Abstract: Ectoparasites, such as fleas, ticks, mites and lice, are removed from a human or animal host after applying a composition that causes the temperature of the treated area to become higher or lower than normal. In one embodiment, treatment is effected by applying a composition that releases heat when contacted with water. The elevated or decreased temperature immobilizes the parasites and facilitates their mechanical removal, such as by combing.
Type:
Grant
Filed:
June 11, 2001
Date of Patent:
February 3, 2004
Assignee:
Schering-Plough HealthCare Products, Inc.
Inventors:
Kurt G. Van Scoik, Marcia S. Schlesinger
Abstract: The invention provides a composition for oral administration comprising a mixture of a statin, docosahexaenoic acid “DHA”, vitamin E, vitamin C, vitamin B6, vitamin B12, folic acid, and calcium together with a suitable carrier. These compositions are particularly useful as dietary supplements administered to reduce the risk factors of cardiovascular disease, such as elevated serum cholesterol levels and high blood pressure.
Abstract: The present invention relates to dietary supplements containing low doses of phytoestrogens for supplementing the specific phytochemical dietary needs of perimenopausal and menopausal women.
Abstract: Physiologically acceptable aqueous solutions and methods for their use are provided. The subject solutions comprise: electrolytes; a dynamic buffering system and an oncotic agent; and do not comprise a conventional biological buffer. The subject solutions find use in a variety of applications, particularly in those applications where at least a portion of a host's blood volume is replaced with a blood substitute.
Type:
Grant
Filed:
April 20, 2000
Date of Patent:
January 20, 2004
Assignee:
BioTime, Inc.
Inventors:
Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall
Abstract: The key to the unique formulation is a combination of specific vitamins, minerals, herbs and nutrients. These essential components in the amounts provided uniquely contribute to improved blood sugar levels and insulin delivery to the cells. The formulation contains essential amounts of Calcium, magnesium Vitamin D, Vitamin K-1, Folic Acid and Soy Isoflavones, as well as other ingredients and healthy filler components.
Abstract: A method of treating SLE symptoms of an SLE patient comprising administering to an SLE patient an amount of vitamin D compound effective to reduce symptoms and observing a reduction in symptoms is disclosed.
Type:
Grant
Filed:
October 21, 1999
Date of Patent:
January 6, 2004
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Hector F. DeLuca, Margherita T. Cantorna, Jean Humpal-Winter
Abstract: Provided are methods and topical pharmaceutical formulations for the treatment of inflammatory dermatoses. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations are particularly suited to the treatment of acne vulgaris.
Type:
Application
Filed:
June 21, 2002
Publication date:
December 25, 2003
Inventors:
Howard I. Maibach, Eric C. Luo, Tsung-Min Hsu
Abstract: Provided are methods and topical pharmaceutical formulations for use in the treatment of warts. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations can be used to treat human papilloma virus infections, particularly cutaneous warts.
Type:
Application
Filed:
June 21, 2002
Publication date:
December 25, 2003
Inventors:
Howard I. Maibach, Eric C. Luo, Tsung-Min Hsu
Abstract: NGF microencapsulation compositions having controlled release characteristics, preferably with increased stability, for the NGF component, particularly human recombinant NGF (“rhNGF”) are provided that yield enhanced stability of NGF for use in promoting nerve cell growth, repair, survival, differentiation, maturation or function. Methods for making and using such compositions are also provided.
Type:
Grant
Filed:
June 11, 1998
Date of Patent:
December 16, 2003
Assignee:
Genentech, Inc.
