective range of ClO2 concentration from about 10 ppm to a maximum of about 110 ppm. In a preferred embodiment, a physiological composition is provided in a thickened form to increase retention in the area being treated.

Abstract: A process for producing aqueous chlorous acid solution in which chlorous acid, which is safe for the human body, is easy to handle, and less generates chlorine dioxide, is yielded and used as a disinfectant for a pretreatment in food processing. To an aqueous sodium chlorate solution is added sulfuric acid or an aqueous solution thereof in such an amount and concentration that the pH of the aqueous solution can be kept at 2.3-3.4 to thereby react them and generate chloric acid. Subsequently, hydrogen peroxide is added to the chloric acid in an amount which is equal to or larger than the amount necessary for a reduction reaction to thereby yield chlorous acid. Any one of inorganic acids, inorganic acid salts, organic acids, and organic acid salts, or two or more thereof, or a combination or these is added to the aqueous solution containing chlorous acid yielded, whereby the chlorous and acid can be present for long and the pH of the aqueous solution is regulated to regulated to 3.2-7.0.

Abstract: A biocide is formed by mixing at least one of ammonium sulfamate and ammonium carbamate with an aqueous solution of a hypochlorite oxidant at a molar ratio of ammonium to hypochlorite of at least 1:1. The biocide is useful in treating microbial or biofilm growth, pulp and paper process water, cooling tower water, waste water, reclaimed waste water, sludge, colloidal suspensions, irrigation water or a medium having a reducing capacity.

Abstract: Methods and compositions to a clathrate that includes chlorine dioxide (ClO2) are provided. Clathrates trap gaseous chlorine dioxide to provide a dry solid material that is stable and easy to use and handle. Stable formulations of gaseous chlorine dioxide are useful as disinfectants.

Abstract: This aims to produce dental sterilizing water having not only a sterilizing action but also an action to break a bio-film. Provided is a sterilizing water producing device (51) comprising a stock solution tank (3) for storing a stock solution (52), a stroke pump (4) connected in communication to the stock solution tank, an electrolytic bath (5) connected in communication to the stroke pump, a discharge pipe (6) connected in communication to the electrolytic bath, and a dilution water tank (8) reserving dilution water (57). The dilution water tank (8) is so positioned relative to the tip position of the discharge pipe (6) that the tip of the discharge pipe (6) may be lower than the water level of the dilution water (57) reserved in the dilution water tank (8). The stock solution (52) is prepared by selecting any of the methods shown at (a-1) to (d).

Abstract: Synergistic mixtures of haloamines and their use to control the growth of microorganisms in aqueous systems are disclosed. The method of using the synergistic mixtures entails adding an effective amount of a monohaloamine and an effective amount of a dihaloamine to an aqueous system.

Abstract: In one aspect, the invention is directed to a biocidal composition, comprising a mixture of a substantially oxidation-resistant thermoplastic polymer having a melting point of about 60° C. to about 100° C.; and a composition for releasing chlorine dioxide gas upon exposure to moisture and having a bulk density less than about 0.15 g/cc, wherein the mixture of the first thermoplastic polymer and the gas releasing composition has a higher bulk density than gas releasing composition and is a substantially free-flowing non-dusting powder. In another aspect, the invention provides a polymeric matrix comprising the biocidal composition and a second thermoplastic polymer. Both the biocidal composition and the biocidal composition in the polymeric matrix are suitable for commercial manufacture of extruded, injection molded or blow molded articles, films, sheets, and the like.

Abstract: The present application refers to pharmaceutical preparations comprising an active ingredient and a carrier wherein the carrier comprises an aqueous electrochemically activated salt solution.

Abstract: Provided are materials that effectively kill pathogenic bacteria and other organisms. Also disclosed are methods that concern the use of materials having biocidal activity, and biocidal systems that incorporate such materials.

Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.

Abstract: The invention provides a bactericidal/algicidal method including adding an oxidant-based bactericidal/algicidal agent and a stabilizer therefor to a target water system, characterized in that the amount of combined chlorine or the stabilizer in the water system is controlled by generating free residual chlorine in the water system, and a bactericidal/algicidal method including adding an oxidant-based bactericidal/algicidal agent and a stabilizer therefor to a target water system, characterized in that the amount of the oxidant-based bactericidal/algicidal agent added is controlled so that the concentration of total residual chlorine in the water system falls within a predetermined range, and the amount of combined chlorine or the stabilizer is controlled so that the concentration of free residual chlorine in the water system falls within a predetermined range.

Abstract: The present invention provides a method of inhibiting at least one of allergic asthma, allergic rhinitis and atopic. The present invention further provides a method for the reduction, prevention or treatment of allergy like symptoms in a subject.

Abstract: The present invention generally relates to an improved two-part oxidizing system, as well as oxidizing compositions and methods for making and using the same, and in a particular embodiment to a two-part oxidizing system that, when mixed, yields an oxidizing composition. The two-part oxidizing system includes a metal chlorite first part, and an acid second part where the acid is sodium acid sulfate or a derivative thereof.

Abstract: A stable oxidizing bromine biocidal composition comprising at least one stable oxidizing bromine compound that is prepared from at least one oxidizing chemical reagent, at least one bromide source and at least one bromine or halogen stabilizer, wherein the molar ratio of bromide source to stable oxidizing bromine compound is at least about 2.1, methods of making the composition and methods of using the composition as a biocide in aqueous systems.

Abstract: Devices are provided which are functionalized to include surface regions having anti-infective agents. Methods are provided for functionalizing various material surfaces to include active surface regions for binding anti-infective agents. Methods are provided by which anti-infective moieties or agents are bonded to functionalized surfaces.

Abstract: The invention relates to an enveloping membrane for discharging an enclosed agent in an aqueous medium. The aqueous solution of an oxidizing chlorine-oxygen compound is enclosed is said enveloping membrane which is insoluble in a neutral aqueous medium. In an advantageous embodiment, the enveloping membrane represents a capsule structure, particularly according to the core/shell principle. The core has a spongy, moist structure and contains the aqueous solution of an oxidizing chlorine-oxygen compound while the shell is water-insoluble and is provided with pores to discharge the chlorine-oxygen compound over an extended period of time, particularly in an aqueous medium.

Abstract: A composition for anti-microbial effect in a water system such as a pulp and paper processing line with an aqueous slurry. The composition comprises a free chlorine-generating biocide comprising a chlorine source, urea, and an alkali in a concentration sufficient to provide a pH greater than 10, and typically at least pH 11.

Abstract: Methods, devices, compositions, and systems for the alleviation of non-oral biological tissue infections by administration of chlorine dioxide are provided.