Inventors:
Jeffrey L. Cleland, Xanthe M. Lam, Eileen T. Duenas
Abstract: A solid orally administrable pharmaceutical dosage form for the treatment of gastric disorders includes a first portion containing a therapeutically effective amount of a histamine H2-receptor antagonist, and a second portion immediately adjacent the first portion without an intervening barrier disposed between the first portion and the second portion, the second portion containing a therapeutically effective amount of an antacid. Physical separation of the active ingredients into two different portions without a separating barrier has been found sufficient to prevent degradation of the histamine H2-receptor antagonist due to contact with the antacid. The invention therefore provides stabilization of a histamine H2-receptor antagonist-antacid combination tablet which is comparable to known multiple portion tablets, but without an intervening barrier between the antacid portion and the histamine H2-receptor antagonist portion.
Abstract: The present invention relates to a new makeup kit comprising a first, goniochromatic pigment composition which is intended to form a base layer and a second, conventional pigment composition having one of the colors of the first pigment, the second composition being intended to form a surface layer comprising decorative motifs. Depending on the viewing angle, therefore, it is possible to see the said motifs appear or disappear. This kit is intended in particular for making up the nails, lips, cheeks or eyelids, or else the body. The invention also relates to a method of making up the human face, lips or body.
Abstract: The present invention provides a formulation for the delivery of bioactive constituents to biological surfaces, wherein said formulation comprises a suspensions or solution of at least one isolated and purified casein protein or salt thereof, in water, together with at least one bioactive constituent.
Abstract: A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral “gum” and other “skin” (epithelial) tissues. The composition is preferably in the form of a paste which promotes ease of application and use of the composition. A variety of instruments can be used in application and cleanup of the composition showing versatile unparalleled friendly usage. The composition preferably comprises aluminum chloride, ferric sulfate (subsulfate), regenerated oxidized cellulose, aluminum ammonium sulfate, absorbable gelatin and a solvent. The composition has many dental and medical procedure applications.
Abstract: A composition includes calcium sulfate hemihydrate, an accelerant material, e.g., calcium sulfate dihydrate, a plasticizing material, a mixing solution, and demineralized bone matrix having a moisture content of between about 10 and about 30 weight percent.
Type:
Grant
Filed:
June 24, 2002
Date of Patent:
November 25, 2003
Assignee:
Wright Medical Technology, Inc.
Inventors:
Kelly Coupe Richelsoph, Leasa C. Miller
Abstract: This invention relates to a method and compositions for the treatment and prevention of disorders associated with endothelial dysfunction consisting of anti-inflammatory agents and dietary supplements.
Abstract: A highly safe bone resorption suppressing agents, which can be used as medicines or admixed to food products or feeds, is produced. Milk-derived basic cystatins and/or milk-derived basic cystatin decomposition products prepared from milk are made into bone resorption suppressing agents, or admixed to drinks, food products and feeds.
Abstract: A method of and composition for diminishing multiple sclerosis symptoms are disclosed. In one embodiment, the method comprises the step of administrating an amount of calcium and a vitamin D compound effect to diminish multiple sclerosis symptoms. In another embodiment, the invention is a pharmaceutical composition comprising an amount of calcium and vitamin D compound effective to diminish multiple sclerosis symptoms.
Type:
Application
Filed:
April 2, 2003
Publication date:
November 6, 2003
Inventors:
Hector F. DeLuca, Margheritea T. Cantorna, Jean Humpal-Winter
Abstract: The field of colonic diagnostic and surgical procedures is hampered by the lack of optimal means available to cleanse the colon. A compromise between convenient, distasteful, solid or low volume, hyperosmotic solutions which cause considerable fluid and electrolyte imbalances in patients and large volume, difficult to consume, iso-osmotic solutions has had to be made heretofore. This invention describes a low volume, hyperosmotic solution consisting of sulfate salts with and with out polyethylene glycol. Unlike prior art, this composition is useful for the cleansing of the bowel and, in lower volumes, as a laxative, without producing clinically significant changes in bodily function.
Abstract: Optimum compounding composition of a local injection preparation for treating rectal submucous lesioned abnormal tissue with local anesthetic is decided to provide a medical composition kit. In a composition kit for the treatment where respective containers are unsealed upon being used and respective contents are mixed to obtain a preparation for injection, a medical composition kit which is characterized in that respective single doses of a therapeutic preparation and local anesthetic are fractionally charged in containers, the said therapeutic preparation contains 1˜10% of a water-soluble aluminum compound and 0.01˜2% of tannic acid and the said local anesthetic contains 0.1˜1% of lidocaine hydrochloride or 0.5˜5% of procaine hydrochloride.
Type:
Application
Filed:
December 31, 2002
Publication date:
October 9, 2003
Inventors:
Kinuko Oku, Takako Iwamoto, Takashi Ono
Abstract: Disinfectant formulations are described which are preferably ecologically friendly and non-toxic to mammals and plants, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having at least one metal ion which is microbicidal to at least one microorganism and potassium sodium tartrate in some form. When potassium sodium tartrate is used with these metal ions, it enhances the complex-forming properties of such metal complexes while concurrently increases their efficacy and potency at the same level of metal ion concentrations. These microbicidal formulations can be diluted in suitable proportions into aqueous systems to produce the desired dosages for each individual case, depending on the level and the severity of the contamination. The microbicidal formulations can be applied by conventional methods, e.g., spraying, soaking, fogging, impregnation, and the like.
Abstract: The present invention relates to method of reducing eye irritation caused by a cosmetic composition comprising incorporating a reducing amount of mineral water into said cosmetic composition.
Type:
Grant
Filed:
June 29, 2000
Date of Patent:
October 7, 2003
Assignee:
Johnson & Johnson Consumer Companies, Inc.
Inventors:
Stanley S. Shapiro, Benjamin C. Wiegand
Abstract: An antiviral agent of an antiviral ability against various viruses and a method of producing the same are provided. A heat treatment is applied to a calcium-containing substance represented by calcium carbonate-containing substances originating from the animal such as clamshell, eggshell, crustacean shell, bone, coral, and pearl, and calcium carbonate-containing minerals such as limestone. When a temperature of the heat treatment is not less than 650° C. and less than a melting point of the calcium component-containing substance, a sufficient time of the heat treatment is 2 to 13 hours.
Abstract: A composition for protecting wood from ultraviolet light degradation, for protecting naturally occurring biological agents in the wood from ultraviolet light degradation, and for protecting organic biological agents added to the wood from ultraviolet light degradation which comprises an aluminum salt-amine compound complex wherein the weight ratio of amine compound to aluminum salt ranges from 1 to 10 to 10 to 1.
Abstract: Decontamination of biological spores occurs by applying a germination solution for spores containing calcium ions, preferably calcium chloride, and dipicolinic acid in combination with a decontaminant. The germination composition may include water and a surfactant. The germination solution allows for lower concentrations of select decontaminants to be effectively used against spore contamination. The germination composition may be applied prior to, concurrently, or sequentially with repeated applications of the decontaminant.
Type:
Application
Filed:
March 6, 2002
Publication date:
September 18, 2003
Inventors:
Amanda S. Schilling, Angela G. Mersiowsky, Susan M. Thomas, Jerry S. Brown, Brian Williamson, Angel A. Fitzgerald, Shelia M. Kuhstoss, Michael Walter
Abstract: A formulation for treating a gastrointestinal disorder is provided. The formulation provides symptomatic relief of symptoms associated with gastrointestinal disorders. Additionally, a method for treating a gastrointestinal disorder comprising administering a therapeutically effective amount of the formulation is provided.
Abstract: A nutrient pharmaceutical formulation composition useful for treating cancer comprising ascorbic acid, L-lysine, L-proline and at least one polyphenol compound selected from the group consisting of epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, catechin and the use of the composition in treating cancer and other tumors are provided. A nutrient pharmaceutical formulation composition of EPICAN FORTE™ and its method of use in treating cancer are also disclosed.
Type:
Application
Filed:
January 13, 2003
Publication date:
September 11, 2003
Inventors:
Shrirang Netke, Aleksandra Niedzwiecki, Matthias Rath
Abstract: The present invention is directed to methods for treating Alzheimer disease and other disorders associated with the presence of neurofibrillary tangles (NFTs) by increasing the activity of a phosphatase towards abnormal hyperphosphorylated tau (“AD P-tau”) present in the NFTs of paired helical filaments in the neurons of patients having Alzheimer disease or other NFT-associated disorder. Pharmaceutical compositions and diagnostic methods are also provided. The inventions provide methods of treatment by administering to a subject a therapeutically effective amount of a composition comprising a molecule which increases protein phosphatase activity toward AD P-tau, a phosphatase which dephosphorylates AD P-tau, or a nucleic acid encoding such a phosphatase.
Type:
Application
Filed:
August 12, 2002
Publication date:
September 4, 2003
Applicant:
Research Foundation for Mental Hygeine, Inc.
Abstract: Compositions and pharmaceutical compositions are described which comprise: a component A comprising one or more flavonol glycosides, a component B comprising one or more tetrahydrofolic acid compounds, a component C comprising one or more calcium supplements, and a component D comprising one or more magnesium supplements. Methods of using such compositions and pharmaceutical compositions to treat and/or prevent osteoporosis and/or an inflammatory joint disease are also described.
Abstract: Improved stability surgical irrigating solutions and methods of use are disclosed. The compositions comprise bifunctional compounds (i.e., compounds comprising antioxidant and antiinflammatory moieties) and physiological antioxidants to stabilize the bifunctional compounds. The compounds are useful in preventing and treating inflammatory and other disorders incident to surgery.
Type:
Application
Filed:
January 10, 2003
Publication date:
July 24, 2003
Inventors:
Mandar V. Shah, Uday Doshi, John C. Liao
Abstract: A material for the enhancement of blood coagulation. The material comprises calcium cations, an inorganic oxide, a clay, an inorganic oxide in combination with calcium cations, a zeolite in combination with calcium cations, a zeolite in combination with an inorganic oxide and combinations thereof. The material when combined with blood reduces the coagulation time of the blood. Also, a method for using the material to promote blood coagulation.
Type:
Application
Filed:
October 25, 2002
Publication date:
July 17, 2003
Inventors:
Francis X. Hursey, Alan Wu, Steven L. Suib, Sandra L. Bushmich, Jia Liu, Beatriz Hincapie
Abstract: The present invention is an orally administered pharmaceutical composition that provides for the controlled release of magnesium. The composition has an interactive agent component and a magnesium component which has an enteric coating that controls the release of the magnesium until the composition is in the small intestine or colon. The other component is released in the stomach and is substantially absorbed prior to the release of the magnesium component. Normally, the interactive agent component decreases the absorption of magnesium when the two components are released simultaneously in the gastrointestinal tract.
Abstract: A method of treating solid neoplastic diseases is disclosed, which involves administering to a host in need of such treatment an effective amount of a pharmaceutically acceptable magnesium salt or complex, which can be a pharmaceutically acceptable inorganic magnesium salt such as magnesium pyrophosphate, or a pharmaceutically acceptable organic magnesium salt. The composition can be administered orally, parenterally, cutaneously or mucosally, and can be given, for example, in an amount of magnesium which is from 2 to 12 mg per kg of body weight daily. Preferred compositions include magnesium lactate, magnesium aspartate, magnesium acetate, and magnesium pyrophosphate. Neoplastic diseases amenable to the method include adenocarcinoma. The method can include administering with the magnesium salt or complex an effective amount of a pharmaceutically acceptable magnesium fixing substance, such as vitamin B6.
Abstract: A method of treating gastric acid disorders by administering to a patient a pharmaceutical composition comprising a proton pump inhibitor (PPI) in a pharmaceutically acceptable carrier.
Abstract: Provided are compositions and methods for prevention or mitigation of allergic reactions in humans and animals. Novel compositions comprised of, e.g., an acidic salt solution of aluminum, calcium or magnesium, are provided for topical or contact application to physically and/or chemically alter an allergenic protein present in the environment and thereby lower the allergenicity of the protein. The compositions of the invention, e.g., comprised of aluminum sulfate, can be used to deactivate many types of proteinaceous allergens such as dust mite and cockroach body dust, animal dander, dried saliva, mold spore antigens, airborne pollen protein and the like. Compositions can be applied on an as needed basis to a wide variety of surfaces, e.g., floor coverings, walls bedding, window coverings, vehicle (e.g., automobile) interiors, furniture, pet bedding, plants (e.g., household plants) and the like. The compositions provided may also be utilized to mitigate allergens present on clothing, e.g.
Abstract: The invention relates to a method and composition for destroying or inhibiting proliferation of microbes using oxidative fluorinator compounds. Fluoride salts that do not dissociate completely in aqueous solutions, such as tri- or tetravalent transition metal fluorides, inert gas fluorides, or tri- or tetravalent rare earth fluorides, are effective antimicrobial agents even at levels up to about 20 ppm, when used alone or in conjunction with a strong oxidizer.
Abstract: The present invention relates to a water soluble acidic copper wood preservative composition with good copper fixation, and without environmental challenged hexavalent chromium. The composition comprises a water soluble acidic copper pesticide combined with aluminum nitrate wherein the weight ratio of aluminum nitrate to copper ranges from 1 to 10 to 10 to 1.
Abstract: A dietary supplement blend composition is disclosed, the basic formulation of the composition containing vitamins, minerals, and carotenoids. The composition can also contain bioflavonoids, cartilage protectors such as glucosamine or chondroitin, &agr;-lipoic acid, coenzyme Q10, and a source of omega-3 fatty acids such as flax seed oil. The composition is beneficial for improving health and preventing disease, particularly for degenerative conditions. A method for supplementing the diet is also disclosed, wherein the quantity of daily rations of the dietary supplement blend composition is determined based on the person's age, body weight, and quality of diet.
Abstract: A treatment for brain, spinal and nerve injury comprising use of a substance P receptor antagonist optionally in combination with a magnesium compound. There is also provided a formulation for use in this treatment comprising a substance P receptor antagonist and a magnesium compound.
Abstract: A method of controlling algae in a municipal water plant including the step of adding an algicide-flocculant solution including 25-50 wt % acidic flocculent, 0-10 wt % polymer flocculant aid, an algicide consisting essentially of copper having a concentration of 0.025-1.275 wt % in the form of a water soluble copper salt, balance water. The algicide-flocculant solution may be added to the water via a clarifier of the water plant, a basin of the water plant, or a mixing chamber. The mixing chamber may be located within the clarifier, adjacent to the basin, or upstream of the clarifier and/or the basin.
Abstract: The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.
Type:
Grant
Filed:
January 24, 2000
Date of Patent:
June 3, 2003
Inventors:
David S. Roberts, Leroy A. Swearingin, Don A. Dearwester
Abstract: Compounds for the prevention and retardation of diabetic retinopathy, and the loss of visual acuity and blindness that can be caused by diabetic retinopathy. The compounds may include a magnesium salt, a vasodilator, aminoguanidine, an anti-inflammatory agent, and an antioxidant.
Type:
Application
Filed:
November 16, 2001
Publication date:
May 29, 2003
Inventors:
Oliver E. Turner, John J. Abbott, David H. Kinder
Abstract: A method of preventing or treating hypomagnesemia in pediatric patients and patients with G-tubes or NG-tubes comprising the step of administering a pharmaceutical composition comprised of a magnesium salt, magnesium-L-aspartate hydrochloride, in a water-soluble powder concentrate. When dissolved in water, the pharmaceutical composition provides a method for preventing or treating hypomagnesemia in such patients without compromising the absorption or efficacy of the pharmaceutical composition.
Type:
Application
Filed:
November 19, 2001
Publication date:
May 29, 2003
Inventors:
Michael B. McMains, Caren D. Geppert, Missy L. Siegel
Abstract: The present disclosure relates to novel nutritional compositions and methods for augmenting the possibility of conception while increasing nutritional stores to aid development of healthy embryos and child growth. The nutritional compositions are intended for use by both males and females planning to conceive a child.
Abstract: A supplement is disclosed for use by naturally or surgically menopausal women. The supplement includes: Estrogen, Selenium, Zinc, Chromium, Calcium, Copper, Phosphorus, Magnesium, Molybdenum, Iodine, Beta Carotene, Ascorbic Acid, Vitamin D, Vitamin E, Vitamin K, Thiamin, Riboflavin, Vitamin B6, Vitamin B12, Folic Acid, Iron, Pantothenic Acid, and Biotin. The supplement provides hormone replacement therapy along with nutritional supplements.
Type:
Application
Filed:
September 23, 2002
Publication date:
May 22, 2003
Inventors:
Caroline Maxine Schloss, Dorothy Jean Fox
Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among children.
Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among adolescents.
Abstract: A method for promoting colon health in a subject comprising administering a dose of calcium to the subject that is effective to reduce carcinogenesis. Particularly provided is a method for reducing the risk of recurrence of colorectal adenomas, comprising administering a dose of calcium carbonate effective to promote colon health. In an example, 1200 mg of elemental calcium (supplied in 3000 mg of calcium carbonate) administered once or twice daily resulted in decreased risk of recurrent colorectal adenomas in patients with a history of colorectal adenomas.
Abstract: A nutritional supplement includes flaxseed oil, ginger, sesame, citrus, garlic, tumeric, vitamins and minerals. The nutritional supplement preferably includes about 400 to 800 mg of flaxseed oil, about 50 to 100 mg of ginger, about 50 to 100 mg of sesame, about 50 to 100 mg of citrus, about 50 to 100 of garlic, about 10 to 30 mg of tumeric, about 6 to 10 mg of Vitamin C, about 1 to 5 IU of Vitamin E, about 0.25 to 1 mg of Vitamin B6, about 0.25 to 1 mg of niacin, about 3 to 6 mg of magnesium, and about 0.25 to 1 mg of zinc. The nutritional supplement may be used in a method of treating inflammation by administering to a patient in need thereof an effective dose of the nutritional supplement.
Abstract: The compositions and dosage forms of the invention are clinically useful as methods for increasing the effectiveness, efficiency and safety of biguanides (metformin) and/or sulfonylureas in the prevention and treatment of insulin resistance and diabetes mellitus, alone or in combination, as a nutrient for humans. The carefully chosen active ingredients of the invention are designed in a modular fashion to prevent and rectify adverse events associated with insulin resistance syndrome and diabetes mellitus, and with the clinical use of biguanides (metformin) and/or the sulfonylureas. These modules are: (1) Mitochondrial Metabolic Group, (2) Plasma and Mitochondrial Membrane Integrity Group, (3) Nocturnal Group and, (4) Insulin Alternative Group. When used in concert with a biguanide, a sulfonylurea or with a combination of both, the invention will broaden the clinical usefulness of these drugs.
Abstract: A method for treating wood, characterized by impregnating wood with a metal-containing treating agent containing lignin and/or lignin derivatives and a metal, a metal compound, and/or a metal ion and oxidizing and/or macromolecularizing of the lignin and/or lignin derivatives in the wood to fix the metal component in the wood, and wood and woody materials obtained by the treating method. According to the method of the present invention, while effectively utilizing lignins, lignosulfonic acids, or lignosulfonic acid salts, leaching of the metal component can be suppressed to a low level to thereby retain the effects due to the incorporation of the metal components for a prolonged period.